Document 5brjxZrYN2mDLxRBBrqdamzvR

->_ T r : , est V i r i i n i i RECEIVED . ero ? M' Miro CLERK APPELLATE CT. FIFTH D1ST. MT. VERNON, IL PLAINTIFFS l EXHIBIT ` jjjsa b /i AV-A M b - Ob-ibi o v e m b e r le, 1 5 5 ' " 7 ^ ....... -- . On November 17, kr. McClain end I accompanied Dr. Suskind of the Kettering Laboratory to a meeting at the Workmen* Compensation Commission in Charleston. Representing the Commission at this meeting were the Occupational Disease Eoard composed of Drs. Erick, B i e m , and Aliff. Mr. Jack Canterbury, Legal Assistant, *r. marry feess of the Oc cupational uiseafe" uivisioh. ' -- Dr. Erick presented e copy of a report by Dr. E. F. Smith and Dr. R. E. Kelly addressed to Mr. Paul Halley dated 1950 and asked Dr. Suskind to comment on the findings reported. Dr. Suskind said that he is familiar with the report and commented on the technio_ue employed reporting that Drs. Adams, Spencer, and Irish \?ho originated this technique using the ears of rabbits have since abandoned it. Xettering Laboratory has attempted to duplicate some of their work and have found the same epithelial hyperplasia and folliculitis as reported, but no acne was produced. Dr. Suskind states that it is not possible to pre-determine acnegenic properties of new compounds by this rabbit ear test. Dr. Brick inquired if there was any difference histochemically between acne vulgaris and chlor-acne. By use cf diagrams Dr. Suskind showed the comparison of the two types of acne and stated that histologically the two ere the sane ritr. the exception that chlor-acne lesions contain srzeTrhst more f r e e cholesterol. Dr. r i e n asked what causes acne, Dr. Suskind said that tris is a la^ge ruestion no ths t th" s.re ir.anv Chincs yet to oe nerrne^a. r horever, it is bili eve - th.-1 cene vai g-'-ri i s -ind cei in th male by tea tostar:ne nd in th ferale cy progesterone. This opinion is based on considerable exteri- other androgenic substances. human forearm tor one wee.-: or mere C&742 8.10 4 r>t# th-t materials in contact with the skin can produce chlor-ccne, but the rossibility that it m:y be produced by other means is not ruled out. Dr. Biern asked whether skin reaction can be due to stress phenomena or from a fear overlay. Dr. Suskind said he would be afraid to hazard a guess, but work has been done at Cor nell Oniversity with young acne vulgaris patients subjected to interview stress. Measurement of sebum output showed a stress increase of as much as 400 in acne cases only; in non-acne cases the increase -as very slight. Khether this pertains to Monsanto chlor-acne cases is difficult to say. Dr. Brick inquired whether the materiel which the board saw being packaged during their plant tour was 2,4,5^T end was told that it was. He then asked whether that was the material which was given to Dr. Suskind for testing, and Dr. Suskind replied that that was one of-the materials sub mitted. At this point Dr. Erick talked about tae air survey made by the State-Department of Health, and when a copy of their report could not be found, he talked to the State In dustrial-Hygienist. He seemed distressed at the report that all samples had shown measurable amounts of 2,4*5-T whereas he had been given the impression that there had been nothing discovered. He has requested the Industrial Hy gienist to furnish the board a copy of the survey report. At this point he insinuated that Monsanto could be more careful in handling the 2,4,5-T and spoke of seeing continuous automatic packaging operations at the duPont plant, ^r. Erick also inferred that much of the information concerning the chlor-acne problem had at one time or another been held secret from the"board. His impressions on these two natters did not appear to be reflected'in the other board members. Dr. Suskind tola briefly of the animal test done with 5^ solution of various materials from the 2,A,5-T process and with Hslorar 1014- He retorted tb.Lt there ras no reectlon or change in any of the cnimsl studies or in human subjects encored to tne same 5% concentration. Dr. Suskind then described the work using Ealorax 1014 ana recrystallized 2,4*5-T on animals and humrns. He reported thit no acne or skin manifestation had been induced in any of the animals by either *0,5 the materials but thst on human skin chlor-acne had been produced with the Halo wax, but there ras absolutely no reEction from the 2,A,5-1. C26743 The conference continued rith conversetion dealing with the overall Espects of the chlor-acne problem, end F:. Eiern reed excerpts from the transcript in the recent Dewey Garton hearing for Dr. Suskind's benefit. The meeting seemed to be appreciated by the commissioner1s representatives, and it is believed that a favorable impression was cres.ted. Both John licClain and I feel "that in view of Dr. Brickfs somewhat critical comments, we should prepare a fairly com prehensive story of the entire chlor-acne situation which should include not only the experimental work done at Mellon and Kettering but investigational work done in the plant in connection with the autoclave incident. We believe that this should be made available to the Occupational Disease Board together with copies of any reports which we heve that have not been made available to them. Such information can be given to them with the stipulation that it is for their evaluation only and'is not to become part of the public records At the end of our conference Et the commission offices, Dr. Suskind together with McClain and I discussed our problem with Mr. Paul Bowles and Mr* A. G. Stone at their offices. Both Dr. Suskind and Mr. Stone feel that it would he wise for us to follow up on the Kettering recommendation that periodic air sampling be made in the 2,4,5-T plant. Both McClain and 1 expressed doubt as to the value of information so obtained unless it be used to counter Dr. Halloran's accusations. We discussed the findings of Dr. K. H. Nestmann concerning psychoneurosis in most of the employees he has examined for us. Mr. Stone is apprehensive as to the implications that may be drawn if this*is submitted as evidence. The attorneys and Dr. Suskind all read a paper which I obtained from Dr. Kestnann Concerning some of his evaluations on other patients using the Cornell Medical Index, and Dr. Suskind suggested tht he could hcve an opinion on the value of this type of testing from Dr. v\ C. Boss a psychiatrist at the Kettering Laboratory. I indicated to him that we "ouii be interested in such c-inion. The future work which has been outlined for consideration at the Kettering Laboratory was reviewed with the attorneys, and Hr. Stone cade the point that while distilling the phenol nay eliminate chlor-acne, it may riot change the incidence of "Halloranfs Disease."" <(J- U Vi e. Bowles geve Dr. Susklnd cocplete set oi the suai the legtl c&ses on Thilch evidence has been tccumulc LCW/fJ 11-18-55 L. C. *eger ca74s *4 S.1045L1.