Document 5LgvmkDzGvZX24v3w0K1ZMk1z

X3TCP.XI-: report FJ3GARDIMG THE BlOWGJCfJ* ACTI7IT7 CT IC/.TLO DVD? to the Cfcreas-Illiuojo Glass Corapary Toledo* Ohio The Saranac Laboratory Saranac Lsho, Verr Terb January 1, 1950 (The report has reference to results of studies up to Uorenhsr 1, 19<9) Submitted by* Arth\s* J* Vorrald, L'#D# Director The Edxard L* Trudoau Foundation In. cooperation r/ith Philip C. Fr-att, U. ihosnis 1!. Durban* 1 Anthony E# Del;hone Ednard C* c* Erbar., This iutcria report? ie essentially a supplcxcnt to the previous report dated April Z9, 1949* It is submitted at this tics in ocsordanco with a plan to issue reports at intorv&ls of ebcufc si:: nonihS' la the ir.toroct of brevity general etatcrants as to the nothcd: ucod and purpocos of each phase cf the c>:perissnts ut-Cor way vre caittcd and tho reader is referred tc tho preceding report for dis cussions of these points* It csy bs stated that tho conduct cf tho or.rorinont has bosa maintained as it was iu earlier stages* aiid that dust counts caring the interval sines the last report hero averaged 179 million psrtiolos per cubic foot of air* la general, tho observtticcn isnde over the past six rcoathn couf err. to those noted previously* However* only tentative conclusions ore t^rrsntod at this tics. It cecss clear that only after all a;iisis h:.v? boon examined nt tbs end of tho full exposure cm the results to cvniuntod* The results to dato ore presented in tables as in tho previous report* Certain oonaonta concerning each table follow: Table 1* (Compare with Table 3*) In the interval alncc the 1a91 report, four additional experimental onlor.is cn being aacrifieod have sbora spreading of their losionc'whilo the con trols have consistently revealed heolisg or boaloo lesieno* Othors of the experimental group have feilod tc show eridonoo of spread* While the observations over this poric5 suggest a slightly ccrercc influence of the dust on the course cf the tubarculous infection, the evidocoo is by no Beaus ooaelusJ.vo, and only uubcoquoat dovolopscstt: and a surrey of tho results in tho ontiro sorioo of anisu&ls c*.in pro** vide a basis for a positive statement ns to the influence of Xaylo o- a simultaneous tuberculous infection* ' Tr.blo c (Ccacaro nith Tabio 3*) Tno of the three animals in phase 1 (in duct 2 months oftor infection) of the re- Detivr.tios experiment which rore Wiled after 12 months in tho dust room chomd gross ovidosce of sprotOisg' disease* Ihir observation s*acoins to be confirmed by microscopic study# * In the other too ph&se:; (is curt -1 months and C tenths nftcr infection),no spreads hrr? boa:?, noted# Hero, too, the eriosnen is obviously incomplotr. and u-*ca so'; warrant evaluation fit tbie tine* Tabio 3# (Cesparo with Tables 1 and Z) Ko spreading disease her bsen noted is the sin cslsals hilled since the lost re port* The courco of the infection is ths controls is thus 3esa to he in accord with prorious experionon* Table 4 (Compare with Table 5*) Tno tablo reveals that ths . onicBSls saorifiosd or dying after dust exposure cf eleven or acre months h&Te cossiotoutly harbored spreading lesicss* Vihile sens of t2se are yot to be confirmed nlcroaccpioally, tho consistency of the findings suggests rather strongly that under those conditions (infoeties lnitietod after 3 months of oust exposure) K&ylo has a distinctly adverse influence on the course of the disease* -2- Table 5* (Ccnpare with Toblo 4.) Tho ocntrol anisalfi c(;aia rorael that the infecticn is follouiag Its usut.1 coarse* . One eoisal, fcillod at 10 ocnths after infostiss* chcrc5 sljght ttloroscopic ridoac cf spreading disease. Ac acted ia the previous report# it is net uncossson for r. eoctsioaal control eaianl be. develop progrsscivo disease following this type of infection* 1a vierr of tho above flodiaje end for purposes of thie report# i<; coeas epproprioto to present for comparison tbs ohcwic-Al and jatregraph enalyoes of Ksylo and of lens fiber asbestos (Table ) At the procent ti* tbs orisonco suggests that Kayla duct cry h:%rc * slightly adverse offoot upon tuborculcus iufoetiou* This effect is by no jsaano as pronounced os that of quart?.# sines sir.'lsr esporisaatr vith quarts result in progressiva spreading cf the lesions in virtual!; nil.animals after 8 or core souths of exposure* The lesions in cuir.sl' exposed to quarts dust are usually sufficiently cxtorsiv3 to cause doc' of sene anicals la the period frew 1Z to 15 nonths* Too future course of tho lesions In the presoat experiment e&aaot bo prodioted* Thoy pay heal during tho next 9 ccnthc# but it ic felt serjioebat acre likely that cninals to be sacrificed Trill shorn on intros incidence of spreading diseaso* tAXLQ * tx SrCTI.tOTEOUS tfadtf izirxl . Of lilAjsr . Death RsmtScs 0*DM r L&crocce.r-. Brou- Bcsotae hroo- Lv;>tV.*. ehlol t*epb chial Ijsv'j Ltato ttdn S^lout tloer Cede i *mz* Ucdoo 3pl 0C2 t-rcr te:*< 4 t i-iA . >0 4 0 0 0 XI#cue oaiol/tti t1 ( ... . 1 C 2 V* 1 J* 6 :* * w. 4 t GO. A4 >-3/4 do. (pl) 4 00 004 00D 4 44 4 pa 0 4 4 < /. 0 V r. ( 2 I 4 so. 4 0 0 4 \ < s 4 so. 44 00* **44, D 4-1/2 so. (pat? 4 444 4 4 D 5-l/S co. (pal) 4 004 40 44 pa A pa 0 0 c* p 0 C` : *1 AV. ... * f* ? b C B3. ?R * 4 0 0 4. . E 6 GO. 04 00D tiuu: cut-olyscf C4 A P%. V( . 4 v (P (. (13 25 til \ (12 r- C so. `4 p * .so. r4 t s 7 S3. pa * 4 r D 7-2/3 no. pa t e 1 CO. c B GO. 44 44 b B-l/2 00. 44 4 X 12 GO. 444 4 i 12 BO. 4 4' 0 0 c 0D 00c 4 l r- 4 0 0 V Titous auto,*yse h p. 4. * 0 00 0 0 '4 lias.::- autaly- 44 <4 4< : 004 44 44 4 4 ( 44 44 . 444 4. - 4 44 444 4 4* V 004 4 44 0c 4 17 V 13-2/2 ao 0 0 0 .0 0 0 B 14 so. pa 0 0 0 0 0 '.6 * IS W. 44 0 .0 0 MB If It GO. 44 4 0 0 0 .i T rosola for oubw^Mwns atudv XSii ' 0 diod f killed for aenplla* ?a e iatorevrrcnt paev-naaio 0 * no tuberculous lesicac oeea * *:* 4* bo&lirs cr booled tj'oorcles ieoletod cproaiinc tJ-tralsc r saer r.;red;ac taborelis w oo:tfiuc:t tuteriulsii* O*aro adercccople eb.crrc;loo tro r.ct roeordid, prc^iraticco kc.ro ot bcc. coafle'Jei, ualooa otS*rwio vtstoC. / uru> 5 larsis * r.i rt-w?zos 6 -?Tir ioaioar. be v uiod b * iilloo for sucpltaf - c tntcrc^rrcnt poeimenia . 0 * tubcrculcus looioa* is * *> *-+ - beaiirg or coaie-j t.uocrcio: ttc.tsrc- icolfttsc wrsiiii::. r aiey *2>rccdLafi tubercler i ecr.fi ucr. tobcrsv-iaci.* rhc.ro aicvoztopic obrritions ta't rot reversiec, hiato'iosf.r pri^aretici'.s *. act bcc:. ocsplctsa, ur.lcss othenriss liz'-Z'-. t 7r.Wc C- ETEC7I0E C3!27?.OLC TO QZO'J? Fv v - -.sal v-V.r Ho 02 of Death Iteration 221 K ! coo. K 2 nos. 127 . D <2 nos. 123 E 4 cos. 124 K 4 nos. Cross tree,'. Hepatic chjLal Lyreph Lur.so lice'es Foie ::j Elver Rode r.i sroioc;). -- Urea- l.coc.tac chid byLd Ira fir Dodos 2plo?o *-f T">' rr.i'r. < < 0 0 4 44 4 V* c4 0 *: ,S 44 *: c- V pn * 4 0 0 C r; 4* a SliC C.*0.v :iy::eu i- < 44 0 0 0 0 V 0 V. A 0 0 *: 125 K 6 nos. 4 0 00 12C K <7 nos. > 4 0 0 0 132 D 6-2/3 cos. 4 0 0 0* 4 0c 0 0C 0c 0- c - 145 125 - D 7+ cos. pn + ? E 0 5>0, A4 E 3 no. f* 0 0 0 0 0C 0 'c 7ir sue nut dyeed 40 4 0 r. r V r- 137 120 0-1/2 no. P= * K 10 no. j* r 0 0 00 04 71 eddyse:. C - 131 E 10 no. 4 4_ 0 04 .v :* C' - > 133 K 12 no. 44 0 00 IS**' * E 12 co. P .*'OT.ain +4 0 00 I D 55 died K - killed for sampling Po s intercurrent pneumonia . 0 # no tuberculous lesions seen + <-+ <44. *<> = hcr.lir.g or boded tubercles = scattered icolatci eprcudiuy tub;* - usry spreading tubercles - confluent tuberculosis Tfiiea mioroeccpic observations ero not x*ecordod, histologic preparations have net been cassloted. ur.lcsa othcr>rj.cc CTree;:. f v' ' L 7*U3c 0 ' iALV3ES CP T.f.TLO (a: rcccj.vco} Chonicn1 ?Gtr<rrTao:i.n Si02 FesOs AI2O3 Ti02 ItaO CnO i*c.o 13.2CT* 1.62 1.27 0.12 0*09 24.24 7.10 IJoafc oC ttvo nat'.'riai oa"ir.j o*T clav* like r.r.wcos which siw c O.c' :V.ii'j-r. pattern not. unllisi c. hyurnur cr.lciir* cillc-bc. <Tho quarts ccnfccst 1: !.c/.r (-r/ababi*Icaa than 1 per cent). AT;ei*1* 5 re:* -%v.v*. of e%lc5.ie 5.0 present. Apprcsinitalv 15-20 jar cent f t.'.v: -.rttv.*! is ehtysobile cr serpentine, wMah 5.; i-.rr !y fibreus. The fibers sr.i turiics : are ucv.uliy corcral cillinevcrr lev,- >-Az:l : csldon shorter thro. 0.3 rdil Inet-r.r* <105 C. 4.52 > 105 C. 15*19 92.42 - ' Chemical Si02 r23 ai2o3 ItiO CaC . Ks 0 N620 k2o C02 HnO ASALYSI5S 07 i.g:c--riES?. asbestos (at* received) rcfcro-rarhic 36.40# 5.52 0.78 0.08 ?ho material contains about 75 psr ccat cL fibrous aocostcc. probably cnrysctilr, wit 007.0 ccrpsatir.s end snail cncuatr, of celei nagnatite and chlorit-ic cr rioacrouc nimr tls. Only c trace 0? quarts \tec core. TV. iroro nhreis oC non-senarsuor. fibers 10 to 50 microns lcz and S to 15 rrJLcrcns z'iiz 0.31 40.18 0.06 - 0.05 ' 0.57 14.00 C(I *?c m no:; cosiaois to cliosps i a::d .. 3d 3f oa to Eurctioa OVoec troo- Hepatic chial Iyrpa hone? Tiodo5 Spleen IfiTsr Uodc t.Ucroftco* >ic iiroo- Uryct chial .Via;?. c llc'lzz Spleen L.ir*er I'or; V 1-l/C no. 4 r 0 00 Ti seuo autolyced K 2 r*o* 4 0 00 4 v * K 2 co. 4 4 0 00 4 4 *' 0 K 4 no. 21 4 so. 44 0 0 4' 4 0 00 0 4 4 4 0 ,v 4 `44 r > 4Tkf 6 no. 4 0 00 2 no. 4 0 00 D 6-1/2 no. 4 4 r 4 44 *. 0 44* 4-4 00 00 44 C 0 v- D 6-2/5 no. na ? 4 0 c 4 Ti ssuo cutelyted 2 5 no. 4 6 no. 4 D 9-1/2 CO, v as 10 no. 0 n 10 eo. < *0 r 0 40 ? 0 4- 0 00 0 *.*c 0 0 + 00 !>* . 0 0 j Tlscuo catalysed I* C 0 c0 0 0 A .i D 10-1/2 no. 4 - 4 2 12 no. 44 -0 V 0 0 Tissue e.utoiyscd 0 +00 K 12 no. 44 0 0 1+0 r- 0 r 14 no. 44 0 14 no. 4 0 00 2 16 no. 4 4 0 0 0 K 15 no, - 4 4_ 0 00 D r died * tilled for sacplin# intorcurronfc pasuconia 0 . eo tuberculous leeions seen * + c hoalia? or hoolec tuborclos - scattsrocl icolatou epreebil- tub'. - sepy spreading tubercles - cosfluent tuberculosis T/here nioroecopic obserrations ore nob recorded, histologic preparations have aot boca ccinlotsd, unless o'chcnrieo stated. POST * Rj ttLSTMtl*"- O J> V P - died 1C tilled for *ctyHa5 ?a c iatercvrrcnt pacvnooia (l s do tubcrul'-ts Ictieac ceca * z fceeUrf cr )jelcu taborclcs iceiais-: c?rc-a-ir; tJintrsl *4+ r. aicy r;rc*dlac tuVerclts u ccnflucit tuee7S*;lsii& TThara siartcsspift cbtcrTa;lon :.*t r.ci rcsordad, histaio^J: prejaraticca te7e act Vtcr. ccajlc;ci, uslcss thermic yiii.