Document 5Lep4BEnMMevBnogMK8xpVqY5

TO: Interoffice Communication FROM: DATE: SUBJ: Dave Penney-Austin Wtt XF; T. G. Grumbles June 12, 1990 OECD HIGH PRODUCTION VOLUME CHEMICAL RISK EVALUATION VISTA The attached describes the subject program and contains the initial list of 53 chemicals to be considered. 1-octadecanol and 1- dodecanol are on the list. We may have something to contribute. Can you follow-up with CMA? Ao------------- T. G. Grumbles dlj .107 cc: J. R. Roheim-Austin Attachment VVV 000013035 Health & SafetyAlert ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT PROGRAM TO INVESTIGATE THE SAFETY OF PRIORITY HIGH PRODUCTION VOLUME CHEMICALS SEEKS HEALTH AND ENVIRONMENTAL DATA The Organization for Economic Cooperation and Development (OECD) Chemicals Program has launched an international voluntary program to screen the potential risks of 53 high production volume (HPV) chemicals. OECD is an organization of 24 Western developed countries, including Japan, that conducts work in economic, trade, and environmental areas. The United States will join with thirteen other OECD member countries in a coordinated effort to share information collection, evaluation, and testing, as appropriate. This cooperative program will result in internationally accepted data for screening potential health and environmental risks. This international cooperative effort represents the first phase of a program to systematically investigate the potential human health and environmental effects of chemicals produced in large quantities worldwide. The 53 HPV chemicals were chosen from a list of 147 chemicals that are produced in excess of 1000 tons per year by any OECD member country and for which little or no safety data are publicly or readily available. Chemical industries within OECD member countries have expressed support of the OECD program through the Business and Industry Advisory Committee (BIAC). The U.S. chemical industry, working through CMA and the Silicones Health Council, has volunteered to take the lead on nine of the 53 priority HPV chemicals. OECD member countries have agreed on a Screening Information Data Set (SIDS) needed for an initial evaluation of the potential hazards of these chemicals. As a first step, OECD is seeking health and environmental data that may already exist on the 53 HPV chemicals. This existing data will be shared with the country taking the lead on a chemical. OECD has developed a questionnaire to assist in collecting existing data on the 53 HPV chemicals. In addition, each of the fourteen countries has designated a national SIDS contact point. U.S. chemical companies are strongly urged to provide any existing health and environmental information on the 53 HPV chemicals listed on the reverse of this notice. For further information about the OECD program or to obtain a questionnaire, please call either R. Garrity Baker, Director, International Affairs, CMA (202/887-1338), or Sandra Tirey, Associate Director, Health Programs, CMA (202/887-1274 or Fax: 202/887-1237). CHEMICAL MANUFACTURERS ASSOCIATION 2501 M Street, NW 202-887-1100 Washington, DC 20037 Telex 89617 (CMA WSH) May 25, 1990 VVV 000013036 OECD LIST OF ALLOCATED HIGH PRODUCTION VOLUME (HPV) CHEMICALS CAS No. Country Chemical Name 59676 70553 75547 75774 75785 75796 75912 77996 78842 88722 99092 101724 105760 107017 108894 108996 109068 109660 112538 112925 116154 121573 122521 123386 126307 126589 128392 141979 143226 147148 156434 294622 504609 536903 556672 584032 590863 682097 693232 836306 872059 1758732 2402791 2431507 2720732 3209221 6386385 6419198 16529569 25265774 n171208 '19 Switzerland 3-Pyridinecarboxylie acid Japan Benzenesulfonamide, 4-methyl France Silane, dichloromethyl- United States Silane, chlorotrimethy1- France Silane, dichlorodimethyl- France Silane, tricholormethyl- Netherlands Hydroperoxide, 1,1-dimethylethyl- Japan 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)- United States Propanal, 2-methyl- Sweden Benzene, 1-methyl-2-nitro- Japan Benzenamine, 3-nitro- United Kingdom 1,4-Benzenediamine, N-(1-methylethyl)-N'-phenyl Austria Maleic acid, dibutyl ester Netherlands 2-Butene Belgium Pyridine, 4-methyl- Belgium Pyridine, 3-methyl- Belgium Pyridine, 2-methyl- Canada Pentane Denmark 1-Dodecanol Denmark l-0ctadecanol Italy 1-Propene, 1,1,2,3,3,3,-hexafluoro- Germany Benzenesulfonic acid, 4-amino- Germany Phosphorous acid, triethyl ester United States Propanal Japan 1,3-Propanedio1, 2,2-dimethy1- Sweden 1,3-Propanediol, 2,2*-{oxybis(methylene)} bis{2-(hydroxymethyl)- Switzerland Phenol, 2,6-bis(1,1-dimethylethyl)- United Kingdom Butanoic acid, 3-oxo-, ethyl ester Netherlands Ethanol, 2-{2-(2-butoxyethoxy)ethoxy}- Japan Copper, (29H,31H-phthalocyaninato(2-) C.I.Pigment blue Japan Benzenamine, 4-ethoxy- France Cyclododecane United States 1,3-Pentadiene Japan Benzenamine, 3-methoxy- United States Cyclotetrasiloxane, octamethyl- Japan 1,2-Butanediol Germany Butanal, 3-methyl- Germany 1-Butanol, 2,2-bis{(2-propenyloxy)methyl} - United States Dodecanedioic acid Belgium Benzenamine, 4-nitro-N-phenyl- Finland 1-Decene Austria Methanesulfinic acid, aminoimino- United States Pyridine, 2,3,5,6-tetrachoro- Germany 1-Butene, 2,3,4-trichloro- Canada Carbonodithioic acid, 0-pentyl ester, potassium salt Japan Benzene, 1,2-dichloro-3-nitro Switzerland Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)- 4-hydroxy-, methyl ester United Kingdom Phosphonic acid, (nitrilotris(methylene)Jtris- France 3-Butenenitrile, 2-methyl- United States Propanoic acid, 2-methyl-, monoester with Switzerland 2,2,4-trimethyl-1,3-pentanediol 6-0cten-l-yn-3-ol, 3,7-dimethyl- n*7 VVV 000013 United States 2-Propenoic acid, isooctyl ester Germany 1,2,4-Butanetricarboxylic acid, 2-phosphono-