Document 5002E75zempvbLb7q29bja89z
R&S 103427
DOW CHEMICAL U.S.A.
MIDLAND, MICHIGAN 48640
17 March 1981
Or. Z. Bell, PPG Dr. T. Benya, Ethyl Dr. C. Cooper Dr. R. Davis, Environmental Hlth. Assoc. Dr. K. Hatfield, Diamond Shamrock Dr. V. Kirkland, Shell Dr. R. Laundrie, General Tire 6 Rubber Co. Dr. I. Tabershaw, Tabershaw Assoc. Dr. C. Tamburro, Univ. of Louisville
LIVER ANGIOSARCOMA REGISTRY
John Stafford has updated his extremely useful Registry of Liver Angio sarcoma. Since you may not have gotten a copy, one is enclosed. As indicated, information about a new case was received by John at the last minute. I have taken the liberty of transcribing this information on Tables 1, 2, and 5, as well as page 22. I have not calculated the information in the other tables although obviously changes will need to be made in them as well.
We all owe John a round of thanks for keeping these records. Any informa tion should be sent to John as early as possible.
Sincerely yours,
T. R. Torkelson, Sc.D. Health and Environmental Sciences, U.S.A. 1803 Building 517/636-5197
9
Enclosure
cc: Dr. John Stafford
bcc: 'gen lis, Sarnia
kory, 2020 120 rneuzen rgen , Rotterdam 803
E.yGooding, 2020 J./Norris, 1803 R/ Oubre, Oyster Creek
AN OPERATING UNIT OP THE DOW CHEMICAL COMPANY
ADDENDUM
TO RECIPIENTS OF 6TH FEBRUARY 1981 ASL REGISTER
Soon after I had sent the 6th February 1981 update of the ASL register to be printed, I received .the sad news from Dr CoBZtonyi Jr that Tenneco Chemicals have had their first ASL death* Dr Gosztonyi, the Corporate Medical Director of Tenneco Chemicals, has given me the following data. Rather than delay*the 6th Feb tables by altering and reprinting them, I-thought you may wish to make the following addition to page 22.
Country and Ref No US30
Name or Initials WVN
Date of Birth 22/07/22
Company Tenneco
Factory
First VCM Exposure
Flemlngton
11/06/64
Date of Diagnosis (30/12/80) 12/02/81
Age at Diagnosis 58
YearB of Exposure to Diagnosis ~16F
i
Years of Exposure 6 + 7 9 (minimal)
Date of Death 30/12/80
Histological Confirmation Estimated Exposure Level
Occupation
(
Yes
6 years - unknown but
6 yrs _ maintenance
varied low to
mechanic
high
1$ yrs - worked
, 1i years - 7 9 years - very low in non
elsewhere 9 yrs _ boiler house
regulated area
operator
This brings the known World Total to 88^ US Total to 27 and the 1980 deaths to 5 of which UK had 2 and US 3. This is bo far the "youngest** plant to have an ASL case as you will find when you will the data into Table,
These data will be Incorporated into the next updated register. I am grateful to Dr Gosztonyi for his extremely prompt and detailed communication.
8ZKI0I. ssu
John Stafford 24th February 198^
/, tXy S'
1 I
\
V
Liver Angiosarcoma Cases
Circulation
Dr K S Williamson Dr G Paddle Dr D P Duffield DrHGF Adams - (5 copies - 1CIA, AECI, Duperlal) Mr D W S Beynon/Mr J G Davies/Dr J H Wilson Dr D W Plester Mr L F Hill, Millbank Mr Brian Hasler, Vinatex Mr A E H Williams, BP Mr R H Hards, BIP Vinyls Dr J T Carter, BP Mr T L Phillips, BP Dr P Lewis, CIA Dr J P Tassignon, Solvay Mr J C Thomas, Rhone-Poulenc Dr Kenzo Mattiussi, Montedison Mr P Lechaude, Solvay Dr B List, Lonza Mr P G Claus, APME Dr J G Kammuller, Shell Mr S Wejdling, Kemanord Mr C Rangnes, Norsk Hydro Dr Terwiesch, CWH Mr H Eraminger, VKE Mr P de Voogd, Shell Dr E Lloyd-Jones, BP Mr Owen Jones, Hillhouse Dr Brian Bennett, Hillhouse Dr Peter Wright, PCD Wilton Dr F W Best, Everberg Dr G Norcross, Everberg Mr G Dupont, APME Dr C Bishop, EMAS Mr B Werner, EMAS Dr Splrtas - NCI/NIH BETHESDA Ms R Kaminski - NIOSH, Cincinattl Dr R Owen - TUC Dr J Stafford (8)
6m0l S9U
Dr T R Torkelson, Dow Mr J Lawrence, SPI Mr J T Seawe 11, CMA Washington Mr R N Wheeler, UCC Dr A Ross Adams, Air Products Dr Mayo Smith, Air Products Dr John Barr, Air Products Dr Walter D Harris, Uniroyal Inc Dr Robert K Hinderer, BF Goodrich (Cleveland) Dr R A Krueger, BF Goodrich Dr M N Johnson, BF Goodrich Dr J Possberg, Wacker Dr Jean Berrod, RP Dr J Rety, RP, St Fons Dr P Lazard, RP, St Auban Dr H P Frledel, Berufsgenossenschaft der chemischen
Industrie, Heidelberg Dr E Ernst, BerufsgenossenBchaft der chemischen
Industrie, Nurnberg Prof Dr Thiess, BASF . Dr D H FerguBon, ICI Americas Mr D Ryerson, ICI Americas Hr A G Mash, ICI Americas Dr Gary Ter Haar, Ethyl Corporation Prof< C Maltoni, Bologna Dr J William Lloyd, Osha Dr David Bryson, AG Division Mr S Nakamura, Japanese PVC Association Dr Peter Baxter, CDC Atlanta Dr A Munn, Monsanto, Brussels Dr R E Gosztonyj Jr, Tenneco Chemicals, Saddle Brook (NJ) Dr Donald W Hillman, Diamond Shamrock Dr G Kent Hatfield, Diamond Shamrock
JS/MM/D-58 6 February 1981
ADDENDUM
TO RECIPIENTS OF 6TU FEBRUARY 1981 ASL REGISTER
Soon after I had Bent the 6th February 1981 update of the ASL register to be printed, I received the sad news from Dr Gosztonyi Jr that Tenneco Chemicals have had Lhelr first ASL death. Dr Gosztonyi, the Corporate Hedlcal Director of Tenneco Chemicals, has given me the following data. Rather than delay the 6th Feb tables by altering and reprinting them, I thought you may wish to stake the following addition to page 22.
Country and Ref No US30
Name or Initials UVN
Date of Birth 22/07/22
Company Tenneco
Factory
First VCM Exposure
Flemington
11/06/64
Date of Diagnosis (30/12/80) 12/02/81
Age at Diagnosis 58
Years of Exposure to Diagnosis 1655
Years of Exposure 6 + ? 9 (minimal)
Date of Death 30/12/80
Histological Confirmation Yes
Estimated Exposure Level 6 years - unknown but
varied low to high l*i years - 7 9 years - very low in non regulated area
Occupation 6 yrs - maintenance
mechanic 1% yrs - worked
elsewhere 9 yrs - boiler house
operator
This brings the known World Total to 88, US Total to 27 and the 1980 deaths to 5 of which UK had 2 and US 3. This is so far the "youngest" plant in the USA to have an ASL case as you will find when you insert the data into Table 9. The Lonza plant at Uald6hut which started in 1962 is the "youngest" plant in Europe to have had ASL cases if one ignores the case of the lab worker at lloechst Knapsack
These data will be incorporated into the next updated register. I am grateful to Dr Gosztonyi for his extremely prompt and detailed communication.
John Stafford 24th February 1984
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PREFACE
ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES AND COMMENTS
French Case 05 was described In yet further detail In La Nouvelle Prease Medlcale, 7th July 1979 page 2485. This paper alleges primary rib tumours as well as ASLi
Canadla Case 06 was described by Delorme In Annales d'Anatomie pathologique, Paris 1978 pp 105-114 which I have seen only recently. Delorme claims that this case had a hepatoma and ASL simultaneously)
I am grateful to Dr F W Best of ICI Europe and Mr H P Frledel of the BG Chemle in Heidelberg for help with Information on the German cases 13-17, Dr Frledel has suggested that I should delete the existing case 14 and move 15, 16 and 17 up one In the numbering system. At the risk of causing confusion between the German case numbers and the numbers given In this register, I will adhere to ay present system of not re-uBlng a case number where the case has subsequently been shown not to be an ASL le there will be a blank ninber where a case Is subsequently dropped.
Interesting details of German Cases 13, 15, 16 and 17 and sparse Information on Case 9 are given In the Annual Report of the North Rhine Westphalia Medical Inspectorate for 1978 pages 347-377.
I am grateful to Rose Kaminski of NIOSH for her letters of 19th June and 5th November 1980 with updates of her NIOSH register with notification of new cases US 29 and Yugoslavia 4 and removal of US 25 which could not be confirmed. NIOSH have however decided to keep US 24 on the register "even though It was diagnosed as Cholangiosarcoma, this neoplasm may also be associated with VCM".
In October 1980 I was told by Dr M N Johnson that the B F Goodrich case US 17 had died recently. This man was diagnosed as having ASL In 1974 and haB lived for 6 years after diagnosis.
My questions regarding the clusters of ASL deaths stimulated replies from Dr Mayo Smith and Dr John Barr of Air Products who wonder whether the clustering Is connected with particular plant design/ventilation combined with specific work practices which have led in the past to high exposures over extended periods. Re chronology they point to major expansions In the US In the late 40*s and late 50*s when new cohorts were exposed. There Is a lot of data yet to be collated and analysed to explain what has happened here* Dr R Splrtas formerly of NIOSH and now NCI/NIH Bethesda In his letter of 30/5/79 advocated the need to continue the docunentatlon of work histories as completely as possible. I agree with Dr Splrtas.
LsrVS- 't;
c
BUT
7 WHAT HAS HAPPENED TO THE ANNUAL RATE OF ASL DEATHS ATTRIBUTABLE TO VCM?
The sample Is too small to allow us to be dogmatic or even to speculate at this stage. However may I draw your attention to Table 1. Have ASL deaths peaked at 10 pa 1975-1978 and dropped to 4 pa In 1979 and 1980? Or has case reporting slowed up now that VCH Is out of the media headlines?
It is interesting to look at new Tables 6 and 7 which I had prepared for the March 1960Bethesda seminar before my offer of a paper was declined by NIOSH/OSHA. Ihave since used these data In a talk to trade union officers In the UK. There are many Interesting questions one can ask about clustering and chronology of deaths in different countries. Quite clearly with the benefit of hindsight, Maltoni's end 1972/early 1973 findings were not going to be confirmed In 1972/3 by human epidemiology in Europe but in Canada and the US there was a good chance that human epidemiology would be showing something.
If we have all data for 1979/80, what a bizarre decline in annual rate and change In clustering viz In 1979, 2 in France and 2 in UKI In 1980, 2 in UK and 2 in USI The UK has had 6 ASL cases 1972, 1974 and now 2 in 1979 and 2 in 19801 The French and Genoan annual clusterings in earlier years are also noteworthy.
I would be grateful to you for re-assurance about the accuracy and completeness of the 1979 and 1980 data
8 In 1977, for a discussion of European producers, I prepared numerous tables giving 'data plant by plant in different regions of the World. The data included ASL cases, startup year of plant, capacity at startup, year of first exposure of ASL cases, capacity at first exposure and capacity as of 1977. I have given simplified versions as Tables 8-12 which miss out capacity data. There are some interesting features to be discerned in the different patterns of incidence of ASL eg in Western Europe compared with USA and Canada. One is tempted to rearrange these arrays of data to examine various hypotheses but draws back when one remembers the vast range of latency periods from 9 to 38 years.
John Stafford Division Manager Health and Environment Protection ICI Plastics Division Bessemer Road Welwyn Garden City ENGLAND
JS/MM/19 February 1981
i
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Table Sequence
Belgium
Canada
Czechoslovakia
France
Germany
Italy
Japan
Norway
Sweden
UK
USA
Yugoalavia
Incidence of Cases pa (Table 1)
Distribution of Cases
by Country
(Table 2)
Pattern of Cases by
Factory
(Table 3)
Latency Periods (Table 4)
Anq^^ Geographical Incidence (Table 5)
IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION
LIVER ANGIOSARCOMA CASES (REVIEW DATA -1 MAY 1980)
1 2-3 4 5-7 8-11 12 13 14 15 16-17 18-22 23 24
*
ASL Case Numbers by year of Death (Table 6)
1
ASL CaBe Numbers by year of first exposure (Table 7)
Western Europe PVC Producers - Start-up Dates vb ASL Cases (Table 8)
USA PVC Producers - Start-up Dates vs ASL Cases (Table 9)
Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10)
East European PVC Producers - Start-up Dates vs ASL Cases (Table 11)
Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12)
,
25
26 *
27 28
i
29 30 31 32 33 34 35
IKTUIAL CHEHICAL lNMISTIIES LIMITED rustics DIVISION
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* All dataa aaa BE eyeten
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PLASTICS B1VISI0M
Ml - NEW - ItM
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** Bata published 1b iaarnal of
LITER Angloearcone Ctm - (hvlew Mai i February 1961)
Occ Had 1978 pagea US-140
*** Hany of dataa altered to fit nOBK 31/1/77 Hat
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PLASTICS DIVISION IMPERIAL CUEHICAL INDUSTRIES LIH1TEI)
MI - HOfrra - im * All diti m K lyitn
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A* Date publ lrhed In Journel of
LIVER intltnrcoM but - (Review Aetei 1 February 1991)
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** Henjr at detee altered tc fit NIOSH 31/3/77 llet
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IMPERIAL CtlEH I CAL INDUSTRIES LIMITED PLASTICS DIVISION
OeraanF Sheet i
Pi|> II
11
1
1l |COUNTRY AND |
| REFERENCE |
1 NO
)
1L GERHART
I1 1
NAME OR | IMTIAIS \
1 1
3 1-------- 1-- 1 3
J1
DATE OF 1
|
BIRTH { COHFAHY | FACTORY
i1
j J1
LIVER Angiosarcoma Citn r (Revltw Data l i Fabruary I9B1)
n--1 1 ---------J-------- i 8 1 9 ) -------15--1
i i* j --n--1--re--
11 | FIRST VC 1
DATE OF _1L ACE AT
1 TEARS OF
1 \i
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i i
| EXPOSURE t DIAGNOSIS i DIAGNOSIS 1 EXPOSURE TQ 1 EXPOSURE 1 DEATH j CONFIRMATION i EXPOSURE | OCCUPATION t
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130th Juna
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|
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IF W Seat
|
[letter of
|
(30th Juna
j
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|
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|
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1
| pagea 347-377 |
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ii ii ii ii
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|
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1
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(01-01-73.
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Is
Re thea-dLa-.2..0.../.3...1.. M1arch
19WI
Dr Haber
saidthan
aen now
IT
canlln-tLd
tatti
laJ Cnamf.
1 I
therefore
1 preeuwed
careej 13 and
II
| wn
now
loateoiriiia 1 histologically confirmed.
On JOtti Juna |980 I ncataed Iron Dr f U Rene of ICI Europa data originating fro* Mr H P Frledal of DC Chants who etsted that caaa II was a confined ASL and case 14 wna not an Ml.. Cnaa 14 la
SfrfrEOI. S9U
IMPERIAL CHEMICAL INDUSTilIt LIMITED PLASTICS DIVISION
Lina An|loaarcoa Ceeae - (Review Data! I February 1981)
10 II
* IhwII thla eaaa ba reuoved frou Iha Half NIMH have It on I hale eappleaantary Hat relatlna to
J8 l/S/77
11 II 14
IS
7aga 11
M
COUNTRY AM) REFERENCE HO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
FACTORY
nan w
EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OP EXPOSURE TO
DIAGNOSIS
YEARS Of
DATE OP
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
CAREER HIGHLIGHTS
ITALY
01 <0n NIOSH urplaaentaty llat)
IS.06.34
00.00.4S 1S.04.I1
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01
13.11.1) Hootadiaan Potto
00.00.S7 13.11.71
43
13
04 00.11.71
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00.01.33 10.07.73
33
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IKFERIAL CHEMICAL INDUST1IE8 LIHITEO FUSTICS DIVISION
6 1LIVES Ii|1ucom Caaoa - (Rtvitw Datat
Fabruary MI)
Page 13
l 1(
1 11 | COUNT*! AMI |
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REFERENCE | INITIALS | SIRTB | COMPANY | 1ACTOR! 1 EIFOSURE 1 DIAGNOSIS 1 DIAGNOSIS 1 EirOSORS TO i urofimi | DEATH i CONFIRMATION | EIFOSURE | OCCUPATION i
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1 I J J -L X X
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125.10.75 not (
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I
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J___________ I
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IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION
LIVE* Antloaatcoaa Caata - (Savlou Data) * rabruary DEI)
ID tt II 13
commi and
reference
m
mm ot INITIALS
DAT! Of INTO
COMPAMT
TACTONT
riftsr vc
DATS or
DIAGNOSIS
ACE AT DIAGNOSIS
sirosuits TO DIAGNOSIS
TSAIS or urosns
DATE or
HISTOLOGICAL CONFIRMATION
ESTIMATED
Birosrn
LEVEL
14
ra(a 14
IS
CARES! HIGHLIGHTS
14
01
11.12.13 Norsk
Haroya
00.03.30 11.11.71
36
11
II 04.01.71
Taa
Nlfth
Foraaaa 4
Hydro
Autoclavo
sporaiaor
Coaflnaad by Dr Ihllslaanaoa of NN. At AMS M( ef 9 Juaa 197S Hr r laaftata atatad that AH had baas a aaabar of a atart-up taao. VCH 6 rVC wart aada In aaaia
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I
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IMPERIAL CHEMICAL INDUSTRIES LIMITED JUSTICE DIVISION
LIVER Anjtoaarcoaa Caaea - (Re.lew DitRi t February 1911)
Vat* IJ
COUNTRT ADD REFERENCE
NO
NAME DR INITIALS
DATE OF BIRTH
COMPANY
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
TEARS OF EXPOSURE TO
DIAGNOSIS
10
TEARS OF EXPOSURE
II
DATE OF HATH
11
HISTOLOGICAL CONFIRMATION
tl
ESTIMATED EXPOSURE
LEVEL
14 OCCUPATION
IS
X
t l CAREER | HIGHLIGHTS |
__________ L
IE
OTHER COtOtEMTS
01 HU
13.06 .11 Eaaanord Sundavail 14.0S.3I . 10.70
43
I)
IS 20.10.70
Taa
Folyworker
01 BL
17.11.11 Eaaanord Sundevall 00.01.43 OO.OS.71
61
17
17 16.0B.il
Taa
HlRh
VCM
production
01
10.06.10 Eaaanord Sundavail 00.03.47 IB.03.76
63
It
*1 14.01.76
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folyuorker
04 AL
16.11.14
hindavail D.00.46 12.03.77
61
II
H 11.03.77
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HlRh
1946-1938
poljaar-
laatloa
vorkar (II
yre) 6 1938-
1977 foreaan
(1* r)
1 IHe SjoeUn'a jlattar of
|2S March 1*70 jconflrae XL |wae a aonoeer | worker riw van |heavllj jaapoeed, (probably even Inora so than |a noraal
|reactor | cleaner
J___________
1 | In
drat
II
lira ol
(oaployaent had
jbean heavily
leapoeed. In
11974, liver
jabnornaltty
land naeroata
|dla|noaad.
| Oata conflraai
jin Or D Byraa
(latter 18.6.7]
|to CEFIC
X I
8t7t?C01- SSU
i
6M?e0l S'SU
IHTERIAL CHEMICAL INDUSTRIES LIMITED runica division
LIVE! bislourccMU Caaaa - ( Ravlaw total I February 1981)
Ult Sheet 1
h|a It
10 It II II It
IS
COUNTRY AND REFERENCE HO
HAW OR INITIALS
DATE OP RIRTH
COWANT
FACTOR1
FIRST VC
MIR OF DIAGNOSIS
RGB AT DIAGNOSIS
TEARS Of EXPOSURE TO
DIAGNOSIS
TRASS Of
DATE OF
HISTOLOGICAL CONFIRMATION
ESTIMATED
Birosuu
LEVEL
OCCUPATION
OTHER CAREER NIGHMCNTS
It
01 WJ 01
20.0t.0l ICI
HIIIhaula Ot.Ot.M
01.11.72
(hi A
Colllar
Pper aapa 13.11.71)
*1
0 2.00.17
tarry
00.01.ft 00.ll.7t
17
Ot JSR
ll.0t.20 ICI
tollhouse lt.0t.3t 00.00.73
33
12 01.11.71
Taa
300 pp. lftt-7 VCN
(Pea t
13t7-8 tolar
Colliar
IStS-tl
aapa
Aatoelaaa oparator
11.11.71)
IMI-tt
tolar
1.3 lt.ll.7t
Taa
SlRh
Au toe lava claanar
Expoaura Halted to l.tt - S.t*
IS 12.10,73
Taa
NaSlw Mfh
5t-3
RasRlnS Plant 33-t tolar Plant S0-3B Aatoelaaa worker 50-tl CbarRahand Drier Plant 01-72 Poraaon C 2/3 Plant
Pre-mr flah naecfkcear_______
tUfr5 aray
vehicle nalntananca
------
flih wktf
IMPERIAL CHEMICAL INDUSTRIER LIMITED PLASTICS DIVISION
LIVEN ln|loearcoaa Caaee - (favla* Data! I (tlruiti 1981 >
linn 2
r*s* ip
I
10 I U II II 1A
IS
16
COUMTEV AMD ERI NO
MAHE OS INITIALS
DATS OP BISTH
COMPANT
PACTORT
PIR5T VC ERPOSURE
DATE Of DIAGNOSIS
ACE AT DIAGNOSIS
TEARS OP EXPOSURE TO
DIAGNOSIS
TEARS OP | DATE OP EXPOSURE |
HISTOLOGICAL COKHRHATION
ESTIMATED
EXPOSURE LEVEL
OCCUPATION
CAREER HIGHLICRTE
UK OS
JR
S0.03.IA SP
Rarrp
08.01.31 00.10.PI
AS
11 It*.11.79
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ts TT
TT jo6.oi.so
Ill.o6.oo
I
1 J_______
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1131-52
Potycleaner 1952-53 Letax 1155-60 Polyfloor 1960-64 Pal; Chartahead 1164-70 Charting operator 1170-72 Drier operator
Craeaor Poly Ploor Polycleaner 1165-5 Recovery 1165-1171
la thalr aupplaoentary Hot NIOSH aro etlll quotint Caaa 02 Iron I0C0 which hae boon SlacountaS In the UK. 10C0 apread naay
polyaiara lncludlnt PVC onto fabrice. The IIK Cove meat
Medical Mvlaory Service alao know of too further con fined ASL caaea In plant lea fabrication uorkera but It la dubloua whether they aver handled
(Sfrgoi. ssu
* 3
i'V
if <. ii 1.-
lHTEIIAL CHEMICAL INDUmiU LIMITED rustics DIVISION
LIVES Aniloaarco** Cmt - (hilw Data I i rtbnu; 1961)
*UE epataa of date* DAT - MOUTH - YEAS
Shoot 1
Soto IS
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IC.f \*+ ??! 3,thto\
res
t i
j1 l
i 11
_L JL_______ L_
1 |R Eaelaahl 116/1/lf
11
(1 1 |R Eaoleekl
l (letter ef
1 (6/4/lf
11 t1
l |R Raoleekl 1 |Lett*re of
t |ISth June IH0(
| |6 Sth Nev t*00|
1 1
C
yeert
,j
lt/t1
1
t
1
j! Apa-Tw'/y
1 1
rt Atfk J
1
_l__________
!/-1, t vrs -- w</f'/fc4 e/xt+sAtr*
U ft
71 -
Vttru /t*ji`vv
v'*
f /*<- fa S*,.
IMPERIAL CHEMICAL INDUSTRIE! LIMITED riAETICS DIVISION
LITER Jngloaarcou Caaea - (Ravlaf Data) 6 Fabauarp 1981 >
fata 1)
10 11 II 1) 1*
IS
IE
COURT*! AHD REFERENCE HO
NAME OR INITIALS
DATE OF BIRTH
COMPAH!
FACTOR!
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT | TEARS OF DIAGNOSIS j EXPOSURE TO
j DIAGNOSIS
TSARS OF EXPOSURE
DATE OF DEATH
IIIETOLOCICAL CONFIRMATION
ESTIMATED
EXPOSURE LEVEL
OCCUPATION
CAREER | CQW.HTE HIGHLIGHTS |
IUOOSLAVIA 01
OS.OA.IA JuRO Vli.il
Spilt
00.00.S3 08.0A.73
59
08.0*.73
Taa
01
1S.11.1I iuo
Spilt
00.00.SO 11.07.71
*2
11
II 11.07.71
Taa*
Tlnll
01
11.11.11 Jugo
Split
OA.Ot.54 11.01.76
AS
12
11 11.01.76
Taa*
Vlnll
II.D6.10
IS.11.50 01.09.70
AO
a
10 03.09.70
Too
VCH Production
VCH Productloo
I I ISARIC at al
|Em Health I Fa rape c tin loI I*. |pp 189-1T2 11978
J___________
|*In hia lattar |o( 1 Oct 1978, |Dr Splrtaa of ~|HIOSH chan*ad jtha atatua of |Caaa 01 to VCH |production janployaa. I Dr Splrtao |atao notified jo nan Caaa 01 |alao a VCH (production |worker
J____________
I |Rote Kanlnakl | Let tar of |19th Juno 1980
I I I
9St0l. S9U
zsteoi- s'?a
:i"3'
TABLE 1
Page 24
Incidence of ASL Cases Per Annina
1955 6 7 8 9
1960
1
2 3 4 5 6 7
6
9 1970
1
2 3 4 5 6 7 8 9 1980
Total
By date of death
1 0 1 0 0 0 1 1
0
1
0
1 1
5 3 2 3 5 7 6 11
11
9 10 4 yr
MW
N.B. 1 Does not include Italian 01 but does Include German 03.
2 Does not Include Japanese suspect cases. Since post mortem examinations are rare events in Japan, confirmation of ASL is a problem as Indeed is its discovery.
3 Hie 1977 total includes US case 24 which is a nglosarcoma.
Distribution of ASL Cases by Country
TABLE 2
usa
Canada W Germany France Sweden Yugoslavia Italy UK Czechoslovakia Norway Belgium Japan
Total
^7 jtr***
10
16 ** 13
i
4 ****
4 *****
2* J
6
2
1
1
2
jr
??
*
* Omit ItOl - atypical case of PVC bag extruder* ** Includes GB03 aerosol can filler* *** Includes case US 24 which was diagnosed as Cholangiosarcoma* **** includes one monomer worker* ***** Includes two monomer workers*
l.e*
North America Western Europe Rest of World
17 3 7 43 yy
8 f.
Total yfr?
8S^01 ssa
Page 25
6Sfr(H SSH
TABLE 3
Page 26
Pattern of ASL Cases by Factory
(a) W Europe Of the 43 cases in H Europe, 35 have occurred in clusters at 10 factories. cases, 14 have occurred in clusters at 4 factories.
Of the 16 German
ASL Cases
Kenanord, Sundsvall PCUK, Brignoud Dynamit, Trolsdorf RP, St Fons Hacker, Burghausen CWH, Karl ICI, Hi11house BP, Barry
Solvay, Tavaux Lonza, HaIdshut
4 5 5 4
4 2
2
4
2 2
35
(b) N America
Of the 36 cases in N America, 31 have occurred at four factories out of a total of 49 factories - in N America 43 plants have not had ASL cases.
BFG, Shawlnigan BFG, Louisville x UCC, S Charleston Goodyear, Niagara
ASL Cases
}0 H
g
4
(c) Rest of World
33
The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases
/tif
TABLE 4 Latency Periods (Years from first Exposure to Diagnosis)
Page 27
N America
W Europe Belglira France Germany Italy Norway Sweden UR
Ho of Cases
1
13 16
2 1
4
6
43
Total Years 18
298 283
37
22
106 125 889
Average 18 22.9 17.7 18.5
22
26.5
20.8
20.7
Rest of World
US Canada
26 634 24.4
10 204 20.4 36 838 23.3
Summary
Czechoslovakia Japan Yugoslavia
2
2
4 a
31 15.5
39 19.5
85 21.2 155 19.4
W Europe N America Rest of World
43
36
8
87
889
838
155 1882
20.7
23.3
19.4
21.6
09t?C0l S*H
* Of the countries with 10 cases, France and USA have average latency period above world average and Germany well below
wwoi ssa
TABLE 5
Page 2B
Annual Incidence of ASL Cases (Pate of Death) by Geographical Area
1955 7
1961
2
4
6
7
8
9 1970
1
2
3 4 5
6
7
8
9 1980
Western Europe
t |
1
((
11
t1 t1
11
t
11
1
11
t1 t1 14
11
13
i6
16
t6 17 14
I2 1 43*
t t
1
1
l
t l i
1
1
1
1
1
1
1
1
North America
1 1 1 1 1
l
1 1
5
2
1 2 1
4
2
4 3 3
2
_____ _______________
36 37
!
Rest of World
l
2 1 1 2 1 8
* Includes G03 aerosol can filler but omits It 01 bag extruder
i 1 Annual Total
1
11
11
11
11
11
11
11
t5 f3
12
13 15 17 I6
1 11
( 11 19 t 10 t4
l ITT
1
|
1 1 1 1
i
1 1 1 1
t
1
| | (
1
t
1
i (
1
\
Page 29
TABLE 6
ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING ITO1)
R&S 103462
i\
1'
1 Viola (Maltonl lGoodrich
I
1
I
1
l 1955
16
17
18
19 1 1960
l1 I2 13 14
15
I6 l7
18
I9 1 1970
1 .1
|2 I3 14
15
16
7
1 1
8
s'
19
i 1980
1
1
l Total |
| WESTERN EUROPE
(
( I FI 1 G1 1 Swl | G2 t Nl,Sw2,0Kl,It2 1 G3** l G4.G5.UK3 | F2,F3,G6,G7,G8,It3 | Bl,F4,F5,F6,F7,Sw3 | F8,R9,G10,Gll,G12,Sw4I F10.F11,G9 ,G13,G15 | G16.G17 | F12,F13,UK4,UK5 | OK6, UK7
\ 43
t | NORTH AMERICA
1 1
1 Cl
1
( C2
|
1
\ US8
I C3
1
| US5
1
1
| C4,C5,US4,US7,US10 t US12.US16 t US11 | C6.US2 1 C7 1 C8,US1,US3,US23 1 C9.DS13 | 086,089,0818,0826 | US19,OS20,0S22, | C10,DS21,US24* l 0827,US28
1
| REST OF WORLD
1 1
1 1 1 1
1
1
I Cz2 l
1 1 1 1 1
1 Y1.Y2 1 Czl 1 Japl | Jap2,Y3
1
| 'Y4
j 0S17, US29
1
| 36
1
1 1 1
l
18
* Cholangiosarcoma ** Aerosol Can Filler
PJST80061400,1-WPX7-2 .
V-v! Page 30
TABLE 7
ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01)
R&S 103463
1 t1
1
1 1 | WESTERN EUROPE | NORTH AMERICA
t 1 11
1 11
1 1 1939 | 1 1 40 l
1 l Prll
2I
1 1 3t
1 I 4 | UK1 1 1 5 | Sw2
1 1 6 | Frl,Fr3,Sw4 1 1 7 | Sw3 1 1 8 | Fr9 1 t 9 | Frl2,Fr4 1 1 50 1 Fr7,Nl 1 ( 1 | Swl,UK5 1 1 2 | G3**
l 1 3 | G15,It3
I
'1
4 | G7,G8,UK4
1 1 5 | Gll,G16
1 1 _ 6 | rR10,Gl
1 I 7 | Fr8,G4,It2,G2 1 1 8 | Fr6,Bl
1 1 9 | Fr2
1 1 60 | G5.G13 1 1 1 | G9,G10,G12,G17
I I 2 | G6.UK6
1 1 3 | Frl3, UK7 1 1 4| 1 N I 5 1 Fr5
l US24*
1
| C3.US27 | US13, US29 | C2.US19 | C1,C5,US5,US7,US28 | C4,US3,US9 | C7,C9,US8,US11,US21 | C6,US22,US26 | US1 t US12 t US16 | US10 | US4 | CIO | US18 | US2,US17,US20
i I US23
1 1
| C8 | US6
1
1 1 6 | UK3 t ( 71
1 1
11
1
1 Viola
1
1
11
11
1 Maltoni I
81
9I 70 (
1| 2I
3I
1 1
1 .............................
1 1
1 i1 1 1 Total| 43
1
1 36
1L 1
1
| REST OF WORLD
1
1
1 1 1 1 1 1
| Y2 I Cz2 l l Japl.Yl | Y3
1 1
| Czl | Jap2,Y4
1
1 1 1
1 1
1 1 1 1 1
1 .......... ............. . I t8
1
* Cholanglosarcoma ** Aerosol Can Filler
PJST80061400,2 WPX7-2
Page 31
TABLE 8
WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING GO3)
START-UP| COUNTRY NAME | COMPANY NAME |
LOCATION
| ASL CASE
|
YEAR OF
YEAR J 1940 1United Kingdom(XCI
1
iHillhouse
( NUMBER 101.04
I 1st Exposure (44 .54
1941 (France
(Rhone-Poulenc 1 St Fons
103.09.10.11
(46,48,56,41
1944 (West Germany I BASF
1Ludwigshafen
1
1
IWest Germany 1 Waeker
1Burghausen
(04.07.11.15
157.54.55.53
1945 (Sweden
IKemanord
1Sundsvall(Stockvik)|01,02,03.04
(51.45,47.46
I Switzerland 1Lonza
lLalden (Visp)
1
1
1946 I France
1Rhone-Poulenc iRousillon
101
146
1947 1 Italy
1 Montedison - 1 Porto Marghera
102
157
1948 (United Kingdom IBP Chem
IBarry
103.05.06.07
166.51.62.63
IWest Germany IHuls
IMarl
109.10
161,61
1949 1Belgium
(Solvic
1Jemeppe
101
(58
1950 I France
iPuk
(Brlgnoud
102.04.05.06.12 (59,49,65,58,49
(France
IRhone-Poulenc iSt Auban
107
150
(Holland
1 Shell
1Pernis
1
1
INorway
I Norsk
1Heroya
(01
150
1951 1 Italy 1952 1 Italy
I Montedison (Montedison
1 Brindisi iTerni
1
1 1
1953 (Austria
(Halvic
IHalleln
1
1
I France
1Solvic
1Tavaux
(08.13
(57.63
1 Italy
1Solvic
(Ferrara
(03
153
1 Spain
|Rlo Rodano
(United Kingdom!BIP
(Hernanl 1Aycliffe
1
1
IWest Germany IHoechst 1954 IWest Germany 1 Dynamic
1Gendorf iTroisdorf
1
(01,02,08,12,16, (56,57,54,61,55,
1955 1956
1958 1960 1962
1
1 Spain |Spain
1
IWest Germany 1 Italy (.Portugal IWest Germany
_1____________________ I Monsanto Iberia! Monzon
ICalqsa
|Sablnanigo
1Hispavlc
(Torrelavega
ISolvay
(Rheinberg
IS C Ravenna
IRavenna
t Cires
1Oporto
(Lonza
IWaldshut
. 117
1 1 1
1
106.13
161 1 1 1
t
I
162.60
1965 1 France 1 Italy
1Rhone-Poulenc 1Montiucon
(Pozzl
(Ferrandlna
1 1
1
l
IWest Germany 1Waeker 1966 IWest Gernmny IHoechst
(Cologne
1
1 Knapsack(Frankfurt) 105*
I (60
1967
1968 1969 1970 1971
1972 1976 1977
1 France
IATO Chimle
IBalan
1 Spain
I Rio Rodano
1Miranda de Ebro
(Greece
|Esso Pappas
(Dlavata Salonika
1 Belgium
IBadlphil
1 Antwerp
(United Kingdom IVinatex '
1Staveley
1 Italy
IRumlanca
I Cagliari Sardina
1Italy
(SIR
IPorto Torres Sar
(United Kingdonit ICI
1 Runcorn
I Italy
IS C Ravenna
1Ravenna
1 Spain
f Hispavlc
IMartorell
1 Sweden
1Kemanord
IStenungsund
1United Kingdom I BP Chem
IBaglan Bay
I Finland
IPekema
t Svartback
1 Ho Hand
IDSM
(Beek Limburg
(.France
(Soc Art D'vinyl IMazingarbe
1 Spain
(Monsanto Iberia|Tarragona
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1
I
1 1 1 1 1
!
1 1 1-1
1 Do 1 (/>
(O
* Lab ratory worker in Research Department
o>
PJST80061400,3-WPX7
R&S 103465
TABLE 9
Page 32
PSA PVC PRODDCERS - START-UP DATES vs ASL CASES
| START-UP | COMPANY NAME
I LOCATION
| ASL CASE { YEAR OF
I YEAR |
1
t- NUMBER
I 1st EXPOSURE
1 1939? l*UCC
| S Charleston
{07,13,19,21,24,144, 42, 43, 46,
f1 1 1940? |*BFG
1
| Louisville
127 , 28 , 29 ...... 139 , 41, 44 , 42 {01,02,03,04,05,148,55,45,52,44,
11
11
1 1946? 1*UCC ( 1947 1 Goodyear
1
1
I Texas City I Niagara Falls
{06,09,16,17,22,{62,45,50,55,47, 128 |47
11
108.10.11.20 ,, 146.51.46.55
1 1948 t Firestone
I Pottstown
{12
{49
1 1 Uniroyal
{ Painesvllle
1 1950 1 Monsanto 1 1952 t Dow
( BFG '
1 Springfield 1 Midland | Avon Lake
1 ______ l 118
_1
1
154
1 1953 I Diamond 1 1954 1 General Tire 1 1956 { Air Products
t Deer Park 1 Ashtabula I Pensacola
1
1
'1 .
1
1 1
1 1- Atlantic Refining I Brooklyn
. 1-_______ _______ I
__________ ___
1 1 Borden
1 Leominster
1
1
1 I Conoco
1 Hebronyille
1 1 BFG
1 Niagara
I
1
1 | Great American | Flitchburg |23
|58
1 ( Plastics
I
11
( Hooker
I I Pantasote 1 1957 1 Atlantic Tubing 1 1 Tenneco
t Hicksvilla 1 Passaic ( Cranston 1 Flemington NJ
1 1 1
1 ....
1
t
1 1958 1 Keysor Century
{ Saugus. Cal
1
1
1 1960 ( BFG 1 i Air Products
| Watson. Cal 1 Calvert City
1
1
1 ( Borden 1 1962 1 Tenneco
I Illlopolis 1 Flemlngton NJ
1
1
1 1963 I Conoco
| Aberdeen. Miss
1
I
1 1 Stauffer
1 Long Beach. Cal 1
1
1 1965 i Conoco
1 Assonet. Mass
1
1
I 1 Ethyl
I Baton Rouge
1
1
1 1966 1 Diamond
( Delaware City
1
1
{ {General Tire/Fantasl Mt Pleasant W Va 1
1
1 I BFG
1 Henry, 111
1 .............. ........ 1 .
1 1 Stauffer
1 Delaware City
1
t
1 1967 t Allied
1 Painesville, 0
1
1
1 1 Hooker
t Burlington NJ
1
1
1 1968 t Firestone
I Perryvllle
. 1 ...
1
1 1969 I BFG
{ Pedrlckton NJ
I
1
............. .
1 ( Goodyear 1 I Olin 1 1971 1 Conoco 1 1972 1 Nat Starch 1 1973 I Borden 1 1 Robintech 1 1974 ( Atlantic Tubing 1 1 Shlntech
1 Plaquemine | Assonet. Mass ( Oklahoma City 1 Meredosla, 111 1 Springfield 1 Painesville. 0 1 Cranston RI 1 Freeport, Tex
1 1
1 ......................
1
1 1
1
I
l 1 ._ ___
1 1
1 ..............................
1
1 1
1 1975 I Certain-teed
1 Lake Charles
i
1
1
1 Georgia Pacific 1 Plaquemine. La
1
- 1 ........ ......................
1 1 Tenneco
1 Pasadena, Tex
t
1
* My databank has no information on PCC before 1946 or BFG before 1950.
NB Some of the plants in this list were closed d wn some have changed ownership over the years.
PJST80061400,4-WPX7/2
Page 33
TABLE 10
CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES
|START-UP 1 YEAR
COMPANY NAME
| 1943 1(1941?)
Goodrich
| 1951
Monsanto*
| 1957 Goodrich
| 1966
Esso
* Terminated 1975
| LOCATION
1
1
| Shawinigan
1
1 1
| La-Salle
1 1
I Welland
1 ....
1
( Sarnia
1
| ASL CASE I NUMBER
| YEAR OF
|
t 1st EXPOSURE I
11
1
101,02,03,04,05 144,43,41,45,44, |
106,07,08,09,10 147,46,61,46,53 |
11
1
1 1 *i
1 1 1
1 ........................... 1
11
I
1
1 1 1
1 1
R&S 103466
i
R&S 103467
F-r " -ht - r -
Page 34
TABLE 11 EASTERN BLOC PVC FACTORIES - START-OP DATES vs ASL CASES
START-OP| COUNTRY NAME ( COMPANY NAME
YEAR 1941 1950 1951 1955
(
1Russia
1 State Comps
(Yugoslavia
(Jugo Vinil
I Czechoslovakia(State Comps
(East Germany {State-Comps
1956 1957
1..................-........ 1 Rumania
1 Poland |Rumania
1
I State Comps 1 State Comps |State Comps
1958 1959 1961 1963 1965 1967 1969 1970
1972 1975
11
1 Rumania
(State Comp8
(Hungary
(State Comps
(Rumania
1 State Comps
(Yugoslavia
lOhis
(Bulgaria
(State Comps
1 Poland
(State Comps
1Russia
1 State Comps
(Rumania
1 State Comps
(Russia
1 State Comps
(Yugoslavia
1Vinilplastlka
(Czechoslovakia I State Comps
1976 1977
1Russia (Yugoslavia (Rumania
1 State Comps (Hip (State Comps.
( LOCATION
( 1Vladimir et al I Split (Novaky |Bitterfeldt 1Schkopau 1Icechim lOsweielm (Dwory) (Timaveni 1Turda IRlsnov IBerente Borsod (Borzestl 1 Skopje (Varna 1 Tamov t D lerllnsk IRimnicu Vilcea (Volgograd 1Zadar (Neratovlce (Kalush Area 1Fancevo IRimnicu Vilcea
PJST80061400.6-WPX7
| ASL CASE ( NUMBER
|
YEAR OF
|
( 1st Exposure 1
1
(01.02.03.04
101.02
1 ....... 153,50.54.48
(57,51
.1 I
|
1 11 11
1 11
1\
1 . .... ........ ..... . 1
1
1 ....1
11 11
1 1 1
1 1 1
1
_............................ 1
1
1
_1 1
11
1
11
1
(
1
1 1 TM 1 1|
! 1i
1
-W 7-C-
Page 35
TABLE 12
JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES
START-UP|
COMPANY NAME
YEAR
1950
Chlsso Corp
Kanegafuchi Kag
Tekkosha
1951
Mitsui Toatsu
1952 - Mitsubishi Mon
Sumitomo Rag
1951
Denkl Kagaku
Nippon Zeon
Toa Gosel
1955
Ryo-Nlchi
1956
Nippon Zeon
Nisshin Kagaku
1957
Kureha Kasei
Shine tsu Kag
I960
Denkl Kagaku
Kanegafuchi Kag
1964 Chlsso Corp
1966
Tokuyama Seksui
1967
San Arrow Kagak
Sumitomo Kag
1968
Ryo-Nlchi
Shinetsu Kag
1970
Chlsso Corp
Denkl Kagaku
Kanegafuchi Kag
Kawasaki Yuki
Mitsui Toatsu
Nissan Kagaku
Shinetsu Kag
1971
Tekkosha
1973 Asahi Glass
1974 1'
Toyo Soda
1975 1977
' Central Kagaku Toyo Soda
I Unknown
PJST800.61400,7-WFX7/2
1 LOCATION
1
I Minamata 1 Osaka ( Sakata t Nagoya
| Yokkaichl t Kikumoto t Shibukawa | Kambara 1 Tckushlma 1 Uozu ( Takoaka t Takeo -I Nlshlkl 1 Naoetsu { Ohml 1 Takasago 1 Chiba 1 Tokuyama | Tokuyama 1 Chiba | Mlzushima 1 Tokuyama | Mlzushima I Goi (Chiba) I Kashlma | Kawasaki | Sakai ( Chiba 1 Kashlma 1 Yokkaichl t Hayatsukl | Sakata 1 Yokkalshi | Kawasaki 1 Yokkaichl ( Kashlma
I ASL CASE I NUMBER
1
1
1 01. 02
1 1 1 1 1
1 1 1 1
t .... t
1 1 1 1
1 YEAR OP | 1st EXPOSURE l
1
| 53. 58
I |
1
1
| |
1
|
1
|
1
I |
|
1
|
1
-
. ,.
11
1 11 11 11
1
1| |
1|
11
1-
11
I|
1 __ L
1
1 1 1
l
1 1 1 1 1 1 1 1 1 1 1
1 1
R&S 103468