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AR226-2883 Material Tested E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 55-80 Haskell No. Ot 1^197---- Chemica Jackson PRIMARY SKIN IRRITATION AMD SENSITIZATION TEST ON GUINEA PIGS Procedure; A range-finding study was conducted with 3 male albino guinea pigs to test for skin Irrita aaterlal was not a skin Irritant as received* The primary irritation test was conducted on 10 unexposed guinea pigs by applying and lightly ru 1002 and 10X dispersion (vol/vol) of the jtest material in distilled water on shaved, intact shoilder The induction phase for sensltizatidn was a series of 4 sacral intradennal Injections of 0*1 ml saline, 1 each week beginning 2 days after the test for primary Irritation. After a 13-day rest period, the test animals were challenged for sensitizatlon by applying and l ol of a 1002 and a WX, dispersion (vol/vol) of test material in distilled water on shaved, intact sho time 9 unexposed guinea pigs (controls) of the same age received identical topical applications. Concentration in distilled water i Laary Irritation Teat - 24 Hours - 48 Hours Challenge Test - - 24 Hours 48 Hours Sensitization Response Ratio*** at 100X (as received) Concentration 0/10 ______Reactions op Intact Guinea Pig Skin Teat Animals Control An (10 Anirals - In. Avg. Wt. - 369 g (10 Animals - la. 10 Aniaals Final Avg. We. 618 g) 9**Aninals Final As Received 10Z As Received 10 Neg. 10 Neg. 10 Neg. 10 Neg. 10 Neg. 10 Neg. 10 Neg. 10 Neg. 9 Neg. 9 Neg. or as a 10Z diapersionliT dermatitis hazard is expected from handling |:his iBateriat ^ gi^ril^ produced no t^LoO(& ^observed at chaJLl ^ nytene tiractices ar<^ ^pl ^'''on^^^-^^^pi^^ ^"*''^-'' ** One control animal died 2 days after;.fcixtt : . *** Sensitlzatlon is defined as a significant aciore icicrls^fee at "cl^llei^ applied initially or on the concurrent cont rots. ''"-^"" "-'"- Range Finding Results: ^'^^.^.S"??^^ I g ^ l ^ - ' - , ^;:,NA W^ti,,.^ . .^.'yA^.:?l<-<'i..y.l'lst-''' '%; .^'H;iidS^ :C." . expected f JEH;jrg Pate Issued; February 7, 1980 Report No. 55-80 Report by; Approved by: I J o K n ^t.>^,^ ., ^j^^-^y^'_____ B. Henry Technician QU^JtA ~f. K'-^ftriL.---- Gerald L. Kefaned Chief, Acute Investigatio