Document 50b8LVjz98Yqk92aRQey6VGXz

Inerottice correspondence 300 ]n)eroffice Correspondence SO ------ -- Sm. CCOONNFFIIDDEENNTTIIAALL SSuubbjejectc:t : MMeeeettiinngg MMiinnuutteess JJuunnee B8,, 11997788 THOSE PRESENT: THOSE PRESENT: RR.. LL.. AAHHLLNNEESSSS R. J. DAVIS [rERt C. W. HANSON LL.. CC.. KKRROOGGHH JJ.. DD.. LLAAZZEERRTTEE JE tow J. E. LONG 13: wat L. J. MAGILL WH PEARLSON W. H. PEARLSON 3B PENDERGRASS J. A. PENDERGRASS RR.. AA.. PPRROOKKOOPP TT.. JJ.. SSCCHHEEUUEERRMMAANN FF.. AA.. UUBBEELL 222233~-66SSEE (" 220-12 Z23-65t 223-6SE 222233--66SSEE 223366--I1 220-2 220-2E 223.656 223-6SE 223-6 223-6SE 220.28 220-2E 223366--33B8 222200--1122E 222200--22E TTFhhleeloaarbbooocvvheeenppteecrrasssoonnssinmmeebttloooondn MHaanadyy 22to22',,de1]t99e7788rmittoonerreeivfviiefelwwuorrreeoccceehnnettmiiicnanlffsoo.rrmmaainttiioobnnloooonnd fl~orochemicals in blood and to determine if fluorochemicals in blood rreepprreesseenntt aa ssuubbssttaannttiiaall rriisskk uunnddeerr the Toxic Substances Control Act. JJ.. EE. Long revieewweedd incomplete results from 90 day animal studies on rats aanndd mmoonnkkeeyyss uussiinngg FFCC--9955,, FFMM--33442222 and FC-143.. The purpose of this work is ttoo oobbttaaiinn ddataa in order to design a two year toxicology and carcciirnao)ggeenniiccity ssttuuddyy.. FFiinnaall dataa on the 90 day rat study is due in about two mounths. FFiinnaall ddaattaa fromm the monkey study will be available in three to four months. The toxicity of FC-95, FH-3422 and FC-143 in rats and monkeys vas reviewed. The toxicity of FC-gS, FM-3422 and FC-143 in rats and monkeys was reviewed. The order of toxicity in rats appears to be: The order ot toxicity in rats appears to be: FFCC--9955 > FFMM--33442222 > FFCC--114433 R95 > FU > Pez SSttuuddiieess oonn monnkkeeyyss using FC-95, FM-3422 and FC-143 are largely incomplete. TThhee oorrddeerr ooff ttooxxiicciittyy aappppeeaarrss ttoo bbee:: FC-95 > FC-143 ~ FM-3422 OOnnee mmoonnkkeeyy ffeedd FFCC--9955 at the 1.5 mg/kg level has died. FFMM--33442222 aatt thhee 30 mg/kkg level has died. Also, one monkey fed RECEI=n JUN 14 1975 RR,Jd.. Dav MMSabadjdeectAAvvtaasiillPaabbllree bboyy 33MtOrdffeooerrrIIcInnsnspPpheeaccltsiimooenneraavnnddSCCW,ooppyNyoii.nnggC 2aas.s 0CC4oo.n6nf3ifid0de5ennttiiaall Informatio Information: Subject to Protective Order In Palmer v. 3M, No. C2-04-6309 11117777..00000011 Exnhiibibtit owsozsoraes hm 3MA02607386 --2- - 2- AAthaqqtuueesspttoiitooannssiooffumtthhfeeonrrooilsleecooonfftrppioobttuaatssissniiguumm tofioonnFC-ii9nn5FFCCf--o99x55iciaatggyaa.iinn Aaanrroosseeex..aggeIIrttatiiessdppaoocssusstiiebbllee btttehooaxxticicaciriptrtoiyyteadssststouiuududtyym oaoinsnontqthhuieesicakcalommynmotonrnaisiiubunumptooisosnrrigbsslootedod.iiuuFmmC-9ss5aalltttooxofifciCCtysyfF.)I7,SSOOA3ngHHexiissaggnneeereeddaeetddedaannaddcutssehhoouulldd be carried out as quickly as possible. ooRrR..ffatsAAtt..hheefePPadarrnnooiikkFmmooCaapp-ll1ss4rr3eefvvfeeiiiddeenwweedFFddoCCs--e11tt4s4hh33eefarallnoneeddnvveellFF1ssN0M--33oot4f4fo2222ff10lld0duu0uuoorrrripioonpnccgmghheemnthtiihahcecdeaallC99sso00f,ddffcaaooCyyuu0nn5ddaanniiliimmennaavllessleessrrstutuouumnddfiiaaeennfssddr..omlliiMMvv21aaeelrlree trtlthoai0hevetes44r99s.saafemmppdpeepmmIdndFooiCinsscn-aao1ggn4tthe3tehreeahihiinsarartdd,dssaeaoemprsrpuaepupm~lrnreooxaafxrinanoim dnndmdaat8BtefIe0lettloyymoatol2I120e22000I0rpp0papttim0tmmisneepiinsspnfmedtlTtehehhssFeaessdiHir-r3CFF4l1CC7i2-Fvi-2111le454rC33arst0s~,iinnleletvFtFhveehelmeeemsailiaslrrleefrobbolrrlfoamoaoottfrsdds1o0m0afafennedddd2t1o HaHIl10ino0vo0dw0we00eevCrv.eygperpfprm,ya,;In5ththh0haae3dedcowtTltneoaoetsststrasasallistdtthfhfe,alalnunnmutooiarrf00lieii..d3de3eedanppdcpcpimonmonfnettiitnmeehnnenattttlheshoeoeefrirfiarurnstsseessorereufrurfmuenumdonnaaennaaFddnnMddr-a3llit4lilve2evesw2sessnrriacwwttthhahaassalenwnvahhsei33igglshhfpppepmdnf((ruuoppFiimnnHtt-oo3ttI0h4h022e2e2i22ir00rto00 llippivppvemme)rr)ss.. and C8F17S0~ was identified in the serum of one rat which was fed FM-3422. WFF.h. oAA.a. reUUebee]xl poddsiisescdcuusstssoeeddflutthoheerocoohrreggnaainnciiacclsff.lluuoorrRiiennceeentlleevvseealmlsspliiinnngsbbllooioondddicooaffteCChhetemhmaotloilittteehewwooorrrgkkaeenrrissc wfeffelomlmhurpuooplolorraotiyiryrneeneaeeeen.se. flxlepeevorTvTeerhsheliilissssdngapaptoertreerehrsisflosoaaunbbno'poo'rsseuuorttcsllheotethnevvheeeemlltiosscaahhamamaalesssep. aoaiinsssncicRrtrtteehiehcaooaoessnssneeeetddwhppsirffarrceermohvovmpimiolodinu4o4uges00sssl..l5yy5ninoffttootdoouuicnn77iad1d1nvteoepepplpxxnmvcct.heee. paptfttPlPlutfflhoaaooenrnrrsascooohnnccregaeeanlallilnciacl eetfoxoxpprodosetsurtuarerenre.m.sifneeIrIrffihntotghhwiissrthapeeisimmdppllplyooeyyrseetoeehne ccoootonrnsgseaaennntiptscso,,sfilhhtiuiiossonr ibbnlwloeohooidcdlhevaaenndlddoesuuisrriinnndoeeetcrw wineiliavllsol ilvnbbegee. sampled weekly fluorochemical sampled weekly to determine how rapidly the organic fluorine level is decreasing. NsNlleieeevwvgweenlelppdeeoorrssftfooonnFFnnCrCe-ee-l11dl 44u33cwwieliiilnlelnnpbtbthleehoeeyiiiinernrvevoobbllellvovoxeoeopddddosuww iinrinleillltthhteeobbeepFpm mCaa-occo1knkn4aiai3gtgtoioinnarreggrededooefttfofofFFeddCCce-e-tt11tiee44vr3r3men.aiainntteeTCChhiihifefesmmommlweoeiittllthhitleooe.dd.sshadvdTTeehhe-ee- high analytical priority. signed to reduce employee high analytical priority. exposure to FC-143 are effective. This will have XcX-a-rlraalyyyss bohhuaanvvdee bfbeleeeunnorittanakekeenninooftfCheChiehrneombllooiliottede. eemmRppellsoouyyleeteesss wwshhhooowhhanavovee ihhnidiggihhcatlleievovneellssofooffflouororrggoaasnniiis--. cally bound fluorine in their blood. Results show no indication of fluorosis. 8iBnllooooJdduness.aammpplLleeessvelffrsroomomf DDoeerccgaaattnuuirrc eefmmlppulloooryyeieeneses eaenxxdppoossFeeCdd-95ttoo infflulsuoeorrrouocmchhewem inliilccaalblsse mw weialilsllurbbeeed.ttaakkeenn in June. Levels of organic fluorine and FC-95 in serum will be measured. ChhEEheaappvnviieedodelebnbmeeiteeoieonnlloowgeegoinnirsggsktaatsesggreedsdffrrowottmohomoddtthweheeoteterekrrSSmmcciwhihnnoioeoetolhl tthhcooeefhfemffPPeiueucbaabalslsliiisccbi.bilHHileiietatTyalyhltethhoofsfataautatnndyttheheeweppiiilddUUleennmm iicivviooeoevlrloreossgrgiiyyttyypessorottusfufdodnyyMMsiiononnnnneessoottaa wpwCooohsrreskkmiiinbnoglglieteaatttowCCodhrheeketnemeorsrloniliitwteneheo ffrwwrohomoenrtkh11ew99r43i86ththttoeocrhepperrmeaeirssceeeannltsatn. yaannddTnheew wgialitslllituvdeaayttttheeewmmaiplplttlth cttoeoofvfffeieirncndtdpseiirswffohniiicstth iiss rMrpeaeoysssuusl2il5tbt,leffr1ro9otmo7m8 edexaxepnptedoorssmururerineeqeuittorwoehffelalutpuhopoerrrrooocxcthhiheeemnam reiticecalaalyrlses,.twaonTyTmhheoennetffgeheasaatsivsfieoibbrilihlciietotaymylpthlssettutuedidfoyyfen.wcwitslilll begin which begin May 25, 1978 and require approximately two months for completion. ceReR.hnm. appnlHH.lgoo. eyyedeAAeehhltlnnoeeeexxsscppsslooosssurrueerervedeviieesttwowoyeesddtFFCeC-mtt-1hh14ee4f3.3il.ssttterepapPPsstlliaaotwwtenehhiiccaauhnhnsddinaagrfrfreeraaammbbeeeBeiiinnr((ggodop-pYeettaonnak)u)kenengnffiilfltttoriotalrtarrteeteirodid.uouncnceeOhhCvaaChsesehnnebbomedelereonnyiliitteneg chfhhaarsasonngbbeeeadeennptuorrleevppcelllaoracsiceezedded asbbtyyytstarreicibmhbbebodofnnilttrobballeettnnhioeddeenrrridbdurbsryyoininingnggblaeaannnBdddeirrd.pp-aaYccokkuaaIngnggidinnuggsftilriitsisea]rnn.ooAwwygddOioovenneneenedpddieriyrraeeisnccugttrllayy- mmfre0oenmntttssheaoof9pf.u2FFl6CvC-e-m11r4g4iz33/emlbreevvaveatetllalssucehiiennfdoutthnhtoede mtoentthsesh9o.2u8ldmbge/m~posvsailbulee. founIdn bpbtpheaeaefccfookkrarraeieggbiibnnttohgghneesasaeerrbeeleaaccnhhaadssnhnheoggorwee.wss llewweIvenvereedreellusssmmatooardfdifeae.l2.2..11H22FFyugummrireattghn/h/eenmer~rjmcciiemoomammppsprrpuaooarrvvereeee-d-daddition, enployees packaging FC-143 must now wear air fed ments should wear air fed hoods. be possible. hoods. In addition, employees packaging FC-143 must now MSMaacudee bAAtvvojaPairlaioebtleleccbatbyibytv3le3MMeOrffdooerrrIInInssnppePeccattliioomnneaavrnn.ddaCCl.ooppyNyoii.nnggG2aas.s0CC4o-on6nfi3fid0de8enntitiaall IInnffoorrmmaattiioonn: Subject to Protective Order In Palmer v. 3M, No. C2-04-6309 1I 117777..00000022 M3MA0A206260077338877 I. -3CrChahaatnnaggyeeessciinnexddprorytyiuinnrgge,, 5ggrriiFnnOdd-i3in5ngsg aaFrnCdd-tappyaacckkaaagngidinnggFELpp1rroZoBccreedduaurrreeess,4,15iin0n oobrerddienergr mttoaoderre.edduuccee ReoACTED employee exposure to FC-95, FC-98, and FC-128, are also being made. REDACTED eon Fsrochintcars. in Cond sovetime AAfftteerr ddiissccuussssiioonn,, iitt wwaass ddeecciiddeedd tthhaatt 33MM eemmppllooyyeeeess sshhoouulldd bbee ggiivveenn iinnffoorrmmaa-- CIR Ranson WITT prepare a schedate for I1nf3ormisnogmeenplos1.es5.. `Krogh and tion on fluorochemicals in blood sometime this summer. L. C. Krogh and Crk. manson w wCi.lilllW. ddeHeccainiddseeon will oonn tthhee pmmreeepcchaharaenniissamm soocfhf eppdrrueelesseenfnottiirnngginfiionnrffmoorirm nmgaattiieoomnnplottooyeCCehshe.emmolCoi.litteeW. eemHmpaplnloosyoyeneeess.. Submited wl "A. proton wer R. A. Prokop RAP:dr ih Wc AvaibylHot for nspocton snd Copying a Cafcntil formation Made Available by 3M for Inspection and Copying as Confidential Information: Beate Pree rae amar Slo 634.35% Subject to Protective Order In Palmer v. 3M, No. C2-04-6309 11117777..00000033 swAzzsorses 3MA02607388 TE oee ly by Wace Avaabyl3eM for Inspection and Gopying as Confidential formation Made Available by 3M for Inspection and Copying as Confidential Information: Secic Proecuss Order baler Hh Ho 53.04.8508 Subject to Protective Order In Palmer v. 3M, No. C2-04-6309 11117777..00004 swao2e07389 3MA02607389