Document 4mbnM0wGM64yV4RvM3MV41EN

Kr F* A* Rideout Bakellta Division 20 frovidenc* St, B oton, Han, Kr. R. A. Celelbet January 17, 1951 Otar Mr* Rideout* This refers to jour report of call on Athol Hfg. Co., Athol, Mats* date f 12/20/50* Had noted the article by Dr* Jordan which appeared in the November 1950 issue of Archives of Dermatology and Syphllology* Believe that the comment f Dr. Richard S. Weiss of Gt. louts, vhtoh follows this article *. page 680 pretty well states the cast* Dr. Vales says, "It seems proper ...to surmise that a cobination of materials, chemicals end perspiration asy be repponelble for the reaction* observed.* In I949 Dr. Creceh and I had eoma eorrespcndec.ee and diaouesion with Dr* Earl D* Osborne of Buffalo, Sr* Jordan*a associate, on the earn* general subject f dermatitis from the use of new chemicals, including plastioo, in products in oooexon public use. Our general attitude then remains essentially the can* today and night be briefly stated about ao followsj the resins tbhaselves are seldom to ony exteat active irritant* or eensitiaers, and most of the' ^oapleted formulation* as they reabh the eonturner are free from such properties. The principal exception would teen to be the flexible, 'highly pl&stialssd formulatiocs v^sre under certain types of Contact aneitls&tton nay occur* Xn general, the properties of a plastic formulation nan not with any accuracy be predicated upon tests made of Individual Ingredients* Patch teete of the finished formulation would be the nor* reliabla method* Wo have found, for instance, that aooa foraalatlona containing known primary irritant* or oeasitisars nay give no reaction, and vs have also fostd that sceie foxvulatlona only ingredients which had failed to show reactions, when combined in the plastic would produce react inns. . .. ' ---------- - -- -In 1945 end 1944 our laboratories at Mellon Institute ran som* series of patch test# n human subjects using son* of the resino applied as the powder er applied sheeted fren a advent. Xn the latter method the resins vers dissolved In a suitable solvact than knife eosted onto surgloal gsuie and air dried for one week before application* The coatings vers heavy enough to bridge over the mesh of the gauso leaving a film of resin between the meshes whan dried* Vhm applied as the powder, there was good opportunity for mechanical irritation, and It is notable that all the reactions with tho powdered rosins were during the initial 7-day period, non* developing Upon retest. Probably Irritation of the powder accounted for these irritations, irrespective of the chemical nature of the resin. When the neehanloal irritation of tho powder was oversea* by applying from solution, It was possible that that reaction* noted were caused by retained solvent* Our laboratories believe, therefor*, that the f llowing results were not eanolusivo (boosuso of tho added factors of mechanical Irritation er retailed solvent) i ucc 063265 Mr. F. K XMmkI i/a/sx V i B!HL guv m tno SQL oi r~v "t): o' i-'-fr *C' -- fra M^nsi: 'J? S' *' .' - .*' V3r*w * -# n_t i ' ' -tv '*' . \.: ____lsa&&g2S&. - _ BmaUlmtlcp* 4 ',j* A'- (* :;. i Z}.rzpx r n ..?$' fj?.* .. cQKwi '''-0r,T ,i.; .,n *w . nl,'C r jj-v-y va. ' i.'. . r Sv "4 <: . st - . ''--ror 1 . \ _ $ i* . 35 _________:..,a.. tits ... m*#- tn^m ' - r.-^:* 1 *f' ::"W r^-hhg-ftrfaet*r> .3 -\: -** \ftoX `/T :-, ri. .>- c-* , *w*m- --iw' = r-"'"--:j'.`%3m "-- rrx* ;i/i-/-- o n -- Jt 1* rs ~<t r'". b* ooaparad to. patch toot* aad* bar on* of our oconltmtf of a uoolm fabric (nd u a oootrol la tb* toot) la which 4 roootloa* ooourrad (200 cub- omparablo to our laboxatorl** "definite* reaction*, but which tb* acoanitlng Jeoto) daroatologict tkcB^twn not indicatiT# of allergenic prupwly twiiii of tb* abacnoe of walforaity la percentage and degree of poeltive rooetloao oa r flrot application coopered to ooooad application. I go Into thlo detail to J that tb* am occurrence of "definite* reaction la a patch toot aot a***iatrl1jr luply allergenicity, but it thould bo iatarpfctod by r- ` riod to do ao la tb* light of uniformity and dogroo of reactlorn noted. i '*'3?^* V. * "' lb 19(6 fir. Qranah vroto aa artlolo oa "Toxicity of 8m f d* 1< Root!**" which appeared la Industrial fiodicla* for February VH$. Jttncelt ha* paxtlncat laformtloa aa aaoloalng rcjrlat for your raady rafaraoeo* ; 1. . ................ V:V*. : IXf-K- c-t- ....................... Toxy truly your` a# " "^5 Ihoa* V. Vale, tU D b H00STBIAL TOZXCOLOQI CXP1KTKEST v-sv ucc 063266 CAUL 0. OftCOfVNC, M. 0. JAMES W. JONDON. M. 0. 471 DELAWARE AVENUE urrALO, n.t. ZONK 2 January 17, 1949 A. G. Cranch, U. 0. Union Carbide and Carbon Corporation 80 East Forty-Second Street New York 17, New York Dear Doctor Cranchs 1 enjoyed reading your letter of January 10, and I might say that I shall welcome the opportunity to talk with you, or Dr. Nale, regarding the problems of chrome, solvents and resins as a cause of dermatitis. What you say in your first paragraph Is entirely true. I have been pestered to death with letters from all sorts of manufacturing companies and societies regarding the press releases. Needless to say, I had nothing whatever to do with it, and it has occasioned me a great deal of trouble. Non-sclentlflc reporters are always trying to make something sensational ait (fa strictly scientific statement. Fortunately, the AP did not carry near as bad a release as did our local papers, who quoted me as saying that fluorescent light was a common caWe of dermatitis. Actually, I told the New York Central Surgeons about three patients 4io had a dermatitis due to the combined use of perfuse locally on their alHna with fluorescent lighting. This, of course, is well known. Three cases, however, out of many thousands of employees is an infinitesimal percentage. It is the same thing in general as regards chrome, solvents and resins. We are talking about these cases as dermatologists. It must be admitted that out of the total number of workmen or housewives exposed to chrome, solvents and resins, the p rcentage that develops a specific hypersensitivity is extremely small, in fact, almost Infinitesimal. However, the fact remains that many people do have dermatitis or comma due to these exposures, and unfortunately this percentage is gradually increasing. You ere entirely right in your conclusion that I was not referring to individuals UCC 063267 tv. A. G. Cranch, H. D. EAftL O. OBBOftNt, M. O. JAMC* W, JORDON. M. D. 471 OEIAWARE AVENUE ZONE buffalo, N. V. --2-- January 17, 1949 who were working in industries where chrome, resins and solvents ere used. Of course the hazard there is recognized and is definite. I was referring particularly to railroad workers. There is a wide use of lacquers, chrome alloys and solvents in the railroad industry. One of the most interesting phases of our work is the investigation of the leather, particularly the shoe cases. Two of the large tanners here in Buffalo ar personal friends of mine. They insist that there is no free chrome that can be detected in chrome tanned leather. The fact of the matter is, however, that we have had several hundred cases of dermatitis due to chrome tanned leather. It is hard for the non-trained individual to appreciate allergy or hypersensitivity. V are dealing with infinitesimal quantities that many times cannot be detected by a quantitative test. Some of our leather cases will give a positive patch test to the leather in question and also to potassium bichromate and chromic acid in dilutions of one to one hundred and one to five hundred, four remarks regarding other substances in leather as a cause of dermatitis is very well taken. Many of our cases in women today are due to the synthetic resins painted or sprayed onto the surface of the lining. lour statement that "resins themselves are seldom to any extent active irritants or sensitizers" is certainly not correct in our experience. I will predict that all forma of resins, as time goes on, will become known as sensitizers. I am quite willing to agree that in the finished plastic there is little skin hazard. However, we do see rather frequently dermatitis around the neck and around the wrist from contact with synthetic resins. We shall greatly appreciate any assistance iftich you can possibly give us in the future in helping us identify the exact ingredients in som particular preparation. UCC 063268 A. G* Cranch, ll D. carl O.OSRQRNC'M.Q. JAMES W. JORDON, M. D. 471 DELAWARE AVENUE surrAio. H.r. SOME t January 17, 1949 That 1b our greatest stumbling block at the present time. It has always been my bell f that aiy Industry which is well-directed and Jiich has scientific laboratories, would gladly welcome ideas such as those we might have. Unfortunately, this is not always so. I shall always remember the deluge of mail I received from cosmetic manufacturers producing nail lacquer Jien I published ay extensive paper on nnti lacquer dermatitis in 1941. We have since had more than twelve hundred such cases, and yet at the time I was subjected to a terrific barrage, and now I believe all manufacturers of nail lacquer recognize the hazard. Sincerely yours. EDOtbs t- Dr* Xirl D. Oibom 71 forth Street Buffalo 2, lew lorfc January 10 1949 Boar Dr* Osborne* Dr* 7. V* Isle, who has taken over ay old departsent here, recently wrote you with reference to the if press release on your talk before the nesting of the Aseoclatior f Surgeons of the lew Iork Central System* Because of the Corporation's interest In hrone products sad plastics this press releese Is constantly being brought to ny attention and the last tine by the Manufacturing Cbanlats Association nhose ledieal Advisory Coaalttee Z an a member. lbs YC1 Is sLso oanesmad as to the indications of this release* Ye all know how often reporters are prone to *play certain stateaents of a speaker, many tinea without reference to the nontext or qualifying roaarks* Also they seen prone to fplck up* certain statenut* of a speaker wfaloh they apparently think nay sound sensational, again without due reference to possible qualification* An sorry that ws have not had an opportunity to see a copy of this paper itself but pertups you have one which you night sand as* If so, X would greatly appreciate It* ^ With reference to the points nt Issue which ere causing so nwoh concern, X wish to write shout then rather frankly and trust that you will not take wy reworks aulas nor as a criticise of your observations* They aieply represent impressions X have fron experience with these materials over e long period ef jeers in aaay applications. X would Ilka to present then for whet they ere worth and If you feed that there Is ether specific information which refutes ny conclusions X would be very glad to hewn it* Yith reference to chrome, we probably have handled this as n netal es long aa any company* Our principal Interest has bean In the nanufacture of fanochrane, which Is used In the formulation ef a wide variety ef chrome bearing metals* Our experience In th nmufactnre ef ferrochrone and that ef our customers In the naaufaetnre ef chrome* bearing netals both scan to Indicate that there is no appreciable Incidence ef dermatitis among those writers as coopered with any ether metal workers in ainilar lines* As far offsets am the public Aram handling eteons-hearing natala, to the beet of our lafexmetien there has bow no resulting Inerease^indaxmatltls* Of eeuzes there are always e fen hypersensitive individuals who nay react to contact with such natala Just as they do an contact with nickel and even gold, but still the general use ef theca Uttar netals sms hardly be said to be responsible for may appreciable incidence ef dermatitis. X on net referring ef course to the dermatitis whleh la a fairly fkoqwnt eeeurrsnee in eoanaetlan with ehrm plating. This la a dlffarent proposition and exposure to ehrowi meld wJvttoi and mists in the course af plating oparatloas exposes a very ninor portion the papal atime and has nothing to do with the throne pi atari natarlala in every day use. chrcne-eontalalhg alloys aod f t m net as fwilier personally with the use ef Shrew In the leather industry Mk X am in the netallnrgle^l Industry but from the beet information at lend, and from axparlanoa of thoao who fanUiar with this application, X believe efazond mas first n*d to bo usaful os a tanwlag agsnt soma nlnsty years am, sad has bean af nmstloal leportaaea In this field far wall aver sixty years. Sine* the term af the eantary It has hesa in wide ass for the taamlig of Isathar and with no great shwgee in the method af its oaplsymwt for this pnrposa. X do not baliewa it likely thatthan ucc 063270  Karl D. Osborne in*) Jan. 10| 1949 products which we have occasion to handle. Only rarely la tho ease of new dereloyeente there attfxt bo tines when wo would not wish to bobs certain Ingredients, X do not know just how soon Dr, Isle or I will bo coatng xp to our operations at Tonswanda or Ilagara Falls but at the first opportunity X *111 try to drop In to so* yon la regard to this Interesting subject which X have Just boon discussing at sons length, . Tory sincerely. / Am G, Craneh, X. D. b UD1CAL 00SSQLTAB7 , V' ucc 063271 TELEPHONE NATIONAL MU NATIONAL MM Manufacturing Chemists' Association, Inc. (POUNDED tin) 246 Woodward Building Washington 6, D. a December 20, 1948 Dr. A. G. Cranch Carbide and Carbon Chemicals Corp. 30 East 42nd Street New York 17, New York Dear Dr. Cranch: I have received a conmrunication which reads in part as follows: "In the New York TILES of November 18th there appeared under the date line 'Buffalo, November 17th1 an article entitled 'Eczema Laid to New Chemicals' in which it was stated by Dr# Earl D. Osborne, head of the Uni versity of Buffalo dermatology department, that eczema has increased at least 50% in the last ten years because of the use of new chemicals such as chrome and plastics# This statement was made in an address before the Twentyfifth Annual Meeting of the Association of Surgeons of the New York Central System. Dr. Osborne further states in every day life, repeated exposure to metals containing chrone, leather tanned with chrome, and ....... is responsible for the major increase in dermatitis or eczema.'" Ify informant feels, and I believe rightly so, that Dr. Osborne was not entirely familiar with the subject matter or that his remarks had been incorrectly reported. We have not been able to obtain a copy of "the paper as yet but are making repeated efforts to secure one. Inso far as metals containing chrome are concerned, I am won dering if you have information relating to the experience of Electrometallurgical Corporation in your files. Surely with the widespread use of stainless steel such eczema, if it really exists, would have been widely publicized and would have come to your attention. Any information that you can give me along this line will be sincerely appreciated. With kind regards and best wishes for a Merry Christmas and a Happy New Year. Very truly yours. MFCJr/emk M. _ .--------, ... Acting Secretary UCC 063272