Document 5b0X9VoG5ZgQ2kyaEy0k4qx0R

FILE NAME: Neighborhood Exposures (NE) DATE: 1969 DOC#: NE030 DOCUMENT DESCRIPTION: Book Excerpt - Occupational Cancer from "Occupational Health" 7?C<?5.M38 7>t/~ / HOecacultphational HAZARDS OF THE WORK ENVIRONMENT May R. Mayers, M.D. Formerly, Assistant Director, Chief of Medical Unit and Editor of Publications Division of Industrial Hygiene, New York State Department of Labor THE WILLIAMS & WILKINS COMPANY BALTIMORE 1969 SO OCCUPATIONAL HAZARDS TO HEALTH tfiionndintegsst,s.a history of exposure, and appropriate cardiorespiratory func asAosnperexveirotiuosnl,y iisndaincatoeudt,steaanrdlyinagndfepatruorgereossfivaesbdeysstopsniesa,, aantdr,esats aisnwthelel Ccaosueghof, wbehriyclhlioissisu,suitalilsyauttnripbruodteudctpivreim, alorsilsyotfowaelvigehotl,arancoaxpiial,lawryeabklnoecsks. faenadturcehsesotf pthaeinsc,linoircapl apinicsturbee.twOenenphtyhseicashl oeuxldaemrsin, ataioren ochnearaficntdesrisrteic duced chest expansion, with diminished breath sounds and resonance. ThAerehimghayinbceidreanlecse aonfdlpulnegurcaalnfcreicrtiaosnsoscoiuantedds. with asbestosis, reported abtytraMcteerdewceotnhseirdethraeblCehaitetfenFtiaocnto. rSyinIcnesptheecntorstuodfieGsreinatNBewritaYinorkin, S1o9u5t5h, Abrforniccaho{g1e2n)i,cWcaalrecsinaonmdaelissewnhoetrecohnafvineecdletaorlypesrhsoownsn tshufafterainhgigfhrormiskaosf dbiessetaosseis,absbuetsttohsaist. sMucehsotuthmeloirosmmataay, walhsiochdeavreelorparien ttuhme oarbss,enhcaeveofbethene fcoeupntidbilinitythoef wpolerukrearsatnodbrpoenrcihtoongeeunmic.cSarmcionkoimnga waphpeenaersxptooseidnctroeaassebessutoss {IS"N).eTighhisboisrhdoioscduscsaesdesf,u"rtahnearlaingoCuhsatpoterth2o4s,eunadsseorcMiateeddicawliPthersbpeeryctlilviuems. Hexeproes,uarles,o,hhaovset dbiefefenrefnocuensdinarsessopcoinasteedarwe istthrikeixnpgo. sure to asbestos dust. REFERENCES 1. Quinby, G. E.: Epidemic nosebleeds in apple packers. J.A.M.A., 197: 165, 1966. 2. DMeerdn.e, h8l:, 5C9.,19U6.6.Health hazards associated with polyurethane foams. J. Occup. 3. Schilling, R. S. F., Hughes, J. P. W., Dingwall-Fordyce, I., and Gilson, J. C.: IAnnduesptrid. eMmeidol.,og12ic:a2l 1s7tu,1d9y55o.f byssinosis among Lancashire cotton workers. Brit. J. 4. Bouhuys, A., Van Duyn, J., and Van Lennep, H. J.: Byssinosis. Arch. Environ. 5. DHreinakltehr,(PC.,hiacnadgoH),a8tc:h4,9T9.,:19I6n1d.ustrial Dusts, Ed. 2. McGraw Hill, Co., New York, 1954. 6. tH:a2rd19y,,1H95.9L. .: Beryllium disease, A review of current knowledge. J. Occup. Med., 7. Vorwald, A. J., and Reeves, A. J.: Pathological changes induced by beryllium compounds. Arch. Industr. Health, 19: 190, 1959. 8. HMyagrr. ,AWssn. .G, 2.6::A2s6b4e,1st9o6s4.exposure during naval vessel overhaul. J. Amer. Industr. 9. Nagelschmidt, Symposium on G.: The Dust content and Biological Effects ocfoAmspboessittoios.nAonfn.LNun.gYs.wAicthad.asSbceis. t1o8s2is:. In 64, 1965. 10. Gross, p., Cralley, L. J., and deTreville, R. T. P .: "Asbestos" bodies: their non- specificity. J. Amer. Industr. Hyg. Assoc., 28: 541, 1967. CHEMICAL AGENTS: THE RESPIRATORY TRACT 51 11. Bader, M. E., Bader, R. A., Tierstein, A. S., and Selikoff, I. J.: Pulmonary func Atiocandi.nSaesi.b,e1s8to2s:is3.91I,n1S9y6m5. posium on The Biological Effects of Asbestos, Ann. N . Y. 12. Selikoffff, JA.M A, 1I.88J:., Ghurg, J., 142, 1964. and Hammond, E. D.: Asbestos exposure and neoplasia. 13. nSeeloipkloafsfi,a.I.J.JA.,.MH.aAm.,m2o04n:d,10E4.,1C96.,8.and Churg, J.: Asbestos exposure smoking and 290 BIOLOGICAL AND MEDICAL PERSPECTIVES 2. SGOo:ld44m7a, n1,96L1..: The multiple reactor in industrial dermatology. Industr. Med. Surg., 3. ASellleyreg,.,H17.:: 2T3h1e,19ge4n6e.ral adaptation syndrome and the diseases of adaptation. J. 4. K(Cehrnic,aRgo.),A4.:: 3E4n, v1i9r6o2n.ment in relation to allergic disease. Arch. Environ. Health 5. Mayers, M. R.: dustrial Bulletin, BNa.kYe.liStetadteerDmeaptti.tiLs.abHoera, l1t5h: h8a-1za0r, d1s93i6n. the plastics industry. In 6. MSilovnerthbelyrgR, eMvi.ewG,.,Na.nYd. HSteaitmeaDnenp, tH. L.:abSotru,dSie3s: Nwoit.h6,p1a9r4a6p.henylene in fur workers. Occupational Cancer theIncavuiseews ooffchaonwcerli,tittleisisofksnoomwen,inatetrtehset tphraetseanftewtimspee,cwifiicthchreefmeriecnalceantdo pabhlyesicoaflpargoednutcsinign cthaencoerc,cuupnadteiorncaelrteanivnircoinrmcuemntstahnacvees,beaennd faotunsdpeccaifpic uprriinmaarryy bsiltaedsdeorf, pthreedilneacstiaoln.siTnuhseesse, stihtees laarreynpxr,imthaerilylunthges, saknind, tthhee pbroenseesn.cWe hoiflektnhoewbni,oloorgiscuaslpmecetcehda,nicsamrcsinaorgeebniyc naogemnetsanisnctlehaer,wthoerkmeenre vuinrdoenrmkennotwpnrocvoidnedsitiaonnsuonfuseuxaplosouprep.orMtuonsittyoftothsetucdhyemthiceasle amgeencthsanwishmicsh, phreored,ucaes eclasnecwehreirne, laspbeocriaetsordyiffaenreimncaelss maraekenoitt ciamrcpionsosgibelneictotoexmtraanp;oalantde sbuechdisltaibngouraistohreyd dpaatthaoltoogimcaalnly. Ifnromgenseimraill,aroctycuppesatioofnaclanccaenr,cewrshiccahnnaroet nNoenv-eorcthceulpeastsi,onoaclciunpaotrioignianl, acnandcewrhsichhavdeevaelofpewat dsiismtinilgaurisphriinmgarcyhasirtaecs. ttehrainsticsism. iTlahretyumaoprpseawrhtiochdaerveelnoopn, -oanccduppartoivoenalfaitnal,oraigtina;ntheeayrliaepr paegaer tpoosduerveesl;oapnadsthaeryesouflttenofarpeppeeaarteldo,ngthaofutgehr tnhoet inneitcieaslseaxriploysucroen,tienvueonusy,eeaxrs aftIetr icsesosbavtiioonusolyf eexspsoesnutriae.l Ttoimied-ednotsifaygeproetleantitoianlshciaprscianroegesntiilcl oabgsecnutrse.in atinoyn. pHarotwiceuvlearr, witoriks eanlsvoiroinmmpeonrtt,anftortopuorpbotasiens opfreccoisnetroelpiadnemd ioplroegviecnal odcactau,paintisoonfaalr aesnvpiorossnimbleen, tass gtoentehrealldyi,stirnibuotridoenr otfo coarbctianiongepnriecciasgeenintsfoirn mdoastaigoen raeslattoionthsheipnsa.tuOrfe voitfalthiempexoprtoasnucreesailnsovoilsvethde, pmreedfeicraalblryeciongntiimtioen- 291 BIOLOGICAL AND MEDICAL PERSPECTIVES ohfypperrek-ecraantcoesreosu, slelueksiaodnesr,msau,chmealsaneoadrleyrmsaig,npsaopfillsokminataat;rocphhayng, easloipnecthiae, sfiungggeersntaiviles ochf alreauckteermisitai.c Tohfersaedipordeecramncaetirtoisu,s alnedsioenasrlyareblonoodt dayllscnreacsieass scahrailllyengoeccnuoptatoionnlyaltoininodruigsitnr.ialThpheiyrsiceiaarnlys, rbeuctogtoniteivoner,ythmereedfiocrael, pirsaca titiIonnethre(1f)ie.ld of occupational cancer, the practicing physician is often ruengauwlaarrewoofrkth, etovitthale csocnatnritbudtiaotnas nhoewcaanvaimlaabklee,. iTnhteheopcopuorrsteunoitfyhiiss usenaiqrcuhe lianbothraattormyu, cohr ionf athuendivaetrasirteyq. uIitremducsatncnoomtebefrodmeveplhoypseidciainnsawrheo pacritvuaatlelyofsfeiceesc,ainncecranccaesre-ss,croerenciansgescloinficssu,sipnecthteedhcoasnpcietar,l oerithpelranitnmthedeiir tcaanlcoef,ficpersa.cItitcailsl,yacmtuaadlelyt,oa orredseerarfcohr pthroeblmemediocfalexptrraacotritdiionnaerry wimhoporis wcuipllaintigontoaldheivsototeryt,heanfdewreepxotrrta, mfoirnuftuersthneerceisnsvaerystitgoattiaokne, apactiaernetfsulsuocs ptheecitredwoofrkh. aSvuinbgseqbeueenntexinpvoesesdtigtaotiocnarcoinf otgheenicwoargkenetsnviinronthmeencot uorsfehoisf pfiarmtieend,t hmoawye,voerr, mheayhansoct,onctornibfiurtmedhnisotsuosnpliyciotons.coWntrhoelnatnhdeypraevreenctioonn ifnielda apsaartiwchuolaler. plant or occupation, but also to basic research in the wiIthn prelafenrtesnhceavitnog kwneolwl no,rgoarnizseudspmecetdeidc,alcadrecpinaortgmeneincts,agreesnetsarcchandabtae dcealveeloxpaemdiniantitohnes.coTuhrsise oisf pbreeipnlgacdeomneentinansdomsueccpelsasnivtse, foaltlotwh-eupprmeseednit stipmecei,fiwc ipthlaantvioepweratotioindse,ntfiofryinpgurpthoesesoccoufpcaotinotnroall caanudsespreovfencatinocne.r Iinn tthioenaflinaclanacnearl,ysbisu,t daelflinoittihveer doactacuwpaittihonraelfedreisnecaesens,otmounslty ctoomoeccfurpoam such studies of workers on the job. EPIDEMIOLOGICAL STUDIES canIncerepoirdeemmipohloygsiecmala,stfuodrieesxaomfpdleis,eaanseds wwhhiicchh adreevceolompmsolonwtoly,thseucchomas menuvniriotynmasenatwalhodlaet,ao,npeaernticcouulnatrelyrs iunnutesrumalsdiofffictiumlteie-sdoinsaagcequreirliantgionpsrehcipisse. Anoctcoduenvtelmopusctabnecetra,kaesn woefllpearssotnhosseexpwohsoeddtoo. cBaorcthinothgeenoicccaugpeanttisonwahl oanddo naroen-doicffciucpualttitoonadleeanlvwiriotnhm; eanntds, pirnesleanrgtea mgreeaastunreumthbeerdoaftavaariraebnleostwsuhficfih- OCCUPATIONAL CANCER 293 tcaiiennetldy fproremcislea.rgMe onruemovbeerr,swohfeinndoinveiduatatlesm, apmtsotnog dthisetrdibifufteeretnhtevdaaritaabloebs, toinvee.teTnhdesntuomcobmeres oouf tcawsietshmtouostfeawlwcaayssesbienlaarngye oenneoucgahtegtoorbyetsotabtiestdiecfailnliy sigInnifsictuandty.iOngthoercwcuispea,ttihoenaclonccaulusseisonosfacraennceecre,sosnareiliyssluimspietecdt. not only by tthhee dteecahrntholoogficinalfocrommaptiloexnitwiehsicohf occacnupbaetioobntaalineendvirforonmmetnhtes,rbecuotradlssonobwy taovaialabwloe.rkEevr'esn pjorebcicsleassoicficcuaptiaotniondaaltaepxrpoovsiudreesi.naSdoecqiaulateseicnufroirtymarteiocnoradss parreoveiqdueaollnylyunthinefolarmstaoticvceupeavteionnw, hwehnicmh apdreobaavbaliylabhlaes. nDoearethlatcieorntiftiocatthees pagantioesnets'sopnredveiaotuhs ceexrptiofsicuaretessoavreer ntehveeryecaornsf.irMmoedreobvyera,umtoapnsyy. oIfnthheosdpii tmalanryecworodrsk,eorsccaurpeatliooonsaellyhcislatosrsiiefisedtenasd "tloabboerecrass,u"awl iothronuotnreexgiastredntt;o atnhde tbyepeen offoupnlda,ntevinenwihnichcatnhceeyr hhoadspibtaeelsn, wonorkthineg.reScuocrhdsdeosfigpnaattiieonntss hwavhoe hgaatdionb,eewnereadfmouitntdedtofurosemcanreciingohgbeonriincgagpelnatns.ts, which, on later investi asTtohatthewocrhkeemrsi,cawl haegnenintstetroviwewheicdh, cthaneyprhoavviedebeveenryexlpitotlseedpriescinsoet dsautra pvrisisiitntgo. aInpfloarnmt,aytieoanrsaasftteordthoseaegveecnat,nisneuvsueralblye foubtitlaeinbeedcaiunsethdisurwinagy.thAe leomnpgloinyetedrvmaalywhhaicvhe chhaadngeeladpcseodm,ptlheteelmy afrteormialws huastetdheayndhatdhebepernocweshseens tbhuesicnaenssc.erAppartoiesnptecwtiavse,emraptlhoeyredthtahnerea; roetrrothsepepcltaivnet mapapyronaochlo,nigsepr rbeefeirn wabalse, atmheprleyfordee,minonesptriadteemdiobloygitchael srteusdeiaerschof woocrckupcaatirornieadl coauntcebr.yTthhies NeAws YoonerkrSevtaietewsOcwcourpkaetriso'naelxpCoasnucreesr Ctoomfamctiottrese i(n1)t.heir work environ hmoewntssewldhoimch tahreeypsoeteemntiatollybeiniamssicoacliattoedhewailtthh, coanneceirs. iAmpgrreesasetdmwaintyh soufbcstaaunscinesg hmigahnlyy itryrpiteastinogf tdoertmheatsoksiens,, fdoor enxoatmnpelec,eswsahricilhy acraeusceapaskbilne aclatnhcoeurg. hA sgormeaet mchaenmyicsaelnscitaizrciningogagenesntsaraere anlosot psoetnesnittiiazilnlyg caargceinnotsg.enAicir, coothnetarmtyinpaenstsof csaepriaobulse poafthoclaougsyingof athceuteuppaenrd recshpriornaticoryirrpiatasstiaogne,s aanndd tchaercilnuonggesn, ica,reasnwote hnaevceessseaernil,ysicliacracindougstenaincd (m#)a.nyWohtihleerafsibberostgoesnidcudsutsitss are not. Beryllium causes lung cancer in animals, but apparently not 294 BIOLOGICAL AND MEDICAL PERSPECTIVES ianremcaanp.abMleanofy psroubdsutcainncgesa ihnemthoerrhcahgeimc iccyalstiatnisd odrymeetihnedmusotgrileosb,inwemhiicah, dfeownoext cceaputsioenbslaadredenr octancchear.raTchteerisotciccaulplyatiaosnsaolcidaitseedasews,ithwitohccrueplaattiivoenlayl cancer. CHARACTERISTIC SITES FOR OCCUPATIONAL CANCER Skin Canceb becSakuinsecapnreccearnicsebroyusfarletshioencsoomnmtohneesstktiynpearoef orecacduiplyativoinsaibllcea, ntcheery; aanrde scuasucseepdtibthlee eoafrlyearslcyrotdaelteccatniocne,rs ainnd cheifmfencetiyveswreemeposv),al.coaSloottar,(wshhiaclhe obilla,ckpitacrhe, aclrleopsoottee,ntaiaslplyhalct,arcfuineolgeonilisc, tcorudthee msiknienr.alInoilt,heanpdetrcoalrebuomn itinodnuss,trwy,ithwaax bporeilsisnmgenpoainntd aobtohveer w70o0rkeFr,s ceaxnpodseevdeltoop psectrroolteaul mcanfrcaecr, Apamrtoincgulaortlhyerwahgeenntsthseuirspetrcotuedserosf bceacuosmineg sskaitnuractaendcerwiatrhe tahresenoiicl, a(8n)d. uheltarvayvioelxept olsiugrhets. tSokinthecasnucne.r Wis onrkoetrsunecxopmosmeodntoameoxntgernfaalrmraedrsiatwiointh, uinnclelusdsinagdeXq-uraatyelyandprofltueoctreodscobpyic perqoupipemr esnhti,elcdainngdeavnedlopotshkeirn ccoanntcreorl manedasLuarebsordaitsocruisesse)d. elsewhere (see Chapters 7 and 17, under Industry sloSwkliyn acnadncecrasnnaorte buesudailflfyeresnqtuiaamtedo,uspactehlol locgairccainlloym, afsr,omwhsiicmh ildaerveskloinp ceaxnpcoesrusr,e iosfinndoinsp-oecncsaubplaet,iothnearlefoorrieg,inf.orAa dciaffreerfeunltiahlisdtoiargynoosfis.significant Lung Canceb poTpuhleatiionnc,idetoncebeofa lumngattcearncoefr misajsourfficcoiennctelryn,grpeaartt,iciunlartlhye bgeecnaeursael iint chreaassebeheans sotecacduirlryedindcurreiansginga pineritohde olafsttretwmoendoor utshrteeechdneoclaodgeisc.alTdheis ovfelcohpemmeincta;l wanhdenphwyosrikcearlsawgeenrets,bseoinmge eoxfpowshedichtoaraenpirnecsreenats,inags ivrarritiaentyt eatncd.; twoxhiecn acior mcmonutnaimtyinaainrtsp,oilnluttihoen fhoarsmgroafdduualsltys, ingcarseeas,sefdu;maens,d mwihstesn, sthmaotktihngesheasfacbteocrosmheaaveunbieveenrsaiml hpaobritta.nItt iins nthaeturinacl reenaosiunggh itnocisdpeenccuelaotef slupnegctivcaenccoenr.triObuntiothnes ooftheearchhaonfdt,heisteisfacdtioffriscu(l4t).toAmdeotnegrmthinee chtheemicreal carcinogens known to be capable of causing lung cancer, are certain of the OCCUPATIONAL CANCER 295 wchirtohmcaatrecsin, ongicekneicl caairrbcoonnytla,maisnbaensttos,s oannedmarussetnbice.aWr ihnenmeivnedr tohnaetisthdeeeayliensg, nciorsceumanstdanucpepse.rOrcecspupiraattioornyalplausnsaggecasnmcearys aarlseocbheariancvtoerlvisetdicuanlldyebr rcoenrcthaoin gepenitihcelciaurmcinoamppaesa, rosf tthoe psrqeucaemdeousthceellaptyppeea.raMnceetapolfasitaheofttuhmeobr.ronTchheisael taufmteorrcsesdsaevtieolnopofselxopwolsyu,reantod thmeaeytionloogticbael cdariacginnoogseendicfaogrenmt.any years Chromates rolBeotohf AcmeretariicnanofantdheEucrhorpoemanateesxpeinrietnhcee hparsodcuocntfiiornmeodfthleunegtioclaongcicear.l ABaseatjerersu(l6t)o, ftthhee cinhdeempiecnadl ecnotmstpuoduiensdsofbMeliaecvhelde atondbGe rergesopriounssib(5le) aanrde tdhicehrhoemxaatvea,leanntd czhirnocmciuhmromcaotme,poinuhnadlse,d Naas daunsdt. KMomstonoofchthreosmeatceaseosr pweearreedfotuonhdavtoe bbeeenbrsounfcfihcoiegnetniinc scoamrceincoamseas.. IAnnmeoxsptocsausrees,ohfow4 eyveear,rsthaepre wofervearayginrgeadt umraatnioynm, obreetwyeeeanrscoefsseaxtpioonsuoref.eAxpcohsaurraecatenrdisttihceladteevnetloppemrioendt, of the lung cancer has been observed. Asbestos wiBthrotnhcehodgiesneiacse,caarscbineostmosai,s,ohriagsinnalolwy tchoomueghtot tboe baeccaespstoecdiataesd dsuoeletloy tthume oinrhiaslautsiounalloyf faosubnedstoins odnuest,ofevthene lionwtehre loabbesse,ncweheorfeaassbbeesstotossis.fibTehres uarpepemr olsotbensumapeproeuasr t(o7)b. eInmoortehecrhtayrpaecsteroifstbicraolnlcyhoingveonlivcedcar(c8i)n.omTuam, tohres hinavteheaplsloeurbaeeanndfopuenrditotnoeudmev.eTlohpeseelspelweuherarel ainndthpeeribtoondeya,l ptaurmtiocurslaarlrye mesotheliomata, a very rare type of cancer at the present time. The tfiaocnt tohfatthetheaysbedsetvoeslofpibearts siintetsheremlunogtes, fhroams rtahiseediniintitaelressitteinsgoqfudeesptioosnis oexfpotrsaendstpooratsbaenstdosmdiugsrta,tiuosnu.allAylldeovfeltohpesaeftetrumveorrys, lofnogunldateinnt ppeerrisoodnss, ebxuptostuhreey. Smoamye aaprpeanreonttldyiagalnsooseddevuenlotipl mfoallnoywiynegaras hrealdatievlaeplysedlimsiintecde the last exposure. The precise type of asbestos fiber appears to be of some imRpoevrtiaenwciengas tahneetciohlaonggiicnagl famcetodric(asleepCichtuapretero4v)e.r the years, resulting from exposure to asbestos dust, Gilson (&) suggests that, in the early N 't BIOLOGICAL AND MEDICAL PERSPECTIVES Tayums,tieoxnpsossuurcehs waesrepnheiguhmaonndia woorrkepruslmdioendaryyoutnugb,erpceurlhoaspiss. fArosm licvoimng- lriedvwaloenrktiinngthceoncdoimtiomnusniimtyp,rwovoerkde, rhsolwiveevdelro,nagndentouubgehrctuolodseivselboepcapmroegrleesss i:ivcoorppuulmlmoonnaaryli. fUibnrdoesirs,maonddernotchoenrdifteioantusreosf eoxfpoassubrees,toosnist,heofotethnerenhdanindg, wa dorekveerslodpevberolonpchoongleynmicocdaerrcainteomdeag.reHees soufgagsebsetssttohsaist,, ainndthleivmeelsoontgheelnioomugah, r3e aasrbeeswtoistnedsussint.g Tthheis viesryanlonign-trearnegsteinegffehcitsstoroifcallowp-egrrsapdeectievxep. osTuhree amthnoygceonnejseisctuorfalthmisoddeilsecaosnestrisucqtsuiatree oubnsdceurreintaetnstihvee ipnrveessetnigtattiiomne., and nEednvitroontmheenwtaolrkeexrpsoseuxrpeossetdo. aHsbeerestowsedufisntd asroe-caapllpeadre"nntleyighnbootrhcooond aleseds,e"vealnoaplmogeonutsoftothtehodsieseafoseunidn pinersroenlastiownhotohabdernyelvlieurmwoerxkpeodsuwrei--th lfestheesupblastnatns.ceCs;onantadctevweinththtohsee dwuhsot olinvewworitkheirns'aclcootnhsinidge,rawbhleenratdhieuys rleanabtrioounghint shoommee ctaosesb,e bluatunndoetreadll,. iIst bhealsievbeedentosugbgeesatedpotshsaibtleothexe-r tletxhiestipnrgesseonutrctiems eo, fmcaoympmlauynitcyonatirribpuotilnlugtiroonl,esw. Thihcehregoareunarepcpoagrneniztelyd rcepaotseddiftfoereanscbeesstoins dinudsti,vibduuat lamsuosncgepptiebrisloitnys nliovtinognliyn tahmeonnegigwhboorkrienrgs immunities. Ionizing Radiation Teshaerelubnegliecvaendcetorsbewhciacuhseddepvreilmopariilny bmyintehres reaxdpoonsegdastogivreandioofafctainvde slindienggr.adation daughters. This has been discussed in Chapter 14, under B ladder Cancer iArosuginhothutetchaesewoofrlldundgurcinangcreer,cebnlatdddeecradceasn,caenr dhatshibsehenasosntimthuelaintecdreainseinrsciivneogreensiecaracrhomasattioc tahmeineetisoliongcilcuadlefabcettoar-snaipnhvothlvyeladm. iInne,inpdaursat-raym, itnhoe ipphhetnhyyll,amauirnaemwinheicahnhdadmlaognegntbae.eBnesnuzsipdeincteedisosftiblleicnognctraorvcienrosigaeln. iAc lipshnaonipghetrhsyulaspmeicnte. ,Ititiswnaoswibmeplireovpeedrltyhaint cbleucdaeudseaimt oisnga cthoentabmlaidndaenrt coafrbcientao- mnua.mAbneirlinoef, cwhheimchicahladagaelsnotsbweehnicshuscpaenct,prisodnuoctecacracnicneorgeonfict.hTe hbelraeddaerer animals, but not in man. OCCUPATIONAL CANCER 297 Beta-Naphthylanrine anBilientea-ndaypesh,thtyolawmhiinceh iwsoarknerisnthearmveedbieaeten einxpothseed msianncuefatchteureearolyf tdhee vSeulbospemqueenntt omf atnhuefadcytuereinodfutshtreyse, idnyeGs eirnmtahney,Unpirtieodr StotatWesocrladrriWedarthiIs. pamotiennet,iablenhzaizdairnde wanitdh aitn.ilIinnethweereearalyll dsuaysps,ecat.lpGhae-hramnadnnbet(a1-0n)apsthutdhiyeld theBpertoa-bnleamphitnhtyelnasmivienley icnanbobthe caobusnotrrbieesdfothrrpouurgphosethseofspkrinev, etnhteionre. spira tvoorlyvedanadrethneotgacsotmropilnetteeslytinuanl dterrasctotso.d,Tbhuet misetbabeloielivcedmethcahtaniitsmiss ninot tnhoegebneetsais-,nabpuhtthryatlahmerinteh,e pperresseen,cwe hoifchitsismreestpaobnosliitbelse ifnorthbelaudrdienre c(a1r1ci). oEfxpaenriimmaelnstawlliyth, ibtethaa-snabpehetnhyslhaomwinne-tihnadtuceexdtrabcltasddmeardceanfcroerm, athree cuarricnie ncaopgaenbilce. oAfnpdrocedrutcaiinngfrbalcatdiodnesr, tmumadoersfroinmatnhiemsealesx. tTrahcetsre, airsegirnedaitvisdpueaclileys scpaencciefricbityy hbeertea-ansapehlstehwyhlaemrei,nien. sSuusccehptciabnilcietyrstocatnhebeindpurocdtiuocnedofibnladdodgesr, forOenxcaemipnldeu,cbeudt,ntohteinblraadbdbeitrs.tumors progress in the .absence of further tehxepotsruigreo.neTohfeythestbalratddaesr,somralalr,ouanpdpairtesnutlryetebreanligonrifipcaeps,illaonmd agtao, onnetaor daeftveerloopnliyntoa feepwithyeeliaorms aotfa.exBploasdudreer, bcuant cmerayhansobtedenevkelnoopwfnorto48deyveealrosp. Othne baengianvneirnaggoe,f e1x0poosrurme,oarnedytehaersdehvaevloepmbeeennt ofofuthned btloaddelearptsuemboert.ween hisTtohrisy toifmeex-lpaogsucrereaistevsitsaelrliyouismdpiofrfticaunltt,iebsecianusdeiftfheeresentiballadddiaegrnocsainsc. erAs aerpeithinedliiosmtinagtauioshfatbhlee bcllaidndicearllwy,hiccyhstaorseconpoinc-aollcyc,uapnadtiohniastloilnogoirciaglilny., Tfrhoemy raerme osviemdilbary, faullsgou,raitnionthtehefyacttentdhatto trheecyur,maentdastbaescizoemeslporwolgyr.esWsivheelny minoarne amnailliingenadnyte apslatnimt ies aglowesayosnr.egAanrydebdlaadsdpeortetnutmiaollrysmeeanliginnaant.worker maTkhee thenetiirreapbplaedardaenrcewaellarmlyaywibthe idnivlaotlavteido.nSoufbmcuacpoilslaalrieteslaanngdiecstmasaelsl haretmeraietus.riaT.hiTsheexpvlialilnosusthpeapeialrlolymaatnad wsohmicehtimfoelslowpromfuasye bbleeedlaintegn, twfitohr mraiasneyd yinearasp.peTahreayncea,reormoflraet. oTftheeny mmualtyiploer tmhaany sninogtleu,lcaenrdatemoary ibne filTtrhatee. clinical manifestations are essentially the same as those as- 298 BIOLOGICAL AND MEDICAL PERSPECTIVES suorgcieantceyd, wdiytshurnioan, -oncoccutupraitaionaanld bhlaedmdaetrurciaan.ceGre:hfrrmeqaunennc(y10o)f, uwrhinoatfiiornst, ihnetmroodrurhceadgicroaurteianse icnystthoescbolpayddaesr, aancdonetarorlly mtuemasourref,orhmasatisohno,wcnanthbaet ofebssteartvioendsinofadthveainrceproesfenbclaed. dPerrosfyumseptbolmeesd,inogr,awnyithothseevrecrelinhiceaml amtuarniai, monalyy, ahofweweverre, dbeblaoovderycelelsarliyn stihgen. uOrinnet,heanodthetershtsanfdo,r thoecrceulmt abyloobde amlsaoy bbeedrueequtoirendonfcoarrctihneogeeanrilcy cdheetmecictiaolnagoefntpsatthoolwohgiyc.hHweomrkaetrusriian cthane aconmilimneondsyyempintodmustorfy omrdainyaryalscoystbietis.exIptosceadn.noHt,emthaetruefroiare,isbealssoolelya dePperenvdeedntuiopnonisfobr apsuerdposuepsonof tdhifefermenotsitalrdigiaidgnoesnigs.ineering and medical ucosunatrlolimmpeoarstuarnecse., Aplalrtmicoudlaalriltyiescoomf pcloentetroelncalnodsuprer,evaenndtiomn eacshsaunmizeatuionn soufbsatlalncpero. cFersesqesueunttilpiezreidodiicn rthevalpuraotdiounctioofna,lloerxiusstein,gocfontthriosl mcheeamsuirceasl wisoerksseer,ntaiasl atno incdhievcikduuapl, ionnvotlhveeisr tchuerruetniltizeaftfiiocancyo.f Parnontueacltiocnystoofsceoapcihc mexeatmabionlaitcionesndto pdreotdeucct tesarolyf bbleatdad-enrapphatthhyolleongey. aArelthosutigllh ombasncyureo,f tthhee ucarinnebeshcohueldmibcealleyxaimdeinnteidfi,edwhaenndevienrtepropsrseitbelde, (f1o2r).suTchhemPeatapbaonliicteoslaoaus qsmueenacry teocfhnipqeureiosdihcavecysbteoesncoppiacrtiecxualamrliynatuiosnefsulinin wreodrkuecrinsg wthheo farere suhnowuilldlinbge tloimsituebdmtiot atos fceywstowsocorkpeyr.s Gasehpromssainbnle,bealnidevtehdatthtahtoseexpleoasvuirnegs tlhateenicnydupsetrryiodshomuoldreobveer,rohuetinehlays fuorlgloewded-wuorpk.erBs ectoausreetuorfn thaet laonnyg fduetvuerleopt.ime for treatment, without charge, should any bladder symptoms OSTEOSARCOMA AND LEUKEMIA folTlohweinogsteWogoerlndicWsaacrroImhaatav,e wbheeicnh ddisecvueslosepdeduninderradRiaudmiumdiaPl opisaoinnitnegrs, iongiCstehahpatesr b7e.enThdeisrceulasstievdeliyn hCighhapintecride1n7c,euonfdelreuXke-mRiaay aLmaobnogrartaodriieosl. Thahsenqoudeesftiinointivaes atnoswwehr,etahseyrete.xposure to benzol can produce leukemia REFERENCES 1. COacnccuerpaCtioomnaml itctaenec.eMr:onathclhyalRleenvgieewt,oNt.hYe . pShtyasteiciDane.ptN. L. aYb.orS, tSaOt;e NOoc.c1u0p,at1i9o5n1a.l OCCUPATIONAL CANCER 299 2. 3. HMeanyderrisc,kMs, .NR..:VI.,nBduersrtryi,alCc.anMc.e,rLoifonthee, Jlu. nGgs.,. aCnodmTphenorsaptei,onJ.MJe.:d.C, a3n:c9e,r 1950. of the scrotum in wax pressmen. Arch. Industr. Health, 19: 524,1959. 4. sHmuoekpee.r,DWis.. CCh.:esEt SnOv:ir1o4n1m, 1e9n5t6a.l causes of cancer of the lung, other than tobacco 5. Machle, W., and Gregorius, J.: Cancer of States chromate-producing industry. Public the respiratory Health Reports, 0sy3s:te1m14,1in94t8h.e United 6. Baetjer, A. M.: Pulmonary carcinoma in chromate workers. Arch. Industr. Hyg. 7. ODuccturap,. FM. eRd..,, a5n:d48C7a,1rn9e5y0,; J6.:D50.:5A,1s9b5e0s.tosis and carcinoma. Arch. Environ. Health 8. I(sCsehlibcaacghoe)r,,10K:.413.6,,1K96la5u.s, H., and Hardy, H. L.: Asbestosis and bronchogenic carcinoma. Amer. J. Med., IS: 721,1953. 9. oGnilBsoino,loJg.icCa.l:ETffheectcshoafnAgisnbgeshtoasz.arAdnsno. fNe.xYpo.sAucraedt.oScais.,b1e3st2o:s69d6u,s1t.96I5n. Symposium 10. JGAe.h.Mrm.Aan.,n1,07G:. H.: 1436, Papilloma 1936. and carcinoma of the bladder in dye workers. 11. HWeialllitahm(sC, Rhi.cTag.o:)M, 7e:ta6b1o2l,i1c9f6a3t.e of foreign compounds and toxicity. Arch. Environ. 12. Boyland, E., and Williams, D. C.: The Biochemistry oj Bladder Cancer. Charles C Thomas, Springfield, 111., 1963.