Document 5bgrYY2JYMyN07de4GXrkND9D

PATRICIA ANN FAIL (NODEN), Reproductive Biologist PROFESSIONAL EXPERIENCE November 1990 to date. Manager, Department of Reproductive Biology, Center for Life Sciences and Toxicology, Chemistry and Life Sciences, Research Triangle Institute, Post Office Box 12194, Research Triangle Park, NC 27709. Additional responsibilities beyond that listed below include coordination of group activities, administrative reporting, and decisions on group direction. Tanuarv 1986 to November 1990. Senior Reproductive Biologist/Toxicologist, Center for Life Sciences and Toxicology, Chemistry and Life Sciences, Research Triangle Institute, Post Office Box 12194, Research Triangle Park, NC 27709. Contract research and testing in reproductive toxicology and endocrinology for industrial, governmental, and university clients, which include: endocrinopathy after drug treatment (Principal Investigator); performing reproductive assessment by Continuous Breeding Protocol in rodents exposed to potential toxicants (Co-Principal Investigator); development of male contraceptive agents (Co-Investigator); bask research on control of sexual maturation in male deer mice; and genetic models of infertility and receptor binding and bioassay of antiprogestational activity. Collaborative research on social stimulation of testicular function in ring doves and endocrinology of reproductive function in prosimian primates. Responsible for contract administration, proposal development, protocol design, writing of Standard Operating Procedures, literature summaries, interim and final reports, and manuscripts for refereed journals, training and supervision of personnel, and supervision of chemical handling and dosage formulation. Studies conform to FDA and EPA guidelines and adhere to Good Laboratory Practices (GLP) regulations. 1987 to date. Visiting professor for minority institutions, sponsored by FASEB. Once or twice yearly, perform workshops and seminars on some aspect of reproduction or toxicology. 1984 to 1989. Research Associate, Department of Psychology, Duke University, Durham, NC Research Consultant on reproductive endocrinology to study social stimulation of testicular function in ring doves and pubertal development of prosimian primates. 1980 to 1985. Assistant Professor of Physiology and Zoology, North Carolina State University, Raleigh, NC. Taught Veterinary Physiology, Special Topics in Physiology of Pregnancy, Histology, Comparative Physiology, and Vertebrate Physiology. Developed a research program on environmental and pituitary control of pubertal development of male rodents, hormonal regulation of prostaglandin synthesis at parturition; graduate training and undergraduate research, 1978 to 1980. Research Associate, Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, MI. Planned, organized, and directed research projects in lipid metabolism in perinates of mothers with diabetes, prostaglandin-forming cyclooxygenase formation by tissues of gestation in rabbits; planned and developed blood chemistry and endocrine laboratory. SL 108408 Patricia A. Fail Page 2 1975: 1977 to 1978. Assistant Professor and Instructor, Science Department, Lansing Community College, Lansing, MI. Taught Human Anatomy, Human Physiology, and Human Sexuality. Coordinated seven sections of Human Anatomy. 1976 to 1977. Research Associate, KUniek Verloskunde, Gynaekologie en KI (Clinic of Veterinary Obstetrics, Gynecology and Artificial Insemination), Rijksuniversiteit te Utrecht, The Netherlands. Research on steriodogenesis in in vitro follicle cultures, purification of equine pituitary hormones, and induction of abortion in horses. 1970 to 1975. Research and Teaching Assistant, Department of Dairy Science and Physiology, Michigan State University, East Lansing, MI. Taught Dairy Science, Animal Reproduction, Human Physiology, and Biological Sciences Laboratories. Conducted research on ovulation control and reproductive endocrinology of horses, influence of vasoligation on sperm production in rats, radioimmunoassay development, and in vitro pituitary monolayer response to releasing hormones. 1966 to 1970. High School Teacher, Science Department, Sanger High School, Sanger, CA. Taught Biology, General Science, and General Mathematics. 1965 to 1966. Histological Research Technician. Experimental pathology. National Aeronautics and Space Administration, Moffett Field, CA. Performed histologic techniques (both routine and developmental) on nerve and brain tissue 1963 to 1965. Research Assistant and Histological Technician, Zoology Department, Kansas State University, Manhattan, KS. Assisted in Human Anatomy and Embryology Laboratories; MS research on embryology of bovine heart; fixed, sectioned, and stained reproductive tissues; serial sectioned bovine and canine embryos. EDUCATION B.S., Kansas State University, Zoology (Embryology), 1964 M.S., Kansas State University, Zoology (Embryology), 1966 -- Fresno State University, Psychology and Biology, 1968 (teaching certificate) Ph.D., Michigan State University, Physiology and Dairy Science, 1975 HONORS Mary Barnes Scholarship, 1960-1962 Friedline Scholarship, 1962-1964 Kansas Heart Association Grant-in-Aid, 1964-1965 Phi Delta Gamma (Graduate Honorary), 1965 Graduate Office Scholarship Award, 1973 Excellence in Teaching Award Nominee, 1974 SL 108409 Patricia A. Fail Page 3 PROFESSIONAL SOCIETIES American Physiological Society American Society of Andrology Association for Study of Animal Science North Carolina Society of Toxicology Sigma Xi Society for Study of Reproduction DISSERTATIONS P. A. Noden, Cardiogenesis in the Bovine to 35 Somites, Masters Thesis, Kansas State University, 1965. P. A. Noden, Estms, Ovulation and Changes in Some Hormones During the Estrus Cycle of Mares and After Prostaglandin F2o Ph.D. Dissertation, Michigan State University, 1975. PUBLICATIONS Ibrahim, M.Z.M., N. Call, and P. Noden (1968). Modifications of the Hortega silver carbonate method adapated for celloidin-embedded and frozen sections, Acta Neuropath., 10,258-260. Haymaker, W., M.Z.M. Ibrahim, J. Miquel, N. Call, P. Noden, W. Ashly, ER. Ballinger, J. Ghidoni, I.R. Lindsay, A.J. Behar, and G. Baker (1972). Acute changes in the central nervous system of monkeys exposed to protons, /. Neuropath. Exp. Neurol., 31,72-101. Hafs, H.D., T.M. Louis, P.A. Noden, and W.D. Oxender (1974). Control of the estrous cycle with prostaglandin F2a in cattle and horses, J. Anim. Sci., 38, Suppl. 1,10-21. Hafs, H.D., W.D. Oxender, P.A. Noden, and R.P. Amann (1974), Testicular function in bulls 10 weeks after unilateral vasectomy, /. Anim. Sci., 38,117-120. Noden, P.A., W.D. Oxender, and H.D. Hafs (1974). Estrus, ovulation, progesterone, and lutenizing hormone after prostaglandin F2a in mares, Proc. Soc. Exp. Biol. Med., 145, 145-105. Oxender, W.D., P.A. Noden, T.M. Louis, and H.D. Hafs (1974). A review of prostaglandin F2o for ovulation control in cows and mares, Amer. J. Vet. Res., 35, 997-1001. Lin, Y.C., P.A. Noden, W.D. Oxender, and H.D. Hals (1975). Androgens in the bovine fetus and dam, K. Mongkonpunya, Proc. Soc, Exp. Biol. Med., 148,489-493. Noden, P.A., W.D. Oxender, and H.D. Hafs (1975). The cycle of oestrus, ovulation and plasma levels of hormones in the mare, /. Reprod. Fertil., 23,189-192. SL 108410 Patricia A. Fail Page 4 Oxender, W.D., P.A. Noden, D.L Bolenbaugh, and RD. Hafs (1975). Control of estrus with prostaglandin F2a in mares: minimal effective dose and stage of estrous cycle. Am. J. Vet. Res., 36,1145-1147. Oxender, W.D., P.A. Noden, and RD. Hafs (1975). Oestrus, ovulation and plasma hormones after prostaglandin F2o in mares, J. Reprod. Fertil., 23,251-255. Oxender, W.D., and P.A. Noden (1976). Can artificial lights be used to initiate estrus and ovulation in mares? Quarter Horse Journal, 28,34-38. Oxender, W.D., and P.A. Noden (1976). Photoperiod initiation of estrus and ovulation in seasonally anestrous mares, Proc. VIII International Congress on Animal Reproduction and Artificial Insemination, Cracow, Poland, VoL III, 160-164. Oxender, W.D., P.A. Noden, and RD. Hafs (1977). Prostaglandins for horses. Quarter Horse Journal, 29,116-117. Britt, J.H., P.A. Noden, and R-S. Emery (1977). Teaching dairy science to a heterogeneous group of students at Michigan State University, J. Dairy Sd., 60,832-835. Oxender, W.D., P.A. Noden, and H.D. Hafs (1977). Estrus, ovulation and serum progesterone, estradiol and LH concentrations in mares after an increased photoperiod during winter. Am. J. Vet. Res., 38,203-207. Oxender, W.D., P.A. Noden, and M.C. Pratt (1977). Serum hitenizing hormone, estrus and ovulation in mares following treatment with prostaglandin F2a and gonadotropinreleasing hormone. Am. J. Vet. Res., 38,649-653. Oxender, W.D., and P.A. Noden (1978). Can hormones be used to cause ovulation in mares? Quarter Horse Journal, 30,36-37. Noden, P.A., W.D. Oxender, and H.F. Hafs (1978). Early changes in serum progesterone, estradiol and LH during prostaglandin FZa-induced hiteolysis in mares, J. Anim. Sd., 47,666-671. Noden, P.A., W.D. Oxender, and H.D. Hafs (1978). Plasma lutenizing hormone, progestogens and estrogens in mares during gestation, parturition and first postpartum estrus (foal estrus), Am. J. Vet. Res., 39,1964-1967. Noden, P.A., W.L. Smith, D.L. DeWitt, and J.F. Roux (1981). Prostaglandin forming cyclooxygenase activity in rabbit amnion, yoiksac splachnopleure, placenta, decidua and uterus at 20 to 30 days gestation, Biol. Reprod., 24,1042-1047. van Leeuwen, W., P.A. Noden, and S.J. Dieleman (1983). Induced abortion with two prostaglandin F2a analogues in mares: plasma progesterone changes. Veterinary Quarterly, 5,97-100. SL 108411 Patricia A. Fail Page 5 Lepri, J.J., and P.F. Noden (1984). Reproductive function is independent of photoperiod in adult male Microtus pinetorum, J. Mammology, 65,696-697. Whitsett, J.M., P.F. Noden, J. Cherry, and A.D. Lawton (1984). Effect of transitional photoperiods on testicular development and puberty in male deer mice (Peromyscus maniculatus), J. Reprod. Fertil, 72,277-286. Stroud, C.M., P.F. Noden, and J.M. Whitsett (1985). Bromoergocryptine decreases serum prolactin and delays sexual maturation in male golden hamsters, Biol. Reprod., 32,1191-1199. Kunze, D.J., and P.F. Noden (1986). The effect of flunixin meglumine on levels of prostaglandins E2 and F in the pony following endotoxin administration, J.N. Moore, N.A. White, and J.L. Beeht (eds.). IN: Proceedings of the Second Colic Symposium, Vol. 2, Veterinary Learning Systems, Lawrenceville, NJ, pp. 233-234. FaiL P.A., and R.P. Reynolds (1987). Influence of cortisol on prostaglandin synthesis by fetal membranes, placenta and uterus of pregnant rabbits, Biol. Reprod., 37,47-54. Fail, P.A., and J. Whitsett (1988). Influence of photoperiod, ambient temperature and melatonin on testosterone synthesis and release during reproductive maturation in male deer mice, J. Andrology, 9,21-30. Izard, M.K., and P.A. Fail (1988). Progesterone levels during pregnancy in the greater thick-tailed galago (Galago cmssicandatus), J. Med. Primatology, 17(3), 125-133. Fail, P.A., J.D. George, H.R. Sauls, S.W. Dennis, and J.C. Seely (1989). Effect of boric add on reproduction and fertility of rodents, Adv. Contra. Deliv. Syst., 5(3,4), 325-333. Fail, P.A., J.D. George, J.C. Seely, T.B. Grizzle, and J.J. Heindel (1991). Reproductive toxidty of boric add in Swiss (CD-I*) mice: assessment using the continuous breeding protocoL Fund. Appl. Tox., 17,225-239. Perry, J.M., M.K. Izard, and P.A. Fail (1991). Observations in reproductive hormones, copulatory behavior, and neonatal mortality in captive Lemur mongai (mongoose Lemur), Zoo. Biol., 11,81-97. Cook, C.E., M.C. Wani, Y.W. Lee, P.A. Fail, and V. Petrow (1992). A striking reversal of activity profile: analogs of RU 486 with strong progestational (agonist) activity. Life Sciences, 52,155-162. Chapin, R.E., D.K. Gulati, P.A. Fail, E. Hope, S.R. Russell, J.J. Heindel, J.D. George, T.B. Grizzle, and J.L. Teague (1993). The effects of feed restriction on reproductive function in Swiss CD-I mice. Fund. Appl. Tox., 20,15-22. Grizzle, T.B., J.D. George, P.A. Fail, J.C. Seely, and J.J. Heindel (1994). Reproductive effects of 4-vinylcyclohexene in Swiss CD-I mice assessed by a continuous breeding protocol. Fund. Appl. Tox., 22,122-129. SL 108412 Patricia A. Fail Page 6 Cooky C.E., Y.-W. Lee, M.C. Warn, P.A. Fail, and V. Petrow (1994). Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of llfl-aiyl steroids. IN: Progesterone Antagonists in Reproductive Medicine and Oncology, H.M. Beier and I.M. Spitz (eds.), Human Reproduction Volume 9, Supplement 1, June 1994, Oxford University Press, pp. 32-39. Heindel, J.J., R.E. Chapin, D.K. Gulati, J.D. George, L.H. Barnes, P.A. Fail, and 1LS.H. Yang (1994). Assessment of the reproductive toxicity of pesticide/fertilizer mixture in mice based on confirmed pesticide contamination in California and Iowa groundwater, Fund. Appl. Tox., 22,605-621. Grizzle, T.B., J.D. George, P.A. Fail, and J.J. Heindel (1995). Carisoprodol: reproductive assessment by continuous breeding in Swiss mice. Fund. Appl. Tox., 24,132-139. Fail, P.A., S.A. Anderson, S.W. Pearce, H.R. Sauls, and R.P. Reynolds (submitted). Endocrine toxicity of nickel: effects on prolactin, thyroxin, and progesterone in rodents after subchronic exposure to nickel chloride in drinking water, Toxicol. Appl. Pharm. Cook, C.E., M.C. Wani, J.M. Jump, Y.-W. Lee, P.A. Fail, S.A. Anderson, Y.-Q. Qu, and V. Petrow (1995). Structure-activity studies of 23,4,4a,5,9b-hexahydroindeo(l,2-c] pyridines as antispermatogenic agents for male contraception, /. Med. Chem. (in press). Fail, P.A., H.R. Sauls, and S.A. Anderson (in preparation). Testicular response to gondatropin after boric add treatment in rodents. Fund. Appl. Tox. George, J.D., P.A. Fail, T.B. Grizzle, and J.J. Heindel (in preparation). Nitrofurazone: reproductive assessment by continuous breeding in Swiss mice. Fund. Appl. Tox. Fail, P.A., J.D. George, T.B. Grizzle, and J.J. Heindel (in preparation). Formamide and dimethylformamide: reproductive assessment by continuous breeding in Swiss mice, Fund. Appl Tox. ABSTRACTS Noden, P.A., H.D. Hafs, and W.D. Oxender (1973). Progesterone, estrus and ovulation after prostaglandin F2a in horses, Abst. Fed. Proc., 32:229. Noden, P.A., W.D. Oxender, and H.D. Hafs (1973). LH after PGF2a in mares, ]. Anim. Sci.,37: 323. Noden, P.A., W.D. Oxender, and H.D. Hafs (1975). Estradiol, estrone and androstenedione after prostaglandin F2a (PGF2w) in mares, Abst. Fed. Proc., 34:316. Noden, P.A., W.D. Oxender, and H.D. Hafs (1975). Mare LH and progesterone during gestation/foaling, J. Anim. Sci., 41:372. Patricia A. Fail Page 7 Oxender, W.D., and P.A. Noden (1976). Photoperiod induced estrus in anestrous mares, /. Anim, Sri., 42:1359. Noden, P.A., and W.D. Oxender (1976). LH and ovulation after GnRH in mares, J. Anim. Sri., 42:1360. Oxender, W.D., and P.A. Noden (1976). Photoperiod initiation of estrus and ovulation in seasonally anestrous mares, Proc. VIII International Congress on Animal Reproduction and Artificial Insemination, Cracow, Poland, Vol. 1:190. Oxender, W.D., P.A. Noden, and H.D. Hafs (1977). Estrous, ovulation and serum hormone concentration in seasonally anestrous mares exposed to 16 hours of light each day for 120 days,/. Am. Vet. Med. Assoc., 170:149. Noden, P.A., W.D. Oxender, and H.D. Hafs (1977). Acute changes in progesterone, estradiol and LH after PGFjq in mares. Am. Soc. Anim. Sri. Absts., July: 192. Noden, P.A., and J.F. Roux (1980). Glucose, cholesterol, triglycerides in the cord blood of infants from high risk pregnancies. Society for Gynecological Investigation, Denver, CO, March: 117. Noden, P.A., and J.F. Roux (1981). Prostaglandin-forming cyclooxygenase in rabbit amnion, yolksac splanchnopleure, placenta, decidua and uterus at 20 to 30 days gestation, Societyfor Gynecological Investigation, St. Louis, MO, March: 89. Reynolds, R.P., P.F. Noden, and M.E. Greene (1983). Cortisol-induced abortion in rabbits: maternal serum progesterone and cyclooxygenase activity in the gestational tissues, Biol. Reprod., 28: Suppl. 1:112. Stroud, C., J.M. Whitsett, and P.F. Noden (1984). 2-bromo-a-ergocryptine decreases serum prolactin, flank gland diameter, total accessory sex gland weight, serum testosterone, and testicular weight in prepubertal male golden hamsters, Biol. Reprod., 30: Suppl. 1:171. Stroud, C., J.M. Whitsett, and P.F. Noden (1984). 2-bromo-a-ergocyrptine (CB154) decreased serum prolactin and testosterone, flank gland diameter, total accessory sex gland and testicular weight in prepubertal male golden hamsters. Physiologist, 27:228. Noden, P., M. Grizzle, M. Greene, and J. Whitsett (1984). Short photoperiod depressed serum testosterone, testes and accessory organ weight during sexual maturation in prairie deer mice. Physiologist, 27: 228. van Leeuwen, W., P.A. Noden, and S.J. Dieleman (1984). Induced abortion with two prostaglandin f2 analogues in mares; plasma progesterone changes, Amer. Assoc. Equine Prac. Newsletter, 3:159 (Abstract 339). Noden, P., and M. Lancaster (1985). Response of testis to HCG in juvenile deer mice: effect of photoperiod, temperature, and melatonin, Biol. Reprod., 32 (SuppL 1): 178. SL 108414 Patricia A. Fail Page 8 Fail, P.A. (1987). Response of testis to HCG in young deer mice: effect of photoperiod, temperature, and melatonin. National Research Council Symposium on Role of Biomarkers in Reproductive and Developmental Toxicology, January 12-13, Washington, DC. Fail, P.A. (1987). Influence of 35C and melatonin (MEL) on testosterone (T), testis, and accessory sex organs (ASO) after HCG in juvenile deer mice, /. Andrology, 8: P23 (Abstract 26). Izard, MX, and P.A. Fail (1987). Progesterone levels during pregnancy in Galago crassecaudatus, Am. /. Primatol., 12:350-351. Fail, P.A., J.D. George, J.C. Seely, T.B. Grizzle, and J.J. Heindel (1989). Reproductive toxicity of boric add (BORA) in male mice, /. Andrology, 10: P-45. Fail, P.A., J.D. George, T.B. Grizzle, and J.J. Heindel (1989). Reproductive toxirity of boric add (BORA) in mice as evaluated by the continuous breeding protocol, The Toxicologist, 9 (1): 266 (Abstract 1066). Grizzle, T.B., H.R Sauls, S.W. Dennis, and P.A. Fail (1989). Response of testis to HCG in Swiss mice (CD-I) following chronic exposure to boric add (BORA), Biol. Reprod. 40 (1): 153 (Abstrad 316). Izard, M., J. Perry, and P. Fail (1989). Reproductive Biology of Captive Lemur rnongoz.,, Am.}. Primatol., 18:149. Reynolds, RP., and PA. Fail (1990). Nickel chloride (Ni+^Mnduced perinatal toxidty in CD-I mice may be due to decreased prolactin secretion. The Toxicologist 10(1): 224 (Abstrad 894). Izard, MX, P.A. Fail, and R Ange (1990). Correlates of puberty in the greater galago, Am.}. Primatol., 20:201. Fail, P.A., H.R. Sauls, and S.W. Dennis (1991). Reproductive toxidty of boric add (BORA) in male deer mice, /. Andrology, 12, Suppl. P62 (Abstrad 151). Fail, P.A., and CS. Stroud (1991). Testicular development in golden hamsters (Mesocricetus auratus) is influenced by prolactin, In: The Male Germ Cell: Spermatogonium to Fertilization, McGill University, (Abstrad 65), p. 90. Izard, K., S. Anderson, H. Sauls, and P. Fail (1991). The use of chronic cannulation in longitudinal endocrinological studies: fiadors influencing longevity of patency, Triangle Consortium for Reproductive Biology Conference: Frontiers of Biotechnology: Molecular Approaches to Reproductive Biology, Research Triangle Park, NC, January. Fail, P.A., J.D. George, T.B. Grizzle, J.C. Seely, and J.J. Heindel (1991). Reproductive toxidty of 4-Vinylcyclohexene (VCH) in mice as evaluated by the continuous breeding protocol. The Toxicobgist, 11 (1): 113 (Abstract 368). SL 108415 Patricia A. Fail Page 9 Fail, P.A., S.A. Anderson, M.G Wani, D. Lee, and C.E Cook (1991). Response of mouse testis to Sandoz 2(M38 (S20438), Biol. Reprod,, 42 (1): 175 (Abstract 490). Bishop, J.B., R.R Chapin, P.A Fail, J.D. George, T.B. Grizzle, B.M. Sadler, and J.J. Heindel (1991). Acrylamide-induced dominant lethality in mice following low dose chronic administration in drinking water. Environ. Molecular Mutagen., 17 (19): 11. Izard, M.K., P.A. Fail, and R. Ange (1992). Cytological and hormonal responses to follicle stimulating hormone (FSH) and human chorionic gonadotropin (HCG) in the greater galago (Galago crassicaudatus), Am. J. Primatol., 27:34. Fail, P.A., H.R. Sauls, S.W. Pearce, S.A. Anderson, and M.K. Izard (1992). Measures of pituitary and testicular function evaluated with an endocrine challenge test (ECT) in cannulated male rats. The Toxicologist, 12 (1): 436 (Abstract 1725). Izard, M.K., P.A. Fail, J.D. George, T.B. Grizzle, and J.J. Heindel (1992). Reproductive toxicity of cresol isomers administered in feed to mouse breeding pairs. The Toxicologist, 12 (1): 198 (Abstract 725). George, J.D., P.A. Fail, T.B. Grizzle, and J.J. Heindel (1992). Reproductive toxicity of nitrofurazone (NTFZ) administered in the feed to mouse breeding pairs. The Toxicologist, 12 (1): 199. Grizzle, T.B., J.D. George, P.A. Fail, and J.J. Heindel (1992). Reproductive toxicity of carisoprodol (CARD as evaluated by the continuous breeding protocol. The Toxicologist, 12(1): 197 (Abstract 723). Anderson, S.A., H.R. Sauls, S.W. Pearce, M.K. Izard, and P.A. Fail (1992). Measures of pituitary and testicular function evaluated with an endocrine challenge test in cannulated male rats, presented at Triangle Conference on Reproductive Biology, Sheraton Imperial Center, RTP, NC January 11. Grizzle, T.B., P.A. Fail, J.D. George, R.D. Austin, R.E Chapin, and J.J. Heindel (1992). Reproductive effects of feed restriction in Swiss (CD-I) mice, presented at Triangle Conference on Reproductive Biology, Sheraton Imperial Center, RTP, NC, January 11. Izard, M.K., P.A. Fail, J.D. George, T.B. Grizzle, and J.J. Heindel (1992). Reproductive toxidty of cresol isomers administered in feed to mouse breeding pairs, presented at Triangle Conference on Reproductive Biology, Sheraton Imperial Center, RTP, NC, January 11. Sauls, H.R., S.W. Dennis, S.W. Pearce, S.A. Anderson, and P.A. Fail (1992). Endocrine responses during boric add (BORA) exposure for eight weeks in male Swiss CD-I mice, presented at Triangle Conference on Reproductive Biology, Sheraton Imperial Center, RTP, NC, January 11. SL 108416 Patricia A. Fail Page 10 Grizzle, T.B., J.D. George, P.A. Fail, and J.J. Heindel (1992). Reproductive toxicity of carisoprodol in Swiss mice, presented at Annual Meeting of North Carolina Society of Toxicology. Fail, P.A., T.B. Grizzle, J.D. George, R.D. Austin, R.E Chapin, and J.J. Heindel (1992). Effect of restricted body weight gain on reproduction in Swiss mice, presented at the 1992 Annual Meeting of North Carolina Society of Toxicology. Anderson, S.A., H.R. Sauls, S.W. Pearce, M.K. Izard, and P.A. Fail (1992). Measures of pituitary and testicular function evaluated with an endocrine challenge test in cannulated male rats, presented at Annual Meeting of North Carolina Society of Toxicology. Sauls, H.R., S.W. Dennis, S.W. Pearce, and S.A. Anderson (1992). Luteinizing hormone, follicle stimulating hormone, and testosterone during boric acid treatment for eight weeks in CD-I Swiss mice. Biology of Reproduction, 46(1): 170 (Abstract 479). Anderson, S.A., H.R. Sauls, S.W. Pearce, and P.A. Fail (1992). Endocrine responses after boric add exposure for 2, 9, or 14 days in cannulated male CD rats. Biology of Reproduction, 46(1): 124 (Abstract 293). Grizzle, T.B., P.A. Fail, J.D. George, R.E Chapin, and J.J. Heindel (1992). Feed restriction affects the reproductive competence of Swiss (CD-I) mice. Biology of Reproduction, 46(1): 170 (Abstract 478). Cook, C.E, Y.W. Lee, M.C Wani, P.A. Fail, and V. Petrow (1992). Synthesis and antagonist/agonist activity of 1 l^-ARYL-19-Norpregnadienediones. Mohawk Mountain Conference, Terra Symposia III, May 25-29,1992. Fail, P.A., J.D. George, T.B. Grizzle, and J.J. Heindel (1993). Potential reproductive toxirity of formamide (FORM) as evaluated by the continuous breeding protocol. The Toxicologist, 13: 76. George, J.D., P.A. Fail, T.B. Grizzle, R.S. Yang, and J.J. Heindel (1993). Reproductive toxicity evaluation of a pesticide/fertilizer mixture administered in the drinking water to Mice, The Toxicologist, 13: 77. Fail, P.A., J.D. George, T.B. Grizzle, and J.J. Heindel (1993). Potential reproductive toxiaty of formamide (FORM) as evaluated by the continuous breeding protocol. Triangle Conference on Reproductive Biology, January. Anderson, S.A., H.R. Sauls, S.W. Pearce, and P.A. Fail (1993). Endocrine responses after boric acid exposure for 2,9, or 14 days in cannulated male CD rats, Triangle Conference on Reproductive Biology, January. Fail, P.A., J.D. George, T.B. Grizzle, J. Bishop, and J.J. Heindel (1993). Dominant lethality of acrylamide and three of its congeners after chronic exposure in Swiss mice. Environmental Mutagen Society Annual Meeting, April. SL 108417 Patricia A. Fail Page 11 Fail, P.A., S.A. Anderson, S.W. Pearce, H.R. Sauls, and R.P. Reynolds (1994). Endocrine toxidty of nickel: effects on prolactin, thyroxine, and progesterone in rodents after subchronic exposure to nickel chloride in drinking water. Presented at Triangle Conference on Reproductive Biology, January 1994. Fail, P.A., S.W. Pearce, S.A. Anderson, and L.E Gray (1994). Methoxychlor alters testosterone and LH response to human chorionic gonadotropin or gonadotropinreleasing hormone in male Long-Evans hooded rats. Biology of Reproduction, 50, Suppl. 1, p. 102 (Abstract 206). Anderson, S.A., P.A. Fail, B.T. McTaggart, R.W. Tyl, and L.E Gray (1994). Reproductive toxidty of methoxychlor in com oil to male and female Long-Evans hooded rats using the alternative reproduction test protocol (ART). Biology of Reproduction, 50, Suppl. 1, p. 101 (Abstract 186). Fail, P.A., S.W. Pearce, S.A. Anderson, R.W. Tyl, and L.E Gray, Jr. (1995). Endocrine and reproductive toxidty of vindozolin (VIN) in male Long-Evans hooded rats. The Toxicologist, 15, Suppl. 1, p. 293 (Abstract 1570). Anderson, S.A., S.W. Pearce, P.A. Fail, B.T. McTaggart, R.W. Tyl, and L.E. Gray, Jr. (1995). Validation of the alternative reproductive test protocol (ART) to assess toxidty of methoxychlor in rats, The Toxicologist, 15, SuppL 1, p. 164 (Abstract 871). Fail, P.A., S.A. Anderson, C.E Cook, L.K. Jost, and D.P. Evenson (1995) Testicular target of indenopyridine analog contraceptive in male mice, presented at XIII Testes Workshop Serono Symposium, Raleigh, NC, March 1995. Cook, C.E., M.C. Wani, J.M. Jump, Y.-W. Lee, P.A. Fail, S.A. Anderson, and V. Petrow (1995) Structure-activity studies toward the development of potential antispermatogenic agents for male contraception, presented at XIII Testes Workshop Serono Symposium, Raleigh, NC, March 1995. Anderson, S.A., P.A. Fail, S.W. Pearce, R.W. Tyl, and L.E Gray, Jr. (1995). Testicular and adrenal response in adult male Long-Evans hooded rats after antiandrogen vindozolin exposure. Journal of Andrology, 15, SuppL 1, p. P-43 (Abstract 78) Fail, P.A., S.A. Anderson, M.C. Wani, Y.W. Lee, J.M. Jump, and C.E Cook (1995). Contraceptive potency of two indenopyridine analogs of sandoz 20-438 tested in Swiss mice. Journal of Andrology, 15, Suppl. 1, p. P-48 (Abstract 99) SL 108418 Patricia A. Fail Page 12 STUDY REPORTS * COMMERCIAL CLIENT Custom-designed endocrine experiments are performed according to Good Laboratory Practices and governmental guidelines for FDA, OECD, or EPA (FIFRA/TSCA). These report titles are not available due to confidential nature of the study. STUDY REPORTS * GOVERNMENT CLIENT Boric Acid (BORA): Reproduction and Fertility Assessment in Swiss (CD-I) Mice When Administered in the Feed. P.A. Fail, J.D. George, T.B. Grizzle, R.E. Chapin, and J.J. Heindel, Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB90253808, April 13,1990. Mixed Chemicals (MIX): Reproduction and Fertility Assessment in Swiss (CD-I) Mice When Administered in the Drinking Water. J.D. George, P.A. Fail, T.B. Grizzle, RE. Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB91158444, November 1,1990. 4-Vinylcyclohexene (VCH): Reproduction and Fertility Assessment in CD-I Mice When Administered by Gavage in Com Oil. J.D. George, P.A. Fail, T.B. Grizzle, RE Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB91211250, May 14,1991. Carisoprodol (CARI): Reproduction and Fertility Assessment in CD-I Mice When Administered by Gavage in Com Oil. J.D. George, P.A. Fail, T.B. Grizzle, J.J. Heindel, and R.E. Chapin. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB92128404, September 10,1991. Influence of Restricted Feeding on Reproduction and Fertility Assessment in CD-I Mice. P.A. Fail, J.D. George, T.B. Grizzle, J.J. Heindel, and RE Chapin. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB92174259, February 21, 1992. Ortho-Cresol (OCRE): Reproduction and Fertility in CD-I Mice When Administered in the Feed, J.D. George, P.A. Fail, M.K. Izard, T.B. Grizzle, J.J. Heindel, and RE Chapin. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB92176890, March 13,1992. Meta-/Para-Cresol (MPCRE): Reproduction and Fertility Assessment in CD-I Mice When Administered in the Feed, M.K. Izard, J.D. George, P.A. Fail, T.B. Grizzle, RE. Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB92191741, May 1,1992. Nitrofurazone (NTFZ): Reproduction and Fertility Assessment in CD-I Mice When Administered in the Feed, J.D. George, P.A. Fail, T.B. Grizzle, J.J. Heindel, and RE. Chapin. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB92217694, July 15,1992. SL 108419 Patricia A. Fail Page 13 Iowa Pesticide/Fertilizer Mixture GWA): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water, J.D. George, P.A. Fail, T.B. Grizzle, R.E. Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB93109270/AS, July 31,1992. Fortnamide (FORM): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water, J.D. George, P.A. Fail, T.B. Grizzle, R.E Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB93109213, July 31,1992. N,N-Dimethylfbrmamide (DMF): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water. J.D. George, P.A. Fail, T.B. Grizzle, R.E. Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB92123842, September 24,1992. Methacrylamide (MACR): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water, P.A. Fail, J.D. George, M.K. Izard, T.B. Grizzle, R.E. Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB93149284, November 10,1992. Acrylamide (ACRL): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water. P.A. Fail, J.D. George, T.B. Grizzle, M.K. Izard, R.E Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB93158285, December 18,1992. N,N'-Methylenebisacrylamide (BACR): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water, P.A. Fail, J.D. George, M.K. Izard, T.B. Grizzle, R.E Chapin, and J.J. Heindel Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB93160976, December 18,1992. NTHydroxymethyD-Acrylamide (HACR): Reproduction and Fertility Assessment in CD-I Mice When Administered in Drinking Water. P.A. Fail, J.D. George, M.K. Izard, T.B. Grizzle, R.E. Chapin, and J.J. Heindel. Final Study Report, NTP/NIEHS Contract No. N01-ES-65141, NTIS No. PB93151561, December 18,1992. Development and Testing of Nonsteroidal Male Contraceptive Agents. C.E. Cook, Y.W. Lee, P.A. Fail, M.C. Wani, November 2, 1990, Fourth Quarterly Report, Project No. 311U-4587/00/06Q, July 1,1990 - September 30,1990. Development and Testing of Nonsteroidal Male Contraceptive Agents. C.E. Cook, Y.W. Lee, P.A. Fail, M.C. Wani, February 6, 1991, Fifth Quarterly Report, Project No. 311U-4587/00/06Q, October 1,1990 - December 31,1991. Development and Testing of Nonsteroidal Male Contraceptive Agents. C.E. Cook, Y.W. Lee, P.A. Fail, M.C. Wani, May 8, 1991, Sixth Quarterly Report, Project No. 311U-4587/00/06Q, January 1,1991 - March 31,1991. SL 108420 Patricia A. Fail Page 14 Development and Testing of Nonsteroidal Male Contraceptive Agents. C.E. Cook, Y.W. Lee, P.A. Fail, M.C. Wani, September 19,1991, Seventh Quarterly Report, Project No. 311U-4587/00/06Q, April 1,1991 - June 30,1991. Development and Testing of Nonsteroidal Male Contraceptive Agents. C.E. Cook, Y.W. Lee, P.A. Fail, M.C. Wani, January 3, 1992, Eighth Quarterly Report, Project No. 311U-4587/00/06Q, July 1,1991 - September 30,1991. Development and Testing of Nonsteroidal Male Contraceptive Agents. CE. Cook, Y.W. Lee, P.A. Fail, M.C. Wani, September 10, 1992, Ninth Quarterly Report, Project 311U4587/00/09Q. 28-Day Toxicology Screen: Indenopyridine RTI4587-056 in Male Sprague-Dawley (CD) Rats. P.A. Fail, S.A. Anderson, H.R. Sauls, and C.E. Cook, January 13, 1993, Project 311U-4587-004. Synthesis and Testing of Male Contraceptive Agents. CR Cook, J.M. Jump, P.A. Fail, and S.A. Anderson, July 1,1994, Fourth Quarterly Report, Project 60U-5539/4Q. Two-generation study of methoxychlor administered in com oil to Long-Evans hooded rats using the alternative reproductive test protocol. Fail, P.A., S.W. Pearce, S.A. Anderson, A Final Report issued to US EPA CR820335-01-0.1995. (Submitted May 1994) Two-generation study of vinclozolin administered in com oil to Long-Evans hooded rats using the alternative reproductive test protocol Fail, P.A., S.W. Pearce, S.A. Anderson, A Final Report issued to US EPA CR820335-01-0.1995. (In preparation) CONFIDENTIAL STUDY REPORTS Mechanistic Studies: Serum Hormone Concentrations after XXXXXX has been Administered in the Feed or by Gavage to Adult Female CD Rats, Experiment 1 and 2. P.A. Fail and MX Izard, 1991, Project No. 311C-4556-10, Submitted August 8, 1991, Confidential Client Chronic Intra-atria] Cannulation and Microassay for Hormones Allows Longitudinal Study Design to Assess Endocrine Changes in Adult Female CD Rats Exposed to Dietary XXXXXX, Project B. MX Izard and P.A. Fail, 1990, Project No. 311C-4556-10, Submitted September 17,1990, Confidential Client. May 1995 SL 108421