Document 5L2NOkpqx61awQ4JN0KzyEXyN

d UNITED STATES DEPARTMENT OF AGRICULTURE Agricultural Research Administration (For P.M. Release December 18) Washington December 16, 1952 Research Shows Lindane Vaporizers Control Flies In Some Commercial Buildinga* Lindane vaporizers, widely used in commercial buildings where flies are a problem, will effectively control this pest under most conditions, research of the U. S. Department of Agriculture shows. The Department has approved the use of lindane vaporizers in certain types of Industrial buildings, if they meet the requirements of the Federal Insecticide, Fungicide, and Rodenticide Act, as administered by USDA, but does not recommend that they be used In homes or other places where the insecticidal vapors might be a hazard to man or animals or might contaminate food. USDA chemist R. A. Fulton, reporting the results of cooperative research with other scientists, told the American Association of Economic Entomologists meeting in Philadelphia today (Dec. 18) that typical lindane vaporizers that disperse about one gram of lindane a day, will control flies in a ventilated but screened room within three hours, others who assisted In the research were entomologist W. N. Sullivan, Jr., and chemist G. F. Siangan, both in the Department. However, as experiments by other USDA entomologists have shown, . insecticide vaporizers do not provide satisfactory fly control in such open structures as dairy bams where flies can readily enter or leave the building. Experiments In which the lindane vaporizers were successful, were carried out in a large room (11,000 cubic feet) that was ventilated with tlree large windows and two doors. It also was equipped with an air conditioner. Tests with lindane vaporizers in this room showed that even with the doom and windows open, as little as 0.4 gram of vaporized lindane (less than seven parts in 10 million in the room's atmosphere) killed between 60 and 70 percent of flies within three hours, with doors and windows closed, practically 100 percent fly-kill was obtained In three hours. Operation of the air conditioning unit in the otherwise closed room did not effect efficiency of the vaporizers. ( ...____ | DSW 550863 jli 7-0 pe 1909 *# USDA 2717-52 STLCOPCB4089280 LXNMHB -MQCLQR* COMBBIATIONS Monsanto Chemical Coaspany ,Phosphate Division St* Louisj Missouri la recent news releases the Bm'e&n of Entoaologf and Plant Quarantine , U. S, Dtpartsient of Agriculture, Beifcsville, l%ryland, s/anoisnesd that results of laboratory and preliminary trial studies show mrlsed Increase in the effective insecticidal life of lindane when chlorinatM polyphenyIs (Monsantoss Aroelors) are i^orporated in the toxicant formulation. A nuraber of chlorinated polypheayls were tested; best results were obtained with Aroelor 5460. For specifis purposes where a r-ery tacky deposit is desired, it asay be possible that Aroclor 4*165? also a reain, ssay fee of interest. If a "wet" deposit is desired, perhaps chlorinated' biphenyls such as Aroelors 1254, 1260 and 1262, which are viscous liquids, will give the desired effect, Lindane is a well established pesticid&l chemical* -When applied as a residue it nay leave an unsightly crystallise deposit and because of its relatively high vapor pressure, its insecticidal value dissipates within a few weeks* The Aroelors have good solvent action on lindane which accounts for their improving th appearance of the pesticid&l residue. Moreover, the Aroelors-function as -relatively non-volatile, aonoxldigs.bia, non-flananafele bonding agents for lindane, imparting strong adhesion to all surfaces and reducing the evaporation of lindane to a marksd degree. The high resistance of Aroelors to water and corrosive influences, no doubt, accounts for the unusually good weather durability of the lindane-Aroclor residue as noted in the preliminary work. Although the biphenyl Aroelors, and especially the lower chlori nated Es&iaibers of the series are known to possess activity as - lousioides, miticides, larvicides and show synergistic action on nicotine, these properties seem to diminish with higher chlori- *Trade name, (chlorinated biphenyl and chlorinated polyphenyls) Reg. U. S. Fat. Office. _____ . . J-LL 2* g oSW 55061 STLCOPCB4089281 Page 2 nation and also seem less prevalent In the terphenyl base Aroclors such as Aroclor 5460. Synergism# aowaver, cannot be rea dily predicted and the possibility of synergism in this Aroclorllndaae mixture la at the present fcise being investigated by the Bureau of Entomology and Plant Quarantine., Understanding of the derraatology and toxicology of Arev-iora is important In their handling and use in Insecticidal fc: irtiom. With reference to Monsanto{s Technical Bulletin P-115 f Page 19 reported data indicates that Aroclcrs 1254 and 5460 sheared no primary irritancy or sensitisation whan tested by standard skin patoh tests Although the vapor pressure of Aroclors is relatively low, if the materials are heated sufficiently to give off vapors it should be noted that such vapors bear a degree of toxicity and should not be breathed continuously, as Indicated in greater detail in Bulletin P-115. Experimental Work and Formulations 50 to 200 milligrams of lindane per square foot of surface has given good insect control on nonporous surfaces. The ratio of lindane to Arcelor 5460 has been varied from 1:1 to 1:4. For most purposes a 1:1 or a 1:2 mixture is satisfactory. Formulations as used in the Bureau's experiments are: l) For application as a solution. Lindane 5 parts by weight Aroclor 5460 5 parts by weight * Carbon Tetraohlorid?50 parts by weight 2) For application as an emulsion. Lindane Aroclor 5460 Xylene Triton X-100 20 parts by weight 20 parts by weight 100 parts by weight 3 parts by weight To obtain a stable lj lindane emulsion, mix 143 parts by weight of the above concentrate to 1857 parts by weight of water. 3) For use as a pressurized spray. a) Lindane Aroclor 5460 Methylene chloride Freon 12 5 parts by weight 5 parts by weight 40 parts by weight 50 parts by weight * Carbon tetrachloride is toxic and should be handled with ex treme caution. Less toxic solvents are being studied. . UJTJit DSW 550865 STLCOPCB4089282 Page 3- b) Lindane Aroclor 5460 Oye lohexaaona Ortho dlohlorobonzene l?reon 12 5 parts by slight F5 parts by weight .0 parts by weight 15 parts by weight 5 parts by weight The Bureau people do not want these formulations or resolt-s with them to be ooastrosd as a x^comsendation for use a s the work is ia the laboratory stage aad has mot had extensive field tasting. Sxparlrayafcal - American Roaches Using Formulas 3a or 3b the toxicant ms applied onto a painted wall depositing about 200 mg,/sq.ft. of lindane and a like amount of Arcelor 5460, At the time of this siting, the toxicant coat is one month old* and it still gives 90 - 1CQ$ hill f American roaches when the roaches contained in a petri dish are placed against the surface of the treated wall for two hears. The research team found that the lindane-Aroelcr 5460 mixture (used at tbs rate of 50 mg. of actual lindane per sq. ft.) would kill 80$ of all cockroaches exposed for 2 hours to a 60 day old treated surface. It remained lethal to 56$ of the roaches after 90 days. Regular lindane sprays used at the E&zae rate, killed only 4$ of the roaches after 60 days. House Flies Deposits of 25 g of lindane plus 25 ag. of Arcelor 5460 applied from carbon tetrachloride onto glass and aluminum (hard surfaces) give 100$ kill of normal house flies exposed for 2 hours to these treated surfaces after they had aged 18 weeks, the duration of the test. The surfaces are still equally active and the test is being continued. Without the Aroclor the hard surfaces treated with lindane alone would be effective only about one week. A lindane plus Aroclor mixture sprayed as an aerosol onto leaves of a willow tree continues to kill house flies after 2 months outdoor weathering. Careful inspection of the treated leaves shows that the toxicant is held firmly to the surface and not withstanding rain and weather, the coating remains in good con dition. Also, within limits of a preliminary inspection there does not seem to be Injury to the willow leaves. DSW 550866 STLCOPCB4089283 Page 4 OoTaslrssXon According to these laboratory tests, it is believed that Arcelor isey increase the effective life of lindane, 10 to 20 times. Since Aroclors are relatively very inexpensive, their use with lindane would offer a great economic value. In addition to use with lindane, the Aroclors say be equally useful with a wide var iety of other insecticidal agents. Studies with Aroclors are continuing at the Bureau of Entomology and Plant Quarantine and it is understood that a paper covering this work will fee given at the December 15-18 meeting of the American Association of Economic Entomologists at Philadelphia, Pennsylvania. Bys P. G. Benignua Monsanto Chemical Co. Dates 11/26/52 rm 7777 7-3 0S\N 550867 STLCOPCB4089284