Document 5LZ6NoJQJz71k4boaNZboLm60

t l i n s o f an in MHKSflHSRS aSk ff gativn Into the possibiallnjurictta effect. of organic load compounds as additions IHCbH B B P " The proposed Introduction of lead te tr a ethyl as an ad mixture to g a solin e should unquestionably be considered from the point of view of it s possible injurious nature to the publlo health. ww.M 1 V fj& r .^ 'TD > There i s every reason to b eliev e that organic lead com founds of th is type as suoh are highly to x ic when Introduced into he human body. The would therefore probably appear In the manufacture of tetra ethyl lead on a large sc a le . The to x ic o lo g ic a l aotlon of th is subotanoe should therefore be in v estig a ted on animals with particular referenos to the amoun poison required to produoe acute and chronic lead poisoning and channels of absorption of the poison Into the animal body. The flCQond h e a lth hazard Involved in the use o f th is ohemio&l would probably oocur through th e a b so rp tio n o f le a d by persons handling g a so lin e oontalning lead te tr a eth y l. Experiments should th erefore be carried out to determine the v o la t ilit y o f lea d t e tr a eth y l as contained in a fin ish e d g a so lin e mixture under v a r io u s c o n d itio n s o f tem perature, and th e to x lo e f f e c t o f such vapors upon an im als. The poisonous e f f e c t o f suofa m ixtures ehould a ls o be e s ta b lis h e d w ith regard to the a b so rp tio n o f le a d when th e m ixture in liq u id form la applied to the sk in . The th ir d h ea lth hazard may c o n s is t in the p o s s i b i l i t y o f p oison in g due to the admixture of lead oxid e to the motor exhaust gases, it is quite p ossib le that gasoline containing lead tetra e th y l might produoe exhaust ga ses co n ta in in g a la rg e amount o f f in e ly d iv id e d le a d o x id e , which would contam inate the a ir o f garages and aOOomobile rep a ir shops to such an ex ten t th a t persons b rea th in g t h is a ir over a considerable period of time might take in s u f f ic ie n t lea d eo as to cause chronic lead poisoning. S im ilar p o s s i b i l i t i e s of le a d p o iso n in g might e x is t in v eh icu la r tu n n els such ae the New York tu n n e l. Tt i s a ls o p o s s ib le th a t in con gested la rg e o i t i e e under fa v o ra b le wind c o n d itio n s enough lead oxid e might accum ulate as a fin e duet in the a ir so as to produoe con d itions which might be dangerous to p*rsone exposed to th is a ir . T oxicological experiments should th erefo re be performed to determine the to x ic e f f e c t of exhaust g a ses developed by motors burning g a s o lin e co n ta in in g lea d te tr a e t h y l, th ese experiments to be performed on various ep eoies o f animals under conditions sim ilar to those ob taining in the actu a l use of t h is f u e l . This would req u ire methods fo r the accu rate e stim a tio n o f le a d in a i r , and methods fo r the e stim a tio n o f le a d in the excreta of animals exposed to lead contaminated a ir . CV/Brd Carl V oegtlin , P rofessor of Pharmaoology. %1! i' ) ... V i Ih i