Document 5D30Omo6DgmqYkGkxLbMwzQy8

FILE NAME: Neighborhood Exposures (NE) DATE: 1967 DOC#: NE023 DOCUMENT DESCRIPTION: Mesothelioma and Its Association With Asbestosis U m a 24 <;y rrx?>. i si (3-97jher- Mesothelioma and Its Association W ith Asbestosis LawreMncaexw!.e. lll.iBvoorrnneus',cM, MDD, ,AalfnrdedXCorobnesrtnt nS,cMliaDlr,l. MD H is i a three-year parted in a com m unity hospital, t o f m esotheliom a, nine o f the pteura and eight lerttoneum. ware found at surgery. Two of our contracted th is m alignancy with only environexposure con sistin g o f living in a com m unity t to the asbe stos m ill. In the sam e hospital, there n a high incidence o f bronchogenic carcinom a A review o f the autopsy m aterial o f the b vmowuwd^iiCie twoen i^eis oeeneoteoj owniiwe isdnodeKnitiwoifilwili ceeiwuue.i .JXRu! fiSilW>aaAlS ouOSsnwAl fLwsondMUVanilaCaVi m%MM Mlllawaon4fl1lullbwlSInNalMIMB lIa i^sw iasm tehe^sa irinBcwkiei^swnnwews oewfe swswbwswswtiowswivsv.f w^wietehee tevhrew application o f th is product in m any different P rimraraertyhattumfoorryseaorfs tthheeysewroesraelcsounrsfiadceersedartoe bsoe mpaothrsocloagnicbceufroiousnidtieins. aThreepfoirrsttbryefeVroenncReotokistuanchsktyu,' wtohnoeuimn 1w85h4icdheshceribceadllepdrim"caorlyloitdumcaonrsceorf."thDeupreinrig tshime inlaerxtty1p0e0s yoefartus,mthoresr.e Hwoewreevsepro,rathdiisc erenptiotrytsreof mtoaiintsedprsoodialledneaftinuered. tBh raotwthnearendwJaoshmnsuocnh*dionub19t 5a1s cmoan)sidtoerbede ttibheeseendmreessouthlteloiaflantuminoflrasm(mmaetsoorytheplrioo c"UeTssosp,tahwtehitpohrloeogsreicgnattnedixaztyatmaiocancdoeoufnthttsehoeffoselulxopuwpdioanstgeed.sltyWatpeirlmilmise'anritny: qasuraatsealantudrinnosnuffcicoinentitnlyuecrtioticbael, ddeisspclraipytiinvgelay liancakdoef taewctaerdenceasrscionfomthae,p"oasnridbibeebaelshoavciaourtioofnesmd athlleurneadde er to pausareosf athneosepetnummoirnsd. Irneg1a9rd5i4n,gAtchkeermexaanc*t iaits?wamsetshoethemlioamjoaristyaonpinraionn tthheayt adlo ' M taiaM M hau , N J < (Dr. etexriisat.fSorintcheeGdoiadgwnions9isinof1p9l5e7urlaalidtumdoowrsnasntrdicWt icnrsi dloiwagnanosdisToafytlhoer*seinne1o9p6la0smfosr hnaesribtoenceoamletummoorersc,otmhe mvaornie.dTshtaetiisnticcidaellnycefroomf p.0ri2m%aryto m.2e%sotohfelaiollmaautohaps sieTs hweitfhirastralatirogeofseornieestooftwcoasiensfaovfodriofffutshee mmeasloe. tPhneeliuommoacownaisosdiisagRnoesseeadrhchistoUlongiticaaltlyJionh1a9n5n7esabtutrhge, eSpoiduethmAic,frWicaa.gnInerteryt ianl,g1ntooteinxgpltahinattahsibsemstoysstbeoridoiuess ctioeunltds,boebtfaoiunnedd idnettahileedlulnifges hoifstsoormiese ooff tthheesier ppaa tsioecnitast.ioBny w1i9t6h0,ththeeyCawpeereoafbGleotood eHstoabpelisahsbanestaoss 3fi3elpdsa,tieonrtsthweitihndhuissttorlioagl icuaslelyopfroavsbenesptoles,urianl m32esoof athcetulioalmlyasw. oTrkheedmwaiitohriatsybeosftothsebseutphaatidenlitvsehdaidn nthoet tvhiecsineitayreoafs othfeexmpoinseusreaansdymouinllgs cahnidldrseonm.eThhaedavleerft athgee tpuemrioordwbaestw2e0etno e4x0poyseuarres. aBnyd 1d9e6v2e,lWopamgennetr oeft aple*rihtoandeadliamgneososethdelaiomtoatsa.l Ionf o8n7lypltewuroalcaasneds wtwaos itht enoatsbpeosstsoibsledutost.esOtafbltihsehsea 8h7istcoarsyeso,f 1e2xphoasdurehatod vinirdounsmtrieanltaelxpexopsuorseuraendfrotmhe lriveimngainindetrhehavdichinaidtyenof mtheesomthielllisomanadanddumaspbse.stTohsiiss waasssomciaadtieonevbenetwmeoerne isnetrriiegsuoinfg72whaeunt,opinsie1s95o5n, Bpoatniseenrtsetwail*thdaessbcerisbtoedsisa, ifnouwnhdi.cShufbosuerqcuaesnestlyo,f MpearnitcounseoalamndesCotohuelltieorm'0afowuenrde faisvbeepsteorsitownoeraklemrs,esaontdheHlioomuraishainnoa,u"touppsoinesreovnie1w,4i9n6g t1h9e17nteocro1p96sy2, ffioleusndof84thceasLesonodfomn eHsoothsepliitoaml afr,o1m7 of the pleura and an equal number of the p^ ___________ i t . ------- tboe--stoais, Aev1enofthfolwugthPinf**a--f*air^therHe i--n s *ao7 1m*yIwarwj,oSfnstiiimckantiarpnatnodthSenaatehbse'*tnspdoursttedTn11thcnattersaomf peritoneal mesothelioma in patients exposed to a- m aInofatnheasttsermospalt stuorfdaecteesrmhaindeawnyherethlaetriomnesehoipthweliiothaaalb"aaattuodaieaxdp8o0s7urceoinnsetchuetiUvenditeeadthSstaatmeso,nSgdaiakboafaftoeat Tinhaeuylatfloounnwd otreknersdeinathNsocrtahuesaesdterbny UmneisteodtheSltiaotmeaa., faodudritipolneu, rathleasnedwsioxrkpeersrithoandealanmaeaoxtthreamBoemlyaah. igInh cdoaiaotnh, arnatdereactttruimbu. tOedf thtoe c3a0n7cdeeraothfs,th4e0.4st%omwacehre, atottroibthuetredcatuosceasn.,cIner,a5s.5e%contod asatubdeaytoweihs,earendth5e4y.1r%e avaiebweaetdoa2h6, tchoenysecfouutinvde afouutorpmsieessoothfelpioamtieanstsofwtihthe pleOurnaeaonfudsth(MreeJBo.f)thhaesphearditothneeuumni.que experienceof owpheoraptirnogv,ewd itthoinhtahveepmasetstowthoeylieoamrsa,.-oSnix11opfattiheenstes wcaeareesoafdthdeedpetoritothnoesuemdaiangdnofisveedofprtheveiopulesulyram. Tahdeesae tpoetraitloonfe1a7lcaansdesnoinfme weseortehpellieoumraal,mofewsohtihcehlieoimghatsw. Aerlel A17rceavsieeswwoefrethdeiaaguntoospesdywmitahtienritahleapt aSsotmtherreseetyHeaores-. npoittald,isScolmoseervainllye,aNddJi,tiforonmal 1c9as4e8stohfromugeshot1h9e6li5omdiad. Ta hraisrehtiugmh coornccaennbteraetixopnlaoinfewdhbayt tihs ecocnlossideeprreodxitmo ibtye othfeaamsbaejsotroassfbibesetrows hmicilhl.isAmppinroexdiminaNteloyrt7h5A%moefriaclal cisilcitoynwvehritcehdistoloccoamtemd oerncliyaltwusoeminileasnfrionmduSsotrmiaelrfsae-t HoTshpietaaLssociation between pulmonary cancer and amsabnsystoysekarhs.asTbheeennurmecboegrnoisfepdaatitetnhtiss aindsmtiittutetidonwfiothr Htheerseyecaornsdmitiaonnysokf tdhifefmicuwltetroe ddeiategrnmosineed, aass pinulmeaor- ntiacrsycofiublrdosbies oobrtasiilniceodsifsr.omThteheonaluytoapcscyumrataetesrtiaaltiosf sthiees pwaesrtedpeecrafdoerm, 1e9d5.5Intoth1i9s65g,rowuhpe,nth1e,r3e30waeureto2p2 ctoassiees, oafsbwroenllchaosgtehneic1c7anccaeserswoitfhmpeuslmothoenlaiorymaas.bAesnitnhteerreeswtienrge loarbgseernvuamtiobnersisofthwaot,mednesaplsitoe etmheplofyaecdt abetstthoissisi,ntdhuesretrikal ofanclyiliotyneanfedmmalaenwy icthonmtreascottehdelaiosmbeastions poularnstebnuset,liavnedd ndeiearnbeyv. eTrbwkoerxkpederiiennctheeisaisn cfroonmtra8sot utothotAhferricraepwohrteerde stehreierse, pwaarsticaulaajrulyifithcaonset wWithemthikghttaettribduuteeotouradbisfefsnwceoooef fienmoaccleuspinatvioolnvaeld nHpoowwewver,boetthweerenstufdluiesmwoaukldnaodt sIuwbisithanwtiarteittwhi.s, as then appears to be a high inincidthenaceviocifnmityeaoof- tfhroemaaSboauattohaAmfriincaaa, moroirnedtuhsatnriehsa.lfInofWthaagpneeor'pslseehriaeds npeoot pbkeahnaedmhpaldoyeendvbiryonthmeeanatablaaetzopaoianodroaedtauye. tTohUaevetiinatgician fthroemvitchineityLoonfdtohne mHiolskpaitnaal, dausmrpesp.oTrtheed ebtay* Nweiwthhoounaeehanaldf Tohfotmhepspona't*ieanrtesvhearvyimngucohntlhyaasnamene,mviraotinomn,eontnael wexopnodseurrsewtohyawsbeeshtaovse. Wnoitthsetehnissiimnfiblar-r ctihrceuremisstaancleasrgien aosbuerstcoosmdmumunpitya,d jeascpeenctiatloly asirnecseideAntniaoltahreera.interesting observation in our aeries is mthaewfaarcet dthiaagtno16seodfwthitehi1n7thpeatpieansttsthwreiteh ymeaersso.thAelrieovbireowugohftthteoaulitgohptsyomnlyateorniael faodrdtihtieonpraelvicoaussedwechaidche minietniatlolyf thhaedabsbeeesntoms ifsidbiearghnoassebde.eSninocnee othfethreefmlnae*yjoerarisn,diut sitsrideisffiicnultthtios egxepolgarianpwhihcyawreeaarfeuronolvyerno6w0 athwaatreinofouthrisgrdoiuspeaosef. pOatnieenptos,asoibnlceeetxhpeladniaatgionnosiiss owbatsaisnusapneacutetdo,psayn winhteennsthifeiepdaetifefnorttdwiedas. Hmoawdeevetor, pmreiosortthoeloioumr raecwoegrneitmioonsot fliktiedleyedniatigtyno, speadtiaesnthsawviinthg ma agceknetoraloizbetadincaarncianuotmopatsoysiws haenndthlietytledidef.fRoretgawrdas loeussr dwishteinthcetrimthpisrersesaiosnontihnagt itshecroerrhecats obreennoat, ditefiistnhietolaisntcfreewasyeeianrsi,ncidence of tide malignancy within & AabHaals ofthe ton (cm X.X120). Report of Cam hoCspAi8tBal1w.--itAh i6n2c-ryeeaasrin-ogldcownshtiitpeamtioann, awnaesnaladrmgeitdteadbdtoomthene oHfeonheadmboenetnh'sredtiurreadtiwonit,hanadmaendiilcla-dl edfiisnaebdilaitbydformominapluplmaino. Hnaerysuafsfbereesdtoeaismayftoecrarwdoirakl iinngfa2r8ctyioenantwaot yaneaansbbesetfoosremaidlL miPsshioynsi.cHaleesxmamokiendatoionnlyroecvceaaslieodnaallsyli.ghtly emphyssmatous cNhoesitntwrait-habhdaormshinbarlematahnseosucnodusldanbde paabldpoamteidnaaltdtihsatetnttiimone.. bCihlaetsetraxl-lrya, yinotefrpthreeteldunagas mdeomatonliksterlaytedduebatsoilaarsbfeibstrooesiiss., Ao fnthaentaerbodpoomsteenridoremxo-rnasytrafitlemd , awgitrhoouuntdcgolnatmrasatppmeaatrearniacle, smuogigdesotinvethoef axs-criatyes.filSmomteakaetntenauftaetrionevaocfuathtieonreocftostihge bpaarriaucmenteenseismyaierldaiesdedapthperopxoimssaibteilliyty1,o6f00a cpcelovficstmraawss-c. oAl opraerdietfalulisde.roSsuarlgsicuarlfaecxepslotorabtieonsturdedveeadlewditthhefinveiscpearpailllaarnyd, amlmesoostht eglrioamnualawr-aliskme,apdreojfercotmionas.bAiopdsiaygsnpoescisimoefnpa(pFiilglom1)a. heForellmowaiinngedansyimntprtaopmeritforneeealanindjecatsicointicoffrgeoeld foArU-n1i9n8e, mmyooncthars.diFalouinrftaerecntiomn.onths after surgery he died from a freAeuotofptsuymoerx.amPlienuartaiolnplarqevueeaslewderpelepurreaslenctavaittitehse tboasbees aedndbtuhlelaree wemerpehmysuemltiaplewaitdhheasnionirsr. eTghuelarlundgeslicdaetme ofnibsrtroastis athrfroeusghhoinutf.aTrchteThheearptewriatsoneenalalrcgaevditwy iythielodldedsc1a,r0r0i0ngccanodf sitliyghotrlgyanmauacaoidweylelllaows itshhe flpuaidri,etaanldpaerllitothneeucmoelwomeriec ccaovv einreddiawmitehtewrhaintedhhaardvinngodaulmesu, cvoairdyianpgpferaorman5cemomn ttohe5 ccumt surface. n o d u le s tIon cmoaalsneyceatroeafsortmherlaergwearstuamtoerndmeanscsyes.foTrhtehetuse mors did not penetrate for any appreciable distance be- S. ram hmursnm lm lisps nfbswal (teas a neMathicrthosecsoupricfaecxe,aamnidnaatliloonthdeermoorngsatnrastwederaenunexretemnasrivkeabinle-. t(eFnigtit2ia).l Tfihberohsyispoerftrtohpehhieudghseawritthshmowaendy aardetastoofefibbordoieeiss tahnedlioamcuatewnitehcrocusibs.oiTdhale cteuimlsosrhwowasincghasoramceterpitsotiocmoofrmphesimo anCdasumpe2r.f-iAcia6l1n-syneialrls-toilodnw. hite man was admitted to Som ewrassetaHn oemsppitlaolybeeecaatuasenoafsbabesdtooms rineafilnpinaginp. lFanokr 2H6aysemaroskheda IsmRetshualnts oonfepphaycskicaolf ecxigamarientatetisonpewr edraey.normal, and all lfaibbroortaictoirnyfislttruadtiieosnwoefreboutnhrelovweaelringlo.bCesh.eAstnx-urpaypesrhogwasetdro tinisteasntidnaglarstoreintitsg.eHnoegrwaapshidcisscehrairegseddeomnonastrreagtiemdendufoodreunli lcaetrercwonitvhalpesocsetpnrcaenodniallyabtodobmeinraelapdaminitatendd asev1e0n-lbmwoenigthhst ltahsesr.eOwnapsanlpoatetinodnetrhneesasb,daonmdeannaepxptreaalruemd binoaalrmd-alisksec,othuoldugbhe pbaarlpiuamtedenthemroaugdhemthoenastnrtaetreidorripgoidrtitioynaonfdthnaerrreocwtainlgwoafllt.hAe stoigmbeoaidlmcoolsotnc.oAmtpsluetreglyeroyb, ltihteeraatbeddobmyinlaarl gceavmitaysswesasoffonuenod pgalansstiacntdisswuaeswinhfiiclhtrahtaindgenthveeloppaerdiettahlepienrtirtao-naebudmom. Ainadliaogr nTohseispoaftiemnetsdoitehdelfiooumramwoansthms aladteerf.rom a biopsy specimen. plaPqeuretisnoenntthfiendpianrgisetaalt palueutorpaaaynidnccloundgeedstinounmaetrothues blaarsgees oedf bboythalulanrggse.,Tyhelelopweirsihto-wnehaitlecahvairtdy twuamsovrirwtuhaicllhy wobalsitceormat fpolretethlyis esnucrafasicneg inthvoelvaebmdeonmt,intahle oorrggaannss (wFeigre 3u)n. reEmxcaerpkt abMle.icroscopic examination demonstrated bronchial pneu mboodnieias. wTihthe atummioldr cpounlmsisotneadryoffibfursoifsoisrmandcemllsaniny aasbheysatolismniesesodthsetlrioommaa (wFiitgh4)p. apillary formation characteristic of hoCspaisteal3w.-iAth 4a7-nyeoanrp-rooldduwcthivitee cmouagnhwaansdadilml-ditetfeidnetdo dthise cchomeaftorxt-riany tfhilme rwigahst nloowrmeral,lobbuet oaf stehceonldunogn,elitkaekeinnittwiaol sdiaoynsinbetfhoreeraigdhmt icsosisotnopdhermenoincsatrnagteled. Ta hsomuaglhl phleeuhraadl befefeun ahne hinasdurwaonrckeedagaesnat satnodckmbooryeinreacennatlsybeastolisquroefrinsianlgespmlaannt, forP1h8ymsicoanlthexs,a2m4iyneaatirosnagaon.d complete work-up were unre vbeioaplisniegs,. iTnchlourdaincogcesnctaelseins eyineloddeed a1n0d0 tcwc oofnesterdalwe -cpolelourreadl ftloumidy wthiteh psoamtieenmt wesaosthfeoluianldcetolls.haAvte eaxpglroeraattloyrythtihcokreanceod plyaraietetalelcatantdicvliuscnegr.alInplceuerrtaaiwn itahr eencathseempeanrtieotfala apnadrtviaisl acenrdalcopulledurnaotwbeereseipnatrimataedte.lyThaedrheerweanst ntoo noondeulaanriotytheorf theAsedrioasganlossuirsfaocfesp.ulmonary asbestoeis and mesothelioma wceaivsemd asdteerofridome aandbicoopbaayltspreacdimiateinon. Pwoistthopasrpaotoivrenlyahpeoore, vaonldvehmeendti.ed ten months later with bilateral pleural in MESOTHELIOMA AND teriathcetrwbeyresuurngreevryeaHorngp.eTrithoeneiotisecionpnyrisanWdMbimopasdye. Tsmhoaalle ppaaptiilelanrtys wpriothjecatsocritesstwuderdeinfgoutnhde tvoiscfaearvaal afrnodmpaardieetaarl spyerruiptoynteouma .thTinbestaraswci-tcicolAordedd cvoanrsiiesd wteenrcey.foTuhnodseonpaetxipenlotrsatwiointhtothheavpealpcoabmleplemteasosbes lmitaesrsaetsiown hoifchthweepreeroitcocnuepaylincgavmityosbtyolfarthgee tcuomeloormWiecbcealiveivtye tahnadt tihnivsapdiicntgurteheis pbaurtiethtael epnedritsotnageuemof. tsheentdaisneaesaer,liwerhisletatgheo. sTe hpiastiiesnstus bwstiathntaisacteitdesbryeptrhee foifndoiunrgpoaftpieanptisllawryhoprhoajveicntigonpsreastesnutergdewryitihn asesvcietreasl wanidthilnarwgehotummoobrlmitearsasteisondeovfeltohpeedpleartietorn, eaaslseceanviatyt auPtoaptsieyn. ts with pleural mesotheliomas all present eefdfuwsioitnh. vAarwyionrgk-duepgwreaess loikfecwhiesestupnarienwaanrddinpglewuirtahl bthioepseyxcinepotinoenpoaftiepnots.itTivhee ffilnudidinign*thfreompleaurapllecuarvail toyrevdafrliuedid,fraonmd athgerotsusmboloroidnyvoelfvfuemakemnttovasrtireadwf-rcooml ppalepuirllaartyo parogjeencetiroanlisseodnthtihcekepnaerdieptaleluarna.dInvisacreeraasl htheerevnitscaenrdalcaonudldpbareiesteaplaprlaetuedraownelyrewinitthimdiitfefliycualtdy. actTivreeagtmoldenatnwd cithhrocmobiuamlt,raanddiactihoenmtohtehrearpayp,y,raudsieod acolounreseoorf itnhiscodmisebainsea.tiFonif,tyhapderclietntlteofeftfheectpoantietnhtes sthuefflieorminga ebiethdewritfhroinmonpeleyueraarlaonrd tpheerirteomneaailndmeresboy the second year. Criteria for Diagnosis tumAoltrhsooufghtheitseirsosnaolwsurafcacceepsteddo ethxiastt amndesopothsdseiassl aregnuatmiobnerasofancheanrtaictyte,rtihsteiccsriwtehriicahfjourstthifey itdheenitrifsiecga ctiuornreonftltyheascecetuprtendoncreitreerisatiflol rhtuhgeedlyiaigmnporseisciosef.thTehsee ptulimedortsoartheotaheatg:ro(u1p)s Twhheicdhiasghnoowsisanshuonueldqubiveoacpal pwreitdhileeictthioenr ntoonseproeradonallyonagsthhaellsoewroisnavlamsieomnborfanthese, umnodrehrlayviengbeoerngaenxsc.lu(d2e)dA. (ll3o)thIfemr seotuarsctaessefsoarrteheprteus ennodt,esth, erayreslhyouolcdcubrerinligmiintedlivteor, tbhoenere,gainodnallunlygm. ph in Sapedciaiaglnsotsaiisnionfgthoirshdisistoealosge.icWteacghnneiqr ueetsaml"ayhaavide sbuyggexaprioesdutrhe attomheytaalcuhrraonmidaatsice)stwaiinthining a(retmumovoarblies sintroanpgaetiveindetnce for the diagnosis of mosotholioma thePatuthmoolorgiiscmCahdaeraucpteorifsmtican.--yImn athlle, eroaurlniedresdt,afgirems, nodalm on the visceral and parietal surfaces. Later, ET AL tthheereterIms ianaclosatlaetseceunscuealolyf cthoensreirinsoodfuslsoel,d,sobraOnadt, tthheicmk wbainthdisn wahdicehnsme cmowamip.arOe ftthene tvhiaeoadtealianneadtioi sn btheatwt etehne panrieitaaluatonpdsyvisdciessraelctpioernitoisnkenupmomh iblolestd, usoe atondthfiisrmenacnadsemmaeynthaTvheea tmumucoirnoisusgaepnpeeraalrlaynwcehoitne theHcisuttoslougrfiacceC. haracteristics.--We have seen two mcoamjomrohnisvtoalroiegtiyc itsypthese oefpimtheesloiathl efloiormmaw. hTehree tmheoraet apraecicluiabroyidaaplpoerarpaonlcyeheodrraalscoellilds pgrrooduupcoinfgcsaOtaubwuiltoh- olyut auncilfeoarrmtubcuellalurlfaorrmsatrtuiocnt.uUres,uablluytthoecrecaissiaonfaalilry btiiczacrreellsnuacrleearteadreclyellsfocuanndb, ebsueetnd. oPuabthlyolonguicclemaitteod aonthdemr vualtriineutycleisatethdetummeosernccehllysmaarel oofrtefnibrsoeuens. tTyphee oinf manesaoltmheolsiotmfaascinicuwlahricphastpteinrndlewcitehllisnaarestarrormanageodf ambauynbdeaanrtrahnygaeldinleoocsoelllyaginenin. dOiscticnacsitofnasaclliycutlhioermceallys ochccaurarcitnerissotilcid onfesmts.esTothheelimomosat sitsrikthineg shtirsutocltougraicl vthaerisaatimone twumhicohr,msoaythoactciunrofnroemaraeraeathteogarnowa twh imthainy hmaevseenecphityhmelaial lasptpruecatruanrec,ewohrilieninbeatnwoetehnercaompubirnealy tions. Pathogenesis plaTshiaeims aotdperoefseancttipoonoorlfyausbnedsetrosstoiondp.rFoudrutchienrgmnoeroe, tahepluiozmzlianginfoeanteumreinhiansgbaereena,twhehiplereinsenanceotohfermmeeion- itnogbaereidaeantfiefiwedm. iTlehsedreistaarnet,twthoemdiaejsoersemhinaisnagsdyiset twriecsttsCinapthe eofRGeopoudblHicoopfeSporuovthinAcef,riccrao. cIindothlieteniso rtthhe fbiobtehr mcrionceidd,owlitheeraenads imn othree iTmrapnosrvtaanatllyasabmesotossitefiealrde, mined. Up to the present time there hag been a 4. Erin* eel typemiiothiMsmi (care t, xEty. MESOTHELIOMA AND ASBESTOSIS-BOROW ET AL MperibtopnreeuvmaleinncenooIrtmhweneostthCelaiopme *ofofGtohoedpHleouprea.aOndn tfhroemotthheerThraanndsvnaoal caasebeesatsosyaertehaaos rbietesnsurerrpoournteddainnpd. eSnhviiirso-nCmreemntearl'*dhifafesresntucedsieidn tthheesgeeotwgroapahriecaasl atonrds hexaacmoimneedtoexthpelacinoendclussaitoisnfathctaotrniloyntehoef tahbesefnacce othfanmfeosor tthheelimominaerianlogthicediTffrearnesnvceaabletrwegeieonn.thOe tthweor alerneagsth, ohfepfrooudnudctinoon ovfartihaetisoenfieinldsthoer ininttheneseitxyteonrt omfotnhaereynavsibroenetmoseins.taIlnpoNllourttihonAamnderiincac,idcehnrcyesootfilpeuils tshitee maraeinprfeibseernmt iinneledsaseltrhaomugohunctrso.cBidootlhiteplaenudraamanodperesrietoxnpeoaseldmteostohtheeseliofimbearsh.ave beat found in work latWingagvnaerri1o7uins d19u6s2tsinindtuocethdempelseouthraellicoamvaitybyoifnoractus. cPrloecuirdaolltituem, cohrsrydseovtielleo,paenddinathfionseelyindoivcuidleadtedsilwiciothn panowd dWera(g9n9e.9r'*%sshioliwcoenddtihoaxtidcer)o. cRideocelintetl,ycShkryidsmotoilree, sinildicuacepdopwldeeurr,alamndestoothaeliloemssaetraeixntegnuti,neaampoisgistea,ftaelrl idnutceerpdlemuraalilgninajnetcttiuomn.oPrseaicnocfokwalsndwiPtheaccroocckid'*oliinte athnedpaamthoosgieten.esAis onfumthbisedr isoefasheyphoavtheebseesentoproepxopslaeidn, fbiursttntohneeoroyf wthaesmthhaatvoefbpeehnyswiciadleliyrriatcactieopntedd.ueThtoe tmhienaplrelsyemncpehaotficassboefsttohse fsibereorssadlespuorsfaitceedsinorthdeuetetro tfholelomwiinggraitniohnalaotfiotnheorasfbroemstotshefibgeurtfarosma trheesullutnogf binegreosftiotinss.uFeisb,eirnschluadvienbgepeanrdieetmalopnlesturraate, dgainstraicnummu coofsfaib,earsnidn sthpelepener,itbounteatlhseurrefahcaevs.e been no reports whAicnhotthheer pcroensecnecpet iosf tahsebeasutotos-ibmodmieusnein the ilsins.aUidptotoelitchiet tphreepserondt uticmtioe,ntohfearne aisbnliotrtmleapl ogsioitbivqeweviitdheneciteheforratshbiesstcoosnisceoprt. nTeohpelasseiraumshoowfspoatnileyntas ismligmhutlnyofrlauioseredectietnetrsftoairntihneg hrhaesunmoattsohiodwfnacetvoird,eanncde oinfgatonnaanntdigRenoe-*a0ntsiubgogdeysteadggtrheagtatteh.e Rcaercceinnotlgye, nHicaitryoufraalsabnesdtocsonmtaamy ibneatreedlaoteilds taosstohceiapterdesewnicthe othfenaast bmeesttaols cfoibmeprleoxrestoincetrhtaeinfibcearrsc.inTohgeenyicfomunetdabthaotr carmoociudnotlsiteof annadturaalmooislsit.eFucrothnetarmineodre, aapllprtehceiabasle obnesdtaorsyfiobielsrsa,sinaclruedsiunlgt cohfraynsoatidled,itmioanyocfonotial itnos(ehce atasmbeisntaotsiodnu.rinFgurtthheerpmroocrees,sianlgmoorstasuanirveesruslatlloyf, ctohne tahsebeositlofsroismtrtahnesjpuotretefdibaenr dissatbosroedrbiendjtuotea bgargesataenxd tenBtobtyh acllhtrhyrseoetitlyepaensdofaamsboessittoes hfiabveer. a significant fuelrarroucos mcopnletxenest,opfairrtoicnu, lsaurlcyhoafscierrotani-ndemxatrcarnomwohleicchiisroknnocwonntetontboefhcihgrhylysoctailreciinsomgeuncihc ilnowaneirmthalasn. Tthhee oRtohee'r" ttwhoatfitbheers.caIrtciinsopgreonpicoseadgebnyt oHraraignegntotsn manady noioltobresetchoenfdiabreyr othibemwshelivchesabreutpreeisthenert othnethneatfuibraelr acunrdreonrtlpyopsseirbfloyrmthiengirboinolcoogmicptleesxt.sTfohre tahuethcoarrcsinaote wgeenreiciintyaopfrethliemseinmarayteforiramls.atHtohweetivmere, othfetsheesrteupdoirets. generic end Trade Nam es of Drug GoRldadAiougo1ld98C-AoullrociodalolidA-u19189,8A, Aurueroetootpoep-eA.u 198, Aurcoecan-193, Tr1a.neR.,okLiotanndsokny.pC.26V6o, n1:85M4.anuel of Path. Anat. Sydenham Soc. rMnOLoUnB"SrooufwrPgnl,e1u8Wr8a:4:J1.3,5-ca4an2ad5aa(JoOofhcPnt)aleo1un9r,5a1lL.F.Cib.:roPmoaetofInInfltaemrlombaatrorFyiss'Turue, wo3r.thWInilcli.s,. 1R9.8A0..: pPa1t8h6o.logy of Tumors, Washington. DC: ButterDC4.: AAcrmkeardmFano,rcLes.VIn.:stAitutltaesoof fPaTthuomloogryP, (aatchtoiolong6y.. pWarats2h3in.1g9t5o6n.. Tph51a.0i0rG.oRdewlaitnio, nMt.oC.L: oDcaiflfisuesde FMibersoouthseMlioemsoatsheWlioimthasC, oCmamnceenrt1i0n: 2968.-3W19in(dMowar,chd-AJpTril)an1d967T.aylor, H R : Malignant Peritoneal Mra7les.MoWtheaesgolinothemerl,aioJsJmCCa.;anSacnlaedgr g1As3,e:C1h2aJ7aL-tn1; 3eai6ns d(EJMaxnpa-orFcsauhbaren) diI.n9P60N.:. oDrtihffuWse ePslteerun C ue Predate. Brit J Imbatr Med 17060-271 (Oct) I960. a1n*3A68n-a2ly78sis(MofaTyh)e1ir96A4s.sociation With Asbestos Exposure, Thorax in1A2.sbEensttokskins,apB,riJt.BJ.,IannddutSlrmMitheedr.2W1:2.0P-.3J1.: (PJearnit)on1e9a6l4.Turnon Bs1tw3.eSeenlikEoxfpf.osIuJr.e; tCohAursgb.esJt.o;s aanndd HMaemsomthoenldio,mFa.C. .N: eRweRlaatigonJe MMe1eds4o.3tNh7e2elw:i5a6hl0oT-u6ua6em5, o(MrMs.iLanr.,cthha)end1L9o6Tn6dh.oonmApenoan., AHnn: NEYpidAecmadioSlorgiy13o3f: c5h7e19m6-6.8icW6ala(DgDnaeeerm,3oJ1.nC)st.1r;a9Mt6i6ou.nndoafy,HDyJaEluLr;oannicd AHrairdinigntonP,leJuRra:l HMieastoathe1t6io. mStausi,sJ-OPematherB, aGd.K8.4::7A3-s7b8es(tJousilsy)in19S63o.uth Africa, Certain GSdeo1g3ra2p:2h1ic5a-2l3a4nd(DEecnv3i1ro)n1m9e3n6.tal Conaidentioaa, Ann N Y Acad mo1u7.rsWoafgnthaer, JP.Cle.u:raExbpyerIimmepnlatanltaPtrioonduoctfioDnuasftsMiananLthabeloiaelatTeeuy An1i6m. aWls,agNnaetru, rJe.C1,9*a1n8d0S-1k3i1dm(Oorcet. J1.3W) .1:9A63s.bestos Duat Deposi t1i9o6n6.and Retention * Rata. Ann N Y Aead Sri U*T7-6 (Dae 31)