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AR 826 -- 1390
Venn, FROM:
PAUL THISTLETON
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E. I. bu PoNT DE NEM&OCUOMRPAS NY
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P.O. Box 1217
- otra mavens samme PARKERSBURG, W. VA. 26101
CC: C. G. McGlone-Tokyo
S. Hayashi-Tokyo D. K. Duncan - Wilm,
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MR. S. TAKADA MITSUI FLUOROCHEMICALS CO. LTD. MIHO 3600
SHIMIZU SHIZUOKA PREFECTURE JAPAN
PROPOSED EMPLOYEE BLOOD SAMPLING PROGRAM
We would like to obtain blood samples from a representative
group of employees at Shimizu Works to determine if there is a
significant difference between C-8 APFC dispersing agent values at
Shimizu and Washington Works. About twelve samples should be
enough. They should include several people who work around the
TEFLON fine powder dryers because we believe that they are a major
source of exposure. Your plant has batch dryers whereas Dordrecht
and Washington Works have continuous dryers. We will analyze the
samples at Du Pont's Experimental Station and return the results to
you so that they can be given to the employees as confidential
medical information.
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BACKGROUND
We have used C-8 at Washington Works for more than 25 years and in earlier years it was handled less carefully than in recent years. Limited data indicates that C-8 is persistent in the human body and we have established a program to monitor selected employees regularly. We have established engineering controls to reduce potential exposure to C-8 and required the use of protective
equipment for some Jobs.
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Significant additional control effort began in 1979 after
3M Company(our supplier of C-8 APFC dispersing agent) advised us of
accumulation of organic fluorine in the blood of some of their
workers. In March, 1981, 3M Company advised us that tests indicated
that oral doses of C-8 caused birth defects in rats. As a result,
we transferred all females of child bearing potential from jobs with
significant potential for C-8 exposure and increased our efforts to
prevent exposure.
Du Pont's Haskell Laboratory is making tests to determine if exposure by inhalation of C-8 causes birth defects and also is making tests with oral doses similar to the 3M tests. We expect
results of these tests in' about a month. 3M Company is repeating
their original study and we expect to receive some information in October, 1981. g
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Samples of blood taken at Washington Works showed that polyrerization operators had an average of about 5 ppm organic fluorine and the maximm value was about 29 ppm. Monomer operators and professionals generally had mich lower values. We sampled some employees in the TEFLON Division at Dordrecht Works in May, 1981, and we fond that the C-8 content of their blood samples was very similar to results at Washington Works. There appears to be no background level of naturally occurring C-8 fn blood samples. A thorough Study of the employees health records showed no conclusive evidence of effects resulting fron exposure to C-8.
We have asked Haskell Laboratory to establish an acceptable level for C-8 fn workers blood that will be the basis for managing our blood monitoring programs.
We will be glad to answer any questions and provide more information that you may need.
PT/nsw or
Paul Thistleton
Sentor Engineer
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Technical Department
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Pregnancies
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Normal child - born April 1981.
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Fisvoenche-pregnent. OnPU 41% Love Fivemonthspregnant. Wyoesl fill-in00st 1151
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Ucnhciolndfi-rm2epdluesy'eyeaantds.tear duct defect.
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Current blood level - in fluorocarbons area only one month before pregnancy.
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