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a H_ie AR226-00333 May 18, 2000 MAIL Dr. Charles Auer Director Chemical Control Division Office Of Pollution Prevention And Toxics United States Environmental Protection Agency 4R0o1omM 4S0tr3eeEta,sStoTuotwhewres(tMail Code 7405) Washington, D. C. 20460 Re: Information On Perfluorooctane Sulfonates And Related Compounds Dear Charlie: Pursuant to our recent communications, 3M is enclosing additional iinnffoorrmmaattiioonn osunpppelrefmleunotrosoicntfaonremsatuilofnonsautbemsiatnteddrteolaytoeud cproemvpioouunsdlys.undTehreceonvcelroosfedour April 21,2000 and Voluntary basis as May 4, partof 2000 letters. our continuing Adgiasicnu,sswieonasrewiptrhovEiPdAingretghairsdiinnfgormation on a fluorochemistry. Please note that someofthis information qualifies as confidential business information (CBI); we also have enclosed a sanitized version of CBI documents. The enclosed information covers perfluorooctane sulfonates and certain related compounds listed in Table 1 of the document entitled: "Sulfonated Perfluorochemicals In The Environment: Sources, Dispersion, Fate And Effects", at 12 (March 1, 2000). Specifically, the information covers the following chemicals: 72-5 (lithium salt). = Perfluorooctane sulfonates, including CAS numbers 1763-23-1 (acid); 29081-56- 9 (ammonium salt); 70225-14-8 (DEA salt); 2795-39-3 (potassium-salt); 29457- = Perfluorooctanesulfonyl fluoride 005983 Charles Auer May 18, 2000 Page 2 = Perfluorooctanesulfonamide = Perfluorooctane sulfonylamido (ethyl) acetate = Perfluorodecanesuifonate = Perfluorohexane sulfonate = N-ethyl perfluorooctanesufonamide = N-methylperfluorooctanesulfonamide = N-ethylperfiuorooctanesulfonamidoethanol = N-methylperfiuorooctane sulfonamidoethanol = N-ethylperfluorooctanestifonamidaocerytlhaytle = N-ethylperfluorooctanestifonamidaocerytlhaytle = N-ethylperfiuorooctanesulfonammeithdaocerytlhaytel = N-methyl perfluorooctanesulfonamidoethyl acrylate previously 3M under has provided you coverof our April with information on perfluorooctane sulfonates 21, 2000 and May 4, 2000 letters. We are enclosing some additional information on perflucrooctane sulfonates located as part of our continuing file search. For each of information includes the following: the foregoing related compounds, the enclosed = Copiesofpost-1976 studies and certain other information relating to the following eennvviirroonnmmeennttaall fsactieenacnedatrreaanss:por(ti); p(hiiy)siecnavliraonndmecnhteamlicmaolniptroorpienrgt;ieasn;d(i(i)iv) secuomtomxaicriyt"y.forFmoart.eac3hMsatlurdey,ad3yMhahsasprporveipdaerdeydoau swiutmhmaargyenienratlheexHePcVut"irvoebust `summary addressing each of these areas under coverofour May 4, 2000 letter. = Cheoaplitehseofffepcotssta-r1e9as7:6 s(ti)udaiceustaentdoxciecirttyai(nii)otgheenortioxnifcoirtmya;tiioin)rreelpateiantgetdo-tdhoesefotlolxiocwiitnyg; (iv) pharmacokinetics; (v) teratology, and (vi) medical surveillance and epidemiology. 3M has included a detailed indexof this information subdivided by each compound. 005984 Charles Auer May 18, 2000 Page 3 = Listsofall studies in progress and planned studies, along with study protocols or study plans, where available. = Abibliography of pre-1876 studies subdivided by each compound. = Athbaitbwlieogarraepphryoovfidaicnugtceotpoixeisciotyf skteuydiaecsutseubsdtiuvdiideesd(wbiythearcefhecreonmcpeotuondth,eeHxPceVpt guidance). = Abibliography of published studies in 3M's possession. = APnleiansdeexnootfestthuadtitehsisini3nd'esx hpaosssbeesesniosnubbmeiltiteevdedatsoCbBeI.in3thMeaFlIrFeaRdAydhoacksetp.rovided the the Agency with a TSCA Section lst of all fluorochemical-related 8(e) docket. submissions made by 3M to information as3aMppirsocpornitaitneu.inAgsitysofuilererveiveiwewthainsdinwfilolrmsautpiopnl,emweentastkhetheantcyloousebdear several points in mind: = The enclosed information spans several boxes. We have organized the information in each To ensure that you box and with your labeled file folders and indices to staff are able to access the most aid EPA's pertinent review. information, we also other information. are attaching to this letter the indices covering studies and = Manyof the studies refer to the test substance only by a 3M product identification bneuemnbeirncwliutdheda,"wT*h,erLe" aovrai"lFaCb"lep,reiftiixs.ofAtletnhonoutghpoasnsailbylseistoofdettheertmeistnesufbrsotmatnhcee has study report tself the identity of the test substance. Thus, we have used the index to provide this information based on 3M's historical records keyed to the p3rMovpirdoedducstpenciufmibceirnftoormdaettieornmoinnettheheicndoemxp,ossiutcihonaosfptehrecetnetstcosmupbosstiatnicoen,ansodlvheanvte rcoanntgexet,resfaelrtsftoorma alonwdeprupruirtiytgyrgardea.deoPfletahseecnoomtpeotuhnadt,thaentder"mnaornrotwherainngdee"xr"ewfiedres tfooramuhliagthieornspuhriatvyegreavdoel.vedFinoavlelry,tihtesyheoaurlsd,baendretchougs,niszoedmethoaft tphreodtuescttsubstances do not constitute current products. = We have included some additional studies on perfluorooctane sulfonates located aysoupawritthofinofuorrmcaotnitoinnuoinngmfiixleturreevsiecwo.ntAasinwineg have discussed, perfluorooctane we plan to sulfonates provide in the near with future. studies Please be advised, however, that and other information on aqueous we already have provided you andor solvent solutions of 005985 Charles Auer May 18, 2000 Page 4 epenrcfllouscerdooicntfaonremastuilofnonlaitkeesw.iseAsintcolutdheesfsotruedgioeisnganredlcaetretdacinomoptoheurnddso,cutmheents on cbootmhpotuhendcso.mpWoeunadrse ansotweplrlovaisdionng atoquyeoouutsodaanyd,/ohrowseovlevern,tisnoflourtmiaotnisoonfotnheosteh.er types of mixtures containing information with you. these compounds and would like to discuss such = Consistent with the information previously provided on perfiuorooctane sulfonates, 3M has related compounds. not provided Rather, we you with all analytical chemistry have enclosed certain analytical reports on chemistry these. reports which may understanding the prove details uosfefaunlaltyotiEcaPlAchinemiinstetrrpyremteitnhgocdesr;taoinr studies; verifying human `and biomonitoring data. = We provided previously under coverofour April 28, 2000 letter to Oscar Hernandez a "Use And Exposure Information Profile" or "UIP for perfluorooctane sulfonates. Our present intention is to provide you with cadodmiptlieontaeldtUimEeIPtofcolrarmisfyfoirndtuhstersiealrehlyagtieednceoamnpdouotnhdesr eraerlleyasneexitnfwoeremka.tio3nMtoneeds ensure that the data is accurate and placed in appropriate context. = The information on perfiuorooctane sulfonates sent under cover of our May 4, 2K0e0n0WaeltlearcienocflutdheedUdnoivceurmseitnytsofrMeilantniensgottoa.ongPolienagsemencohtaentihsattitchirsesreeasrecahrcbhyaDlrs.o eUnnicvoermspiatsysoefsRotchheessetreerlaMteeddiccoalmpCoeunntdesr.is Ipneradfdoirtmiionn,g cDro.mpMaarraitoinveAnmdeetrasbooflitshme research there are relating to perfluorooctane sulfonates and these related not documents yet available relating to this research. chemicals; 005986 Charles Auer May 18, 2000 Page 5 3M looks forward to discussing the enclosed information with you and other EPA staff. In the meantime, please do not hesitate to contact me withany questions. Very truly yours Hillis QS fpr William A. Weppner, Ph.D Director of Environmental, Health, And Regulatory Affairs Specialty Materials Markets 3M Bldg 236-1B-10 3M Center St. Paul, MN 55144 (651) 733-6374 (phone) (651) 733-1958 (fax) E-mail: waweppner@mmm.com Safety Enclosures 005987 Perfluorooctane sulfonylamido(ethyl)acetate = PFOSAA S12y9n,onEy2m1s1:3,FEC2-516069.,2,FCR-119000.4X, FC-128, FC- PhysicallChemical Properties Eintveironmental Fate and Transport [[TEencvhioRnempeornttaFa(stica)o(fWaFrubourrogmhreerspmiircoamsetnerFmethod for biodegradston of FC-128) TabAoruatthoorry or|| Comaptleeted Tyee Tab`oAruantoorryor|| comDpalteeted Ew Lab| 1276 | Rebust sumrmeaproryt, Gehan ee ____ _-------- ------| [Fish dota sheets wopon data sheets [ [Ready bodegradaboifiFyC-108X - BODICOD Labor1 aPtaocreies. --ROc-- oUmTpu-- tseurmmra-- ersyu,sc-- roopymof Mimaspols, WN arches Siutmemary Reports TabAourtahtoorry or " Tyee iEctoteoxiciy Elements |Acute toxic of FC-128 to fathead minnow __| |Acute toxicty of FG-12 to fathead minnow |Acute toxicty of FG-128 to fathead minnow |A[TcouxitceittyooxficFC-o1f2F7C-to12a7citvoatfaetdhselauddmgeinnow | respiration LabAourtahtoorry or| CompDlaetetion aM Env. Lab| starz 6074 ansrr7 3M Env. Lab | 724781 MEnv. Lab| artast Tipe Robust sduatmamasrhyee.tcsopes of Robust dsaulmamasrheye,tscopies of Robust sdautmamasrheye.tcsopies of Robust dsautmamasrheye.tcsomes of Robust dsautmamasrhyee,tscopies of 005988 S[RceraedeyniBnigodTeegsrta'dafboiritFyi:uor"aMdodFiCf-i1ed29OECD RSCwCit,zelrtiinagnedn,| 0/19/84 [[AMcitcirvoabtiecdsSMiiucdrogteoxReTsopxiicritaytioTneIsnthi-biFtCi-on10-9F-CX-100]| 3M Env. Lab| 10rtsie7 x 3MEnv. Lab| 103087 ABC |Acute Toxicity of E2566-2 to Daphnia magna_| CLoalbuomrbaitao,ryM,O|_ 1/0/88 |Acute Toxicity of 2566-2 to Fathead Minnow | ABC Laboratory, (Pimephales promelas Columbia, MO| 1/12/88 Pace Labornact.o,ries, [s[uBbisodteagnrcaed)ation (methylene blue active Minneapolis, MN 215089 ASC |Acute Toxicity of R104 to Daphnia magna CDourlpuotrha,tiMoN_n|, 617197 [Growth Inhibition of R1904 for Green Alga ASCH Corporation, Selenastrum capricomutum) Duluth MN_| eraser [Acute Toxicity of R1904 to Fathead Minnow Asal | Corporation, (Pimephales promelas Duluth, MN_| _er27787 CorpoArSaCtHion, |Microbics Microtox Toxicity Test - FC-120 Duluth MN_| 7/9167 Inhibition of R1904 for Activated Sludge CorpoArSactlion, Respiration Duluth, MN_| 711017 ASCH [R1904 BODRepoforr3tM Company CoDruplourtaht,iMoNn_, | _yuro7 aRboobuutssttusduymrmealrabyi.ltmy,efminoal [Robust sumrmepaorryt. copies of Rabust sduamtamasrhye.stcsopies of data sheets Robust summary, final report Robust sruempomratry, final [Robruespotrts,umcmoapireys, ocfodmaptuater] sheets Robust sruepmomratry, final Robust summary, final report Robust sruepmomratry, final Robust summary, copies off data sheets Robust sruempomratry, inal Robust sruepmomratry, final 005989 N-MeFOSE Alcohol 7Sy9n0o(nMymesE: tFFMOS39E25m,ixL)45c2c87,96L--1403,09F,MPP3A9-7749,1c,c P7P9A6-3 Physical/Chemical Properties [Tech Rep-oSolrubitlty of FM 3925 oTrabAoruatthoorry||ComDpaltee.ted Type [Rleoxbcuersptt sfurmommaTreyc.h (reecphorrtep-ort. 3MEnv. | 1/879, Lab | 17179 |[ASnuaplpyotritc,al1M1e7t7ho0dology and [TEintveironmental Fato and Transport oTrabAoruatthoorry|| Compplaetteion, Tye Tech [Tech RRepeortp-- CBohieodmreigctraaldaOtxiyogneSntuDdiees monaoFfnMFd3M92359,25| 3M Env Lab| 118179, 1/8/78 [Robust [reports summary,2 technical Tech Report- Distribution |Octanoiwater coefficient of FM 3525 in n-| 3M Env. tab | 11079 [Robust |report summary, technical [Tech Repo-Adrsortption of FM-3925 on Soil 3MEnv. Lab | | 3/22/79, 519/93 [R|oS bBuosytdsu(MmSmU)a.ryt,ecchrintiicqaulefrrepoomrt [[TTeencnh. RReipvoerrtF-isBhi,oTaeccchu.muRlatieon-oFp flFuiouo roorcohcrehmeimct iaclaslsinin [Tennessee River Fish, Ar No. 7238 -Determination of| 3M Env. | 1520/22281/7799,, [R|Jo.bW.uGsitllseutmtm(aCroym,eyc)ri,ti3que from [Fivorinated Alcohols in Fish Extracts Lab | 1023779 [technical reports `SummaryReports Moe ---- oTrabAourtahtoorry|| Compplateetion 11] [EFciotteoxicityElements [Tech Report- Aquatic Toxicity Studies: FM 3925 oTrabAourtahtoorry||Compplaetetion Type 3M Env. [[dRaopbhunsita,sucompmiaersioefsdfaotrafisshheeatnsd, Lab 1879_ technical repo 005990 POSF Synonyms: Fx8 Physicachamica Properties Watersoubity estimate (screen) TovAourthsotroroyr || comopwleetes sMEny tab | 517191834, |E[RoTbuucstkesruimmbawrayr.icsrhieqsutesby Envicormental Fat and Transport Taborstoroyr |Gampieton [[RP EensvreoonrmseartlaolfAPsOpSeFctesnvO ionment Fare S | owieennevv..rLLaabb[T |rTmaDastoe || TTS eeechhmenacrtrrapeopnor----] Summary Ropors Taborbsetroroyr ComBaptrear Toe Wp ore ------ epe Ecioteoxicty Elaments Toborstoorry Campion Tove o6-nour Toy toFatheadMinow ber Bate Mem tab | amma [RsohboGotast suada [rTe-stinute Exposure Actvaied Sludge ToxsTy Men Lab | sits _R[osnbeuestst samira Ga 005991 Methyl FOSEA PhysicaitchamicalProperties [S037 Sabi ofMeFOSEA Tn Aqueous Burs CabAourthaotroorr|y] comaptleeted Tove pUestiencgtiGonas Chromatography with Atomic Emission 6/14/69 [RToebcuhsnitcaSluRmempaorrty and Environmenta Fate and Transport ([ODcettaenromiinWaattieorn)ooffhTe-5P96a9r.t4.on Cosfiaert(N- Tabourtahtaorryof : Lo sm Env tab| 19994 [TReocbhunsitcaSluRmempaorrty ard 005992 Ethyl FOSEA Simonyms: FX.13 81226, 0:1 Erythema rere Teto| commres = eosyetmryis ncrasricaitproopatonsat |Cr pi2ny 0 van. dpen] 21450 | postsummary. eer Envtonmentat reantTape Fem Sedo TPTEOE Coavey|| Caoem LL fi easy Soseradainy Testor0-1 mCpragay csccumuaton suoSample 0-1 wit Cap| Ohant Robust uSmoa, al Rous summary, tal ---- atrryor|| Com = cue toy ofp13tonesmin | em tab | ari Roa baTsi 005993 Perfluorodecanesulfonate, Ammonium Salt (PFDS) Synonyms: FC-120, FC-121, LR 42004 PhysicallChemical Properties [p NoneAvarabe e Tab`oAurtahtororoyr|] c] omBpalteeted Toe Environments Fate and Transport TabAourthsotroorry|] ComBpalteeted 800/COD Testing Resuts Fe-120 [BODICOD Testing Resuts Fo-121:x Summary Reports (oneavaible ---- iPnaccoerporated, Muinnneapois, sum r[eRpoobrutst summary, ab LPaabcoreatories, Miinnc,neapois, [Robust summary, ab wn 1187 report Teb`oAurtshtoroorry|] comBpalteeted Toe Ecotosicity Elements [Foxy of FC-TtoW2ieTroXor [Fowety oT FC-1Tos2ca7reXd sud [Acute ToxiofcEi25t66y-1to Dap magh na(n FC-i 121a -X) lro[AmceileaTso)it of 26661 1 Fathead Minnow(imephales aboaurtahtoor| orry] ComDpalteetion Tove Tn. Lab Rosbutmmsaraymshae,et65 Ew. (3b| T0307 | Robussutmmsaurmymahroys.tiT CLoalbuomrAbaBtioaCr,iMesO,) Robust s"uompomratry, final | LaborAaBtoCries, | Calambi, MO) W588 | Roburstomsufimnmaarreyp.oretxo mEnsviDriovsisyisotne, [[SPtiamtiecpAhcaluetse pTorxoimceiityaosf FG-120 to the Fathead Minnow, [[ARneasloyusrtcseIc. Hampton, Ni ware, 102 [Rroepbourstt summary, final 005994 [stDaatpihcnAiacmutaegTnoaricty of FC-120 to the Daphid [OECD Activated STudge Respiration Tan Test irobies Misrotox Test- F120 EmnsviDiovsiysisotne, |Raensaoisutrsc,enc Hampton, Ni|_rev. 1952 Rreopbourstt summary, final Robust summary, Gata 3 Env. Lab sRhoebeutsst summary, da 005995 BiAbtltiaocghrmaepnhtysoftoPuLbetltiesrhetdo CLi.tAeuraetrurdeatiend3MM'asyP1o8s,se2s0s0i0on 1. POSF - Perfluorooctanesulfonyl fluoride No literature located. 2. FOSA - Perfluorooctanesulfonamide Aitmsemnadjaolre,meRtaFb,olJi.tTe.iSntreawtarbtl,ooRd. bMyancnoilndgo,n-acnodlBu.mnViitnajyeacvtiiroansucka.pilDleartyerGmCi-nEaCtiDo.n oJfoGurXn-a0l7o1fand Agricultural and Food Chemistry 37 (1989) 1130-1135. Certohsysl,peTr.fJl.u,oarnodocRt-anGe.sSuclhfnoenlalmmiadnen.(NMEePcFhOaSn)i,smaonfd ittosxmiceittayboofliateunpierqfuleupoersotoicctiadneeNs-ulfonamide (PFOS) to isolated rabbit renal cortical mitochondria (RCM). Toxicologist 9 (1989) 224. Gdirsotsrisbmuatino,n,M.eRli.minTaitsisoune,aannaldypsoitseontfaiafllfuoorribniaotaecdcusmuullfaotniaomnidienpoersatlilcyideex:pAosneedvraaltsu.atMioSn Tohfesis, UniversityofGeorgia, Athens, 1990. Lfloufogrroeanl,ipCh.aSt.i,c Ws.uAlf.onBeasntkos,thRe.Kr.edViamnpdoerrteMdeefirr,e aanntd, SDo.Fl.enWoiplsliisamisn.vicRreasi(dHuyamlentooxpitceirtay,of some Formicidac). Florida Entomologist 72 (1989) 140-146 MSualnfnliunrgam,iRd.,0a,,uJn.iVq.ueBrpuoclkynfeluro,rMin.aEt.edMiisnpseacgteilc,idea,ndinJ.tMh.e rBato.wDernu.gMMeettaabboolliissmmaanndddiDsipsopsoistiitoinonof 19.(1990) 205-211 Schnellmann, R.G., and R.O. Manning. uncoupler of oxidative phosphorylation. Perfluorooctane sulfonamide: a Biochinica et Bicphysica Acta structurally 1016 (1990) novel 344-348 dVealnadyeerd-Maecetrio,nRi-nKs.e,ctCiSc.ideLsoffogrrecno,ntarnold oDf.S.olWeinlolpisaimss.inFiilcutoaro(aHlyimpehnaotpitcesrual:fonFeosr:miAcindaeew).clJaossuronfal of Economic Entomology 78 (1985) 1190-1197. Williams, D.F., invicta: control C.S. with Lofgren, and R-K. Vander luoroaliphatic sulfone bait Meer. The toxicants. red imported fire ant, Solenopsis Journalof Agricultural Entomology 4 (1987) 41-47. 3. PFOSAA - Perfluorooctane sulfonylamido (ethyl) acetate No literature located. 4. PFDS - Perfluorodecanesulfonate No literature located. 5. PFHS - Perfluorohexanesulfonate No literature located. 00599 BiAbtltiaocghrmaepnhtysoftoPuLbelttiesrhetdo LCi.tAeuraetrurdeatiend3MMa'yP1o8s,se2s0s0i0on 6. N-EFOSA -- N-cthyl perfluorooctanesulfonamide aAgpapienls,t At.hGe,G,earnmdaSnFc.ocAkbrd-oEalcghha(fDaicrt.yoTpotxeircai:ty,Blsautbtleleltihdaale)e.ffJeotusr,naanldofpeErcfoonromamnicceoEnftSoumlofllougryam8i3d (1990) 1409-1414. (ADpipcetly,opAteGr.a:LaBbloarttaetlolriydaacn)dcofniterlodl.perJfoourrnmaalncoefoEfccoonnosmuimceErnbtaoimtoplroogduyc8t3s (f1or99G0e)r1m5a3n-1c5o9c.kroach iAtmsemnadjaolre,meRtaFb,olIitTe.iSntreawtarbtl,ooRd. bMyancnoilndgo,n-acnodlBu.mnViitnajyeacvtiiroanscuakp.ilDlaertyerGmCi-nEatCiDo.noJfoGurXn-a0l71ofand Agricultural and Food Chemistry 37 (1989) 1130-1135. eCrtohsysl,peTr.fJl.,uoarnodocRt-aGne. sSuclhfnoenlalmmiadnen.(NMEePcFhOaSn)i,smaonfd ittosxmiceittayboolfiateupneirqfuleupoersotoicctiadneeNs-ulfonamide (PFOS) to isolated rabbit renal cortical mitochondria (RCM). Toxicologist 9 (1989) 224. Forschler, Argentine B.T., ants, LainndepEivtahnesm,aGh.Mu.milPeer(iMmaeytre)r (tHryemaetnmoepnttesrtar:ateFgoyrumsiicnigdaceo)nt(aaibnsterraiczte)d. to J. manage Entomol. Sei. 29 (1994) 264-267. Grossman, during and M.R., Mispagel, MLE, after prolonged dietary and Bowen, exposure to aJ.hMi.ghDliystfrliubourtiinoanteadndsutlifsosuneameildimeipneasttiiocnidien. rats Journalof Agric. Food Chem. 40 (1992) 2505-2509. dGirsotsrisbmuatnio,n,MeRl.iminTaitsisoune,aannaldypsoitseontafiafllfuoorrbiniaotaecdcusmuullfaotniaomnidienpoersatlicliydee:xpAosneedvraaltus.atMioSn Tohfesis, University of Georgia, Athens, 1990. fLloufogrroeanl,ipCh.aSt.i,cWs.uAl.fonBeasntkos,thReKr.edViamnpdoerrteMdeefirr,e aanntd, SDo.lFe.noWpislilsiaimnsv.icRreasi(dHuyamlentooxpitceirtay,of some Formicidac). Florida Entomologist 72 (1989) 140-146. SMualnfnliunrgam,iRd.,Oa,,unJ.iVq.ueBproulcykfnleuro,riMn.aEt.edMiinsspeacgteilci,dae,ndinJtMh.e rBato.wDernu.gMMeettaabboolliissmmaanndddiDsipsopsoistiitoinonof 19.(1990) 205-211 PNraobtbeienf.eldA, tDhJe.sisAnsubImnvietstteidgattoitohnoefGtrhaeduEaftfeecStcshoofoFlloufotrhoechUenmiivcearslistoyonfMLiivnenreFsaotttay,AcApirdi-lBi1n9d98i,ng aRcetiido,nBi.Ln.s,ectGi.ciWd.e,Baegnanientstt, tahnedGSe.Jr.mBaanrccaoyc.krTooapcihca(lDiacntdyooprtaelrtao:xiBcliattytlolfidSaucl)f.luJroaumrinda,l aodfelayed- Economic Entomolo8g3y (1990) 148-152. (SDcihcatly,opCt.erSau:lfBlluatrtaemlildidraees)is(atbasntcreacatn).d vJ.apMoerdtiocxailciEtnytionmfoilelodg-yco2l9l(ec2t)e(d1G9e9r2)ma2n07c-o2c1k5r.oaches uSncchonueplllemraonfn,oxRi.dGa.t,iavnedphRo.s0p.hoMraynlnaitniogn..PBeirofclhuiomriooccateatneBiscuplhfyosniacmaidAec:taa 1st0r1u6ct(u1ra9l9l0y)n3o4v4e-l348 eStchhynleplelrmfalnuno,roRo-ctGa.neThseulcfeolnlaumlairdee)ffoecntsraobbfaiturneinqalueprpeosxtiimcaildetuSbuullfelsu.rTamoixdic(oNl-ogy in Vitro 4 (1990) 71-74. 005997 BiAbtltiaocghrmaephnytsoftoPuLbetltiesrhetdo LCi.tAeruaetrurdeatiend3MM'asyP1o8s,se2s0s0i0on cSmoictkhr,oaLchMe,s (ADpipcetlyo,pAteGr.a: TBloaxtitciidtayc,)r(eapbesltlreancct)e., aJ.ndEceoffne.ctEsnotfomsotla.rv8at9i(o2n) compared among (1996) 402-410. brown SSutlufmupr,amDiGd;oNnePmreec-,anMdDP;osHtolnsatoanl,DIeF;vePlioccpamreinllto,, MVaJt;urMaatrieosn, aJTn.d FSetrutidlyiotyfitnhethEefRfaecbtbsitof Toxicology (1997) 357. FS1u7o,5r.mNo-sYa.n, aanndd cRaHs.teSmcshuebftfrearhrna.neLaanbtoerramtiotresy.eJvoaulrunatailoonfofEctownoosmliocw-Eancttoimnogltoogxyic8a4nt(s1a9g9a1i)ns1t70- aSgua,iNn-st-Y(.w,oansudbtReHr.ranSechaenfftrearhmni.teTsopxeicciietsyIasnopdtelretahRalhitniomteeorfmiNt-icdtach.ylFpleorrfilduaorEonotcotmaonleosguilsftonTaLmide (1988) 73-78, aSgua,iNns-tYs.u,blTeorktoarnoe,anM.t,eramnidteRs (HI.soSpctheerfafrRahhinn.otEesrtmiimtaitdiancg) o(rabasltrtaocxti)c.ityJo.fEscloonwo-maictciEnngttoomxoilcaongtys87 (1994) 398-401. SU.uSl.flEurPaAmidO.ffWiacseohfiPnegsttoinc,iDdeCs and Toxic 1989. Substances. Pesticide fact sheet number 205. United States Air Facility. 5 pages. Force, Tyndal AFB, Florida. Environmentally Acceptable Live Fire Training dVealnadyeedr-Maecetiro,nRf-lKu.o,riCn.aSt.edLotfoxgirceann,tsa.nPdeDstFi.cidWeilSlciiaemnsc.eC1o7nt(r1o9l8o6f)S4o4l9e-n4o5p5s.is invicta with odVfealEnacdyoeernd-oMamecietcrio,EnRn-itKn.so,emctCoiScli.odeg7Ls8yoffog(rr1ec9no8,n5t)arno1ld19oD0f-FS1o.1l9eW7in.lolpisaimss.inFiilcutoaro(aHlyimpehnaotipctesrualf:onFeosr:miAcindeaew).clJaosusronfal i`nWviilcltiaa:msc,onDt.rFo.l, wCi.tSh. fLloufogrroeanl,ipahnadtiRc-sKu.lfVoanendbeairtMteoexirc.anTthse. JroeudrinmaploorfteAdgrfiicruelatnutr,aSloElnentoopmsoilsogy 4 (1987) 41-47. 7. N-MeFOSA -- N-methyl perfluorooctanesulfonamide No literature located. 8. N-EtFOSE alcohol - N-ethyl perfluorooctane sulfonamidoethanol PNraobtbeeifne.ldA, tDhJe.sisAnsubImnvietstteidgattoitohneofGtrhaeduEaftfeecStcshoooflFloufotrhoechUenimviecraslistyonofLMiivnenreFsaotttay,AcApirdi-lBi1n9d9i8n.g 9. N-MeFOSE alcohol - N-methyl perfluorooctane sulfonamidocthanol No literature located. 005995 BiAbtltiaocghrmaephnytsoftoPuLbetltiesrhetdo LCi.tAeruaetrurdeatiend3MM'asyP1o8s,se2s0s0i0on 10. N-EtFOSEA ~ N-ethyl perfluorooctane sulfonamidoethyl acrylate No literature located. 11. N-EtFOSEMA ~ N-ethylperfluorooctane sulfonamidoethyl methacrylate No literature located. 12. N-McFOSEA ~ N-methylperfluorooctane sulfonamidoethyl acrylate (Laabswtsroacnt,).R.JG. ,ChJeurms., P.C. Inf. Cluster Comput. Saenia.ly3si0so(f19a9c0r)yl1a3t7e-s14to4.guide sampling for toxicity testing Lawson, RG, (erratum). J. Jurs, Chem. P.C. Inf. Cluster Comput. aScnia.ly3si1so(f19a9c1r)yl3a6t1e.s to guide sampling for toxicity testing 13. PFOS~ Additional references on Perfluorooctane sulfonate PFOS sStchhynleplelrmfalnunor,oRo-cGt.aneThseulcfeolnlaumlairdee)ffoecntsraobbfit 71-74, urneinqalueprpoesxtiimcaildetuSbuullfesl.uraTmoixdic(oNl-ogy in Vitro 4 (1990) PFOSH alDcieviredbrseml(,iabcMsrt.ro,ascHot)om.seosBkbiaoywlavo,agriMic.oau,ls&SpaetProhfhal,ruTomr.aicnDeaiutftefidecrfaealtntcByeuaslcliiendtsit,nhem1e9it(na5db)uocl(ti1ic9oa9nl6ol)fyc7ia6nr5eb-rot76sd7ye.lreisvatteirvaesseofRLfAattiyn rat BPHieaorucfghliuhmoo.rmo,oBciBto.ap,nhoayisnc.dAAOcc.tiaSd.p(y1dP1eF2vO8o[Al1)d],.(P1Te9hr9ef2l)Muoe6r5co.ho7ac2nt.ainsemSUunldpehrolnyicinAgctihde (HPypFoOlSiAp)emaincd ECflfoefcitbroifc Acid. wHietnhwoliotdh,iuSm.pMe.r,flMucoKreoeo-cPteasneiks,ulPf.o,nCaotseteilnlroa,bbAi.tCs.(sObssitmraict)z., TT.eGr.atDoelovgeylo4p9m(e5)nt(a1l99t4ox)i3c9i5t.y study pCeorstfelluloor,ooAc.tCa.n,eHseunlfwoonoadte, i$n.rMa.b,biOtssim(iatbszt,raTc.tG).. DToexviecloolpogmiesntta1l4(t1o)xi(c1i9t9y4s)tu1d6y1 with lithium sHuartfoa,ctMa.n,tsanindwSahtienrod(aab,stKr.actS)o.luNbiilpiptoynanKdagcraiktiucaZlamsischeil9l1e(c1o)nc(e1n9t7r0a)ti2o7n-s3o1.f fluorinated ((Hp1ee9,r9fM0.l),u7ora3o9no-dc7tF4au2n,.eXs.ulfKoinniectiaccsida)ndcaltianleyazrefdreeesteenriefrigcyatrieolna(taibosntsrhaicpto).f sWuipierHacuiadxPueOSXiAebao 6(6) liHvoesromkiacwrao,sMo.m,esanbdyTp.eSraftlouho.riDniaftefderfeantcteysaciindst.heXeinndoubcitoiroincoafc2a3rb(o1x9y9l3e)s1t1e2r5a-s1e13i3s,ozymes in rat 4Ik5e0daa,ndT.p,eKr.oxFiuskoudmae,pr1o.lMifoerria,tiMo.n iEnnroa moltiove,rTb.yKpoemrafliu,orainndatTe.dSoucgtaa.neInsduulcpthioonniocfcacyitdo(cPhFrOSo)m,e P- 005999 BiAbtltiaocghrmaepnhtysoftoPuLbetltiesrhetdo LCi.tAeuraetrurdeatiend3MM'asyP1o8s,se2s0s0i0on P1e9r8a7,xi3s0o4m-e3s08i.n Biology and Medicine. H.D. Fahimi and H. Sies, Eds., Berlin: Springer-Verlag, soKtforpzueucrtkouaxr,eisHa.onmdaYilanmdfaautdctiayn,agcJ,iacdtHoioxvriiitdeya,t(iaSob.ns,-tWrraeaclttaa)t.neadBbeieon,czhTy.em,me.SsuPgihana,rraTm.a,lciIovklee.rdab4,y1T(d.4r)uCg(hsa1r9ra9ec1lt)aetr6ii1os7nt.si6hc2iso3pfs,ibnedtuwceteinon fLoyrocnh,arPa.cA.t,erTiozimnegr,flKuo.rBo.a,lGkranoesssu,lfMo.nLa.tesF.astAnaatlo.mCbhoemmb.aSr7d(m1e4n)t(1a9n8d5)ta2n9d8e4m-2m9a8s9.s spectrometry aRneamedreob,iAc.c,oanndditDieonbsus(,absR.tracBti)o.deCgrhaedmaobsilpihteyroef3f2l(u8o)ri(n1a9t9ed6)su1r5f6a3ct-a1n5t7s4.under acrobic and 1sS0uolhbfleoennaiifcufsea-cc,tiedAd.ibKs.ya,ppAeotrMeo.nxtiEsirnoidmkuescspeorrnoo,lfipCfe.errHaotoxogirssstoirnmoamml,oufMsa.tetKyliiavmcelri.adnPBdh-,oaxJrimWda.actoiDleopnoigeayrnrdae.notdPheeTrrofralicuctoiorvliootogicyets7akn2enown (1993) 90. PFOS.K salt BPurbolwinc,HeR.aBl.thTEhnegiTnreeeraitnmge,ntUnainvderDsiistpyoosaflNoefwAqSuouetohusWaFlielsm,FAousrtmrianliga,Fo1a98m6., Masters Thesis in tCraevaaltlmie,ntL.p,laAn.t.GeEllnevriar,oannmdenAt.alLaTnodxoinceo.logLyasanrdemCohveamlisatnrdyb1i2od(e1g9r9a3d)at1i7o7n7-i1n7a8w8,astewater fCihraenf,igDhtBi.ng faonadm.ESEKn.virCohnimaen.ntaElcoPrnoogmriecsssofmNeo.mb2r, aMnaeyt1r9e8a6t,me1n0t4o-f10w9a.stewaters containing 3Ch4a7n8,-0D6B,.CivDiilspEonsgailneoefrwiansgtLeawbaotreartocroyn,taNianvianlg Calif. 93043, April 1978, 19 pes. aqueous film Construction BfaotrtmailnigonfCoeanmte(rA,FPFoFr)t. TM No. Hueneme, M- BcCahhteatmnai.lciaDolnB.pCreonDctieessrps,oessPa.olrotTfHMwuaeNsnot.eemwMea-,t5e4Cra-l7ci9fo-.n1t9a93i,0n4Ci3in,vgiaSleqEpunte.goiu1ns9e7ef9ri,iln2mg1fLopgarsbm.oirnagtofroya,mN(aAvaFlFFC)on-sibryupchtyisoinco- N(CohA.aFnFM,F:)-D5.-4B-A.80Ts-ouxm1i0mc,aCsriuyvboisltfaEpnnrcgoeig:nreeDesirssiptnoogsadLalatboeofrwoanatsodtreeyvw,ealNtoaepvrmaelcnoCtnotonasfitnarilulncgAtaiFqonuFeBoatutrsteaafltiimloemnntfCoepnrrtmoeciren,sgsPefosor,atmTM Hueneme, Calif. 93043, August, 1980,6 pgs. UfChSoia:amnN,(aABvF.ySF.FCKi).v,iwlTasEPtn.egsiWnfueore,rriaenncgdovLRearWbyoo.rfatRiootrswyla,acnPtiodvr.et iHMnuegermenbdeiremanetn,se.CtArGeea9ot3rm0ge4in3ato,IfOnascttqi.utue1to9eo8u0fs,fT1ie0lcmphgnfsoo.rlmoignygfor E1Dn9av9r5iw,rion6n,7m-Re7.n3t.L:.,AR.DeE.licOatttemaBna,laEn.ceC.. NNaotrimoannal,FJi. rEe.PGroottte,catniodnCA.sPs.ocHianaatuisoknaJ.ouFrnoaalm, aMnady!thJeune PDliaMnta.io1,0pLe.raRt.i,oannsdPRr.ogFr.eLsasn3ge(.19E8f4f)ec4t2o-f46W.ater Quality on Fire Fighting Foams. 006009 Attachments to Letter to C. Auer dated May 18, 2000 Bibliography of Published Literature in 3M'sPossession RpHriyoldjtgeocent.,NaPTt.riDeo.pn,aarlaenLddafbJoo.rrF.atthWoearlUyk,SerAA.uigrE.nFvo1ir9r8co9en,um5ne5dnetpraglsI.nstteudriaegsenicnysAupgproeretmoeftntheDOliEve 1fi4r8e9t-r1a4i8ni9n-gAlfacbiyliOtiaeks Johnson, J.D, S.J. Gibson, and R.E. Ober. Cholestyramine-enhanced fecal Carbon-14 in rats after administration of ammonium perfluorooctanoate or elimination potassium of perfluorooctanesulfonate. Fundamental and Applied Toxicology 4 (1984) 972-976. Kroop, RH. and Technical Report J.E. No. Martin. Treatabilityofaqueous film-forming foams AFWL-TR-73-279, Air Force Weapons Labor used for firefighting. New Mexico, 87117, Feb. 1974, 94 pgs. atory (DEE), KirtlandAFB, Available from NTIS, order no. AD-755 336, fLoarntdroena-tmAemnotlodf,waS.s,taenwdatDe.rB.coCnhtaani.niAnpgpalifciarteifoignohtfirnogtaagteinntg (bAiFoFloFg)i,caulndcaontteadcrteopro(rtR,B/C7p)gpsr.ocess Landon-Arnold, S.E. Microbial treatabilityof aqueous film forming foam (AFFF) with a chemostat and a rotating biological contactor. Ph.D. Dissertation, University of Oklahoma, 4N8o1r0m6a,n8,0O0k-l5a2.1-908620.0,(UOnridveerrsNiot.y83M0i2cr4o5f2i)l.ms International, 300 N. Zeeb Road, Ann Arbor, Mich. McKay, J.C., August 1988, and B. 457-8. Mason. Improved fire training facility plan. The Military Engineer $23 Mueller, fighting J.A., foam E.-W. waste. Poth, and Regional W.W. Melvin. REHL(K) Environmental Health La b6o7r-a1t4orBiyo(lAogFiLcCa)l,trUeSaAtmFe,ntKoeflfliyrAeFB, TX, 78241, Sept. 1967, 38 pgs. O'Brien, A. F. Treatmentof Aqueous Film Forming Foam (AFFF) Wastewater at Andrews Air Force Base, Maryland. December 1, 1994. Masters `Thesis, University of Maryland, College Park, Maryland, Saam, R-D., P.A. Rakowski, and GM. Aydlett. Treatabilityoffirefighting school wastewaters: U.S. Navy Compliance with POTW pretreatment Purdue Industrial Waste Conference, undated, 40 requirements. pgs. Presented at the 34th Annual Salazar, Review S. M. Toxicity ofAqueous and Biological Assessment. Film Forming Foams to Marine Organisms: Literature Naval Ocean Systems Center, San Diego,California, `Technical Document 825, July 1985. aShnidnloidqau,idK.m,ixatnurdesT.. NBoamsuircas,tuMdiisecsoifbioliiltyroefpfelluleonrtoacanrdbfoinreaenxdti`nhgyudirsohcianrgboangesnutrsf.Jacotuarntnsalinomficelles Physical Chemistry 84 (1980) 365-369. S1Vce9an8tl6uel-MlNio,ocrvRoe.cmoMbs.emsrB.i3o0Dd,eegp1ra9a8rd7t,amte3in4otpnoaogffeBsAi.qouleogoyu,sUFniilvmerFsoitrymoifngDaFyotaomn,CDoamyptoonn,enOtH.in NLoavboermabteorr3y0, PFOS.Lisalt Costello, Henwood, and Osimitz, Sulfonate in Rabbits" (abstract) "Developmental Toxicity Study with Lithium Perfluorooctane 006001 BiAbtltiaocghrmaepnhtyosfPtoubLeltitsehretdo CLi.tAeruaetrurdeatiend3MMasyP1o8s,se2s0s0i0on EPA, "New Pesiicide Fact Sheet; Lithium Perfluorooctane Sulfonate (LPOS)" (abstract) SHuelnfwoonaotde,iCnoRsattesl"lo(aabnsdtrOascit)mitz, "Developmental Toxicity Study with Lithium Perfluorooctane JMloiautshrinuuadml,otefHtC.r,oadlNel.coyikldesdaunsld,fIantMte.earAnfrdaatlcoietnShoic,uiSme.npcKeearnf1le5us4ohri(on1oa9c,9t2aa)nned45sK4u.l-f4Mo6on0a,ttoemirnat.heSatdusdoyrobnedtfhielmmimsycicbcillliety of eeSnnhttihinaoaldlpaym,iacKn.e,dllMee.nctoKrnoocbpeyaonytfarsashtoiil,ountaionofdnlNoi.ftphYaiaruammfapfgeiurncfchlhuiao.ironEofccfoteacmntpeoosufuln"fdioscn:eabtTeerh.geJ"oefufofrrencmatalotfiOoftnoePmhfpyweartaetruroenonthet.he Chemist9ry1 (1987) 5292-5294. sical pbTeeahrmafovrliiuo,orrKao.no,d-cKdt.yannKaeimshiaucrlafp,oronHp.aetrSetai/neddsai,ientKm.hiaExnseoudlmhsiey,psKtt.eamdMseeocgfauafrnloiu,oonCri.ocT-ah2nu-dnuincgad,teiacoannamdincmoHosl.umnHreioftafcftmaanntns.ltPhhiausnes S{cDieEnFceU2M7A0Q(1a9n9d2)li8t8h3i-um89d3o.decy sulfate DEFUMAC aqueous mixtures. CoulhamynlcdhPlooorliiydmeder 006002