Document 5bN5OJ9dLv7VQVvKMrb6mywde

CHEMICAL MANUFACTURERS ASSOCIATION February 6, 1980 To: Vinyl Chloride Panel and Vinyl chloride Research Coordinators Attached are two announcements received on February 4, 1980 from Dr. Bailus Walker, Director, Health Standards Programs, Occupational Safety and Health Administration. The first, concerns the "Request for Information on Vinyl Chloride and Polyvinyl Chloride" wherein the deadline for submitting written comments on vinyl chloride and polyvinyl chloride is extended to May 9, 1980. The second pertains to the conference to be sponsored by OSHA, NIOSH and NIEHS on March 20, 21, 1980 and having as its theme "A Reevaluation of the Toxicity of Vinyl Chloride, Polyvinyl Chloride, and Structural Analogues". Please note that the conference announcement is to be supplemented at a later date with specific titles of the papers to be presented. Sincerely, JTS:das Enclosures J. T. Seawell Project Administrator Vinyl Chloride CMA 004389 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 1825 Connecticut Avenue NW Washington DC 20009 Telephone 202'328-4200 Telex 89617 CMAWSH i U.S. DEPARTMENT OF LABOR Occupational Safety and Health Administration Washington, d c. 20110 -' __j Mr. Joseph T. Seawell Chemical Manufacturing Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009 Gentlemen: Enclosed is a copy of the December 18, 1979 "Reauest for Information on Vinyl Chloride and Polyvinyl Chloride", and a copy of the notice extending the deadline to May 9, 1980. Attached also is a preliminary agenda for the March 20 and 21, 1980, conference entitled "A Reevaluation of the Toxicity of Vinyl Chloride, Polyvinyl Chloride, and Structural Analogues." We would appreciate your forwarding cooies of this information to interested persons within your organization. Thank you for your cooperation. Sincerely, Bailus Walker, Ph.D. M.P.H Director Health Standards Programs Enclosures CMA 004390 Notice of Meeting OSHA, NIOSH, and NIEHS are jointly sponsoring a conference on March 20 and 21, 1980. The conference is titled "A Reevalua tion of the Toxicity of Vinyl Chloride, Polyvinyl Chloride, and Structural Analogues." The location will be in the Masur Audit Bldg.10, Clement Center NIH Campus Bethesda, Maryland. Topics will include: (1) Carcinogenesis Bioassays of Vinyl Chloride Monomer and PVC (2) Toxicology Studies of PVC; (3) Morbidity and Mortality Studies of Vinyl Chloride and PVC Workers; (4) Industrial Hygiene Measurements of VC and PVC in PVC operations; (5) Reproductive Effects of VC (6) Community Exposure to VC and PVC (7) Carcinogenicity of Some Structural Analogues of VC (8) Research Needs and Public Health Intervention Program announcements and specific titles of presentations will be forthcoming. Further information may be obtained by contacting either Ms. Jolie Appel (202) 357-0325 or Dr. P. Landrigan's secretary (513) 684-2761. CMA 004391 I 668 Federal Register / Vol.. 45, Mo. 20 / Tuesday. January 22. 1080 / Notices ary tine ai'ar compliance with .'ha Antitrust Pr3'-*h ires a.-,d Percales Act. Tie proposed fud^enl provides-that were has been r.o by anyone with respect to ary iij-j? oi fact rr :aw. Under the provisions of S'a] or -he Antitrust Procedures and rs.`j'.`-'s Act, `-.-.try of the consent judgment by the court .a ccnaitioned upon a cctarmtrabon of the court that the proposed jubment is in the public interest. The crooosed judgment will prohibit the Jos. 5c.-.:;t2 Brewing Company form e.otenng into any screement or arrangement with any other person to fix. raise, or stabilize v. oj '3.*;a cr ron3uciar prices oi beer in iisv.-a.:. The proposed judgment also enjoins the Jcs. B-.t.'.m Brewing Company from tixang. redttoir. j or eiiminattng discounts on beer sV : ' ;rvan ana from fixing 'ha terms or cur.dittor.s of sale of beer sold in Hawaii. Tie judgment also prohibits it from engaging in specified types of communications. Section V i of die proposed judgment enjoins defendant from directly or indirectly rcucmmandir.g. suggesting, soliciting or d:.-'c`:.cg any person to participate in any proscribed agreement as discussed in the preceding paragrapn. Defendant Jos. Schiitz Brewing Company is further restrained from requiring, compelling or coercing any beer wholesaler to set or establish a specific price, dijcount or term of sai* for beef in Hawaii. The judgment hurther prohibits defendant from crmtr.ur.icaung or exchanging information about me price of beer in Hawaii with any c-her brewer of beer. By the terms oi the proposed judgment, de'endu-ct agrees mat if. during the ten-year per-od of lire decree, it should sell all or substantially ail of the assets of its beer operations in Hawaii, the purchaser will agree to be bound by the provisions of this judgment. The judgment further provides that should defendant sail its Hawaiian assets and yet continue to distribute its beer products in Hawaii, the terms of the judgment shall continue to be applicable to defendant Jos. Schiib Brewing Company. The proposed judgment is designed to prevent any recurrence of the activitiee alleged m the complaint The prohibitions in the judgment are intended to ensure that future price actions of (he defendant will be independently determined without the restraining aad artificial influences which result from communication and agreements among competitors. The judgment provides methods for determining the defendant's compliance with the terms of the judgment. Officers, employes, and agents of the defendant may i. Li stewed by inly .lUthyrieed represeuiauvss of the Department of Jusnce .-"Hiding the defendant's compliance with the judgment. The Government, on reasonable notice, is entitled to examine the records of the defendant far possible violations of the judgment, in addition, upon written request, the Government may require the defendant to submit reports on matters contained in the judgment. Finally, the defendant is required to serve a cany of the jud 'meet upon successors of the officers, director*, and employees of defendant who hove responsibility far making beer pricing decisions. IV. Exemptions or Modifications in the Decree Section V'.'.J Trovers met the prohibitions in the prooos*a ;ud ;-nen: do not to relations between riiimtidni Jm. Srnniz jrywir.g Comcany a- d -3 parent or subsidiary .vn.ic.s ire under common control. The Government did not object to this provision because ihs decree is not intended to limit communications between a parent and its subsidiary concerning prices to oa charged by toe parent or subsidiary but rather `o i.mi: tommuaicaticns emrr.g competiiors concerning 'ha prices to be charged for Peer in Hawaii. V. P.errpdies A variable ;. Potential Private Liripanis _ Section 4 of the Clayton Act [IS U.S.C. 115] provides that any person who has been injured as a result or" conduct prohibited by the antitrust laws may bring suit in federal court to recover three times the damage such person has suffered, as wall as costs and reasonable attorney fees. Entiy of iha proposed consent judgment in Jus proceeding will neither impair nor assist bringing of any such private antitrust action. Under the provisions of Section 3(a) (IS U.S.C. 5 19(a)), this consent judgment has no prima facie effect in a lawsuits which have been or may be brought against these defendants. VI. Procedures A variable for Modification of the Proposed Judgment As provided by the Antitrust Procedures and Penalties Act any person believing that the proposed consent judgment should be modified may send written comments to Anthony 5. Desmond. Department of Justice. Antitrust Division. 450 Golden Cate Avenue, Box 30C44 Ban Francisco. California 94102, within sixty days. These comments and responses to thsm will be filed with the court and published in the Federal Register. Ail comments will be given due consideration by the Department of Justice which remains tree to withdraw its consent to the proposed consent judgment at any time prior to entry if it should determine that some modification is necessary. The proposed judgment provide* that the court retains jurisdiction. The parties mey apply io the court for such orders as may be necessary or appropriate for modification of the judgment. vn. A.lterncrives to tha Proposed Consent /udpttent Considerai by tbs D.a;:a`> States An alternative to the proposed : 'figment considered by the Department of Justice was a full trial on the merits. It was determined that such a trial involved substantial expense to tha United States and was not warranted since the equitable remedies set forth in the proposed consent judgment will restore competition in the beer industry in Hawaii. vm. Determinedve Bbcumentr Thera ara no materials or documents which were determinative in f'jrmuiatjfg.Siprcposal for a consent judgment and. therefore, none are being filed by the Government pursuant to Section 2(b) of :he Antitrust Procedures tied Prosifies .Act (15 U.S.C. 5 ".e(b|). Duisd; January 21.2330. Christopher S. Crook. Gary R. Spratliug, Attorneys, Department ofJustice. [FS Doc. 30-^314 f;(d t*Z0-4fe Ml an) ?;lung code DEPARTMENT OF LASCft Occupational Safety and Health Acjmtni3ti"Jtion Occupational Exposure to Viny) Chloride and Polyvinyl Chloride AG2NCV! Occupational Safety and Health Administration. Department of Labor. action: Extension of time for written comments. . summary: This notice extends tha timeperiod for submission of written comments in response to a request for' information on vinyl chloride and polyvinyl chloride which was published on December 13, 1973 (44 FR 74923). The December 13 notice had requested the submission of written comments not later than February 10.1380. Subsequently, several interested parties requested extension of the deadline by which their comments should be submitted. These-requests were based on the need for additional time to ' coordinate efforts within the industrial groups to collect and collate the information requested-in a manner that would be most beneficial to all parties concerned. CSKA finds validity in these requests and has granted an extension of time to submit written comments. Written submissions should be received by the OSKA Docket Officer, no later than May 9,1S80. Oats The period for submitting written comments is extended to May 9,130a ADORtss The information requested on December 13.1979 (44 FR "4923] nhouia be su'oinutsu to tha Docket Officer. Docket So. H-034, Room S8212. U.S. Department of Labor. OSHA. 200 Constitution Ave,, N.W., Washington. D.C 20210. (202) 323-7394. FOR FURTHW INFORMATION CONTACT: Dr. Peter Infante, Office of Carcinogen Identification and Classification, Directorate of Health Standards Programs, Room N3713, U3. Department of Labor. OSHA, 200 Constitution Ave, N.W, Washington. D.C 20210. Teiephone (202) 237-0325. CMA 004392 Federal Register ! Voi. 45. So- ~0 ! Tuesday. Tanunry ID. 1960 / Notices 5659 at Washington. D.C `.hi* 22.nd day sM !;'/ I jfiO. .r-v?vy 0>L`i<jvt:nna i>, v?y and v' s^.'/S , *: k.j-wO- <., * ^9D-:s-Xi Aoorovad State Pans far Saforcam-int jr State Standards; Approval of Ulan pun Supplement agv:cy: Occupational Suftty ir.d H. util Administration. aCVOH; CSHA assumes author.;-/ for . ./a: -ant r ar.riru-. it Hill .\lr Force Case in .he State vi Utah. summary: This document approves a Slaie-iniriated change supplement which refloats rhe-Utan State Attorney General's opinion that Utah does not have authority to enter Hill Air Force Base for the purpose of making general inspections under the Utah Occupational Safety and Health Act. The Occupational Safety and Health Administration assumed full authority tor making inspections at the Hill- Air Force Base on .-Vonary 1.1973. .=7cCTty3 BATE January 23. I960. fcb PjTreea information contact; Charles Boyd. Frawct Off:car. Office of State Prosrams. Occupational Safety and Hesith Administration. U.S. Cepartment of Labor. 200 Cons a.adon Avenue N'\V,, Room N-2813, Washington. D.C 20210. (202) 523-608L SU.fTMJLMSNTARY INFORMATION: 3/ letter dated March 2fc, 1979, the State submitted a State-initiated plan change to CSHA'* Denver Regional OfF.ce. Tha letter provided r.oiice that the State dos3 r.o! have authority to enter the Hill Air Force Bisa for the purpose of making genera! inspections under the Utah Occupational Safety and Health Act, and that Federal OSHA will assume authority for the enforcement of standards at tha base. This action was : ikon as a result oi OSHA Instruction STP 2.14 which asked regional administrators to determine tha r-ci'.-.Ci" of Stat* safety md h-*alth p..- -iiins io ar:v *'eempsijvera ..i >f*as of ` exclusive Federal Jurisdiction '. The Directive also requested States vrith approved State plans to provide a State attorney general's ruling us to the status of Federal enclaves within the State and the intentions of the State to seek entry for tha purpose of enforcing State occv.p nional safety and health laws. Description of the Supplement !'u*suunt to Suboar: S of 29 OFF. Fart iSijJ, the S'ote submitted a Stateim.iiatcd piun change which provides for Fallen! CSHA `J assume full amhoiity for me "p.forconant or Li-viy ->r.d hsjn.i s: inrfsrds it the Hill Air Force Base, atractive F;o.~uo:y :. ;'-j75. Location of ::-.e Plan or.d its Supplement for fospecaun and Copying A copy of 'he State's plan ar.d its supploment may he i-.spwtcd .md co IdC :r,r S r-cmvil : iismsss aours at ; locations: Gffica c: S-ata %rjLrr>3. 0<~cuca tiora1 Safety ar.d ? 'h A n is ma ti?.:, U.S. O^partman .uL^nr. Foam N-3313., 220 Constitulic! in'.:s ' ;w... Washing'ion. D.C 2C21C: f! 2^ ^1. ..-'m>:str-!for. Occupauuaai Safety .md Hseit.t Administration. Room 1534. Federal Office Building. 1951 Stout rest, Denver. Colorado 30234; an the Utah Industrial Commission, UGi LA Offices at 143 South 4C0 Fast. Salt L. .e City. Utah 34111. Public Participation Under J 1953.2(c) of this chapter the Assistant Secretary of Labor for Occupational Safety and Health (hereinafter called the Assistant Secretary] may prescribe alternative procedures to expedite the review process or for any other good cause which may be consistent wi;h applicable law. The Assistant Secretary finds that the Utah supplement described above is consistent with the provisions in OSHA Instruction STP 114. Application of State Safety and Health Provisions to private Employers in Areas of 'Exclusive Federal Jurisdiction". Accordingly, it is found that further public comment is unnecessary. Decision After careful consideration, the Utah plan supplement described above is hereby approved under Subpart E of 29 CFR Part 1953 of this Chapter. This decision incorporates the requirements of :he Act and implementing regulation* applicable to State plans generally. Signed at Washington, D.C, this 22nd day u firuavy ::?n. .-iCj.'s-'a.i; SsC.-ef--.U.O.V. ,?a Uor..T-tM* l-:s->C: CCS - i| aiujaa ccos ano-is-w IV-30-1J General Electric C04 AppFcarian for Variance and Denial of interim Order agency: Occupational Safaty and Health Admtnistrat;;:"., G-v mtmenr cf Labor. actions: ft) No'ice of application far variance and ntar.m order 1--j Denial of inmrm order. summary: This not'ce a.-mounces t. appU...;',;o:'i of Gmural Siectrtc Oci,,;pany for a vu.-'.ar.ots ir.d .r.'.eiwn orb--.' pending a dscisicr. on me application for variance from `he standard prescribed in 20 CTF. `.912.22! c) concerning cuveis and/or guardrails for opan pita, it also announces li;s denial of the interm order. CATH5: The last day for inferos----persons to submit comments is February 23.1350. The last date foraffected ample;, ers nr.-i employees to reouesf .i hearing on the application is-February 28,1380. addresses; Send comments or requests for hearing to: Otfice of Variance Determination. Occupational Safe*/ ar.d Health Administration. U.S. Department of Labor. Third Street and Constitution. Avenue NW.. Room N2062, Washington, D.C 20210. FOR FURTHER INFORMATION CONTACTS Mr. James J. Concannon. Director. Office of Variance Determination. at the above address, telephone; (202) 523-7144. or the following Regional and Area Offices: U.S. Department of Labor. Occupational Safety and Health Administmiion, Gateway Ouildlra. Suite 2130, 3505 Market Sirent, Philadelphia. Pa. 1T.04. U5. Department oi Labor, Occupational Safety and I leeith Administration. I47`W.. 18th Street, Ere, Pa. 13301. Node* of Application Notice is hereby given that Ceneral Electric Company, Transportation Systems Business Division. 2901 East Lake Road, Erie, Pa. 15531 has made application pursuant to section 6(d) of the Occupational Safety and Health Act 0! 1970 (84 StaL 1396: 29 U.S.C. 655) and 29 CFR 1905.11 for a variance, and an interim order pending a decision on the application for a variance, from the standards prescribed in 29 CFR lSH0~;c) which stats that covers and/ or guardrails shad be provided to protect personnel from the hazards of open pits, tanks, vats, ditches, etc. T'-i-s ti.ibrrs3 of the piece i.f empiuv.iiv-nt chut .v-.i be .`.ffectsd by -4upplication is as follows: Ceneral Electric Company. Tiansportatlon Systems Business Division. 2901 East Lake Road. Erie. Pa. 16331. The applicant certifies that employee* who would be affected by the variance have been notified of the application by giving a copy of it to their authorized employee representative, and by posting a copy at ail places where notices io employees are normally yosiad. Employees have also be-n informed of CMA 004393 71028 Federal Register / Vol. 44. No. 244 / Tuesday. December 18. 1979 / Notices Dated: Decamber 10.1979. Frank H. Madden. AID Advisory Committee Representative, Join'. Committee an Agricultural Development, Board for International Food and Agricultural Development. [fH tlot Filed 11-17-79: til UO| OILUHG COOI 4710-W-M DEPARTMENT OF LABOR Occupational Safety and Health Administration Occupational Exposure to Vinyl Chloride and Polyvinyl Chloride agency: Occupational Safety and health Administration, Department of Labor. action: Request for information on vinyl chloride and polyvinyl chloride. OATE: The information requested in this notice must be submitted in quadruplicate on or before February 10. 1980. ADORZSKThe information requested in this notice should be submitted to the Docket Officer, Docket No. H-034. Room S0212, U.S. Department of Labor, OSHA. 200 Constitution Avenue, N.W.. Washington. D.C. 20210. (202-523-7894). FOR FURTHER INFORMATION CONTACT; Dr. Peter Infante, Office of Carcinogen Identification and Classification. Directorate of Health Standards Programs. Room N3718, U.S. Department of Labor. OSHA, 200 Constitution Avenue. N.W.. Washington, D.C 20210, (202-357-0325). SUPPLEMENTARY INFORMATION; Background summary: This notice requests Vinyl chloride fCiHiCl CAS No. TS information on vinyl chloride (CAS No. OI^: chloroethene) is a colorless gas at 75-01-4) and on polyvinyl chloride (CAS room temperature and pressure. After No. S002-88-2). Vinyl chloride-(VC), a synthesis from VC monomer, polyvinyl synthetic chemical was once chloride ((C,H,C1),; CAS No. S002-88-2; synthesized by the addition of hydrogen chloroethene homopolymer} is in the chloride to acetylene. Currendy, the form of white or colorless granules. most common route of production is by Residual vinyl chloride monomer can the halogenation of ethylene. In this become trapped in the PVC particles. latter process, ethylene is reacted with However, recent processing methods hydrogen chloride and oxygen to give can reduce considerably the amount of ethylene dichloride, which is residual VC trapped in the polymer subsequently cracked thermally to resins. produce vinyl chlcrida and hydrogen The vinyl chloride industry can be chloride. Vinyl chloride is used divided into three major components: primarily to produce polyvinyl chloride VC synthesis. VC polymerization, and (PVC). a plastic resin, through PVC fabrication. It has been estimated conversion of the VC monomer into a that in the U.S., 15 plants manufacture polymer or copolymer form. Vinyl vinyl choride, 43 plants polymerize chloride is also used in the production of polyvinyl chloride, and at least 7,500 methyl chloroform and in the production plants are engaged in the fabrication of of resins as a comonomer with PVC During 1978,3.47 million tons of vinylidene chloride. PVC is used in the VC and 2.94 million tons of PVC were manufacture of a variety of industrial and consumer products, such as containers, wrapping film, electrical insulation, and pipes. In 1975, OSHA regulated vinyl chloride as a carcinogen, based primarily on evidence of excess liver angiosarcoma incidence following VC " exposure (29 CFR 1910.10171. OSHA did not regulate exposure to PVC dint in the same standard. Therefore, it continues produced. The present permissible limit for occupational exposure to vinyl chloride Is 1.0 ppm averaged over any 8-hour period, and 5.0 ppm averaged over any period not exceeding 15 minutes (29 CFR 1910.1017). For polyvinyl chloride dust, the standard is 15 mg/m1, averaged over any 8-hour period (29 CFR 1919.1000). Laboratory Studies to be regulated as an inert or nuisance Experimental bioassays have air contaminant (29 CFR 1910.1000, demonstrated the induction of cancer by Table Z-3). VC at levels of exposure lower than Research since 1975 has provided those previously reported. In VC considerably more information inhalation studies of rats. Maltoni (1) concerning the carcinogenic and other has induced liver angiosarcomas at 25 toxic effects of VC and PVC exposure. ppm and mammary carcinomas at one OSHA is currently in the process of ppm. In addition, several different test evaluating the available evidence systems have provided evidence for the pertaining to the potential occupational mutagenic potential of VC, i.e.. coll, S. health hazards of VC and of PVC and, typhimurium, S. pomba, insects, plants, by this notice, is requesting information and cultured mammalian cells (2). VC related to several important issues.:': :'',. ' tdsro has*>BiTniBrinws*rftedrto have a" transplacental effect in rats. Inhalation exposure of pregnant rats to VC concentrations of 0,000 and 10,000 ppm have resulted in VC-dependent tumors in their offspring (1). There is also evidence from animal studies that PVC may induce nonmalignant respiratory disease. It has been reported that after seven months of exposure, rats and guinea pigs caged in work areas where sacks were being filled with PVC powder developed pulmonary pathological changes and granulomatous lesions containing foreign particles thought to be PVC dust (3). Epidemiologic Studies Several investigations of employee populations have indicated that VC/ PVC exposure is associated with an increased carcinogenic risk to several organ sites in addition to the liver. A NIOSH retrospective cohort study of workers from four VC polmerization plant showed an excess number of deaths due to cancer of the liver, lung, lympho-hematopoieitc system, and central nervous system (4). Of further concern is the finding that the carcinogenic risk may extend to industries fabricating polyvinyl chloride. A proportionate mortality study of plastic workers in Great Britain, which included PVC fabricators, demonstrated a statistically significant excess of stomach cancer (5). Also, an excess of mortality from digestive system cancer among PVC fabricators of both sexes was found by Chiazze eL al. in the U.S. (S). Among white females in the study, observed deaths from breast and urinary tract cancers were also greater than expected. Waxweiler eL aL performed a detailed study of the excess lung cancer risk previously observed at a synthetic plastics and rubber plant (7). Analysis of lung cancer cases by cell type demonstrated a greater frequency of adenocarcinomas (Type 3) and large cell undifferented (Type 4) cancer. Neither ceil type is believed to be strongly assoicated with cigarette smoking. Of 12 chemicals analyzed, only PVC dust exposure proved to be statistically significant. The authors suggested that the excess of Type 3 and 4 lung cancer cases in this plant was related to PVC dust exposure. A recent epidemiologic study suggests that PVC may be related to pneumoconiosis (8). Employees of a polyvinyl chloride production factory in Italy were submitted to chest X-ray examination. Twenty subjects were diagnosed as having pneumoconiosis. All of these cases had worked five or more years in departments with demonstrated PVC dust pollution. No CMA 004394 Fed ral Register / Val. 44. No. 244 / Tuesday, December 18, 1379 / Notices 74923 pneumoconiosis was observed in iubiects who worked in area* free of i'VC dust These findings are consistent with earlier case reports of pneumoconiosis among workers exposed to PVC dust (9.10). The Institute of Oncology and Tumor Center in dologrta. Italy has demonstrated a higher frequency of cytolgoically abnormal sputum cells among the workers employed in the VC/PVC industry in contrast either to workers in the general chemical industry or to individuals who are heavy smokers (11). Epidemiologic studies also exist which demonstrate the mutagenicity of VC in humans. Chromosomal aberrations in lymphocytes of male workers, in excess of the number observed in non-exposed workers, have been reported in several studies (2). Moraver. a study of miscarriages among the wives of men occupationally exposed to VC detected a significant excess in fetal mortality following the husband's exposure to VC (12). Information requested oo vinyl chloride and polyvinyl chloride The date recently received by OSHA suggest that a reassessment of the known health effects of vinyl chloride and polyvinyl chloride is appropriate at this time. Additional information in sev ral areas is naedad before a reassessment can be completed. The requested information includes, but la not limited to. tbe following; (1) Experimental test results for carcinogenicity of vinyl chloride at atmospheric exposures of less than SO ppm. (2) Studies of transplacental carcinogenic and teratogenic effects in humans or animals at any level of exposure to vinyl chloride. (3) Experimental studies of carcinogenicity and other toxic manifestions for any level of polyvinyl chloride exposure. These effects should include, but are not limited to, mutagenicity, teratogenicity, embryotoxicity, and other transplacental effects, as weQ as cytotoxic and cytogenetic effects on sprrm calls. To the greatest extent possihle, complete information concerning the industrial source of the polyvinyl chloride, the size and characteristics of the particles, and exposure levels or concentrations of PVC and residual VC should be included for each study. (1) Epidemiologic studies of either vinyl chloride or of polyvinyl chloride (i.e. cohort, cross-sectional, or casecontrol). (5) Case reports and case series of brain, lympho-hematopoietic, lung and liver cancers by facility and relevant demographic variables, such as age, sex. race, date of diagnosis, date of death, date of Grst exposure, and length of exposure for either vinyl chloride or polyvinyl chloride. (6) Mutagenicity study results of vinyl chloride or polyvinyi chloride as measured by the analysis of human body fluids, e.q., direct mutagenic testing with peripheral blood lymphocytes, non-disjunction in humans with YFF sperm test and w vivo cytogenetics. (7} Body burden measurements of vinyl chloride in humans. (8) For operations involving polyvinyl chloride, the types of resin in use. the concentration of vinyl chloride trapped in the resin, and the concentration of VC and PVC dust in the atmosphere where individuals are working This information should include estimates of the particles sizes and concentrations of particles that fall within the respirable range. (9) In PVC bagging and milling operations, atmospheric levels of PVC and VC monitoring devices used to detect VC and the type of respirator protection program for individuals working in these operations. This should include the sensitivity and validity of analytic techniques in use. (10) Types of occupations, job classifiesdoit*, and industries where exposure to either VC or PVC at any level may occur, and the numbers of employees involved in each vinyl chloride and polyvinyl chloride exposure situation, separated by sex and race. (11) Appropriate engineering controls, work practices, and personal protective equipment available to reduce levels of exposure to VC or PVC below the currant standards, or to the lowest levels feasible. SUBMITTALS OF INFORMATION REQUESTED Interested persons are invited to submit written data, views, and comments with respect to the issues described abv*. AU communications should be submitted in quadruplicate, by February It). lOea to the Docket Officer. Docket H-OM. Room S*2iz. U S. Department of Labor. 2CO Constitution Avenue. N.W.. Washington. U.C. 20210 (202-523-7894). References The following document*, referred to in this notice, are available tor inspection and copying at the OSHA Technical C..u Center. Room San- U.S. Department of Libor. 2uo Constitution Avenue. N.W. W j.-e-jr.ix D.C. 20210. 1. Maltoni. C. Vinyl chloride carcinogenicity: An experimental model for carcinogenesis studies. Qnyjns of Homan Cancer. Cold Spring Harbor Laboratory. 1377. pp. 119-148. 2. Wagoner, J. K. and P. F. Infanta. Vinyl chloride: A cose for the use of laboratory tioassay in the regulatory control procedure. Origins of Human Cancer, Cold Spring Harbor Laboratory. 1977, pp. 1737-iaos. 3. Frongia, N, A. Spmazzola andA. BucartllL Lssiom polmonaxi sperimentali da inalanona prolungata di poiveri di PVC in ambient* di laronx (Expermental lung damage from prolonged inhalation of airborne PVC dust). La Medidaadel Lavaret SSi 321-144 1974. 4. Waxweiler. R.!- W. Stringer.). K. Wagoner,}. Jonas. H. Falk, and C. Carter. Neoplastic risk among worker* exposed to vinyl chloride. Annals of the Now York Academy ofScience*. 271:40-48.1378. 5. Baxter. P. J. and A. f. Fax Angiosarcoma of the Uvar in PVC fabricator*. Lowed ti 244248.1978. S. Chian*. I-- W. E, Nichols, and (X Wang. Mortality among employees of PVC fabricator*. Journal of Occupational Medicine, 19:833-628.1977. 7. Waxweiler. R. J, A. H. Smith. H. A. Tyroler. aod H. Falk An epidemiologic investigation of as exesaa lung cancer risk in a synthetic chemical* plant Presented at th* XIX International Congress on Occupational Health. Dubrovnik Yugoslavia, 25-30 September 1978. 8. Mattroengeki. C. M. Manse. C- Marian G. B. Bertolucci. C. GemignanL G. Saiadlwx L Simonato. end B. Saia. Poiyvtnyi chloride pneutaoconioate: Epidemiological study of exposed worker*,foanrai of Ocaapatianaf Median* 2V. SIO S42.1979. 9. Szaod*. S- K. Lapis. A. Name*. and A. Pinter. Pneumoconiosis caused by tbe inhalation of polyvinyi chloride dust La Medicina del Larons. SI: 423-438.197a 10. Amend. A- P. Pammisr ds Send, U Garbs. H. Payatt and J. Otarpfa. Polyvinyl chloride pneumoconiosis. Thorax, 3X19-25. 1978. 11. Maltoni. & Precursor lesion* in exposed populations as indicators of occupational cancer risk.Annals of the New York Academy ofSciencea, 277.* 444-447,1978. 12. Infante. P. p,, J. K. Wagoner, A. J. MeMichasL R. J. Waxweiler. and H. Falk Genetic risks of vinyi chloride. LaaeeL 1:734735,197a Signed at Washington, DX. this ath day of Dacsmbar 1979. Etda Bingham, Assistant Secretary ofLabor. it* tv* r ** wn ta-ts-m %**< SIU1MO COOS Pension and Weifare Benefit Programs (Prohibited Transaction Exemption 79-79; Exemption Application No. D-S37) Exemption from the Prohibitions for Certain Transactions Involving Colieg Retirement Equities Fund agency: Department of Labor. CMA 004395