Document 5L9oKdQj0p0Kj717YpXN3KrdR
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r. T.C. Tolcy -- \'o:j York " r. Taul I,j<-ue - -i. Louis "r. 75 ,L. Jenkins -- Anniston l^aaara. ~drur I. Hardy
J.F. r.ceres (2) A.U. ZUcnbureR.?. Loewea
Beceiabcr SO, 1947
Colaneoe Corporation of America Central Research Laboratory v 3umit, Rev Jersey
Gentleman:
Dr. L. 3* Bixnbsua
As suggested by Qr R L. Jen.vins in hie letter to you an Decentor 23, we ere nleaced to write cbnut /.raclor toxicity considerations.
The boat published information .*:'aout the toxicity of /.rosier rsporo
with reference to possible dona re to tie liwer Is in a series of
three ortloles written for tho Tirarr-tl of Industrial Hyriene and
Toxicology. The first article eppecrin* in the September 1937 issue,--"* -
Vol. 19, No. 7 and the second article published in the February 1938
issue, VoL20, No. 2 :ero written by C..K. Drinker, if. ?. "Tarrcn, and
C. A. Sennet and cower only Aroclor &4$3. The third article rerltten
by Dr. Drinker alone is sore co-pietc as it Hires information about
Aroclors 4463, 1234, 1268 end 5AGO. o particularly wish to rofer
you to this article entitled, '"urther Obscrwatlons on the Possible
Dyotenic Toxicity of Certain of the chlorinated Hydrocarbons with
suggestions for Pemieoible C -- ontr-Cions '.c the Air of Tortoooms",
by Ceeil S. Drinker, The Jour.-.l of I:~ urtriel Hygiene end Toxlcolopy.
Vol. 21, Ho. 3, Key, TSST.
In this artlele Dr. Drinker tjV.lttt^s the cemissible Halts of the eonpouads la ag. per euble crier of sir in rorkrooas. The following date la aa sxaerpt pertaining to pernlssibla Halts of warious Aroclors:
ifcterlsl
SO. 6 No. 9 So. 13 Ho. 14
Aroelor 4463 Aroelor 1234 Aroelor 1268
Aroelor 3460
Peraiooibl# Limit te. per Cu. M.
0.3 0.3 10.0 0.3
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yroa this. It is aoted that there is a carkod wariatloa la the toxicity
of the weporn of different ,\r -c ior " "'o ruata Dr. Drinker, "Aroclors
1268 is alcost aoD-toxic*. T7k werors of the other Aroclors studied are
toxic sad
bo awoidod. --i ."xrul, the acre highly chlorinated
biphenyls are lese to^o than tv-o It -er ehlorinated deriwatiwes, probe--
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bly duo to decreased aolublll';'. r-e chlorinated tcr^hcnyls appear
to b nor* toxic than ooriu-
a`.'.>vitt*.tod biphonyla,
'
:.'hero tbe cold or solvnnt. rtV *;! i,-
for the lrnre/^natlon of
Aroclars usually only normal Trcsutior.s or ordinary cleanliness
of corncrclal plant practlco -ro fr>ilor.ei*. Mien the .\roelcrs are
appllod by hot asthods, 300* * . or hi-her, the wortaroons should be
ventilated by Intake and tv." -.t r...c of nufflelent voiuaa and
oloclty to renoro the najorlty of tho funes. Where ercr drying
ovens are used, the Vapors mst bo ramrod. 9u/*reatioas about this
are circa In the ortlcle entitled, *Obsarvntlsaa on the Toxio Sffecta
Resulting froa Exposure to Ch?.orlnotod Naphthalene and Chlorinated
?heayls with Sugcostions for '.`revactlan", by Dr. 3. Ton ?edel, Dr. Ea.
A. Colin and Dr. Jasea Denton, published In The Rubber Ace. Tol. 53.
No. 5, August 1943.
.
In General, it Is bellevod that the
peralsslble amount at
Aroelor vapor in the workrooa is evident to the warknen because of
an irritating influence an the eye acsbrunes. It therefore becomes
a self-revealing signal when dangerous lovals ars reached.
If you desire, se will be glad to lend you an instrument t&ich va have with full instructions for Its operation to scasure Arcelor vapors in your tjorkroon atnsspheres. This vxild be tho nost certain nethod to detenaine that your working conditions ere safe.
*
In your letter of Deesabor 19 to Dr. Jenkins, you asked whether studies hove been node of tho possible toxicity or dcractltid due to finished maufaetuxed itone containing Aroelars es an ingredient.
! It wee determined by tbe skin patch test proesdure given by Dr. Louis cchnartz end Dr. "venial 2c. I\jek in reprint flb. 2553 fron tho Public -
I Health Reports, Tol. 39, Ho. 17 (April 23, 1944) that canvas painted with Aroelor 5460 and an oil rodlfiod alkyd resin In such a rnnner that oaeh aijuare inch of fhbrio contained 10.3 mg. of Aroelor 5460, wee soIther a s)dn irritant nor a .ter.3ltir.ar.
The fallowing eoisacreiel apslloatlocs are asms typteol large current
outlets for Aroeloro and to our knowledge, there is no Instance of .
difficulty about toxicity even though in a number of these eppllcatiohe
elevated tenponturss are used and eonsuaara some in rather close'
cootoot with Die finished ear^odlty containing Aroelor.
sen 021424
1. Actuating fluid for thrrsosteta.
2. Heat transfer aedium. 3. Hon-floanable hydraulic fluid, especially .
for die easting necklace.
4. Adhesives for easy -urpsreti
5. rood preservative and scalar treatments.
6. Air ooapressur lubricant.
7. Plasticiser for nitrocellulose, ethyl cellulose .
and polyvinylchloride costings. (Zh a Baxter of
applications of this type the eonwiser cones in
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intimate contaat mith the citing* compositions.
A good example la contod heels of ladles* shoes).
8. Plasticizer far Purlon end Pliolite paints sad
coatings.
9. Plasticizer for wire lasuitting compounds.
10. In transformers and capaoltors.
11. As an lnpregonnt for paper products.
12. Treasure sensitive sealers.
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13. In fire retardant pa into and coatings.
14. Inpreencnt for textiles.
15. Industrial printin': Inks.
16. Stop-off luoquero for electroplating.
17. Ceramic, glaze printing.
18. Plasticizer for asoh.-.lt conposltions.
19. In the manufacture of dentures.
Based on our practical experience in the nannfaeture and sale of millions of pounds of Aroelors annually, the point that are mould emphasize is that markers should not he exposed to Aroelar vapora and that the sen working mlth .'.mclors should observe *.?ood house
keeping" rules about keeping tholr clothing and skins frss of ths satsrisl and avoid Insertion of it.
Adequate ventilation has proved successful in keening the stnoepbsre free froa harmful amounts of .".roelors around machinery and In
plants.
V.'hea you have had opportunity to "ive consideration to o'ir shove consents, plcasa let ua hsve ycur thoughts sad let us know if we
can he of further asslstanco to you.
.
Tours very truly.
rh Coaled hy rm
*3. poolms Dovelopoant Department
SCH D*1"5
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