Document 4xb9Jna89g3QjdQ1Q6kYVvRa

F e b r u a r y 21, 1955 D r . A drien V er Bru ggh en ' 122 Sou th M ic h iga n A v e n u e Ch icago, Illin ois D ear D octor Q ruggh en : On look in g in to th e m a t t e r , follow in g o u r co n v e r sat io n in th e U n iv e r sit y Clu b in C h icago , 1fin d th at we (an d ou r a sso c ia t e s in Cin cin n ati} h ave p u b lish ed litt le or n oth in g on th e p r ob lem of lead poison in g in ch ild ren sin ce 1933, a t w hich t im e I put to ge th e r an accu m u lation of d ata on th e n o r m al le ad m e tab o lism of le ad in in fan cy an d ch ildh ood. D u rin g th at p e r io d , h ow ever, we h ave den e qu ite a b it of in v estigative v/erk on c a se m a t e r ia l, o u r se lv e s b ein g la r g e ly in th e p o sit io n of c o lla b o r a t o r s on the d iagn ostic (m pre recen tly on the th erapeu tic) approach to th e problem . O ur p r in cip al con tribu tion h as been th at of th e ap p lication of sam p lin g an d an aly tical tech n iqu es a s m ean s of in terpretin g th e sign ifican ce of the exp osu re to and ab so r p tio n of le ad . Th ese h ave grow n out of ou r exten siv e w ork on in d u str ial le ad p oison in g, it s d iagn o sis an d prven tion . It is b ecau se of th ese d evelop m en ts, no doubt, th at th e in ciden ce of lead poison in g am on g ch ild ren in Cin cin n ati (as w ell a s in Baltim o r e) ap p e ar s to be m uch h igh er th an it i s in m o st c it ie s, i.o . th e d iagn ostic tech rdque, to w h ich p e d iat r ic ia n s h ave been ale r t e d in th is m ed ical ce n t e r , is su ch th at c a se fin d in g, w h ile n ot en tir ely ce r t ain , h as been gr e at ly im p roved . I sen d you a list givin g th e n u m b er s of c a se s by y e a r s, in w h ich it is p o ssib le to se e th e effe cts o f la p se s of in te r e st (based cn m ore con cen trated atten tion to seem in gly m o r e u rgen t m atte r s) on the p art of the st affs of the two p r in cip al h o sp it als to w h ich o u r c a se s h ave com e. I h ave no doubt th at th actu al flow of c a se s o v e r the la st fifteen o r tw en ty y e a r s h as un dergon e but lit t le ch an ge. I cou ld b e w ron g in t h is, but I h ar d ly th in k so . I can n ot sen d you th e r e p r in t s of th e a r t ic le s w h ich m ay be of in t e r e st to you in th is con n ection , but I cite th e r e fe r e n c e s on th e at tach ed sh e e t . I h ave in duced th e people a t th e Ch ild ren 's an d the Cin cin n ati G en eral h o sp itals to begin to get th eir d ata togeth er so n s to pu blish a se r ie s of a r t ic le s on t h e ir c a se s. T h is, I h ope, w ill be don e in th e n e a r fu tu r e. M ean w h ile I can giv e you th e fig u r e s w h ich Sam Tr u fan t gav e m e a few d ay s a g o , w h ich b e a r on th e m a t t e r w h ich we tou ch ed on in C h icago. T h ese a lso a r e list e d in tab u lar fo r m on th e attach ed sh eet. I can a lso say th at th e grou p h ere is of the opin ion ,ten tatively, th at the u se o f d isod iu m calciu m K-E 0019313 D r , A d r ien V er Br u ggh e n - (2) - F e b r u a r y 21, 1955 , eth vle'P ediam in etetraaeetic acid (officially known a s edath am ii carciu m d isod iu m ), h as bean m o r e b e n e ficial ill th ese c a se s th an h as an y oth er m eth od cf th erapy envoieyed . O b viou sly th e car e fu l exam in ation of the d ata fr o m a se r ie s oi c a se s w ill b e of m u ch m o r e valu e titan t h e se im o re s s io n s. . I r e gr e t th at ou r in form ation is n ot in b etter ior rn , but su ch a s it is, I sen d it. . C ord ially y ou rs. EAK ef R o b e r t A . K e h o e , Ivi. D . KE" 0019914 ! DATA ON CA SES O F P O ISO N IN G (C H ILD R EN ) C ases C a se s in volvin g sm rgical de- R esu lt Compy f~F *'7! 2 Favorab le outcom e 1 Som e b en efit 5 No ben efit 3 Num ber of cases C ase s not in volvin g su r gical d ecom p ression 3 5 S oVCxC 31 F avo radale ou t som e Som e b en efit No ben efit Num ber of case s 0 2 3 5 Note: The sad cot of r e su lt s, e sp e c ially in th e m or e se v e r e ^ c a se s, con vin ced the n eu rosu rgeon s th at th eir th erapeu tic in terven tion w as e sse n t ially fu tile, an d th e p roced u re h as been aban don ed. KE 0019915 R eferen ces On th e N or m al Ab-sorption an d E x c r e t io n of Le a d IV. Le ad A b so r p t io n an d E xcr e t io n in '.n fan ts an d C h ild r en ; Jo u r n al o f in d u st r ial H ygien e ih d 301, 1933. (Se e t h e o t h e r a r t i c l e s in t h is s e r i e s {p a ge 25 t h r o u gh 340) fo r so u r c e s Of le ad ab sor p tion , am ou n ts in n orm al t issu e s, etc. La t e r a r t ic le s give m e r e in form ation on ad u lts but h ot on ch ild r en . ) 0019916