Document 5bxVva8jQ7w7YJmmmONL1wL5e
AR226-2830
Material Tested: Material Submitted by
Copies Co:
E. I. du Font de Nemours and Company
Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 245-71
rganic Chemicals Department [Jackson Laboratory
Haskell No.: Otner Codes:
6918
ACUTE ORAL TEST
Procedure: The test material, as an aqueous suspension, was administered by intragastric intubation ChR-CD male rats in single doses. Survivors were sacrificed 14 days later; the livers were removed analysis.
Results:
Suspension
^
Dose ('"R/kg)
Mortality*
Weight When Killed (g)
Body
Liver
25
11,000+
25
7,500+
25
5,000
25
3,400
15
2,250
25
1,500
25
1,000
15
670
14 d. 14 d. 14 d. 14 d. 14 d. 14 d. 14 d.
14 d.
325 330 334 343 345 318 331 364
16.20 16.38 15.27 16.18
14.62 13.22 13.65 16.00
* S - ( ) d. = Sacrificed ( ) days after dosing
+ Administered in divided doses
L.W./B.W. X 100
5.0 5.0 4.6 4.7 4.2 4.2 4.1 4.4
Clinical Sign
None
TEN-DOSE ORAL SUBACUTE TEST
Procedure: The test material was administered by intragastric intubation, as a 15% aqueous suspensi six young adult ChR-CD male rats, five times a week for two weeks; another group cf six rats served and was intubated with water. Three test and three control rats from each group were sacrificed app four hours and 14 days after the last dose.
Results:
Dose
(mg/kg/day)
Mortality
Weight of Animals
After lUth
Dose
Liver (s)
Killed:
14 Days
After
10th Dose
L.W./B.W. X 100
Animals Killed:
After 14 Days
10th
After
Dose 10th Dose
Gross Pathology^
on Liver
Animals Killed; After 14 Days
10th Dose
After
10th Dose
2200
0/6
18.2
14.3
19.7
17.6
21.2
18.2
5.9
3.6
6.0
4.8
7.2
5.4
0
(Control)
0/6
13.0
17.1
13.9
13.3
8.4
18.1
4.2
4.3
4.2.
4.0
3.6
4.1
In addition, the following organs were examined histologically: brain, eyes, stomach, du spleen, bone marrow, pancreas, adrenal, kidney, testis, epididymis, lung, and trachea; no compound histologic changes were observed in any of these organs.
Gross
and histopathologic code
No abnormality detected Large and heavy Slightly ' -ge and heavy
Reduction jf number of centrilobular
Focal RE cell hyperplasia
cytoplasmic
vesicles
^
^ R4
.Sunimar^:!|HBHHH^BI^Bi^HilB^HHBQhas low toxicity when administered orally to young ad male raw; its Approximate Lethal Dose (ALD) ft greater than 11,000 mg/kg of body weight. There was
gross nor gravimetric evidence of liver enlargement 14 days after dosing.
Repeated administration of the test compound to rats at a rate of 2200 mg/kg/day for ten large and heavy livers at the end of the test phase, but these livers were within the normal range the 14-day recovery phase. Histologically, the compound caused a reduction of the number of centril cytoplasmic vesicles after the tenth dose and after the 14-day recovery period. This type of liver considered reversible; this reversibility probably would have been manifest with a longer recovery
Da te: July 20. 1971
Report by:
Joan A..
Oral Toxico
^'JIof hn/A. Approved by: _____^JfjL-H
.
....
/./
'/;cs
/
..'Dir