Document 50mYxoqgpXjkRVRQQZpqdM0qJ
ra*.QNIB CULLMAN i-r;i
LOWELL WADMOND
BIOLOGICAL EFFECTS Ofl ASBESTOS
Conference Cochairmen'
I. J. Selikoff
J. Churg
l Presideal`, '-"j\ ~ "v sdioe Director. '
CONTENTS
Elect
NORU TSUTSUr,, Vicf-Presidem
ROSS F. NIGRELLI
...
Corresponding Secretary' ", ' `
i.V I; : ` L. WILLIAM MAX . WALTER E. TOLLES
H. CHRISTINE REILLY
Oirictar
\
'ICAL SCIENCES-'
*.
RMAN COHEN, Vice-C&lrman
IXXSY -y r.
...... _. ,i
vAL MALEFUT,. Vice-Chairman "ATtON'-d--'^ .
E. SUCKLING, Vice-Chairman
JDOY
GAUGHRAN, Vice-Chairman X?K `
-UDT SEXTON, Vice-Chairman
:SCIENCES !R HAMMOND, Vi^-OauTM,*
IENCES -
OBERT ROUSE, Vic^CW*,,,
stry;
i\
N. LA DU, JR,, Vice-Chairman
CHEMISTRY .. .: L . : i
lORUTSUTSUT. Vice-Chairman
hence:
-.
K. IMMERGUT, Vice-Chairman 'IENCES'
CE C. HEEZEN, Vice-Chairman tENCES-
ARD KRAMER, Vice-Chairman
TCS *.'.*' ' /
IKA PULLMAN, Vice-Chairman
UNO- -' : .
"AN D. TEBO, Vice-Chairman TICS -
ES LEWIS, S.J., Vice-Chairman IENCES - ' ,
. SCHOTLAND, Vice-Chairman
J5:5'icoh,f The Nedwui?Y"oCrkthAecaadceamdeymoicf
ipedel procnuna.-
Preface. By Eunice Thomas Miner.................... Opening Remarks. By Irving J. Selikoff........ Man and Asbestos. By J. C. Gilson..................
Section I. Asbestos Materials in Modern Technology
The Geology, Occurrences, and Major Uses of Asbestos. By N. W. Hendry. . The Physical and Molecular Structure of Asbestos." By Richard Gaze............ Chemical Studies of Asbestos. By J. S. Harington. ...".......... :..........................
12 23 31
Section II. Lung Tissue and Mineral Matter: Problems of Pathogenesis
The Detection and Localization of Mineral Fibers in Tissue. By C; Berkley, J. Churg, I. J. Selikoff- and W. E. Smith................................................ .. 48
Some Observations of the Dust Content and Composition in Lungs with Asbes- " tosis. Made During Work on Coal Miners Pneumoconiosis. By G. Nagelschmidt................................................................................................................... 64
Asbestos Dust Deposition and Retention in Rats. By J. C. Wagner and J. W. Skidmore. ___ ". .................................. ................. ............ ................. 77
Experimental Asbestosis with Four Types of Fibers: Importance of Small Particles. By P: F. Holt, J. Mills and D. K. Young.......... ............ '... 87
Electron-Microscope Studies of Asbestosis in Man and Animals. By J. M. G. Davis....................................................................................................................... 98
Rheumatoid Factor in' Serum of Individuals Exposed to Asbestos. By B. Pernis, E. C. Viguani and I. J. Selikoff--......................... .................... 112
Discussion.............................................................................................................. v....................... 121
Section III. Human Exposure to Asbestos.- Industrial Populations
Asbestosis in Great Britain.. By J. C. McVittie. .. .......... ................................. 128 The Occurrence of Asbestosis Among Insulation Workers in the United States.
By I. J. Selikoff, J. Churg and E. C. Hammond. .... --..................... 139 Mortality Among Asbestos Products Workers:in the United States. By PHILIP, -
E. Enterline........................................... ........................................ ................ 156 Secular Changes in Asbestosis in an Asbestos Factory. By W. J. SmitheR. .'.. 166
Discussion..............................:............... .................................................... . .......... -182
*This series of papers is the result of a conference entitled Biological Effects of
Athextox held by The New York Academy of Sciences on October 19, 20, and 21,
1964 and supported in part by grant No. OH-00192-01 from the National 'Institutes
of Health, Bethesda, Md.
'" "
I igiif i
iTfi v' r-tal
ASARCO ALV 0007381
)
o*
Oi o> 1/5 0IO0
C-- --J* O Uf l(O- 00o
ci ewt az
fi gZ s<
o z<
^*0 '. Ip .
*E2 **
o o
JS
?
u o
-- !C c
*ra o
3c
cs ^
noL>
<-5
A c
-S $
e< ON
c oi
.2 53 w* ,S<
2
2 . g e: la u . C f- CU
S" : c z "
g*
<ss-
d35 |u IFc ^&
Si S <w
a C0*"0
ca jEns c
CQ
1.3 1^. ccca ;a <0 a to
u q.
o
ca --< oQ
15
- ca^5 C5 . H w 58*
2 *C Ott
.Sir * <a
32 C/3 -*
S *
c_
O 2
C/ cc. ><g;
-- < *o o -
ei a; --
p
| S ta.5 1
6c Sa E
'C (i*iS -Oe
a x W
u
s
Sf
c *j
Sa S" 5
k:
E
a;
^
:Sh < = 8 3 -
tl&. ** 2
o"
<
S
30 K . 15 x
&,<f`
<%
a
c'-1 a "z .c: <. _ a:
SS?
oCJ s
o u fi < ca
ft.
"e2 w
3
*7 a;
KZ
S'*
a.
o 2 * S
a
f-
s< J3
3na
<3 5"
O si
-
e || fi J
W 5 w.C/3
W2
fi
Pi v.
< 2CO OS|T|S3 5.S.i
2 <
X g e .
0 H
a .
7:
t%ca saT.
<
js O rt
^123 $^e: oac
c c
*-- *Xc3a 71
rcs Xoz
Q
o> at si .
So *aS 2
j
n "*
Id
XQ W"21
E? o a>
S< 1
o So
IS 3 w
i? _ w ca *:*
gj .2 0
^Is s< Ih
D U 2
23 c 3C 1:1 1> s-3c
11^g^3
ob wO
tn ca * **
so
S5.-J gu, Zw
=?
"6a .9-0
3=0 ~^os g
Q"25 o Mn
=
S
oa >>5
>> -Oo c 0 cu o
< is p
5.56 C <u
Jao-2^
>,2 5 . =2
O jj
S<
1^
o 7%
-If
ca 3t 5
*3 w
ES OD
S 'jet 'eo: w
c o
3
z2
a
o a
2
2
a5
2 D.
a .8
WQ
> a>
W CQ
2
O.
S to
<P Ow o
2 s .0
J
tf CO
a S
.
*
5
?
*0 a> ca
5 * e c5 ' 3*>
e
o ox. W
CO 0J> 2
T3 1
C ca
>.
w > C te 4> #2 T3 o
2 U
O z 2 u
3
g % :
2z 3 0.< Q
g
3 E-<
z Cu
E*
<u st
CO o
.0 tt s 'o
M
><^TO-
*0
0)
-s
. ca A 1
a
31.
S
2w
Q
3 o as
ws
`b a-
|d
| o? c2 C " w t
E^ Jgb z
- ca O 'S* w u .2 0
o 5i<2
wIsSgg
-g
0 $23
cO , h^ssM rt
g ga
1 "
3
.P
co 'S >; .2i^_3
IE
3
S "g 2 bfl t-. h*
o Si !| "S1
3 i jg**
a5 JS
KS
-f5e *t0i **? ^"
c
co
8
r2
< Je
s M
33 c7a o S 0. 52 x
aus ta. A
2 <
3 .3
s a j 3 O
Q b
wC
cn
Aca
%o J3
J=
< E-
2
c 2>
F 3to wt>
aS c.2
E W o2 Oh = -oO.
0 a
3
sr
o e
"
S'
eg-
^
f-
fc
SS ..
2M 2a
w6
-- n '-r
^U . o 6 0 :< T3 3 C ; CQ
Za S*
is
uI ** 01 *QjsH) U^ <
is
Pm 5O 2OT
$
E
*TJ c U
c o
>% J2
o M "OC7 ?2j3 *49319
|>
g 0
SOI.
C3o u
oil!
" S'
M
a
?
ffiS w ca
Jrfaii "~S P<
.c sta
**
og M .1
, fc
^ Pi 0
fe
&J *-> S
O*W (S 1
2&
* i i3 ssa c a 5 >
"o o
gw
=W C. -cO 3^
to *S
S3
tcj c<a 3
2 *S <
&o 22
o
Z 5 J= A
|Io a ** 3
Ji g*R g
B
. ^c
O2 _u
.2 a n CL, O S =
03 S !
O. 3 Xl
-5 ^
^c
~o
22
3
5? SJ 3
o
a
cr a e^ os
c
z
s
CO
e 2 <
.hs ^Z cj
|s!
si S
' ;
:
i
9 tO 9) U3
N CO
eo co co co
o
3 "s
o 58 :
PbS 8^ :
1z
3
f-
.*:
ee g5
;
% fi M O ca
^c4:
-S
.. * a
|o ~ c
fci
* *
3
g>'
ScuaSS
:o T3
JO 4J
3
"o<3 Cfi . t-
g -s'PS afi
a 3
g 3 5J.--3- J>*
t-0- a
C ea
t c
a
ES
ea 3
Q 2^
is
< XO 3
*51
*5
|fe |
W .S3
Q"2 *2 0.8&,
< fc E-8
2< *.
w E .
< 2%S *S 4a
fi o "o - M
CJ
0 E2 e
c*-5 5 iS
gS s *-,2 $ fi
ss 11 jsiz *3 5^
O -G ago
e^ Oj w C Ea*a3
s SiC stf Z B i 1W <
J2 c
o>
g3 S>j
aO
'I m E5
OO t<0
.1
CoEmft
g
O 3 Q
8|
WQ
OtC
o
e-S
*
S-2
oJ 2
:
30 S*
tOa O' GO x 3 -S u s ca
O
05 0 *t|
`i
.
fi
? 0-3 g
O O
*.2gs^
0,8x
<a
" -f'* *"* a~ g
1^8
535"*ra
3t A
1-S S fi
ao c o a^
X"
Ve .t*o0
sa$ CwO o_, .
.2 <
3 05
0- o M
`o5
a .2
2so .(3a ca fj.
&2o
o|e
S-S< = bS
:
: :
8 a
r
H -^S
a"0
---a-E1*g1 gr*
>ea 1e ?
tot. J
sug
g *-J : bo "a c 03 8^(5
|S
j S
:*
o J5
CJ-
.
sIti
<e :
Hu. *
*C3 vo. o-- &:.
^
g|t
|DC3
|i 8
w g SS
5" s S 5S SE^
.s
||.S-
-3
*"5
w|s g<8i;<2
*s J
^8
g*-, g-H .3 o o.r
si | *ggl E H
IT*So sg 5
50-5 >
J 3 -
"I?
**a^?
gK"a s*-
<.2X .
60 *"* O V sx 0 Ooq
S QJ s
'Eott~ ^2 o M ,2wS
.>0 m5 c . cc
aS jCcJ S
CA h* D K
S5
-,s ca O VHJ as os ca
1
c E^S
bc< fi ^
a
a <
e
M (a >r tWj* CO
00 i c *J
*2?
*
Sw
o = :^
to . o ,2
. 05
8o 9 : n
c ca -3?
3j
81
>> o *E
E
3 a &3
*Cc5
f3 0 fe 2
War ..o 0ca
`S3 <
5A
ga
o*1 SS 30*
= 1 Ph sa
;agS
Wffi
C o
C<On
5*5 J3I*S-,
J ^
>f gom w *3 eh >>
; '-gS-i
cw 3^
2A 2 T3
C S.O C14C3
e
.fi85! to Jz CL
b=;s
J^
J o
gw
'C s
e
sjg s? 8| o
!<
B&* 3
Qe
iS
ci E-
W ?l w O Ol 1* I- l- l"
CL 3
a
ps
aE
V
ca E
*T3
3
s E
e
* *f
* *
S*
s
2H
^tm : q^
3 Qw
u
&
o.
o. a.
< <<
H .2
5o h 3" 32
5 * 2 .. u * 7= < -
aU4.i ^5
2
A Z*
|S .
6 Sg s^
io.
jCttl* 68 |3 -- 3 ^2-
8Ei0-;SS
-| 6 P
c.5. KB "S-S -
8.22 *fc=
bS r vSi *C .CO weo%KS ^5
ie'5s'5!
toj cO-313 ^5 v
5* S--
>< rs.-^g
gjfS.
ft 15
f.gE-sC
S b-*S
,V5 ga wp ." "a-l
?5-S
8*1
ASARCO ALV 0007382