Document 55vwBYmMqb9EZqbdLrwQN65V

CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) DUE TO VCM REVIEW DATE FEBRUARY 1991 r< Collated by: J. R. Drurnwright, M. D. Vista Chemical Company Manager Medical 900 Threadneedle Houston, Tx. USA Telephone (713) 588-3044 Fax (713) 588-3107 Tlx 794557 R&S 142955 LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER BAGSHAU Dr I M M BAND Dr P R 3ARRAT Dr G BAXTER Dr P BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BEYNON DUS BISHOP Dr C BORRELLI F E BRAUN Dr C L J SROGDEN M E BROUN Dr H G BYREN Dr David CAMPION Dr Catherine CARTER Dr J T CHIOZZINI Dr Giorgio CLARICE Dr E A CONTASSOT Dr J C COULES Dr Salty DELORME Or F DEPLAN Dr F DIETZ Dr H U DOLL Prof Sir Richard DOMBROUSKI S L S DOORNBOS Dr N DRUMWRIGHT Dr J R ` DUPONT G EMHINGER H ERNST Dr U EVANS Dr A E J FALIC Dr H FAVRE Dr FIELDING Miss C CONFIDENTIAL FEBRUARY 1991 Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Coluitoia, Vacouver, Canada AECRP, Contnentry, France University of Cantoridge UK Atochem, Chauny, France Rhone Poulenc, Aubervitiers, France Naphtaehimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy ICI Runcorn, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands ICI Runcorn, UK Shell, An Oen Haag, The Netherlands Nobel Industrier, Sundsvall, Sweden Health 4 Safety Executive, Bootle, UK EMAS, London, UK Ospedale Untoerto I, Venice, Italy Ontario Cancer Foundation, Toronto, Canada Atochem, Saint-Fons, France Shell Oil, Houston, Tx. USA Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Find, Oxford University, UK Dow Chemical, Midland, Michigan, USA DSM, Seek, The Netherlands Vista Chemical, Houston, Texas, USA APME, Brussels, Belgiun VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Uarrington, UK Centers for Disease Control, Atlanta, Georgia, USA Atochem, Montluel, France ICI Millbank, London, UK R&S 142956 FILLINGER J FINGHAM Ms Shirley FOA Prof V FORMAN Dr 0 FRASE R U FRIEDEL Dr H P GAFFEY Dr W GILLI GAN Or. R. GIUOICE Dr S GOTTESMAN Dr R T GOUGH M GROISMAN D HAMILL OP PW HILLMAN Dr D U HOWARD Dr J K HOWE Susan R. HOWE Dr W HUMPHRY Or N f JOHNSON Roy N KAIPERT Dr J H KALNAS Dr J LAGAST Or H LANHAM Or John LANOUZ1ERE Dr Ctaudine LAWRENCE-JONES Sir C LEE Dr F I LEESER Dr Jenny LELBACH Prof Dr UK LEVEOUE Or G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO MARTIRE Prof N LUSS R 0 LUSSATO Or Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Or R MOTT I Dr A A MUNDT Dr K A MUNOZ MOUTON Dr M MacSUEEN Prof RNM NAKAMURA Dr S NORTHROP Dr H L OSMAN Dr J OWEN Dr R PADDLE Or G M Solvay, Brussels, Belgiun Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA Occidental, Oallas, Tx, USA Montedipe, Venice, Italy The Vinyl Institute, Wayne, NJ, USA Centre for Risk Management, Washington Electrochemical Industries, Acre, Israel Hamill Associates Inc. Annapolis, Md, USA Oiamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, Neu Zealand CMA, Washington DC, USA I Cl Runcorn, UK ICI Australia, Melbourne, Australia GenCorp, Fairiawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Imperial Oil, Sarnia, Ontario, Canada Solvay, Brussels, Belgiun Oow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK ICI Runcorn, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Hilan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Boue, France Institute di Oncologia, Bologna, Italy Envelope Returned No Address Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France ICI Duperial, Buenos Aires, Argentina University of Hassachussetts, Amberst, Ma. USA Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo, Japan ICI Americas, Wilmington, De, USA Health & Safety Executive, Bootle, UK Harpenten, Herts, Ok USA ICI Central Medical Group, Alderley Park, UK R&S 142957 PAQUET Dr Christiane PARIS Dr A PATERSON Dr J C PINAUO r PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAN Dr J RAMBAUD Or J RICHARD Dr A ROBSON Mrs 0 ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIRPER Dr H SCHUCKMANN Dr F SERONNE Dr D SCOURIS Dr G SIGRIST Dr J SIMONATO Dr L SMITH Prof Allan h SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr TACHEC1 Dr H TAMBURRO Prof CH TENKHOFF Or N TEPPER Dr L B TERUIESCH Dr B THERIAULT Or Gilles THIIS-EVENSEN Dr E TOHATIS Dr L TONER H P VAN DER HERUE Dr H J UALTEMATE H UEJ01ING S 0 UELLHAN Dr J WEN Dr C P UILLIAMS Dr OMJ WILSON Prof R YORK J ZOBER Dr M A Atochem, Serquigny, France Rhone * Poulenc, Roussillon, France ICl Runcorn, UK Petroquimica Colombians, Cartagena, Columbia Istituto Superiore di Sanita, Rome, Italy Uacker'Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada *- RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimica, Salvador, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Uinnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA EKO Chemicals, Thessaloniki, Greece Shell Chimie, Berre L'Etang, France University of Podua, Italy University of California, Berkeley, USA Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA Huls AG, Harl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Hontreal, Canada Norsk Hydro, Porsgrunn, Norway IARC, Lyon, France Society of the Plastics Industry, Washington DC, AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden Goodyear Tire & Rubber, Akron, Ohio, USA Chevron, Houston, Tx., USA BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgiun 8ASF, Ludwigshafen, Germany From: J. R. Orumwright, M, D., Vista Chemical Company 900 Threadneedle, Houston, Texas, USA R&S 142958 CONFIDENTIAL Register of Cases of Angiosarcoma of the Liver Due to Vinyl Chloride Review Date - February 1991 As you're aware, Dr. Brian Bennett left ICI on September 30, 1990. The responsibility for maintaining the ASL Register was passed on to me. All data has been reviewed, updated and prepared for the 1991 Register based on information supplied by Dr. Bennett. Your suggestions for change, additions/deletions for the future Registers will be appreciated. ctfully Submitted, - J) R. Drumwright, M7D. PREFACE: Acknowledgements, Significant Changes, Comments & Requests 1) The four new cases in the Register are: Australia 01; Germany 40; Italy 08 & 09. The Australian case is the first notified from that country. (Currently, two cases in the US are under review for confirmation of diagnosis.) 2) There have been no deletions for the 1991 Register. 4 3) Amendments from previous Register include new page for Australia; Table 2: Total Western Europe cases increased to 99 with world total to 161 cases of ASL; Table 4A, 4B, 4F, 5, 6, 7, 12: Recalculations due to new cases . 4) Based on current data, the following cases are still alive: France 15 & 28; US 33 & 36. If new information is available for these cases, please advise me. 5) Thanks are in order for new cases, information/clarification and reports to: Drs. Friedel; Johnson; Northrop; Lagast; Richard; with special thanks to B. Bennett. 6) Research: I respectfully request that each recipient of the Register continue to keep me informed of any new cases, etc. and/ or provide me with the name and address of the appropriate individual who can supply the necessary details. (A blank sheet is enclosed at the end of the Register to assist you in reporting the appropriate information.) Also, please continue to provide any relevant information about earlier cases, factory data, etc.) as well as individual retirements, changes of address, etc. for the Register mailing list. From: J. R. Drumwright, M.D., FACOM Manager Medical Vista Chemical Company P.O. Box 19029 Houston, Texas 77224 USA Telephone (713) 588-3044 Telex (713) 588-3107 R&S 142959 LIVER ANGIOSARCOMA CASES (REVIEW DATE - FEBRUARY 1991) INDEX Table Sequence Australia................................................................................................................................................... 1 Belgium.................................................................................................................................................... 2 Canada.................................................................................................................................................. 3-4 Czechoslovakia....................................................................................................................................... 5 France................................................................................................................................................. 6-11 Germany........................................................................................................................................... 12-19 Italy................................................................................................................................................ 20-21 Japan..................................................................................................................................................... 22 Norway...................................................................................................................................................23 Spain..................................................................................................................................................... 24 Sweden...................................................................................................................................................25 UK.................................................................................................................................................... 26-29 USA.................................................................................................................................................. 30-38 Yugoslavia............................................................................................................................................. 39 Incidence of Cases per annum (Table 1).......................................................................................... 40 Distribution of Cases by County (Table 2)...................................................................................... 41 Pattern of Cases by Factory (Table 3)............................................................................................. 42 Latency Periods (Table 4A)................................................................................................................ 43 Distribution of Latency Periods (Tables 4B-4H)........................................................................44-50 Annual Geographical Incidence (Table 5)....................................................................................... 51 ASL Case Numbers by year of Death (Table 6).............................................................................52 ASL Case Numbers by year of first exposure (Table 7).............................................................. 53 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8).........................54-55 USA PVC Producers - Start-up Dates vs ASL Cases(Table 9)..............................................56-57 Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10)........................................ 58 East European PVC Producter - Start-up Dates vs ASL Cases (Table 11)............................... 59 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12)...........................................60 South & Central American PVC Producers - Start-up Dates (Table 13)......................................... 61 Austra/Asian PVC Producers - Start-up Dates (Table 14).............................................................62 Middle Eastern PVC Producers - Start-up Dates (Table 15)......................................................... 63 Number of PVC Factories in the World (Table 16)........................................................................64 Blank form for notifying new cases..................................................................................................65 R&S 142960 AUSTRAL I A 1 county amd REFERENCE HO 2 MAKE Oft INITIALS 3 DATE Of BIftTH A COMPANY 1 IVI K Afvy (Ui*ircu(wi Coses Review dale fcbnury 1991) 5 fACTOftY 6 MRS! VC EXPOSURE 7 DATE OF DJADfONiS a AG* A1 OiAGki^lS 9 TEARS Of EXPOSURE TO DIAGNOSIS 10 TEARS Of EXPO SURE 11 DATE OF DEATH 12 Ml SlOt OGfCAl CQXfIkHAtlQH 13 ESTIKAUO EXPOSURE ItVEt H OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER CGHHLHIS 01 PM Feb 39 ICI Botany July 1965 April 55 25 10 April Yea Austral it NSU t990 1990 Lou PVC Uaretio use letter; Dr Nf Hungry, CMcl Shiftman Medical Officer, 1CI July6S to Australia, Ji.ro 1990 Mar.67 (20 onths) Hedu<a Autoclave Cleaner Mar.67 to Aug.75 (A years 3 months) 1963171- SSU 1 Bt Hi IUM J COUNIRY AND RE F RfMCE WO 01 NAHE OR INITIALS DATE OF BIRTH 12.01.13 Solvay 02 29 09 AO Solve/ FACTORY Jemcppe Jemeppe LlVLft Angiosarcoma Coses (Review Dote Fcbiumy 1991) FIRST VC EXPOSURE 00.07.58 7 OATE Of DIAGNOSIS 00.05.76 8 AGE AT DIAGNOSIS YEARS OF EXPOSURE 10 DIAGNOSIS I 63 i I I ,0 YEARS OF EXPOSURE 11 DATE OF death 17 39.06.76 t i i i 20 08 62 00.10.79 39 17 9 2) 10 S3 ! 12 histological CONFIRHA1ION Yes Yes r 14 " u 15 16 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER highlights OTHER COMMENTS High Autocleaner 14 yrs 1958'1968 exposed to Pol/worker 200 ppm 3 yrs for 8 hrs per day end certainly under 500 ppm {036 to 9m autoclaves 1968-1972 exposed to 50*200 ppm 6 hrs per day*in 25m autoclaves 1972-1974 exposed to 50-200 ppm In euto- cleve room 1974-100 ppm 1975* 50 ppm RETIRED 1 feb 1975 Driller In a foundry (2 yrs) farmer (15 yrs) Uark in glass Ind. & chemi* cal industry Hepatic tests in Oct 1974 were normal. Retired feb 1975 Hospitalised Hay 1976 Complete Clinical and career details are given (n a paper by Hubtet et al In Arch. Belg. Med. Soc., Hyg. Hed. Trav. Med. Leg. 1977 pages 601*622 08.62-03. 63 01.67 10.71 > 200 ppm Sh/day 04.63-12. 66 < 200 ppm Autocteaner fireman since 5 yra 5 mthj 10 71. Operator 3 yra 9mths. 1st sign July 79: thoracic pain 07, 79. Hepatic tests altered 10.79. Positive echography 11.79. Hepatectomy 02.00. Chemotherapy, Information given in letter 12 Nov 1984 from Dr De Sloover. 2962171- SSU 2 LIVER Angiosm ctwfvi Cases (Review Date February 1991) DAY - MONTH - YEAR All dates use UK system 1 COUNTRY AMD RE f E RE MCE MO CANADA 01 2 NAME QR INITIALS 3 DATE OF 81R1H 15.12.13 02 06.03.14 01 26.08.19 04 05.04.19 OS 07,05.11 04 15.12.19 02 09.11.19 08 13.05.20 09 19.07.21 45 CCKPAWY factory SHAU1* I GAN 6 FIRST VC EXPOSURE 7 DATE OF DIAGNOSIS 8 AGE AT DIAGNOSIS 9 10 YEARS OF exposure TO DIAGNOSIS YEARS OF EXPOSURE n PATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 14 ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHUGHIS 16 Ot HER COHMEH15 19 44 1943 1941 1955 1957 1962 41 43 42 11,, M 02.09.55 Yes 14 14 21.12.57 Yes 21 20 23.03.62 Yes Reactor cleaner Operator Smoker polymerisation Maintenance, Operator mi 1twrlght, pipefitter Worked overtime Smoker Operator, foreman Uorked overtime Non-smoker 1945 1967 48 22 22 21.01.68 Yes 1944 1968 57 24 05 05.07.68 Yes Reactor cleaner Reactor cleaner Operator, foreman, water cooling unit Worked overtime Smoker Uater cooling u>( t Worked overtime Smoker 1947 1971 51 24 23 10.04.71 Yes Reactor cleaner Maintenance, millwright Worked overtime Smoker * 1946 1972 53 26 25 24,12,72 Yes 1961 1973 53 12 05 12.06.23 Yes 1946 1974 53 28 26 04.09.74 Yes Reactor cleaner Machine shop operator and poly unit Worked overtime Smoker Reactor cleaner Maintenance machine shop in ptant 25 yrsi Smoker Furnace op. pipefitter maintenance Worked overtime Smoker * Paper by Dr f DELORME n Annales d'Anatomie pathologique Parts, 1978 Vol 21 mo 2 pp105-1H claims this case had both a hepatoma and ASL simultaneously. C962H SSH 3 1 CANADA Shed 2 1 j2 jJ COUMlftY AND RLTEREMCE NO CANADA to NAME OR DATE Of IMIIAIS | SIRIH -- 1------------ 16.05.15 - lG 13.10.25 12 ec U.09.20 u ss 10.06.26 4 COMPANY Cut f Gulf BfG 5 FACTORY LIVER A09ios.11 toma Cases (Review Date february 1991Y OAT MOUTH - YEAR Alt doles use UK system _ - r 1 6 r- 9~ -1 10 11 t2 13 FIRST VC exposure DATE Of DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Of EXPOSURE date of DEATH HISTOLOGICAL confirmation ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Shawl n 1 gar1 195 J 1976 61 23 14 00.04.77 Yes _ Reactor cleaner Furnace op. maintenance, packaging Ex-smoker Shewintgar1 1943 Nov 65 60 42 5 05.04.66 Yes High 1943-47 Operator 4 Supervltor VC Plant Retired 1972 (Age 47) tetters from Or fernand Delorme, Pathologist 1 H Bibeau, 6FG Shawiniga 1 1945 Mar 62 61 17 27 31.01.82 Yes High 1945-55 Retired 1972 Letters from Autoclave (Age 52) Dr Fernand Operator, Delorme, pvc Realm Pathologist 1 H Blbeau, BFG Low 1955-65 VC Manufacture Medina 1965-72 Autoclave Operator, PVC Retina Niagara 1957 1967 60 30 23 26.1.87 Yes 1957-70 Poly cleaner Retired 1980 Information Uelland High 4 Operator (Age 54) Iron Or H W Olett, 1970-80 Supervisor BfG, 1988 Low _- ___ .. . t _____ . . fe962H S'Jd 4 CZECHOSLOVAKIA - -- -r country and REFERENCE NO NAME OR INITIALS V"i * 0AIE Of 8 IRTH COMPANY '"V' factory LIVER Angiosarconw Cases (Review Dale February 1991) 6 FIRST VC EXPOSURE 7 DATE Of DIAGNOSIS 8 ACE Af DIAGNOSIS 9 YEARS Of exposure to DIAGNOSIS 10 TEARS Of EXPOSURE 11 DATE Of DEATH 12 HlSTOtOGICAE CONFIRMATION 13 14 ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHIS 16 OTHER COMMENTS CZECHOSLOVAMA 01 28.06.28 State Co Movaky 01.07.57 24.I2.H 45 16 16 24.12.73 Yes Autoclave Cleaner (ARC tetter of 1*4*82 giving detail* from Prof A David of Centre Ind Hygiene and Occ diseases. 0? 06.07,27 State Cd Novaky oi.n.so 27.11.64 57 u 15 26.11.64 Ye$ Autoclave Cleaner 1 ARC letter of 1-4-82 gave somewhat altered dates tor this case, 1 have accepted the changes since the dates come from Prof A David of the Centre of Industrial Hygiene and Occupational Diseases. My dales come originally from KIOSH. S962frL SSH 5 FRANCE Sheet l 1 23 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 01 H 15.04.24 02 SIH 03.06.11 03 NAV 06.01.20 04 MOR 27.01.27 05 B 29.01.38 LIVER Angiosarcoma Cases * (Review Date February 1991) 4 '5 COMPANY fAC10RY RP Rouss* H ton 6 FIRST VC exposure 00.01.46 7 DATE OF DIAGNOSIS 18.02.67 a AGE AT DIAGNOSIS 43 9 TEARS OF EXPOSURE tO DIAGNOSIS 21 TO 11 TEARS OF EXPOSURE DATE OF DEATH 19 19.02.67 12 HISTOLOGICAL confirmation Yes PCUX Brignoud 06.07.59 15.01.75 63 16 12 24.01.75 Yes (M10SH no comment) RP Si Fons 00.00.46 15.01.75 55 29 29 29.06.75 Tes pcuic Brignoud 19.10.49 16.01.76 49 26 26 04.01.76 Tes PCUK Brignoud 18.01.65 13.05.76 38 11 11 13.05.76 Tes 13 14 estimated EXPOSURE LEVEL OCCUPATION High Autoclave worker and cleaner 19 yra 15 16 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Ref. Ravler et al Arch. Mai. Prof. 1 30 n' 3 Hov 75 p 171-177 High 2 yrt on monomer TO yri on polymer* isatlon Its!ian origin Ref. G Bonnet on et al "Nouvelle presse medicate" 5 Nov 1977 p 735 High Polyworker: TO yrt at autoclave cleaner. Compounding 3 yr* VCM production Ref. Rety et 16 yrs. at Arch. Mot. Italian POW. Prof, 1 37 n1 Shepherd, 6 June 77 Sawyer, Mason p 551-555 High High Monomer production worker 8 yrs. PVC f 11 tratIon 18 yrt Polyworker 11 yrt 1JThoracotomy Ref* P Coudere 9th Feb 1976 et al "Semaine costal des hospitftuK angiosarcoma TO Septemtore 2)Scintigraphy 1976 foend ASL Previously had 3(Haemorrhage bone from ASl angiosarcoma" 4 might Also Hepatectooiy Pilfchowski el al "La Nouvelle Presse Medicate 7th July 1979 Page 2405. 9962171 SSU Sheet 2 1 a3 COUNtfiY AND REFERENCE HO NAME OR INITIALS DATE OF BIRIN 06 p 14.04.34 07 G1R 2b.0k.Z7 OS 0 01.04*34 - 09 Ft F X 08.10,14 4 COMPANY PCUK RP Solvay ftp LIVER Ang t osar coma Cases (Review Dote February 1991) 56 - FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS Brignoud 01.03.5fl 12.08.76 St kutoan 1avau* 01.07.50 23.05.57 After death NIOSH says 00.07.76 03.12.75 St Fons 10.01.48 26.04.76 - 9a AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS kZ ia 49 26 42 19 61 2a 10 YEARS OF EXPOSURE ii DATE Of DEATH 12 HISTOLOGICAL CONFIRMATION 13 11,09.76 (NIOSH says 12.09.76) res 22 02.07.76 Yes (NIOSH no comment) 19 30.01.77 Yes 28 25.12.77 Yes ii n 15 16 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER C0MHEHIS Hoderete (1958-1960) 2 yrs (II tret Ion 10-11 yrs polyworker end uorks lab? This man had AOL prior to AS. Arm. de Hal. Prof. July *77 p 645 A 6. AOL was found In 1971 five yrs before ASL High Plant fore man In polymer isation 1972-6 edaln section In St kuban Died of septicaemia Small liver lesion found after autopsy Moderate 6 yrs packer i autoclave cl nr 14 yra autoclave worker Had been tunnel worker previously Very High 1948-1966 Lesser Exposure 1964-1976 Polymer to yrs In isation operator, sulphuric add factory, autocleaner, storekeeper 1 autoclave general maintenance services Operated 4.76 for removal of tunour from, Uver and died after second surgical operation for bit !o bronchial fistula Paper by Dr Rety et al in Archives de Naiades Professionals vol 40 Ho 6 1979 pages 741-3* z96zn ssu 7. " i "' "V " "4 COUNTRY ANO RCFERCHCE NO ,0 NAME DR IMHULS DATE OF BIRTH -- VP 2*.05.10 COMPANY RP 5 FACTORY St Fons 11 1 15.02.12 RP St Fons 1? 16.08.14 PCUK Brignoud 13 19.01.J1 Solvay 1avaux 14 MJ 05-04-24 Chtoe CHmie (Formerly RP) St Fon$ llVER Angiosarccxiui Cases (Review Date February 1991) 6 78 9 10 11 FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE A) DIAGNOSIS YEARS Of EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE DATE Of DEAlH 00.12.56 10.01,78 58 21 21 10.01.78 00,01,41 12.08.78 66 37 31 13.11.78 09.02,49 00.05.79 65 30 27 23.06.79 23.09.63 26.06.79 40 16 13 22.08.79 1943 00.07.81 I 1 1 1 l 1 57 30 36 29.07.81 12 HISTOLOGICAL CONFIRMATION Yes Yes Yes Yes Yes i j L' 13 16 ESTIMATED EXPOSURE LEVEL OCCUPATION 01 HER CAREER HIGHLIGNIS OTHER CGMHENtS High Autoclave cleaner 10 yrs in mechanical engineering Industry 1946-1956 Died of pulmonary ttrfcol 1 sm 5 days after surgery High 1941-1946 polymer isation general purpose worker. 1946*1972 VCH synthesis (HC1 t Acetylene) Foreman (agent de maltrlae) 1972 ret 1 red High Monomer production and polymer* Isatlon operator Autocleaner 2 yra, Auto operator 9 yr, Copolymer* 4 yra 2 yrs as cycle Cigarette mechanic. smoker unti1 10 yrs as 1974. Ill all enamel(er in of 1977 due to sanitary wart Oesophageal manufacture varices. Surgical InterventIon 25.05.79 (right hepatectonry) Very High 1943-1975 1975- 1979 1943-1975 A11 types of maintenance and jobs on work Intcrmftt* manufacture ently & maintenanc 1975-1979 in VCM Poly Process 8963H S'Jd 8 FRANCE Sheet 4 1 COUNTRY AND REFERENCE NO 2 NAME OR INITIALS 3 DATE Of a tRiH 6 COMPANY 5 FACTORY 15 DEP 03.01.37 Chtoe Chfmie (formerly RP) St fons 16 GIM 13.07.22 Chloe Ch1mie (Formerly RP) St fons 17 HAD 22.02.23 Chloe Chimie (Formerly RP) St fons LIVER Angiosarcoma Cases * (Review Date febfuary 1991) 6 fIRST VC EXPOSURE 7 DATE OF DIAGNOSIS 07,07.55 28.09.82 a 9 10 11 AGE AT DIAGNOSIS YEARS Of YEARS OF EXPOSURE TO EXPOSURE DIAGNOSIS DATE Of DEA1H 65 27 27 Alive 17.10,61 05.01.83 61 ;i i 3a 03.06.81 17.06.68 03.06.81 60 36 28 01.06.83 12 13 TA 15 16 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER career HIGHLIGHTS OTHER COMMENTS Yes High-20 yr Autoclave Moderate cleaner 7 yrs 1955-1962 autoclave operator 1962-19B2 Left Hepatectomy 1983, J C Contassot Letters of 5 10 63 and 29 7 Me Yes Higb-33 yrs Polymerisat Moderate* ion Process low - 5 yrs Man Maintenance Marker Retired Jan 1979. J C Contassot Letters of 5 10 1983 and 25 7 64. Health t Safety Agent Yes High * Autoc t eve Other aectora Retired 23 yrs Cleaner of St Fons 01.01.79 1968-1971 Factory 1971- J C Contassot 1978 Letter of 5 10 1983 ta R 16.07.62 Solvay 1aveux 09.09,63 21.03.B6 62 21 21 27.12.86 21.03.86 High-12 yrs Autoclave Low * 9 yrs Cleaner _____ 09.03.64 Right Hepatectomy 05.05.6424.09.64 chemotherapy for lurvg- metastasis : partial remission. 06.64 - liver recurrence. 10.84 * lung: evolution of the disease 696m S9U 9 frawCE Shrct 5 _ -i- * LIVER Arig ioiiif coma Cases - (Review Date February 1991) 56 7 8 9 10 n 12 13 14 15 16 COUNTRY AND REFERENCE NO f RAMCE 19 20 21 22 25 HAH Oft INITIALS DATE OF BIRTH COMPANY MAZ IS..32 Atochem BS 02.03.23 Atochem Pa 01.10.AO RP AL 13.08.28 Atochcm DO 07,02.27 Atoch em FACTORY FIRS! VC EXPOSURE DATE Of DIAGNOSIS ACE At DIAGNOSIS 6rt gnoud 07.04.S9 26.10.86 52 Srignoud 1951 27.12.83 65 SEP Montlucon 1955 05,06.86 45 St Auban 01.09.58 05.11.87 59 St Fons 1944 1988 65 TEARS OF EXPOSURE 10 DIAGNOSIS TEARS Of EXPOSURE DATE Of DEAIH HISTOLOGICAL COMFIRMA 11OH ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Autoclave operator and 25 25 06.11.85 Yes High cleaner Myocardial infarction 1980.Coronary bypass 1981, Letter From Dr Contassot 5,4,86 Portal 34 22 26.12.85 Yes High Autoclave In other parts fibrosis from operator and of factory 26.04.74, The cleaner (Inca 1966 illness was diagnosed as presumably work related on 20.04,74. Letter from Dr Contassot 05.04.86 27 4 28,06,86 Yes High Autocleaner Maintenance Hepatic test 4 years worker May 84 normal. Hepatic test Hay 86 showed abnormal (ties. Letter from Dr Barret 18.07.86. 29 26 08.09.88 Tes Nigh 12 ycara 1958-70 Autoclavt worker. Low 1970-86 16 yeara In Control Room Letters from Dr Contassot. Atochem 2.12.87, 29 7 88, 24.01.89 44 28 21.09.89 Yes High Autoclave Cleaner' 1 all PVC production jobs Partial HepMectomy, Apr 88, Chemotherapy Information from Dr J C Contassot Atochem, 1988/89 016ZM S$U 10 franc Sheet 6 LtVIR Angioma! coma Cases - (Review Date February 1991) 12 COUNTRY AND reference NO NAH OR INITIALS DATE Of BIRTH oa.24 MA 12.26 25 BB 02,03,30 4 COMPANY Atothem Solvay 56 a7 9 10 It 12 13 U 15 16 FACTORY FIRST VC EXPOSURE YEARS OF DATE OF AGE AT EXPOSURE TEARS Of DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE Of DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHEJt CAREER HIGHLIGHTS OTHER COMMENTS Brignoud 1941 i9&a 62 Iavaux 1962 I9B5 58 45 35 01.12.65 Yes High PVC Product on - 2 years mcv Detectb n - 3 years PVC Product on maintenance 30 years 2126 07,05.66 Yes 11 years) Potyclearver High) * 5 years Polyfloor * 6 years 12 years Control Root i low 12 years Liver transplant Hay 1966. Information from Or J C Contassot, Atochem, 1966/69 Primary Liver Tunour Hetestases lung, brain, bone, spleen, kidney. Information from Dr K Legast, Solvay, November 1966 26 HG 29.11.40 Solvey Tavaux 16.04.61 25.io.aa 48 25 15 02.11,66 Yes High Autoclave 12 years Cleaner Low for 15 3 years years Died by haemorragic rupture of the tunour. No surgery, letter from Or H Legast, Solvay, 26.4.69. 27 RC 1929 Atochem St Tons 1954 1966 59 34 30 00.01.69 Yes 1954-74 Autoclave Nigh Cleaner and 1974-84 all PVC Low production jobs Notified by Or Contassot, Atochefii, Deeenber 1969 28 JG 1926 Atochem St Fons 1942 1909 63 47 20 Alive Yes 20 years 10 years High monomer analysis (labs) 10 years product ion PVC Notified by Dr Contassot, Atochem, Decefffcer 1969 _____ _____ LZ6ZPL SSU n GERMANY Sheet 1 1 rOUNfRt AMD REFERENCE NO GERMANY 01 23 NAMt OR INITIALS DATE OF BIRTH 00.00,30 A COMPANY A LIVER Angiosarcoma Cases (Review Date February 1991) 5 FACTORY 6 FIRST VC Exposure 7 DATE OF DIAGNOSIS B AGE AT DIAGNOSIS 9 10 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 11 1A ESTIMATED EXPOSURE level OCCUPATION A 01.10.54 19.09.68 3A 12^ 12 25.01.69 Yes (NlOSH) Polyworker 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 02 00.00.31 A A 14. 10.57 25.09.70 39 13 11 14.12.71 Yes (NlOSH) Polyworker 03 00.00.30 12 12 09.04.52 00.03.73 A3 21 16 10.10.73 Yes (NlOSH) Filling pesticide Reported under non polymer aerosol cans isation with VC workers in NlOSH list of 31,3.77. this of course is strictly correct. However 1 wonder whether this man had high exposure to VCH in Ms can filling operation? o; 00,00.30 a A 16.0A.57 26.11.7A 44 ir 17 25.11.74 res (Nlosio 200*500 ppm Polyvorlter 1 1950 was Clintcal but high teffponry autocleaner details in during 1 yr outocleamr for 1 yr paper by autocleaner Gokel et at Virchows Arch A Path 1976 372 P 195*203 ZLGZbl ssa 12 GERMANY Sheet 2 1 23 COUWtAY AND REFERENCE NO NAHE OR INITIALS DATE OF BIR1K GtRKAHT 05 00.00.34 (NIOSH gives as Cose 06) 06 (NIOSH gives os Case 05) 07 OO.OQ.32 00,DO.26 06 00.00.17 LIVER Angiosarcoma Cases - (Review Date February 1991) 4 company 11 7 " '6 rACtORY FIRST VC EXPOSURE DATE OF DIAGNOSIS 11 02,04.40 10,12.71 7 16.12.62 00.00.75 6 AGE AT DIAGNOSIS 38 43 9 10 YEARS OF EXPOSURE TO DIAGNOSIS YEARS Of EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 11 05 16.12.74 Yes (NIOSH) 13 12 09.01.75 Yes 13 ESTIMATED EXPOSURE IfVEl 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 80 Chemie says "chemistry laboratorian in the Techno logical Research Department** (NIOSH say* assistant Factory chemist which may be wrong translation) PVC - Manu facture Shift Leader 16 OTHER COMMENTS Coni 1rmed Reported tinder non*polymerIsatIon workers in NIOSH list or 31.3.77 and 1.78. 1 don't think this is a correct classification by NIOSH. The men may have been involved in VCH polymerisation in pilot plant or in main pt ant. 6 6 15.04.54 12.11.75 49 21 21 13.11.75 Yes (NIOSH says 12) 4 4 19.07.54 06.04.75 58 20 20 25.12.75 Yes PVC Manu facture and all work Incl autoclunlng 12 yr* (1954-66) Foreman Tech Day 6 yra (1967-1975) 7 Potyvorker 7 ez6zn s?ti 13. fjJ RHANT Shoot 3 COUNTRY AND REFERENCE NO GERMANY 09 NAME OR initials date of BIRIM 00.00.34 10 (N1 OSH gives as Case 11) .. 00.00.36 11 (HIOSM gives as Case 10) i? DG.00,29 00.00.38 ~4 COMPANY 2 2 8 4 "V . ^ - FACTORY FIRST VC EXPOSURE LIVtR Angiosorconwi Cases * (Review Date February 1991) "" DATE OF DIAGNOSIS 8 AGE At | YEARS OF QIAGNOS1S EXPOSURE TO DIAGNOSIS ' ,0 YEARS Of EXPOSURE DATE OF DEA1H 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 2 20.02,61 16.06.76 41 15^ 2 01.01.61 00.01.77 40 16 8 10.10.55 28.06.77 a 21 4 00.00.61 00.10.77 . 39 16 13 24.03.78 YCS High peaks 12 yrs poly* worker loci 17* auto clave cleaning Control room 1 yr 10 07.03.77 Yes High peaks 10 yra polyworker Incl 17* auto clave cleaning 22 28.06.77 Yes 6 07.10.77 Yes High ? 3 yra auto clave cleaner 19 yra Miter operetor PVC Hanu* faeture Autoclave worker For 6 yrt 10/76 Confirmed Average exposure First 9 yrs 150 ppm, occ 1000 ppm. Next 3 yrs av, 75 ppm. Last. yr av 35 ppm Average exposure first 9 yrs 150 ppm, occ 1000 ppm. Last yr av 75 ppm. CWH letter of 21.04.78 ... ____________ .................................. PZ6ZH s$y GERMANY Sheet 4 COUNTRY AND REFERENCE NO n -U- 1 . ---------- ^---------- name or INITIALS DA1C OF BIRTH COMPANY FACTORY 00.00.K 7 7 UVER Angiosarcoma Cases * (Review Date February 1991) i i o l ~T~ ~ s FIRST VC EXPOSURE DATE Of DIAGNOSIS AGE AT DIAGNOSIS 00.00.60 08.04,78 63 YEARS or EXPOSURE TO diagnosis 18 to 11 YEARS Of EXPOSURE DATE Of DEATH it 19.05.78 12 HISTOLOGICAL CONFIRMATION Yes 13 ESTIMATED EXPOSURE LEVEL K OCCUPATION <U) ( (NIOSH gives ` this a$ Case 13) Hot an Angiosarcoma In his tetter of 21 12 81t Mr friedel said this was a "Plattencpithelkar*inom Der Speiserohre" (a carcinoma ol the oesophagus) not attribut able to VCH 1 not recognised as on indust rial disease fl00.00.29 6 19. 10.53 09.10.78 49 25 25 23.10.78 Yes ? Autoclave cleaner and worker. Drier operator. Later shift leader 15 16 OTHER CAREER HIGHLIGHTS OTHER COMMENTS F U Best letter ol 30th June I960 enclosing data from Mr H P Friedel of BG Chemle F U Best letter of 30th June 1980 enclosing data from H P Friedel of BQ Chemle withdrawlng This case Angiosarcoma coni1rmed 09/79. Some detail of this C also cases 9, 13, 15, 16 1 17 given in NRu Report for 1978 SZ6ZH SSd 15. GERMANY Sheet S COUNTRY AND REFERENCE NO 16 NAME OR INITIALS DATE OF BIRTH 00.00.23 1? (NIOSH gives as Case 15) 00.00.37 18 00.00.13 00,00.25 COMPANY FACTORY LIVER Angiosarcoma Cases (Review Date: February 1991) FIRST VC EXPOSURE 7 DAJE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS of EXPOSURE DATE OF DEATH 12 histological CONFIRMATION u ESTIMATED EXPOSURE LEVEL K OCCUPATION 10.01.55 07.08.78 (Lelbach | suspected ASl at Feb 1975 1 aparotonry) j 23 07.08.78 Yes ASL end Hepatocellular Carcinoma High Autoclave worker till 1964. Leader end master 1 i i 01.11.61 14.08.78 16 28.08.78 Yes High Autoclave worker 00.00.55 25.12.79 24 21 25.t2.79 Yes Autoclave Worker 18.10.54 00.08.79 54 25 22.02.80 Yes Hctastasing ASL High Autoclave Worker 15 16 OTHER CAREER HIGHLIGHTS OTHER COHMEHIS Angiosarcoma confirmed, full details of illness since March 1973 given In NRW Med |nsp Rep for 197ft. Different details given fn "VC Associated Disease*' by lelbach end Herstetler (1981) p/1. No Angiosarcoma confirmed. Annuel report of the North Rhine Westphalfa Medical Inspectorate for 1978 pages 347-377 gives full details. Vinyl chloride disease diagnosed 02-02-71. Oesophageal varices. Radiologically confIrmed aero osteolysis. Dr 8esche letter of 13*04-82 to Or W G F Adams 9462H S9U 16. GERMANY Sheet 6 1 COUNTRY AND REFERENCE NO 20 21 l 22 23 24 25 (26) 27 l IVER Angi os,-|i coma Cases ( Review Date: February 1991) 2 5 1* ~ - -- - & 7 a 9 10 11 12 M u 15 16 NAME OR INITIALS DATE OF FIRST VC 8IRTH COMPANY FACTORY EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS 00.00.IS k k 14.02.61 00.04.BO 65 00,00,13 k 00.00.21 4 k 01.01.62 00.09.79 pr onounc ed ctInical liver symptoms) k IS.10.61 28.08.80 66 59 00.00.27 8 A 1955 26.03.29 52 00.00.28 A 8 1069 11.10.82 54 00.00.23 A a 1960 2B.09.B1 58 YEARS OF EXPOSURE TO DIAGNOSIS 19 16 19 24 13 21 YEARS OF EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESIIHATED EXPOSURE LEVEL OCCUPATION 13 19.10.80 Yes High Autoclave Haemangio Worker Endotheli<xna of liver t<i th Metastase OTHER CAREER HIGHLIGHTS OTHER COMMENTS Dr Besche letter of 13-04-62 to Dr W G f Adams 13 19.06.BO Yes High Autoclave Haemangioj Worker and Endothel ionva worked In of tiver with drying shop Metastascs Dr Besche letter of 13-04-62 to Or W G F Adams 11 06.12.81 Yes High Autoclave Chargehand, Dr Besche letter of Metastasir9 Worker subsequently 13-04-82 to ASL Foreman Or W G f Adams 21 29.09.81 Yes High Chemistry (300 ppm) Worker Primary hepatocellar carcinoma; proliferation of the sinusiodal ceils with sinusoidal ectasia, Friedel letter 23.12.66. 12 28.05.83 Yes High Autoclove (>300 ppm) Cleaner Prof Eder (Munich) letter 22.08.63, friedel letter 19,04,65. 13 14.01.83 Yes High Polyclave Worker and Autoclave Cleaner Prof Selmalr (Munich) letter 22.08.83. Friedel letter 19,04.65 Oeleted o i advice o Dr lenkhof Deceaber 19 9: Alcohol ic Cirrhosis not VCH as related. 00.00.28 k k 19SS 18.01.83 55 28 1A 02.03.84 Tes High Autoclave Cleaner tilt t 1972 Lelbach. friedel letter 19.04.65 ZZ6SU S9H 17 f.IRHANY Sheet__7 LIVER Angiosarcoma Cases (Review Dole fehiuaiy 1991) :. ......... 2 34 3 6 CCt}H IH r AND REfEtttHCE NO WAME 0# IKIUHS - DATE Of birth 21.11.23 COMPANY JAC10RY T7 flftSf VC EXPOSURE 01,10.60 29 30 31 32 00.00,22 00.00.u 00.00.23 2 4 fl 2 1962 4 19$ 1 8 .1953 00.00,30 8 8 1955 33 00,00.17 S s 1953 34 00.00.34 4 4 1956 IS 00.00,24 4 4 1968 7 DAIE Of DIAGNOSIS 11.08,85 15.02.83 07,01.00 30.06.85 00.04,85 19,03.83 13.05,85 18.2.73 8 ACC Af DIAGNOSIS 61 61 62 61 55 67 51 49 9 TEARS Of EXPOSURE 10 DIAGNOSIS 25 2) 29 32 30 30 29 5 10 11 YEARS Of EXPOSURE DATE Of DEAIM 25 25.08.85 19 15.02.84 25 25,05.83 20 31.01,36 21 15.02.86 21 25,03.85 16 12.09.85 4 16.10.84 12 U HISIO LOGICAL CONFIRM ATION estimated EXPOSURE LEVEL 14 OCCUPATION Yes High Process worker 1924-84 01.10.60 31.03.84 PVC production, agitator area Yes Nigh Chemistry worker Yes High Polyworker Shift leader Yes High Autoclave cleaner Yes High Polyworker Autoclave cleaner Yes High Autoclave Cleaner, Chemistry Worker Yes High Shift leader Yes High Autoclave Cleaner 15 OTHER CAREER HIGHLIGHTS t 16 OTHER COMMENTS Annual VCH screening 24.04.65: no complaint, no abnormality detected, 1970 two-thirds gastrectomy (or ulcers. 1971 Coronary thrombosis 1933 femoral implantation 1984 Pulmonary embolism end pleuropncLihonfa, Landers letters 13.09,85 and 04.02.37. Haemangiosarkoma. frledcl letter 23.12.86. Haemangiosarkoma. frtedel letter 23.12.86. Haemangiosarkoma. frledcl letter* 23.12.86, 15.11.39 A fendel 16.2.69. Hecmangiosarkoma. Also Developed Cholangiosarcoma friedel letters 23.12.86. 15.11.39 and fendel 16.2.69 tetter from Dr friedel 15.11.89 letter from Or friedel 15.11.89 1975 disease of lIver parenchyma; at last SOX. letter from Or friedel 15.11.39 82.6m S'Sd 18. C( HHftHI S^eet 8 LIVER Angiosarcoma Cast* (Review Date fehruary 199H \ 23 4 $ 6 7 8 9 to 11 12 13 14 15 16 oihniry ash RFIFRESL'E so NAME Ok IKlit US /M/A OF RIRtll (O.W/MAt 1H oo.oo.n 4 J7 I 00,00.25 00.00,22 4 4 1 39 40 00.00.42 4 00,00.40 4 FACIORY 4 4 4 4 4 Hksr ir KXt'OWRK 1953 1969 1954 im ion HUE of IHAliMMS 19 01.76 am: AT diaososis 57 YEXRS OF EYPtlSURE w DIAGNOSIS 23 YEARS OF i:\msukF 25 09 OS $5 16,05.ii 59 66 16 54 6 19 00 10 66 44 1$ i 20.08 17 47 19 4 /M/A' OF UFA! it 14 02,66 I1ISW IJHllCAt, CONFlRAl Aims Yt i 05.09 66 16.09.66 Yti Yes OJ. 11.16 Yei tiout Yet ES1IMA1E D EXPOSURE LEVEL 111,1, tilth tilth nith OCCUPA THIN Automate Worker Lab, Mu. Shift Uoder at the tutorInert Later tm at Use tumbler Autoelaee Qeaner Automate Qeamer OWER CAREER iiiaituo NTS OTHER COMMUNIS letter from /V, Friedrl 15.11.69 an* b\formaitoiv from Ur, Tcnlhaff Ike, 69 l4tter from Or. fVtfrfrl M.fU* letter from Or, FrUdel 15,11,69 Pemba from 74*64 60% taler on 100% Utter from Dr, FrUdet tS.U.Mand Information from Hr, TenXhofflNe 69 Pension from 72*67 later on ehotantbiartoma, histologically confirmed, taken from /V. Friede 15.11,69 and 27.3.90 6Z62H ssa 19 malt Sheet 1 LIVER Angiosarcoma Cases - (Review Date February 1991) ----COUNIRY AMD RU ERENCE NO 2 NAME OR INITIALS 5 DATE OF BfRIH 0, (On NlOSM suw>lmentary list) LG 15.06,34 4 COMPANY PAWSAC 5 FACTORY Mira Venice 67 FIRST VC EXPOSURE DATE OF DIAGNOSIS 00.00.65 19.04.71 8 AGE AT DIAGNOSIS 36 9 10 11 YEARS OF EXPOSURE TO DIAGNOSIS years of EXPOSURE DATE Of DEA1N 06 03 16.04.71 12 HISTOLOGICAL CONFIRMATION ?Ye$ 13 K estimated EXPOSURE LEVEL OCCUPAT TOM PVC Bag extruder 15 16 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Primary tunour may have been pericardium. Not homo geneous with other cases. * it 02 Sf 13.11.29 Montedison Porto 00.00.57 13.12.72 43 15 06 27.12.72 Yes Harghera Polyworker ft * VG 14.Q3.20 Solvay Ferrara 00.01,53 10.07.75 55 22 21 10.07.75 Yes High Autocleaner 1972-5 did fl yrs <195361) Autoclsv operator a variety of Jobs Including ft ft 12 yrs (1961 PVC packing. 72) 04 FB 20.07.37 AN 1C Ravenna 00.04.59 00.01.81 43 21 21 30.03.81 Yes 12 yrs - 1 yr - Never cleaned Very High Monomer operator autoclaves. See paper by * ft 5 yrs * CH1APPIMO et Non-smoker. Medium 20 yrs at Med lavoro Con$uned Autoclave Vol 6 (1962) little 4 yrs operator t pp 555*563 alcohol. No LOW other duties AOL. In tuspens- Ion polymer isation. OS G Danesin 19.03.37 PAMSAC Mira 00,00.67 07.03.83 Venice 46 16 Area Foreman In same Dept since 1975. 8 06.04.83 Tes Hediun*7 Bag extruder High 1967-1975 Coftiherclal Oept 1976- 1983 S Paglialunga telex of 2 Aug 1963 * See Haltoni Med di Lavoro 65 p445, 1974, further details in tetter from Dr Hontcsano of IARC on April 1st 1962. ** Also see Maltoni and Rondihella in Acta Oneologiea Vol 1 19flQ pages 35 49. 0862^1 S9U 20 I rxi r Sheet 2 1 3^ 24 COUNTRY AMD REFERENCE NO NAHE OR IHI11AIS DATE Of BIRTH COMPANY 56 LIVER Angiosarcoma Cases (Review pate February 1991) a7 9 10 11 12 15 14 15 FACTORY FIRST VC EXPOSURE YEARS OF DATE OF AGE at EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEAtH histological ESTIMATED confirmation EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 06 C2 21.06.36 Montedison Porto 01.10.60 06.12.85 49 25 25 13.02.86 Yes High PVC Harghera, 1960*71 manufacture Venice Medium 11 years a$ 1971*74 Autoclave Low cleaner 1975*85 1960*71. 14 years in Control Room 1971-85 Letters from Dr Chlozzini, Venice, 22.09.87 and 11.01,88 07 Af> 09.02.25 Hoplcfan Terni 1958 21.01.86 60 28 22 05.04.86 Yes 1958-74 Maintained High VC Maehiner (not opcrating or cleaning autoclaves) 1974*00 VC levels Medium reduced f rcw i 1973 / 74 Information from La medicina del lavotOt Italy, Vo| 79 No.1 Jan-Feb M, and Dr Benetta, EnlChem. 08 U.L . 03.06.36 E.v.c. Ravenna 02.10.61 10.02.89 53 28 2fi 21.09.89 Yes 1961-66 autoclave Italy 500 ppe cleaner for *02.10.`61 - 02.04.`63 1967-72 IB months* 500-200 ppn autoclave operator 1973 75 and reactor 200-50ppm area 1976-78 operator 50-5pprti 1979-89 <5ppm 09 o.o. 29.10.24 Cooperativa Ravenna 1972 09.06.89 65 -------- f7-- --rs-- it.08.89 res 1972-82 helper in Retired Candiano Italy 200<5ppm reactor are 31.03.`85 1982-85 <5 ppm bagger ._ -_ _ ______ . , - .. _ .. ._ . - .... L863P1- S?ti 21. JAPAN IIVER Angiosarcoma Cai.es (Review Date febmory 199)) 3 4 56 7 3 9 10 11 12 15 u 15 16 CUINtRY AND reference NO NAME Oft INITIALS DATE OF BIRTH COMPANY TACIORY fIRS! VC Exposure DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS Of EXPOSURE TO DIAGNOSIS years or EXPOSURE DA1E Of DEATH HISTOLOGICAL COHfIRMATION ESt(MATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 01 I tmoi 1 01.08.?? Mltsui Nagoya 00.04.53 24.10.75 Hori Toatsu 53 22 .3 24.10.75 Yes PVC Assoc 13 yrt auto* says not clave known. cleaner Japan 1964 Times assigned to indicated different on 25.10.75 work since exposures had III olten at health 3000 ppm 141 [- to 1974 Japan rimes 25.10.75 L Japanese PVC Assoc letters of 51.01.78 1 50.11.87 0, sc 05 YS 02.06.39 Kanegafuchi Osaka Chemical 00.11.50 10,08.74 37 01.09.30 Mitsui Toatsu Nagoya . . __ 00.07.65 26,06.85 54 _ 17 20 13 10.06.76 Yes Not known In polymer* isatlon work including autoclave cleaning 5 14.09.35 Yes High 5 years Autoclave cleaner Japanese PVC Assoc 1 at ion letters of 31.03.73 t 30.11.87 Letter from Dr Nakenura, Japanese PVC Association 30.11.37 Z86m S$d 22 NURUAT 1 " 3 cclmiry and reference NO name or INITIALS DATE OF BIRTH 4 COMPANY LIVER Angiosarcoma Cases (Review Date February 1991) r 03 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE OF DIAGNOSIS AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS l -" 10 I " t" YEARS OF ! DATE OF EXPOSURE DEATH 12 HISTOLOGICAL CONFIRMATION 13 14 ESTIMATED Exposure ICVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 1 1 01 AN 23.12.15 Norsk Hcroya 00.01.50 21.12,71 56 22 21 jo4.01.72 Yes High Foreman t Hydro Autoclave supervisor 1 I 1 1 1 1 1 - 1 | Conf 1 rmed by Or 1h1Is* Evensen of NH. At APME Htg of 9 June 1978 Mr P Rangnes Stated that AH had been a mefr*>er of a starfup team, VCK t PVC were made In same building. The VCK was made from acetylene ! i i i I i i i__________ 862H SSU 23. SPAIN - --- --- i COUNTRY AND REFERENCE NO NAME OR INITIALS 3 DATE OF BIRTH 4 COMPANY LIVER Angiosarcoma Cases * (Review Dote February 1991) 56 7 B 9 10 11 12 13 K FACTORY FIRST VC EXPOSURE date of DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO OIACHQSIS YEARS OF EXPOSURE date of DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OtHER COMMENTS 01 HCG 26.03.tO Kispovic orrelaveg 01,02.64 10.11.69 49 25 13 09.11,89 Yes High Autoclave from 1.1.76 Cause of death: 12 years Operator production of multiple 12 years. hydrogen cerebral peroxide haemorrhages. Median latex No metastasis. 1 year 1 year Letter from Dr Lagast, Solvay, 04.01.9C fr862P I- SSH 24 SwtOEM LIVER Angiosarcoma Cases (Review Date February 1991) . -.1.- j * i COUNTRY AND NAME OR REFERENCE INITIALS MO 1 01 [no 02 jec 1 1 1 1 I 1 1 1 1 1 1 01 JnE DATE OF BIRTH 21.06.27 27.11.11 10.06.10 04 At 1 1 1 1 1 1 1 1 1 I l ps ! i i i i 16.11.14 12.03.19 - ----46 7 COMPANY fAC TORY FIRST VC EXPOSURE DATE OF DIAGNOSIS Kemanord Xemanord Stmdsval l u.oa.si Sundsvalt 00.01*4$ 20.10.70 oo.oa.72* Ketnanord Xemonord Sundsval1 00.05.47 Sundsval1 00.00.46 18.03.76 12.05.77 Kemanord Sundsvall ll .05 .64 22.11.80 8 AGE A! DIAGNOSIS 41 6, 65 62 61 9 YEARS OF EXPOSURE 10 Diagnosis 19 27 - 29 31 16 10 YEARS OF EXPOSURE 11 DATE OF deaih 12 HISTOLOGICAL CONFIRMATION 18 20.10.70 27 16.08.72 Yes Yes 21 19.03.76 31 12.05.77 Yes Yes 16 22.11.80 Yes r ' ,5 r _ j4 -- 13 14 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS High Pol/worker VCH product ion High High Polyworker 1966-1958 polymer isation worker (12 yr*) t 19581977 foreman (19 yrs) High 6 Years low 10 Years 1964-1970 centrifuge operator 1970*1960 drier operator Mr Sjoelin's letter of 26 March 1976 confirms 8L was a monomer worker who was heavily exposed, probably even more so than a normal reactor cleaner In first 12 yrs of employment had been heavily exposed, tn 1974t liver abnormal Ity and necrosis diagnosed. Data confirmed in Dr 0 Byren letter 16.6.7? to CEFIC Letter of 2nd Nov 1961 from Dr David Byren In his Inter of 1st April 1982, Or Honies.inu of 1 ARC says Sweden's Hattonal Board of OS Health gives 20 02-70 as dote of diagnosis lor Cose 01 and 15-05-72 for Cose 02. Q86Ztr V 25 UK Shi-i*i 1 1 CUJMIRT AND rcterence MO NAME Oft INITIALS DAIE OF BIRTH COMPANY LIVER Angtosdjcoma Cases (Review Date Febfu.iry 1991) fACIOftY FIRST VC EXPOSURE DATE OF 0IAGMQS1S 6 ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 10 years of EXPOSURE DA1E OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OtHER CAREER HIGHLIGHTS 16 OTHER COMMENTS UK 01 20.04.01 ICI Hi1(house 04.04.44 03,12.72 71 26 22 03,12.72 < Fok l (Fox & CoU ier Cotlier paper says paper 23.12.72) says 23.12.72) 500 ppm 1944*7 VCM 1947-6 Drier 1948-61 Autoclave operator 1961-66 Drier Lee and Harry Lancet 29-06*74 pages 1316-6 (02) 03 04 02.06,37 Barry 00.02.66 00.12.74 37 23.06,20 ICI Hill house 26.04.34 00.06.79 59 09 3.5 24.12,74 25 16 12.10,79 Dubious fabric!ion case High Autoclave cleaner Exposure limited to 2.66 - 9.69 Medinahigh 1954-5 Staging Plant 1955-6 Drier Pltnt 1956-B Autocleve worker 1958-61 Chargehand Drier Pltnt 1961-72 7 or ernan C 2/3 Pltnt Pre-war fish packer 1939*45 army vehicle maintenance 1945-54 fish packer 9863U S'SH 26 UK Slu-Ct l t country and REFERENCE NO OS NAME Oft initials DATE OF birth 30.03.14 06 cep 1931 07 RGB 26,04.20 BP 08 VlM 08.05,24 IIVER Angiosarcoma Cases - (RcvU'u Date February 1991) FACTORY Barry Barry Barry Barry MftSI VC EXPOSURE 08.01.51 1962 1963 19.09.50 DATE Of DIAGNOSIS AGE A| DIAGNOSIS 00.10.79 09,01.80 4fl/9 oo.oo.ao j 60 27. 11,61 57 TEARS OF EXPOSURE TO diagnosis 28 17 31 10 YEARS OF EXPOSURE 11 date of DEATH 21 T9.U.79 12 09.01.80 8.2 ij.06.ao 24 25.12.81 12 13 U 15 16 NISFOTOG/CAt CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Yes 1951-52 Further Polycleaner 1952-55 informat ion 1969 from Latex Dr P M Smith 1955-60 and Or 0 M J Polyfloor 1960*64 williems Poly Chargehand 1964-70 Charging operator 1970-72 drier operator Yes 7 yrs Further Poly Moor informat ion Operator 1989 from 5 yrs Dr P M Smith Greaser on and Dr 0 M J Poly Floor William$ Yes Polycleaner further Inform* 1963-5 atton 1969 from Recovery Dr P M Smith t 1965-1971 Dr D N j UltlUfT Tes 1950-1958 1950-51 1935-I94A further 500 ppm Autoclave Motor Mechanic informat ion 1968-1974 200 ppm operator 1951-1957 Chargeman 1948-195Q Operator on Acetylene 1989 from Dr P M Smith and Dr 0 M J autoclave Product ion U1111 om$ bulIdlng Plant 1957-1974 Shift supervisor autoclave building' - Never cleaned autoclaves but supervisor's job entailed entering autoclaves to inspect them Z862U S9U 27. 1 CCxiNTRT AND R1Tf RE MCE NO 09 -~ NAME OR INITIALS 3 DATE Of fltRlH ...... E ICP 07,05.25 10 GJt 04.04,47 4 COMPANY BP BP ' FACTORY Barry Barry LIVER Angiosarcoma Cases (Review Date February 1991) i-- MRS! VC EXPOSURE 7 date of diagnosis 8 ACE A1 DIAGNOSIS 9 YEARS Of EXPOSURE 10 DIAGNOSIS 10 TEARS OF EXPOSURE 1t DATE OF DEAtH 15,02.50 02.0J.BJ 58 n 29 24.02.85 27,04.68 0) 05 54 37 18 4,2 16.05*54 12 u 14 15 16 HISIOLOGJCAL CONFIRMATION estimated EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OtHER COMMENTS Yes Medium Polyworker 2 years on Acrylonitrile Resin Plant. Also prior to 1950. 4 years RAF maintenance, 3 years motor car paintshop. 2 years In Graving Dock. Yes High * 11 Potyclcner Heavy foods Informat ion months (500 1966-67. vehicle driver given In ppm). Low* Spr.y-drier until final letter 18 months tagger 1967- Hines. 18,06.84 from (50 ppm). Median - 68. Slow-down Or 0 M J Wi11iams 21 months stripper (200 ppm) operator 1968-70. U CLP 08.05.28 BP Barry 19.12.65 02.06,85 57 19 16 02.06.85 res High Patycleener 1965 -69 1965-68. Med 69*79 Service Low 79*82 operator 68-69. Poly Operator 69*79. leading Hand 79-82. Letter of 04.06.85 Or Paul Smith and letter of 04.06.85 Or D M 0 Evans Oesophageal haemorrhage due to oesophageal varices due to Angiosarcoma of liver 12 Jt 25.01.J7 in Hi 11house 16.09.57 0S.06.B5 48 28 28 06.12.85 Yes Low 1957-59 Spare man, HlflTt 59-74 bagging low 74-85 floor 1957-59.1 Autoclave Operator 1959*85 Letter 26.06,65 Or f 1 Lee .... . 886ZPL S'SU ,,K iii_i i 1 vtR Angiosarcoma Cases - {Review Date: Tebfuary 1991) 2 3 1 4 ' 5 " '6 -i ~8 ` 9 10 11 12 ~13 14 15 16 COUNTRY AMD reference NO 13 NAME OR DA1 Of initials BIRTH COMPANY MJ 02.03.4fl BP FACTORY Barry FIRS1 vc EXPOSURE 1966 TEARS Of DATE Of AGE AT EXPOSURE TEARS Of DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE Of DEATH HISTO LOGICAL ESTIMATED CONFIRM* EXPOSURE AT ION LEVEL OCCUPATION Jan 86 37 16 3 02.06.86 Yes High Polycleaner 1968-69 Low Central Depot 1969-70 High PolyUoor 1970*1971 OTHER career HIGHLIGHTS OTHER COMMENTS Moved to Remained well, working Acrylonitrile actively! until Jan 1986 Plant until left BP 1963. Manager of 1C l SS ltd at Cardiff Airport 1963-66 H GS 15,06.4 BP Barry 07.07.66 27.08.67 45 21 11 01.12.66 Yes 10 months Polycleaner High 1966-67 10 years PolyUoor constant worker at times Hediun between but on 1968-1982 inter mittent jobs Letters from Dr OMD Evans, Pathologist, Penarth, Walts and Dr DMJ Williams, BP, Barry IS BCP 23.06.2 BP Barry 1956 1988 66 32 16 01.05.86 Yes 9 years Poly cleaner l ) Information from High 5 years Hediun 2 years Operator ) Blow 1 flecovery)E*Psure Operator jP^rtod. Ut111ty jintermittent Dr D M J Williams, BP, end Dr Paul Smith, Pathologist 1988. Low Operator ) 16 RT 25.05.2 1CI Hi Uhouse 1963 1988 66 25 12 12.11.66 Yes 1 year ) Packer Low ) 9 years) High ) 2 years) Low ) Autoclave Operator 17 RH 14.01.31 ICI Hi (thouse 08.04.63 1989 58 26 25 17.09,89 Yes 1963-63 Packer Low 2 months 1963* 74 High ) ) Autoclave (11 years ) Operator 1974-88 ) 25 years low ) (14 yoaJ s ) Hepatic fibrosis 1974 Oesophageal varices Porta-caval shunt 1975 Information from Or B Bennett, ICI, and Dr f 1 Lee, Blackpool Victoria Hospital 1988. Information from Or 8 Bennett ICI, and Dr f 1 Lee, Blackpool Victoria Hospital, 1989, 686m S'Sd 29 USA Sheet i _ _u COUHtRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 4 COMPANY 5 FACTORY 6 F iRsr VC EXPOSURE LIVER Angiosarcoma Cases - (Review Date Fcbiuary 1991) _____ 78 10 11 DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS Of EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEA1K UK system of dates DAY - HONtH YEAR 12 ii i; HISTOLOGICAL CONFIRMATION ESI1MATED EXPOSURE LEVEE OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 other comments c, Earl 17.10.21 6FC Louis 09.12.48 03.03.n 49 2; 21 03.03.73 Yes Parts ville 0? 19.08.33 BFG Louis* 15.11.55 00.05.70 37 14 13 27.09.71 Yes vj I le (HIOSH says 28.09.71) 01 Edward 25.05.15 BFG Louis 28.11.45 19.12.71 58 28 28 19.12.73 Yes Dinwiddle ville ________ .. 04 1 15.01.2R BFG Louis 06.07.52 19.08.67 43 15 15 07.01.68 Yes -- 01 -.1| ville 25.01,12 BFG Louis 19.06.44 09.04.64 52 20 20 09.04.64 Yes -1 -______ ville 04 Ray 21.11.28 BFG Austin Louis ville 17.01.62 00.02.75 ;s 12 12 24.07.75 Yes Jones? 07 Charles 03.05.22 ucc S Charle 27.08.44 00.00.66 45 24 17 23.03.68 Yes T Smart ston os J 06.05.20 Goodyear Niagara 07.10.16 00.08.61 41 15 15 29.08.61 Yes 1 1 1i . Pot Cleantr (lock Jama 197;) P 53 History given Rol1 log Stone In Annals NY Art ACAD SCIENCES Ref l HY Acad Vol 329 (1979) of Sc Syirp page 190 In 1974 Paper by Also Block B R Cottine of Jama 1.7.74 OSHA P 53 Pot Cleaner (Cf Block) Ref 1 Also Block JAMA 1.7.74 P 5J Pot Cleaner (Cf Block) Louisville Courier Journal 02-09-80 Ref 1 Also Block Pot Cleaner (Cf Block) Ref 1 Also Block Pot Cleaner (Cf Block) Ref 1 Alto Block US Air Foret Pot Cltantr (CF Block) Ref 1 * Louisville limes 23.7.75 Retired April 1974 Also Block Ref 1 Ref 1 0662fr|. S^U 30 COUKlRT AND REFERENCE NO '' 3 NAME OR IM1UALS DATE OF BIRTH 09 Raymond 08.11.31 Gettle* fInger? 10 16.08.13 11 27.05.09 12 Francis A 17.11.18 Bachman 13 Richard 01.12.21 Edward Clendenm 4 COMPANY 56 FACTORY FIRST VC EXPOSURE 8FG Louis 26,05.45 ville Goodyear Niagara 12.06.51 Goodyear Niagara U. 10,46 firestone Pottstown 13.07.49 Pa UCC S Charle 11.12.42 ston UVIR Angiosarcoma Cases (Review Date: February 1991) -- 7 OAtE OF OlAGNOStS 01.03.74 8 AGE AT DIAGNOSIS 43 9 YEARS Of EXPOSURE TO DIAGNOSIS 29 10 11 YEARS OF EXPOSURE DATE Of DEATH 24 11.03.75 00.05.66 55 17 17 10.05,66 00.03.70 61 23 23 16.03.70 02.05.69 50 20 19 02.05.69 00.05.74 52 32 26 07.04.74 UK system of dotes OAT * MONTH YEAR 12 13 " 14 15 16 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Yes 2000 ppm Ref 1 has wrong figures re first exposure. Louisville 1 lines 29,tO.74, 12.3.75, 10.3.76 Yes Ref 1 Yes Ret 1 Yes High 10 yrs 10 yra a* Utility 1 fief 1 letter reactor op. Service op. of 26 April (not cleaner Bagger 1978 from * separate Dryer op. Russell A Park crew cleaned Stripping op. to J I Seawell autoclaves) 3 yrs prior of MCA service in tyre plant Yes 2000 pp Charleston Daily Hall 21,7.75 (14) (13) ... . _ _____ i i ii ii !. _ .. 1 _______ Never dlagj nosed as ang iosarcoma of liver. Inform at Ion given In letter 22 May 1984 from J A Satfl, Accountant; ASL - No evi dence of VCM exposure. L66m S'Sd 31 ' 2 , ----- --- country and REFERENCE NO NAME Oft INITIALS PATE OF BIRTH COMPANY .9 James 04,11,27 Bf G Howard 17 Peerenboom 06.05.31 BFG 16 Chariie 22.04.28 BfG Arthur .. 19 Virgil 00.00,15 ucc Christian 56 FACTORY FIRST VC EXPOSURE Louis* vi U e 08.05.50 Louis ville 23.06.55 Avon lake 15,09.54 S Charle* 00.00.43 ston IIVIR Angiosartcm.i C.v-cs ' '? a (Review Onto: fcbm.ny 1991) 9 10 UK System of dates DAT HOMIH - TEAR 1? 13 15 16 DA1E OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE or DEATH HISTOLOGICAL CONFIRMATION estimated EXPOSURE llVtt OCCUPATION Ol HER CAREER HIGHLIGHTS OIHER C0HMENIS 00.00.69 41 19 04 27,03.69 Yes 1951*4 VCM polymer isation From 1954 Table 4 In onuards In wagoner Army and other testimony to service. US Senate 46-50 Army Confirmed In M N Johnson Itr 07.06.76 Yes 11.10,74 43 19 19 16.10.80 on 11.10.74 but no post-mortem 16.10.60 Or M N Johnson letter of 24.2.81 con firmed death 6 years after diagnosis oo.oo.75 46 21 13 02.11.75 Yes 13 yr* Navy aulocleaner 6 yra on Estol lyre Store plasticiser i Carboset operatIon Confirmed in M N Johnson Itr 07.08.78 Also RollIng Stone mag. 15.01.76 19.06.75 60 32 32 06.04.76 Yes 2000 ppm Williamsport Sin Gazette 21 June 1975 Charleston ' Dally Mall 21.7.75 20 31.08.1? Goodyear N i agars 00,00.55 30.01.76 58 21 18 30.01.76 Yes NOISH tetter of 25.10.79 21 Chester 02.09.09 ucc S Charle 00,12.46 Early 7? 67 30 22 02.01.77 Yes Hinkle ston 28 yrs uith UCC at SC Retired News release 23.2.77 3663H S'SH 32 USA 5{ji`l 5 lIVtH Angiosauonui C.iM's (Rfvu>w (liilc: Icbruafy IVV1) UK syslom o| d.itcs DAT - HONIN' TEAM 1 ?3 C0UN1RY AND REFERENCE NO NAME OR INITIALS DATE Of BIRTH Zb John Berry 07,07.23 V JL 11.05.16 Forrest i& 11.04.17 29 12.10.07 30 WVN 22.07.22 ________1 4 COMPANY 56 FACTORY FIRST VC Exposure BFG Louis* 03.10.47 vi lie UCC S Charie* 01.07.41 st on UCC S Charle 00.08.44 ston UCC 5 Charle 00.05.42 ston Terwteeo Chemical s Hem mg ton 11.06.64 i i i i i i 7 DATE Of DIAGNOSIS 00.00.77 (up to 2 years after death) 30.11.78 03.11.78 00.03.00 30.12.00 S AGE At DIAGNOSIS 52 (death) 67 61 77 58 9 10 11 YEARS OF EXPOSURE tO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEAIK 20 (death) 10 U.02.75 37 20 75.It.78 (NIOSH says 27 and C Doily Hdit 25) 34 33 01. It.78 30 16 01.03.80 17 15 30,17.80 12 13 14 15 16 HISTOLOGICAL CONFIRMATION ESTIHAIED EXPOSURE l-EVEl OCCUPAtlON OtHER CAREER HIGHLIGHTS OTHER COMMENTS Yes Exposed in Various jobs some degree in PVC to 22 plants from chemicals cold -room to but mein paste exposure recovery to was to VCM, PVC charging probably operator to high paste charging. Ill August 1965. terminated employment Jan 1966 R Kaminski letter of 26/2/79 ami Prof, lairtxjrro tetter of 9/1/79 Tes High Operator to Exposure in R N Whetler 10.10.76 buik and Itr of 4 Jan dispersion PVC 1979 and manufacture Charleston Daily Hail 30.11.70 and R Kaminski 26/2/79 Yes R Kaminski !ett*r of 6/4/79 Yes R Kaminski Letters of 19th June I960 4 5th Nov I960 Yes 6 - Unknown Maintenance 9 * Minimal Mechanic 6 yrs Elsewhere 16 yrs Boiler house Curator 9 yrs P662U SSd 34.  'l 2 1 "V 5 6 llvER Anglosarcoma Case* * (Review Date: February 1991) 7 89 10 u 12 13 U UK system of dates * DAY - MONTH YEAR 15 16 COUNTRY AHO RElERtMCE NO NAME OR DATE OF initials BIRTH Hr Byrirt 29-01-16 COMPANY 0FG FIRST VC FACTORY exposure louisviII * 1955 DATE OF DIAGNOSIS ACE A1 DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS YEARS OF Exposure DATE OF DCAIH 03-11-82 68 10 06.08.83 HISTO LOGICAL COHf|RHATIOW ESTIMATED EXPOSURE OCCUPATION LEVEL Yes 1955*74 Poly High Operator + 1975*82 Autoclave LOW Cleaner 1955-65 OIHER CAREER HIGHLIGHTS OIHER COMMENTS 1965 left Dr M N Johnson letter of 3 Nov 1982, BFG to 2ft Feb 1983 and 9 August 1964. become a Clergyman. 35 09-03-12 UCC S Charle 23 07-44 IB-07-83 71 39 ston 16 U.O. 27-05-32 The Genera Ashtabula 11-06-56 21*08*83 Price 11 re and Rubber Co 50 27 37 J Payton 29,08.29 BFC Louis ville 1953 06.08.84 54 31 ---------- ----------- j----- --__ _ -- 38 JU8 28,08.22 Air Products Calvert City 00.02,63 19.01.86 6, 20 ._ . U 18-07-83 Yes High from 1966 to 1955. Hod from 1955-1958 27 Alive Yes Moderate 1956-56 labourer 1956-57 prod helper 1957-70 operator 1970-75 electrician 1975-83 operator 22 06.08.86 Yes Nigh Worked regularly in PVC area In the early days was a reactor cleaner 1953-75, 20 28.10.83 Yes High Normal 1965*1982 progression From helper to senior operator, cleaned reactors, stripping l recovery areas as well as charging operator. Dr Dacey letter of 5 September 1983. R U Laundfle letter of 12 Sept spotted at medical May 1983. Testing conraenced May 1983 Roy N. Johnson letters Feb t March t99Q 1983: Information given In letter 09.08.84 from Or M N Johnson Thronbo cytopenla and leukopenia since 1976. Gold treatment for arthritis 1976* Under Dr,1! care about 6 months before death, had passed standard physical examination 3 months earlier, j. Barr letters of 22.10.84 and 23.01.85. 9663171- S$H 36 USA Sheet 8 LIVER Angiosarcoma Cases * (Review Dale: February 1991) UK system of dates OAT - MONTH YEAR t 2 -5 * 5 6 7 a9 10 .. 12 13 14 15 16 COUWIRY AND REFERENCE NO NAME OR DATE OF INITIALS BIRTH --1 COHPANY FACTORY FIRST VC EXPOSURE DA1E OF AGE AT diagnosis DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE PATE or DEATH HISTO LOGICAL ESTIHAtED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS OTHER comments 39 J Memice 27.06.18 Pantasote Passaic 1960 Nerch 1954 65 40 P P 26.10.14 6FG GiImer LouisWile 22*05,42 1987 72 41 R Buckle' 2.02.15 Goodyear Niagara 1949 Falls 1987 72 . ..... Never in hospital for any chronic or 24 23 29*06.54 Yes Low 29.09.60 - Worked scute medical problems. Death certificate Hay 66 before states cause of death cardio-pulmonary Vinyl 1960 arrest secondary to angiosarcoma of Fabrication with US liver. Plant Air Letter of t5.G7.86 from John E Ertel High Hay 66 - Force. of Pantasote with letter of 24.02.56 Aug 70 united from Dr Auerbach. Pathologist. Utility Wool Resin Dyers Operator and (inc Jul 66 Okanite * Sep 67 Reactor Operator) Low Sep 70-82 Monomer Operator Low 1982*83 Mill Operator, Calendar Shop, until retIrement 45 51 01.01.87 Yes High Chemical 1942-1974 Worker 1942-45 | Low ! 1975-1976 Foreman t i 1945*76 Letter from Dr Dleti, BFG, 10.3.67 58 27 20,08.57 Yes High 1949-65 Retired Letters from Prof Tanixjrro Chemical Op r 1977 University of Louisville, 1987 Shift Sup/ Foreman, (Age 62) and Dr C A Johnson, Goodyear. 1988 PVC Resin Product ion Hediun 1965-77 NF Plant .... _(Left PVC area for 6 f lonths in V 65] _____ . . L. J Z662H S$H 37. COUNTRY AN[> REFERENCE NO 42 -- . NAME OR DATE OF INITIALS BIRTH COMPANY MeMul1en 02.O5.t1 01 in 5 (AC10RY Assonet 11VIR Angiosarcoma Coses (Review Date; February 1991) UK system of dates DAY * MONTH YEAR 6 7 a9 10 11 12 11 14 r" 15 " ,6 " MRSI VC EXPOSURE DATE OF diagnosis TEARS OF AGE AT EXPOSURE DIAGNOSIS 10 diagnosis YEARS Of EXPOSURE DA1E or DEATH HISIO- logical ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION level OTHER CAREER HIGHLIGHTS OTHER COMMENTS 00.04.66 00.04.82 41 14 6 09.07.B2 Yes High Labourer in Pot area; pot eleanou regularly Letter from Dr Peter Hamid 11.04.89 41 J R 06.09.21 CenCorp Asht abula 1t.Ot.55 26.11.8a 67 Succ i (formerly Ohio General Tire) 33 28 10.01.89 Yes Pvc Resin Retired Letter* from Roy N Johnson, GenCorp High Plant; 01.01.8t Maintenance 03.05.69 and 30.05.39 Cleaner 1.6 years Shift Medina Mechanic 2 years Plant Low Electrician 24.IQ years 8662n S?U 38 YUGOSLAVIA LIVER Angiosarcoma Cases (Review Date February 1991) 1 ?3 CCUMIRY AMO REFERENCE MO NAME OR INI 1IALS DATE OF BIRTH 4 COMPANY 56 7 89 10 11 12 13 14 15 YEARS OF FIRST VC DATE OF AGE AT EXPOSURE YEARS OF FACTORY EXPOSURE OIACMOSIS DIAGNOSIS TO EXPOSURE OTAGNQSIS DATE OF DEATH HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS 16 OTHER COHEHIS YUCOSt AVI A 01 05.04,14 Jugo Vinil Spl i t ' 00.00.53 OB,04.23 59 * 20 20 08.04.73 Yes SARIC et al paper Inv Health Perspective Vol 17. pp 189*192 1976 02 15.11.31 Jugo Spl 11 00.00.50 12.02.23 42 23 IB 12.02.23 Yes* VCH VinU Product ion In his letter of 3 Oct 1978, Or Spirtas of Hi OSH changed the status of Case 02 to VCH production employe*. Or Spirtas also notified a new Cast 03 also a VCH production worker. 03 21.12.31 Jugo Split 04.06.54 11,01.76 45 22 n 11.01.26 Yes* VCH vinil Product ion ia04 11.06.30 Jugo Spl 11 15.12.58 03.09.78 48 20 03.09,78 Yes VinU Rose Kaminski letter of 19 June 1980 and (ARC letter of 1 April 1962 6663H SSU ______ 39 Incidence of ASL Cases Per Amn - By Date of Death TABLE 1 1955 6 7 8 9 1960 1 2 1 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 ................................ ................................ ................................ ................................ ................................ ................................ ................................ 1 0 1 0 0 0 1 ....................................... ................................ ..................... ................................ ................................ 1 0 2 0 0 ................................ 1 ................................ 5 ................................ 3 ....................................... 2 ................................ 3 ................................ 5 ..................... 8 ................................ 5 ................................ 11 ................................ 11 ..................... 8 ................................ 10 ................................ 5 ................................ 10 ................................ 5 ................................ 3 ................................ 10 ..................... 8 ..................... 8 ................................ 11 ................................ 3 ................................ 7 ................................ 5 Total 153 (Review Date February 1991) MOTES 1 Does not include Italian 01, 2 The 1977 total now excludes US24, Choi angiosarcoma: deleted, 3 The 1982 total now excludes G26 Alcoholic Cirrhosis: deleted, 4 Does not Include the following who are still alive, so far as known: Fr15 and 28, US33 and 36. i ooom S9u 40 v TABLE 2 (Review Date - February 1991) Distribution of ASL Cases by_Country (These are listed in descending order of number of cases.) USA W Germany F ranee UK Canada Sweden l taly Yugoslavia Japan Ciechoslovakie Belgium Norway Spa i n Australia Total J9 *' 38 **' 28 ** 16 13 5 *** 8* ^ ft*** 3 2 2 1 1 1 161 ie Western Europe North Aaerico Rest of World Total 99 52 10 161 -- * emit ItOI - atypical case of PVC bag extruder. includes Fr15 and 28, US33 & 3&, who are still alive, so far as known. *** Includes one monomer worker. **** Includes two monomer workers. ***** Excludes G26 and US 24: deleted. lOOCVl 41. Pattern of ASL Cases by Factory (a) U Europe TABLE 3 (Review Date February 1991) OF the 99 cases in W Europe, 80 have occurred in clusters at 10 Factories. Of the 38 German cases, 34 have occurred in clusters at 4 factories. ASL Cases Dynamit (now Huls), Troisdorf, Germany BP, Barry, UK Atochem (formerly Chloe Chimie, formerly RP), St Fons, france Wacker, Burghausen, Germany Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden IC1, Hilihouse, UK Solvay, Tavaux, France CUK/Huls, Marl, Germany Lonia, Waldshut, Germany 19 11 11 io 8 5 5 5 J 3 80 WB: There are 32 pre 1962 PVC plants in V) Europe; 20 of these have had ASL cases (Ref Table 8) (b) H America Of the 52 cases in N America, 41 have occurred at four factories out of a total of 55 factories. In M America 41 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 9 5 41 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref (c) Rest of World Hinc of the cases are believed to be in one cluster of 4 and two clusters of 2 cases. Australia 1 9 1 10 zoom ssd 42. (Review Date February 1991) 1ACU 4A latency Periods (Years from first Exposure to Diagnosis) U Europe Country Belgium f ranee Germany 1 tal y Norway Spain Ho of Cases 2 28 38 8 1 1 total Years 35 795 783 172 22 25 Average 17.50 28.39 * 20.61 * 21.50 22.00 25.00 N America Sweden UK US 5 122 24.50 16 376 23.50 * 96 2267 23.61 W Europe Average 39 1002 25.69 * Canada 13 314 24.15 * 52 1316 25.30 N America Average Rest of World Australia 1 25 25.00 Czechoslovakia Japan 2 3 30 15.00 59 19.66 Stmaary Yugoslavia U Europe 96 v flO j 85 199 2267 21.20 20.00 Rest of World Average 23.61 N Amc ric a 52 1316 25.30 Rest of World 10 161 199 384 5 20.00 23.88 * World Average " Of the countries with > 10 cases, France, USA 1. Canada have an average latency period above world average; Germany below world average. eooeu s'su DISTRIBUTION OF LATENCY PERlOOS TABLE 4B (Review Date February 1991) 1- i Australia J Belgium j Canada J Czechoslovakia J f r anc e j Germany | Italy j Japan Norway Spam Sweden UK USA Yugoslavia 0-9 yrs 1 1 10-K yrs 3 1 1 5 1 3 IS -19 yrs 2 1 4. 12 2 1 2 5 7 20*24 yrs 5 3 10 2 2 1 1 9 4 25-29 yrs 1 2 10 6 3 1 2 6 a 30-34 yrs * 1 J 35* yrs j 1 Total Average Latency Period (Table 4A) 1 25.00 ' ! 17.50 2 I 24.15 2 15.00 4 6 28 28.39 4 38 20.61 8 21.50 3 19.66 1 22.00 1 25.00 1 5 24.50 3 16 23.50 6 6 39 25.69 4 21.20 TOTAL 2 K 36 37 39 19 14 161 23.88 VOOCfrl- S'SU AA. TABLE AC (Review date february 1991) LATENCY PER100 Of ASl CASES TABULATED BY YEAR Of fIRSI EXPOSURE MAX POSSIBLE LATENCY PERIOO 51 A9 A8 A7 A6 A2 A1 37 36 32 31 27 26 22 2) 17 16 year OF FI (EXPOSURE 1939 19A0 A1 A2 A3 AA A5 A6 A7 AB A9 1950 51 52 53 5A 55 56 57 58 59 1960 61 62 63 6A 65 66 67 68 69 1970 71 72 n 7A TOTAJ. LATENCY PERIOO (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 37,21,37,A1 32,38, AS, A7" 38,1A,32,A2,A5 28,11,2A,20,2A,3A,39, AA 27,22,28,29,37 21,29.31,26.28,15,23,30,35 29,2A,29,28 28,2A,3A 30,26,20,38 26,22,31,19,23,1A,33 19,28,17,28.3A,29 21*, 15 25,23,22,20,31,22,32,30,23 21,21,25,25,21,28**, 22,3A,3A 22,23,2A,H, 19,21,27 27**,2A,28,30,33 21,12,27**,32,29 19,17,15,13,16,28,30 298 = 37.25 8 886 = 28.58 31 559 = 25.A1 22 A2 | 1 7SJ -T o 16,18,15,17,20,29,28, 16,21,25,27 13,18,21,25,2A,25 15.16,16,16,19,19,12,28 13,18,17,12,18,21,26 16,17,20,21,25,25,26 16,17,25 11,19,20 9,18,21 16 18,5,18,1A,19 13,16 13 161 CASES 626 = 19.56 32 3A7 = 19.23 18 116 = 1A.50 8 38A6 = 23.89 161 VIOLA HALTONI GOODRICH * Aerosol con filler C 03. ** The following are still olive, so far as known Fr 15 and 28, US 33 and 36 45 SOOVV (Review date February 1991) TABIE 4t> IA1ENCY PER loos Of ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AMD GEOGRAPHICAL IOCA11 OH MAX POSSIBtE LATENCY PERI0O 51 ` " 49 48 47 4& 42 YEAR OF j FIRST EXPOSURE IATENCY PERIOOS IN WESTERN EUROPE NORTH AMERICA 1939 1940 1 2 3 5 6 7 { 37,41 47" 38,45 20,44 27 21,29,31,33 29 21,37 32,38,45 14,32,42 11,24,20,24,34,39 22,28,29,37 26,28,15,21,30,35 24,29,28 ROW 41 8 28,34 24 9 30,26 20,38 1950 26,22.31 19 1 19,28,34,29, 17,28 37 2 21* 15 23,14 36 3 25,22,32,30,23 23,31 22,20 4 21,21,25,25,34,34 21,28" 22 5 22,23,24,27**24,28 14,19,21,27 30 6 21,12,32,29 27** 32 7 19,17,15,13,2B 30 16 31 a 18,18,29,28 15 9 16,21,25,27, 1960 13,18,21,25,25 24 1 15,16,16,16,19,19,28 12 27 2 13,18,17,18,21,26 12 17,20 26 3 16,17,21,25,25,26 20 4 16,25 17 5 11,19 6 9,18,21 22 7 16 20,25 1 21 8 18,5,18,19 9 13,16 14 VIOLA 1970 1 2 17 MALTONI 3 j TOTAL CASES 99 52 10 * Aerosol can filler G 03. * Ihe following are still olive, so far as known Fr15 and 28, US33 and 36. 46. 900&U S9U PL AW r TROISFORF W GERMAN'f LOUISVILLE USA SHAWINIGAN CANADA BARRY UK SJ FONS FRANCE BURGHAUSEN W GERMANY START UP DATE 1954 19407 1943 09417) 1948 1939 1933 lAUlEJi (Review Date febiuaiy 1991) LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR HORE CASES) 12,13, I*. '6,1(5.19,19,21,23,25,28,29,29, 5,23,16,34,18 12,14,15,19,19,20,24,27,28,28,28,29,29, 31,45 11,12,14,21,22,23,24,24,26,28,42,37 NO OF CASES 18 15 12 AVERAGE LATENCY PERIOD 20.22 24.53 23.66 9,17,18,28,31,33,18,19,18,21,32 11 22.18 21,28,29,37,38,27,41,34,44,34,47 11 34.53 17,21,22.25,24,13,21,32,30,30 10 23.50 IQQZW sw hi. (Review (Kite February 1991) TABU AF FAICWCY PERIOO OF ASL CASES TA8UCATEP Br TEAR OF FIRSf EXPOSURE AMD SPECIFIC PIAM1 (10 OR MORE CASES) 8oou s'sa 48 (Review date February 1991 > TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES S CHARLESTON USE 1939? 24,30,32,32,34,35,37,38,39 9 brignoud FRANCE 1950 11,16,18,23,30,25,34,45 0 AVERAGE PERIOD 301 = 33.44 9 25.62 SUNDSVALL SWEDEN 1945 16,19,27,29,31 5 24.4 NIAGARA FALL S USA 1947 15,17,21,23,38 5 22.8 TAVAUX FRANCE H1UH0USE UK 1953 1940 19,16,21,26,25 (it FR26) 28,25,28,25,26 (ie UK17) 5 107 * 21.4 5 5 132 = 26.4 5 SPLIT YUGOSLAVIA 1950 20,20,22,23 4 21.25 600en S9U A 9. TABLE 4H (Review date February 199]) lAjfNCY PERIOO OF ASL CASES TAGULATEO BY TEAR Of FIRST EXPOSURE AND SPECIFIC PLAHT (4*9 CASES) ~ "- ; TEAR OF S CHARLESTON [first exposure USA j 1939 BRIGNOUO FRANCE 19A.0 1 2 3 A 5 6 7 37 32,38 32 24,34,39 30,35 45 SUNOSVALl SWEDEN NIAGARA FALLS USA T AVAUX FRANCE H1LLHOUSE SPLIT UK YUGOSLAVIA * 27* 31 15,23 29 28 8 9 1950 1 2 24,30 34 19 38 17 23* 3 4 5 6 7 8 9 1960 18 14,25 25 21 19 28 20 22* 20 2 26 3 14,21,25 25,26 4 16 $ 11 6 7 8 9 1970 2 `Monomer worker cuoeu sa 50 TABLE 5 (Review Date - February 1991) Annual Incidence of ASl Cases (Date of Death) by Geographical Area Ucstern Europe North America Rest of World Annual Total Cumulative Total key Events 1955 7 1961 2 A 7 8 9 1970 1 2 3 A 5 6 7 8 9 1980 1 2 3 k 5 6 7 8 9 1990 .. . r i i i i A 1 3 6 6 6 7 5 6 5 7 6 7 10 8 6 1 1 1 1 1 5 2 1 2 1 A 2 A 3 2 2 A 3 3 2 1 3 1 1 1 1 1 12 1 5 3 2 3 5 38 5 1 11 2 11 a 1 10 5 10 5 3 10 8 18 11 3 7 5 1 1 2 3 A 6 7 12 15 17 Viola 20 25 33 Hattoni 38 Goodrich A9 60 68 78 83 93 98 101 111 119 127 138 1A1 1AB 153 TOTAL 97* ** * Onits it 01 bag extruder 50** "_________ i 153 ** Docs not include the following who are still alive, so far as known: Fr15 and 28, US33 & 36 NOTE: G26 and US2A deleted. VlOCH 51 . TABLE 6 (Review Daie February 1991) ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING h.OH KEY EVENTS 1955 6 7 8 9 1960 2 3 4 5 6 7 8 9 WESTERN EUROPE FI Cl Viola 1970 SwI 1 G2 2 Nl.Sw2.UKl ,62 Maltool 3 G3* Goodrich 4 G4.G5.UK3 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 1990 F2J3.G6.G7.GS.U3 BI.F4.F5,F6,F7,Sw3 FS,F9.GI0,GlI,G12^w4 F10.FI1,G9,G13.G15 G16.G17 FI2JF13.UK4.UK5.GIS UK6.UK7.G 19.Sw5 .G20.G21 &4FI4,UK8,G22,G23 UK09,H5,F 17,B2,G24,G25.G30 UK10,F16.F18.G27.G29,G35 UKI 1,UK12,F19,F20,G2S,G33, G34 F21,UK13,h6,lt7,G31,G32. G36.G37.G38.G39 F25.F26.UK14.UK15.UK16.G40 F22J23.F24,FZ7,Spl,UK17, L8Jr9 TOTAL 97** Aerosol can Eller (G3) ** Docb not Include the folk)wing who are still alive, so Car aa known: F15 and 2B, US33 and 36 NOTE: G26 mod US24 deleted NORTH AMERICA Cl - C2 USS C3 USS C4,C5,US4,US7,US10 US 12. US 16 US 11 C6.US2 C7 C8.USI.US3.US23 C9.USI3 US6.US9.US18.US26 US19.US20.US22, C10.US21 US27.US28 US17.US29.US30.US32 US3I.US42.C12 US35.US34.US3S US37.US39 Cll US40.US41.C13 US43 50** 52 REST OF WORLD Ce2 Yl.Y2.Czl ipi l*p2,Y3 Y4 Jap3 AiuOl 10 5 to P* wo to TABLE 7 (Review date February 1991) ASL CASE NUMBERS BY TEAR OF FIRST EXPOSURE ANu GEOGRAPHICAL LOCATIOH (EXCLUOING It.01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola 1939 40 1 2 3 * 5 6 7 a 9 50 1 2 3 4 5 6 7 6 9 60 1 2 3 4 5 6 7 a 9 Erl 1,Fr16 Fr28** FrK,Fr24 UK1,frZ3 Sw2 Frl,Fr3,Sw4 Su3 Fr9, Fr17 Fr12,Fr4 Fr7,Nl,UK8,UK9 Sw1,UK5,Fr20,G30 G3 G15,113,G31,G33,G36 G7,G8,G19,G38,Fr27,UK4 C11,G16,G18, Fr15** G23,G28,G32 FR10,G1,G34.UK15 Fr8,G4,lt2,G2,UK12 Fr6,B1,Fr22,lt7 Fr2,lt4,Fr19,Fr21 G5,G13,C25,G28,lt6 G9,G10,G12,G17,G20,G22 It.08, G6,UK6,G21,B2,G29,Fr25 Fr13, UK7,Fr1B,UK16, UK 17,Fr26 Sw5,Sp1 Fr5,UK11 UK3, UK 10,UK 14 ItS UK13,G35,G39 G24.G37 C3.US27 US13, US29.US40 C2,US19,C11 ci.cs.uss^.usza.usss C4,US3,US9,C12 C7,C9,US8,l(S11,US21,US31 C6,US22,US26 US1 US12,USA 1 US16 US10, US32 T2, Cz2 USA CIO, US37 Japl.YI US1B.US33** T3 US2,US17,US20,US34,US43 US3&** C13 US23 Cll Jap2,Y4 US39 C8 US6 US38 US30 Jap3 Aus 01 US42 70 1 2 It 09 Haltoni 3 Total 99 * 52 ---- 10 Aerosol can filler (G3) Tr15, Fr2B, US3I t 36 are still alive, so far as known 53 ei-oen s?u START-UP YEAR 1931 1933 1936 1939 1940 1945 1946 1946 1949 1950 1951 1952 1953 1954 COUNTRY NAME West Germany West Germany Italy France United Kingdom United Kingdom Sweden France United Kigndom Uest Geraany Betgiin France France Holland Norway Switzerland 1 taly Italy Austria France Italy Spain United Kingdom West Germany Uest Germany 1955 Spain t HOgfrl gjjy TABLE B UESTERN EUROPE PVC PRODUCERS - START-UP DATES VS ASl CASES (OH1TTIHG G0"3I, I--t---0--81. It 09) COMPANY NAME LOCATION ASL CASE NUMBER BASF Ludzigshafen Uacker Burghausen 04.07,11.15.23.24 25,31.32.33 Montecatini Acna Rhone-Poulenc/ Qitoe/Atochem St Fons 03,09,10.11.14 15,16,17.23,27,28 ICI/EVC ICI/EVC Kemanord/Nobel Runcorn (closed 1948) Hillhouse Smdsvall (Stockyik) 01.04,12,16.17 01,02,03.04,05 Rhone-Poulenc Roussillon (Closed 1-1-B7) 01 BP Chem/ICI/EVC CWH/Muis Barry Marl 03.05.06,07,08,09 10,11,13,14,15 09,10,29 Solvay Jemcppe 01,02 PCUK/Atochem Rhone-Poulenc/ Chlow/Atochem Shell Norsk Brignoud St Aii>an Pernis, Rotterdam Heroya, Porsqrum 02,04,05,06,12,19 20,24 07.22 01 Lonza/ICI/EVC Sins Montedison/ Moplefan Montedison/EVC Temi 07 Halvic/Solvay Solvay Solvay Rio Rodano BXL/BIP7N0RSK Hoechst Porto Kart^iera Hallein Tavaux Ferrara Hernani Aycliffe Gendorf 02,06 08,13.18,25,26 03 18 Dynamit/Huis (since 1.1.89) Troisdorf 01,02,08,12,16,17 19,20.21,22,27,30 34.35,36.37,38,39 Monsanto Iberia Horizon Torrclavegp 54 Review Date February 1991 . YEAR OF 1ST EXPOSURE 57,54,55.53,55,69,60,53 55.53 46,48,56,41,43, 55.41,48,44,54,42 44,54,57,63,63 51,45,47,46,64 46 66,51,62,63,50,50 66,65,68,66,56 61,61,62 58,62 59,49,65,58,49,59, 51,43 50,58 50 58 57,60 57.63,63.62,63 53 55 56,57,54,61,55,61, 54,61.62,61,55,51 56.68,53,69,54,68 START-UP TEAR COUNTRY NAME TABLE 8 WESTERN EUROPE PVC PRODUCERS - START-UP DATES VS ASL CASES (CHITTING G03. It 08. It 09) COMPANY NAME LOCATION ASL CASE NUMBER 1956 1958 1960 1961 1965 1966 1967 1968 1969 1970 1971 1972 1976 1977 1982 Spain West Germany 1 taly West Germany Portugal France Italy I taly West Germany West Germany France Spain Greece Belgiim united kingdom Italy Italy United kingdom Spain Sweden United kingdom Finland Holland France Spain Uc$t Germany Caigso Hispavic/Solvay Solvay ANIC/SC Ravenna EVC Lonza/ICI/EVC Cires Rhone-Poulenc Pozzi Pensac Slacker Hoechst Atochen Rio Rodano Esso Pappas Badiphil Vinatex/Norsk Rtmanica/EVC SIR ICt/EVC Hispavic/Solvay kemanord/Norsk BP Cheat Pekcma DSM Soc Art D'vinyl (CDF) Monsanto Iberia 1CI/EVC * Laboratory Worker in Research Department Rheinberg Ravenna Ualdshut - Oporto Montlucon Ferrandina Mira,Venice Cologne knapsack(Frankfurt) Balan Miranda de Ebro Diavata Salonika Antwerp Staveley Cagliari Sardina Porto Torres Sar Rirtcorn Martorell Stenungscnd Baglan Bay Svartback Beek Lixburg Mazirtgarbe Tarragona Vos Lapp Ui IheliRshaven 01 04 06,13,28 21 05 05* Review Date February 1991 YEAR OF 1ST EXPOSURE 64 59 62,60,60 59 67 60 9L0m S9d 55. (Review date February 19'M) TABLE 9 USA TVC PRODUCERS - START-UP DATES vs ASL CASES START-ur | COMPANY NAME | LOCATION i ASL CASE | YEAR OF i YEAR 1939? |*UCC I | S Charleston NUMBER 1 1st EXPOSURE 107,13,19.21.27 |99,92,93,96,91 | Dow 1 | Midland (made 128.29.31.35 199.92.96.99 1 Saran cooolvmerl 1990? | *BFG | Louisville 101,02,03,09,05, 198,55,95,52.99, 199 6 1*UCC/Dow 1 |06,09,16,17,22, |62,95,50,55,97, 1............................ 126,33.39,37,90 197.59.55.53.92 1 Texas City (Partially closed 19771 199 7 199 8 1 Goodyear | Firestone/ 1 Occidental | Uniroyal 1950 | Monsanto 1 Niagara Falls | Pottstown .1 ... | Palnesville 1 (closed 19751 | Springfield 108.10.11.20.91 112 1 1 1 J 32 196.51.96.55.99 j 99 | 51 1952 1 Dow 1 (Closed 1975 1 1 Midland (No PVC since c 19751 1 BFG 1 Avon Lake 118 159 1953 1 Diamond/BFG 1 Deer Park 1959 1 General Tire/ ** | Ashtabula I .. 136,93 156,55 1 DiversiTech 1(Closed 1983. Reonened 1986 bv Vveen) 1956 1 Air Products 1 Pensacola (Pacel I__________ 1 Atlantic Refining 1 Brooklvn(Closed late 1960sl 1 Borden 1 Leominster (Closed 1989) 1 Conoco I Hebronville (Closed 1975) 1 BFG | Great American 1 Niagara | Fitchburg 1 | 23 | 58 1 Plastics 1 (Closed 1983) I 1 Hooker 1 Hicksville (Closed 1980-81) 1 Pantasote 1 Passaic(Closed 19891 39 160 1957 1 Atlantic Tubing 1 Cranston (Closed 1967) | Tenneco/ | Flemington NJ | 30 | 59 1958 1 Occidental 1 Kevsor Centurv | Air Products 1 (Closed 1985) 1 1 Saugus. Cal 1 | Calvert City(Paduc ah) 38 1 | 63 1 .._1 1 (Closed March 1982 Re-ooened October 1983) .................... Continued 56. 91-Oefrt s * * USA PVC PRODUCERS - START-UP DATES vs ASI. CASES I ' ................. 1 START-UP | COMPANY NAME I 1.0CAT10N j ASE CASE YEAR 1 1 NUMBER 1960 | BFG 1 Long Beach, Cal (No PVC now. 1 Formerly shown as Watson) 1 Borden I Illiooolis 1 1962 1 Tenneco/Occidental 1 Burlington NJ 1 1963 1 Conoco/Vista 1 Aberdeen. Miss 1 1 Stauffer 1 Long Beach. Cal (Closed 1982) 1965 | Conoco/Olin 1 Assonet, Mass | 42 X(Closed bv Olin 1975) 1 Ethvl X Baton Rouge (Closed 1984) 1966 | Diamond/Georgia 1 Delaware City | 1 Gulf 1 1 IGen Tire/Pantasote 1 Mt Pleasant V) Va 1 (Closed 1982) 1 BFG 1 Henry. Ill 1 i | YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 | 68 1 1 1 1 1 1 1967 1 Stauffer/Formosa 1 Delaware City (Sold to Formosa 1981) | Allied/Robintech/ 1 Painesville, 0. (No PVC made by Robintech. 1 Georgia Pacific I GP converted to polystyrene) 1 1 Hooker/Occidental X Burlington NJ 1 1968 1 Firestone/Occidental Perrwille (Closed 1982) 1 1 1969 1971 1972 1973 1974 1975 1979 1983 1986 .......... . 1 BFG 1 Pedrlcktown NJ 1 1 Goodvear/BFG 1 Plaauemlne 1 1 Conoco/Vista 1 Oklahoma City 1 1 Nat Starch 1 Meredosia. Ill 1 1 Borden 1 Springfield 1 | Atlantic Tubing/ 1 Tallvrand 1 Shintech 1 Cranston R1 (Closed 1982) X1 1 Freeport. Tex 1 1 Certain-teed 1 Lake Charles 1 | Georgia Pacific/ 1 Plaquemine, La 1 Georgia Gulf X | 1 1 Tenneco/Occidental1 Pasadena. Tex 1 | Firestone/ 1 Occidental 1 Addis (formerly shown as 1 Plaauemlne) 1 1 Formosa 1 Point Comfort. Tex 1 1 Vygen -i_ . ** X Ashtabula. Ohio 1 .1.. .. 1 . ............ .. 1 1 1 1 1 I 1 I 1 1 1 1 1 1 1 1 . .1 ........ . _ _ * My databank has no Information on UCC before 1946 or BFG before 1950NB ** Refer to same plant at Ashtabula, bought by Vygen from DlverslTech. Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. 57. ZLOEfrl- S'SU (Review time February 1991) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES | START-UP| | YEAR COMPANY NAME LOCATION l................................... | ASL CASE | NUMBER j YEAR OF 1st EXPOSURE | 1943 |(1941?) | Goodrich | (Formerly Gulf) Shawinigan | (Formerly Shawinigan Chemicals) | (Formerly Canadian Resins * Chemicals) 101.02,03,04,05 46,43 ,41,45,44 |06,07,08,0^,10, 47,46,61,46,53 111. 12 43,45 1 ! | 1951 | Monsanto 1 La Salle (Closed 1975) | | 1957 | Goodrich 1 Welland (Niagara) |13 1 57 ...................... - | 1966 | Esso (Imperial Oil) Sarnia 1 1 1 ............ - ' ! | 1979 | Diamond Shamrock Alb/ Fort Saskatchewan I | BF Goodrich 1 8 wen s'Sd 58. (Review dale Fehrunry 1991) TABLE I 1 EASTERN BLOC PV C FACTORIES - START-UP DATES vs ASL CASES START-UP | COUNTRY NAME | COMPANY NAME | LOCATION i........... ...... | ASL CASE YEAR J 1. Pre 1939 lEast Germany 1 State Comoanv 1991 1 Russia 1 State Comes 1950 1 Yugoslavia IJugo Vinll 1951 I Czechoslovakia 1 State ComDS 1 1SchoDau 1 Vladimir et al 1 Solit 1Novakv 1 NUMBER 1 101.02.03.09 101.02 1955 lEast Cermanv IState ComDS 1956 tRumania 1 State Comos 1957 1Po1 and IState Comes |Rumania | State Comps J 1958 1 Rumania 1 IState Comes 1959 1Uunearv IState Comos 1961 1 Rumania IState ComDS 1963 1 Yugoslavia 1 Oh is 1965 1 Bulgaria IState Comos 1967 1 Poland IState Comes 1969 1 Russia IState ComDS 1970 1 Rumania IState Comos 1 Russia IState Comos 1972 1 Yugoslavia 1VinilDlastika 1975 1 Czechoslovakia IState ComDS 1 Russia IState Comos 1976 1 Yugoslavia 1 Hip 1977 1 Rumania l 1_ . _. _ ............ IState ComDS 1 1 Bi tterfeldt. 1Icechlm lOsweicim (Dworvl |Tirnaveni 1Turda 1Rlsnov IBerente Borsod 1Borzesti 1SkoD1e 1 Varna 1Tarnow 1Dier1Insk IRlmnlcu Vilcea 1 Volgograd 1 Zadar 1Neratovice IKalush Area 1Pancevo IRlmnlcu Vilcea i 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 ! i | YEAR OF | 1 1st Exoosure 1 11 1 153.50.59.58 .1 1 157.50 1 11 11 11 11 11 11 11 11 11 11 11 1 __ 1 .. ................ 1 1 1 1_ _ 1 1 1 1 1 .t 11 1 6l-0t'l- S'Sd 59. TABLE 12 (Review dale February 1991) JAPANESE FVC PRODUCERS - START UP DATES VS ASL CASES 34 Factories of which 8 are closed - Total 26 60. 33 0 CO 4* CO oro o (Review date February 1991) TABUi 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP | COMPANY NAME YEAR 1 1953 1 Monsanto Mexlca 1959 1 Policvd 1955 1 Ceon Do Brazil 1956 1 Elchlor/Solvav I960 | Electrochlor 1 Viplastic 1961 1 InduDa 1965 1 PET Columbiana 1966 1 Carburo De Col 1967 1 Plasticos Omega 1 SOC Paramonga 1968 1 Primex 1970 | Policasa 1 Petro Dow 1971 1 Polimeros Mex 1975 1 Rico Chemicals 1976 1 Petroplas 1977 1 Indust Resistoc 1978 | Huls Brasil | Polychem 1 Policvd 1979 1 PET Camacari | LOCATION 1 II 1 Lecheria (Mexico) | 1 Mexico Citv (Mexico) | 1 Sao Paulo (Brazil) | 1 Sao Caetano (Brazil) | |Capitan Bermudez(Argentina) 1 1 Mendoz (Argentina) | 1 Cinco Saltos (Argentina) | 1 Cartagena (Colombia) I 1 Medellin (Colombia) | 1 Mexico | 1 Paramonga (Peru) | 1 Puebla (Mexico) | | Managua (Nicaragua) 1 Concoction (Chile) 1 | 1 St Martin Puebla (Mexico) | I Guvanilla (Puerto Rico) | 1 EL Tablazo (Venezuela) | 1 Tlazcala (Mexico) | | Cubato (Brazil) | El Salvador 1 Coatzacoalcos (Mexico) 1 1 | 1 Camacari Bahia (Brazil) ASL CASE NUMBER - | 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 --I YEAR OF 1st EXPOSURE i-zoen ssa 61. (Review date February 1991) TABLE 19 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP | COMPANY NAME YEAR | LOCATION | Hid 1950s | 1CI Australia | 1960s | B F Coodrich I Late 1970s| ICIAustralia 1 ...... _____ i Botany, Sydney Melbourne Laverton 1 Melbourne ..I-- | l | j ASL CASE NUMBER 01 I YEAR OF I 1st EXPOSURE 1 1 65 1 1 I 1 1 zzoen ssu 62. (Review dace February 1991) table is MIDDLE EASTERN PVC PRODUCERS START-UP DATES | START-UP I DATE Sept 1986 COUNTRY NAME Saudi Arabia ----------- ---_ company name LOCATION National Plastic Company (Ibn Hayan) Arabian Petrochemical Company Madiant Al-Jubail Al-Sinahyah .................................... _____................................................ 1 ! ezoen ssu 63. (Review Date February 1991) TABLE 16 NWBJR OF FACTORIES IN THE WORLD PRODUCING PVC So far as known at 1 January 1.991 (See Tables 8-15 of this ASL Register) Western Europe USA Canada Eastern Bloc Japan South and Central America Australasia Middle East bZOEPL S?U CLOSED 1 20 1 8 22 OPEN 53 30 4 23 26 22 3 ____ 1 172 64. % 1 UORLO REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER (ASL) due to VC* 1 z3 COUNTRY AMD reference MO NAME OR INITIALS DATE Of BIRTH 4 COMPANY 56 r a9 10 11 u 13 U 15 FACTORY FIRST VC EXPOSURE YEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE Of DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATIOM LEVEL OTHER CAREER HIGHLIGHTS <6 OTHER COMMENTS ___ ___ szoen ssa 65