Document 5bdOeX8qrz8vRDjxDVz2VBKZR

FILE NAME: Chemical Abstracts (CHAB) DATE: 1959 DOC#: CHAB042 OCUMENT DESCRIPTION: Abstract Originally Published in 1958 by Schmal I n 1950 22413 U G --Pathology 22414 5 3 H-V Med. J. Australia 1959-11, 105--13.--A lecture on per turbidity with cancer serums. It is postulated that rapidly nicious anemia, Co, and vitamin Bu. _ Erich Hirsch berg growing tumor cells attack the hyaluronic acid-heparin bar Isoniazid and the organism. Experimental physiopatho- rier built up against them in the organism, liberating muco logical research. Gennaro Di Macco (Univ. Rome). Sci. polysaccharides demonstrable in the circulation by the agar Med. Ital. (Eng. ed.) 7, 243-53(1958).--Studies on the ca- a binding reaction. Erich Hirschberg pacity of isoniazid to change the reactivity of the organ ism to Influence of dehydroascorbic acid on tumor metabolism. pathological stimuli indicate that, on the whole, the n euro E. Heise, W. Liihrs, and O. XeunhoelTer (Deut. Akad. vegetative orientation tends to be predominantly cholinergic. Wiss., Berlin). Z. Krebsforsch. 62, 509-15(1958).--De Erich Hirschberg hydroascorbic acid (I) reduces anaerobic glycolysis, propor Alterations in liver nucleic acids in rats during carcino---tionately to its concn., by 34-68%; aerobic glycolysis is genesis with 4-dimethylaminoazobenzene. A. Khadzhilov reduced 24% and respiration increases by 42%. I is not (Med. Fac., Sofia, Bulgaria). Z. Krebsforsch. 62, 361-9 toxic up to 500 mg./kg. administered to nits. At 2 mg./ (1958).--Histochem. and biochem. detns. indicate that kg., intravenous injections of I retarded the growth of Jen during the first 45-50 days of carcinogenesis hepatic ribo- ^ sen sarcoma and Walker carcinosarcoma 256 in rats and of nucleic acid (RNA) decreases while deoxyribonucleic acid the Ehrlich ascites tumor in mice. Higher doses of I were (DNA) increases. RNA disappears from dying hepatic cells not more effective. Erich Hirschberg and is low in rapidly growing cholangioepithelial cells. At Influence of zymosan on experimental animal tumor a later period (95-100 days), the content of RNA begins growth. W. Liihrs, E. Heise, and H. Berndt (Deut. Akad. to increase, together with the amt. of DNA. Hepatomas --'W iss., Berlin). Z. Krebsforsch. 62, 516-18(1958).--The and cholangiomas are characterized by a high level of RNA intravenous injection of 20 mg./kg. zymosan into rats bear and DNA. Erich Hirschberg ing the Jensen sarcoma or the Walker carcinosarcoma 256 Glycogen content in carcinomas of the oral cavity. Er retards tumor growth, presumably by influencing the level hard Fasskc and Konrad Morgenrotli (Stadt. Krankenan of properdin. Erich Hirschberg stalten, Essen, Ger.). Z. Krebsforsch. 62, 375-82(1958).-- Uptake of methionine-5" by the mitochondria of neo Histochem. measurements indicate that a larger percent of plastic cells. G. Giudice and V. Mutolo (Cancer Research oral malignant carcinomas than of carcinomas of the portio Center, Palermo, Italy). Z. Krebsforsch. 62, 548-51(1958) uteri contain glycogen. Detns. in normal oral mucosa are (in English).--DL-Methioninc-A" was injected into normal also presented. Glycogen content does not depend on th e _ - mice and mice bearing the Ehrlich ascites tumor. Normal level of circulating insulin. Erich Hirschberg liver cells and ascites tumor cells were fractionated, and the Anticancer experiments. H. Okamoto, S. Koshimura, sp. activities of the fractions were studied. Tumor mito R. Hirata, K. Murasawa, Y. Bando, and R. Shimizu (Univ. chondria took up the labeled methionine at ~ lower rate Kanzawa). Z. Krebsforsch. 62, 408H8(1958)(in English).-- ' than those of normal liver cells. After 3 firs., '.he trichloro Living hemolytic streptococci inhibit the growth of the " acetic acid-sol. fraction was more active in the tumor cells Ehrlich ascites carcinoma and the Yoshida ascites sarcoma, than in the normal cells. These differences were not found presumably by forming streptolysin S at the expense of tu when the labeled methionine was administered in vitro to mor ribonucleic acid. Other microorganisms (e.g. Strepto cultures of normal or malignant cells. Erich Hirschberg coccus faecalis, Staphylococcus aureus, Diplococcus pneu- _ - Influence of adrenochrome on tumor cell metabolism. moniae, Escherichia coli, Neisseria gonorrhoeae) do not have these effects. The Yoshida tumor is inhibited by nitromin E. Heise, W. Luhrs, and O. Neunhoeffer (Deut. Akad. Wiss., Berlin). Z. Krebsforsch. 62, 555-60(1058).--Adreno and by G-(2-hydroxy-3,5-dibrotnophenylazo)-4-hexylresorci- chrome increases the respiration of cells of Jensen sarcoma nol (I), but not by 6 hydroxybenzylidenes, 5 phenoxazones, i or Walker carcinosarcoma 256 to double the normal amt. 11 quinones, and 24 miscellaneous compds. tested in these t' but does not influence aerobic and anaerobic glycolysis when expts. Inhibition of the Ehrlich tumor hy I was more added at a level of 0.3 ml. of a O.Olrlf soln. Adrenochrome striking than that by mitomycin, carzinophilin, actinomycin has no effect on the growth of Jensen sarcoma in rats. Ad J, 6-mercaptopurine, triethylenethiophosphoramide, or 1,6- renaline probably can be oxidized to adrenochrome by means bis(2-chloroethylamiuo)-l ,6-deoxy-D-mannitol. I also in _ of dehydroascorbic acid. Erich Hirschberg hibited the ascitic form of sarcoma 180. E. Hirschberg ~ Energy reactions inducing anoxygenic synthesis demon Carcinogenic effect of asbestos implanted into rats,/) strable in human tumors. F. Windisch (Deut. Akad. Dietrich Schmahl (Univ. Bonn, Ger.). Z. Krebsforsch. 62, > Wiss., Berlin), W. Nordheim, and W. Heumann. Z. 561-7(1958).--Asbestos fibers and small fragments were/ Krebsforsch. 62, 423-33(1958).--Decoctions of various hu- j. applied subcutaneously and intrapcritoneally in 39 rats.' man cancer tissues may cause a marked generative effect on Of the 30 rats which survived 15 months, 11 developed anabiotic fermenting yeast cells, but have no influence on the sarcomas at the site of implantation. Erich Hirschberg growth of respiring cells. Erich Hirschberg Reactions of lymphoid tissue to stimulation by antigen. Chemically defined substances, identical in action with Albert H. Coons (Harvard Med. School, Boston, Mass.). materials present in cancer, endowed with an anoxygeni---Ilarvey Lectures 53, 113-29(1959); cf. C.A. 49, 15011A, cally energy-liberating potential. F. Windisch, U. Ger 15012a.--A review. Julia O. Holmes hardt, W. Nordheim, W. Heumann, and H. Kcruer (Deut. Significance of serum Fe determination in diagnosis of Akad. Wiss., Berlin). Z. Krebsforsch. 62, 568-84(1958).-- hepatobiliary diseases. Chin-Yuan Kuo, K 'uo-Huan A microbiol. test with Saccharnmyces carlsbergenesis strain , Liang, Sun-Yi Wang, and Hsiang-Sheng Huang. Chung U (preceding abstr.) is used to det. the ability of various 1 Iiua Nei K 'o Tsa Chih 6, 340-5( 1958).--Serum Fe was detd. materials to cause cell multiplication under strictly anaero by the c^a'-dipyridyl method of Bothwell and Mallet ( C.A. bic conditions. The test is pos. with a series of plant and 49, 9720c), with slight modification. The color developed animal oils and lipide-contg. materials, e.g. sunflower oil, was read against a series of Fe standards in a Klctt plmto- butter, and egg yolk (but not with liquid paraffin); with -- electric colorimeter. Among 20 normal subjects the av. crude and purified lecithin (but not with lysolecithin); with serum Fe value was 118 y %, 135.5 y % for 10 males and crude cepludin and some of its fractions; with oleic, lino- 100.5 y % for 10 females. In 27 cases of acute hepatitis the lcic, litioienic, arachidonic, and clupanodonic acids (but not av. scrum Fe value was clearly above normal: 225.1 y %. witli pctroselinic or erucaic acids). DL-6,8-Dimercapto- There was no definite correlation between serum Fe and octanoic acid is inactive at noncytostatic concns. Dipltos- -h bilirubin in the different disease stages of hepatitis exunid. phopyridine nucleotide is inactive under these anaerobic In 5 cases of chronical hepatitis the av. serum Fe value in conditions but active with aerobiosis. 63 references. creased to 218.4 y %. In cirrhosis of the liver, the serum Erich Hirschberg content of Fe was normal: the av. for 32 cases was llo y A new procedure for cancer diagnosis. The agar-binding _ %. In obstructive jaundice serum Fe value was either equal reaction. G. Csaba and I. Toro (Med. Univ., Budapest, to or below normal. The av. of 11 cases with gall stone was Hung.). Z. Krebsforsch. 62, 481-94(1958).--A pos. re was 96.9 y %, significantly different from that of acute hep action consists in the appearance of turbidity when the serum a t i t i s . In neoplastic liver diseases the s e ru m Fe value was of cancer patients is added to agar under defined conditions. lower than normal while in cases of hepatic necrosis, in The reaction was pos. in 86% of 375 histologically proven i' flammations of the gall bladder and bile duct the scrum he carcinomas, in 13% of 528 patients with a wide variety of values were within the normal range. Microcytic anemia, other diseases, and in 7% of normal subjects. In expts. acute infectious hepatitis, and malignant liver tumor showed dealing with the theoretical basis of this reaction, heparin, lower than normal serum Fe. These clinical studies showed galactose, glucose, and fructose irdiibited the formation of that detn. of serum Fe was an effective method in testing