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December 20, 1983
TO:
FROM: SUBJECT:
Vinyl Institute Executive Board Vinyl Institute Manufacturing Practices Committee
Dr. Roy T. Gottesman
Vinyl Chloride and TSCA
RECEIVED
JJtt09'b4 Rftiita- -------------
Copy:
X-F:
I attach a copy of a paper entitled, "Vinyl Chloride and TSCA" presented by John T. Barr of Air Products and Chemicals, Inc. at the CMA Seminar on Risk Management of Existing Chemicals on December 9 which I think you will find of interest.
RTG: Jmd Attachment
7 Gottesman
A Divisionof THE SOCIETY OF THE PLASTICS INDUSTRY, INC.
355 LEXINGTON AVENUE NEW YORK, N.Y. 10017 (212) 573-9400
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A
VINYL CHLORIDE AND TSCA
3. T. Barr Air Products and Chemicals. Inc.*
The well known regulatory history of vinyl chloride and It's role as a bellwether of current regulatory philosophy makes It a useful paradigm for examining the relationship of existing laws and TSCA for control of chronic hazards.
To this end. we will first review some of the highlights of its regulatory history, and then engage In some speculation as to the response these events might elicit today under TSCA.
Vinyl chloride became of industrial Importance about fifty years ago. about a hundred years after Its discovery, when Semons discovered that Its polymer could be converted Into useful articles by plastlzatlon with phthalate esters. Commercial development began first In Europe and then In this country In the late thirties, largely using existing rubber processing equipment, for It was rubber which It Initially replaced In the market. For the same reason, the use of PVC was sequestered by the government during the war years, and It was not until the early fifties that widespread consumer applications developed. PVC Is now a mature product, and its growth rate falls In step with the Gross National Product. Presently, about six billion pounds are used annually In this country, and about four times that In the world.
Some of the broader toxicological attributes of VC were recognized In the thirties. It was known to be an anesthetic, but problems with cardiac arrythmla prevented Its use In that applicatlond). As pathological techniques Improved, Industry scientists recommended In the early sixties that exposure be limited to 50 ppm, because of temporary liver enlargement in animals at that level<2), but the American Conference of Government and Industrial Hygienists considered this overly conservative and accepted Instead the 500 ppm recommendation of Harvard sdent1sts(3). This was the value adopted by OSHA In Its formative days.
Also in the early sixties, the European Industry recognized among Its workers a disease termed acroosteolysls, AOL, which Is a degenerative disease of the bone tufts, particularly In the fingers, that Is Accompanied by Reynaud's phenomonon<4). An extensive epidemological survey here and In Europe found about a hundred possible cases which were associated closely with manual cleaning of reactor walls between polymerization batches, but neither the precise etiological agent nor the disease mechanism was 1dent1f1ed(5,6).
An attempt was made to reproduce this disease in rats by the medical department of one of the European producers. An exact duplication of the human disease was not seen, but many of the rats developed tumors at numerous sites. The reporting of this finding by V1ola<7> in 1970 evoked little Interest In the regulatory community, possibly because of the very high doses used, several thousand ppm, which were frankly toxic to the animals, and the fact that the tumors largely were metastatic from the Zymbal gland, an organ not present in humans.
Air Products and Chemicals, Inc., 1983
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Nevertheless, both the European and domestic producers formed consortia to perform bioassays at lower concentrations and also began epidemiological surveys of their employees.
Preliminary results of the European bioassay became available first in early 1973, and showed tumor development at much lower concentrations In organs which do have human counterparts. This result was transmitted to regulatory officials that summer, and Industry screening of employee records was intenslf1ed<8). This resulted In the recognition that winter by an Industry medical director of a cluster of 3 rare liver tumors termed angiosarcoma, or ASL, In the employees of one fac111ty(9>. Reporting of this fact to government officials led to the current regulatory status of vinyl chloride.
It also led to a virtual explosion of research on the chronic toxicity of VC. The body of scientific literature on the oncogenicity of vinyl chloride Is as large as that for any other substance. It Is recognized that VC Is a classical procarcinogen. Metabolism by the mixed function oxidase In the liver converts it to the ultimate carcinogen, an epoxide. Detoxification of this Intermediate by the sulfhydryl group of glutathione or other proteins removes the toxic potential(10). Both of those mechanisms are saturable(ll). An overload of the metabolic step assures that the vinyl chloride will pass through the liver and some will be metabolized In other organs. An overload of the detoxification step allows escape of the toxicant Into the sinusoidal passages of the liver where Interaction with the chromosomal protein causes ASL to develop. An overload of both mechanisms can lead to tumor development outside of the liver, as Is seen In mice and rats at very high doses. Despite the large data base, however. Information on the precise mechanism of these various steps still Is lacking. We do not even understand why some persons respond with AOl and some with ASL, but none with both diseases.
OSHA proceeded promptly In early 1974 to set an emergency temporary limit of SO ppm for worker exposure, and later that year reduced the limit to 1 ppm, the current figure. Industry was given a grace period during which respirators could be used to meet this requirement, but now that level must be met by engineering pract1ces<12).
The EPA promulgated a combined engineering and works practice standard In 1976 which has resulted in ambient concentrations In the fractional ppb range near producing or using fac111t1es(13).
In the meanwhile, FDA and CPSC established prohibitions on the use of VC In aerosol or other consumer applications, a practice which had been discontinued In 1973. The BATF had already banned the use of PVC liquor bottles in 1973 because of concern for taste effects from migration of residual VC Into the contents. In 1975 the FDA proposed revocation of the GRAS status of rigid PVC packaging under the Oelaney clause, also because of migration concerns, but that proposal never has been promulgated, and the FDA has stated that it Is considering withdrawal of the proposal and recommending to BATF the reauthorization of plastic liquor bottles In light of the current very low residual monomer levels In fabricated PVC articles.
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Other regulations have followed as new statutes and rules have cone Into play. The DOT and the Coast Guard regulate the transportation of VC, of course, and VC Is listed as a priority pollutant and hazardous waste under various water and solid waste rules, and has a reportable quantity of one pound under Superfund.
Did the existing laws operate satisfactorily at the time of discovery of the chronic hazards of VC? It appears that they did. A leading medical authority who was deeply Involved In the worker health evaluation In 1974 has termed VC a "success story". Reevaluation of the risk to employees under the 1 ppm standard by a conservative nonthreshold extrapolation method(14) yields a lifetime estimate of less than 10'*, a risk level which Is not thought to be of concern. The comparable risk estimate for the general populace Is several orders of magnitude lower. ERA has stated on several occasions that It believes that vinyl chloride Is regulated adequately.
Risk assessment has been a popular avocation among those Interested In VC, and more thah a dozen have been performed(15). These can be divided generally Into two classes: those which rely solely on animal data; and those which attempt to Incorporate the human experience.
Those In the first class yield similar results, and show the normal spread of estimates from the various mathematical models In common use. These range from 1500 to 10"* ppb for a lifetime risk of 10'*, or 8 orders of magnitude. It Is necessary to eliminate the high dose data points, that Is. those over 2,500 ppm from the Maltonf data(16) In order to get reasonable fits to most models, because these doses show broad systemic toxicity. The lower doses, 500 ppm and below, as a group fall Into a general pattern on a log-problt plot, but Individual 2 or 3 dose experiments show tremendous differences In slope when plotted separately. The popular multi hit model predicts a life time risk of 10"* at fractional ppb levels.
The human factor was accounted for In two ways. The EPA used some preliminary employee epidemiological data to confirm Its animal-based extrapolation^). Unfortunately, the human data were selected from those locations known to have ASL cases, while other facility data were omitted. They also were In error on the past exposures by more than an order of magnitude. This resulted In an estimate of 20 cases per year from the estimated 1974 ambient concentrations for the population within 5 miles of production and processing facilities.
The EPA seldom bothers to check its estimates against available data, so it sometimes comes up with results such as that made for arsenic a few years ago that would have predicted 18 million cases of skin cancer a year in this country If it had been applied to Agency data on the average arsenic concentrations In drinking water. Similarly, a survey of all known ASL cases in this country for the 10 years before 1974 showed no cases associated with residency near such plants(18), rather than the 200 predicted cases. It Is reasonable to assume that If any cases had developed since that time the publicity associated with It would have brought them to light. Thus we have 110 million-person years of negative history for near-by residents. This places a. upper limit on risk of less than 10~7 per ppm-yr.
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Two studies applied pharmacokinetics in an attempt to obtain relevant human data. Gehrig and coworkers estimated a lifetime risk of 10'* at 1 ppm from the probit model, based on a biotransformation of rat data. The unconstrained linear model predicted no risk at less than 99 ppm<14).
Anderson, Hoel and Kaplan carried this procedure one step further, and applied It to bound metabolic products, rather than to the total amount metabolized. Their results gave a lifetime risk of 10"T at less than 1 ppm, with the probit model, or at less than 2 ppm with the linearized multistep model<19).
Thus we see that risk Is In the eye of the estimator, but it Is clear that estimates Incorporating human data reflect the human experience for VC far better than do the direct application of animal data.
There was understandable uncertainty on the part of both the regulators and Industry in 1974. This was the first commodity chemical to be regulated under the relatively new statutory situation as the result of new information. Nevertheless both the regulatory agencies and Industry acted promptly to reduce exposures and emissions to an acceptable level.
The current count of occupational ASL cases Is about 100 worldwide, with 30 of these in this country(20). All of these cases had their first exposure In 1964 or earlier, and there appears to be room for optimism that the steps taken In the mid-sixties because of the AOt Information will have prevented any significant number of cases developing from exposures commencing after that date. Certainly It Is reasonable to expect that there have been no new cases initiated after the early seventies.
Had TSCA been In place In the mid-sixties, would it have made any difference In the course of events? It appears unlikely that it would. Certainly the AOL discovery would have resulted In a series of 8(e) notices to TSCA. The probable outcome of that would have been either a recoamwndatlon from ITC for more tests, or a Sec. 4 testing requirement. It is possible that, because of Its commercial Importance, VC could have been placed on the ITC list before the AOL data became available. Additional data could have been called for under secs. 8(a) and (d). The result of all this most likely would have been a negotiated testing rule, under which industry would have Initiated a series of studies which would have culminated In a bioassay, and the carcinogenicity of VC would have been discovered In due time. Yet, this is precisely what did happen In the absence of TSCA, except that the preliminaries were omitted, and the bioassay was performed concurrently with the screening tests. Thus it Is possible that the final critical data were obtained earlier than would have occurred under present conditions.
Bear In mind that most of today's powerful testing methods were not available twenty years ago. That fact would not have been changed by legislative flat, and any decision made at that time had to be made In light of the available knowledge.
If the data of Viola suddenly became available today instead, would there be any significant difference in the outcome, or the timing of that outcome? Probably so, but only because of the vastly more powerful scientific tools which we have available to us now. Neither the speed of agency motion nor the
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rate at which Industrial facilities can be built or modified has Increased* If anything, the latter has slowed, given the multiplicity of permits and approvals now required. Overall, it Is possible that If today we knew nothing more about VC than was known In 1970, we would arrive at a regulated state a few months earlier than was achieved In 1974, but scientific progress, and not legislative or regulatory advancement, should get the credit.
Hhat If VC were to become a new product today? Hould It run the same course In which It would be 40 years before there was full recognition of Its chronic potential? Certainly not. Again, however, the reason Is due more largely to scientific progress rather than statutory development.
One change might be apparent. If VC were the subject of a PMN today, rather than being the model to which all other aliphatic olefins are compared for structure-activity analysis, it would be judged by the others In Its family. This comparison would be less dogmatic than the reverse now is. Ethylene and vlnylldene chloride are not animal carcinogens; the relevance to humans of the carcinogenicity of high doses of TCE Is equivocal and controversial; and vinyl acetate has only a preliminary "non-negative" report. Thus this class of substances would have lost Its leader for structure activity comparison, and a decision as to the need for further testing from that analysis would not be clear-cut, based on analogous compounds.
Neither would a full NPD set be of great assistance. VC responds poorly.to the classical In-vitro tests, and only recently has It become possible to obtain reproducible positive results in many of these. If the position were taken that any positive result triggers further testing, then we would be left exactly where we were in the late sixties, recognizing the need for a bioassay.
One other point should be considered before the requirements of Sec. 9 of TSCA to give primacy to existing statutes Is ignored. Section 2 of TSCA requires the consideration of economic factors in actions taken under TSCA, while the OSH Act and the Clean Air Act Section 112 do not. In fact, at the time that VC was being regulated, these two statutes were being interpreted as forbidding economic consideration. Had TSCA been the regulatory vehicle of 1974, It is unlikely that the final regulations could have been as strict as they actually became, because of this factor.
It is difficult to separate cleanly the compliance costs for the OSHA and EPA rules on VC because of the overlapping time periods. The best estimate for OSHA costs made by the Industry In a presentation to the Presidential Task Force on Regulatory Relief was something over $200 million of capital, with over $25 million per year of annual costs. The EPA has reported to Congress<21> that compliance with Its rule has cost about $100 million per year since 1978. Thus, about $900 million has been expended thus far. Various published costs per life saved have ranged from $4 to 200 million for the OSHA standard, depending on which exposure starting point was used. The more costly EPA standard appears not to have prevented any cases of ASL, based on epidemiology, and thus has an infinite cost(15). This suggests that the proponents of strong TSCA activity for existing chemicals should reconsider their position on Sec. 9 If their long term goal is more stringent regulations.
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There seems to be no sure method of preventing some surprises In toxicology. Improved surveillance and diagnostic methods assure that we will know more about chronic effects In the future than we do now. New substances simply cannot be subjected to full-scale testing before they show strong commercial promise. If there were no other reasons for this, the limitation on test facilities dictates that we direct our Immediate effort toward substances of major Import, and this is being done at capacity. It Is proper that we concentrate our efforts on present exposures. Fortunately, recent medical advances help us to recognize these surprises earlier, and to minimize their Impact.
Existing statutes, that is, non-TSCA derived regulations, appear to be able to regulate existing substances adequately. The history of vinyl chloride bears this out. The principal value of the TSCA derived activities seems to be In the gathering of surveillance data on these substances to assure that the relevant data are made available to the proper agencies, and In future oversight of new substances as they develop Into commercial Items.
The reexamination of the hazards of all existing chemicals Is an overwhelming task for which ERA has no special expertlse(22). Just the establishment of priorities for such a reexamination Is beyond the present capacity of the Agency<23). The Agency has recognized some of the problems which It faces, and the recent "TSCA Priorities and Progress, 1983" report discusses a much more sharply dellniated existing chemicals program. Even here, however, the division between TSCA and existing statutes Is not defined clearly. Further, the Agency appears to be entering the realm of risk management through Its Advisory and Chips series. One unfortunate result of this Is the generation of another tainted list of substances which becomes an invitation for pressure to regulate. The temptation to prepare these "little lists" for the executioners apparently Is too great to be res1sted(24), as Lester Lave pointed out recently.
We believe that EPA can best obey its statutory mandate by developing a more efficient system for establishing priorities, and by Implementing more effectively Its Section 9 procedures.
Prepared for presentation at the Chemical Manufacturers Association Seminar on Risk Management of Existing Chemicals, 9 December 1983, Washington, D.C.
0368C
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REFERENCES
1. H. F. von Oettigin, Public Health Service Publication No. 414, U. S. Department of Health, Education and Welfare, Washington, D.C., 1955.
2. T. R. Torkelson, F. Oyers, and V. K. Rowe, Anu Ind. Hyq. Assoc. J^, 22 354 (1961).
3. American Conference of Governmental and Industrial Hygienists, "Documentation of the Threshold Limit Value, 1963".
4. S. Suctu, J. Drejman, and M. Valaskai, Med. Intern., 21 967 (1963).
5. 8. 0. Dtman, et. al., Arch. Environ. Health 22 61 (1971).
6. W. A. cook, et. al., ibid 22 74 (1971).
7. P. L. Viola, Hedlclna del Lavoro 6i 174 (1970).
8. A. H. Barnes, Chem. Eng. News p. 21, July 8 (1974).
9. J. L. Creech and M. N. Johnson, J^ Occup. Med., 1_6 150 (1974).
10. H. K. Lelbach and H. J. Marsteller in "Advance In Internal Medicine and Pediatrics", v. 47, Sprlnger-Verlag, New York, 1981.
11. R. Hefner. P. Hatanabe. and P. Gehrinq. Tox. AddI. Pharmacal., 34 529 (1975).
12. OSHA Standard for Vinyl Chloride, 29CFR1910.1017.
13. EPA Standard for Vinyl Chloride, 40CFR61.60.
14. P. J. Gehrlng, P. G. Hatanabe, and C. N. Park, Tox. Appl. Pharmacol.. 49 15 (1979).
15. J. T. Barr, "Risk Assessment for Vinyl Chloride in Perspective", Paper 82-9.2. 75th Annual Meeting of the Air Pollution Control Assn., New Orleans, LA, Line 20-25, 1982.
16. C. Maltoni, et. al., "Vinyl Chloride Carcinogenicity Bioassays (BT Project)", presented at "Le Club de Cancerogenese Chemique", Institute Curie, Paris Nov. 10, 1979.
17. A. M. Kusmack and R. E. McGoughy "Quantitative Risk Assessment for community Exposure to Vinyl Chloride", U.S. EPA, Washington, Dec. 5, 1975.
18. H. Popper, et. al., AnL Pathol. 92 349 (1978).
19. M. W. Anderson, D. G. Hoel, and N. L. Kaplan. Tox. Appl. Pharmacol.. 55 154 (1980).
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REFERENCES (Continued) 20. J. Stafford, personal connunlcation. 21. Environmental Protection Agency "The Cost of Clean Air and Clean Hater". Annual Report to Congress. Dec. 1979. Senate Document 96-38. 22. National Research Council. "Regulating Pesticides". Environmental Studies Board. Committee on National Resources. 1980. Washington. D.C. 23. J. T. Barr. Toxic Sub. 4 290 (1983). 24. L. Lave. "The High Cost of Regulating Low Risks"; Hall Street J.. August 19, 1983.
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Chemical Fact Sheet*
ffto VINYL CHLORIDE
- Pit
November 1981
The Information In this sheet applies to workplace exposure resulting from processing, manufacturing, storing or handling and Is not designed for the population at large. Any generalization beyond occupational exposures should not be made. The best Industrial hygiene practice Is to maintain concentration's of all chemicals at levels as low as is practical.
Chemical Names: Chloroethylene.chloroethene, ethylene monochloride, monochloroethene, monochloroethylene; CAS 75-01-4.
Trade Names: VC, VCM, Trovldur, and others.
Uses: In the manufacture of plastics, as a refrigerant^ and in organic synthesis
PHYSICAL IMFORHATftOH..*
Appearance: Colorless gas; may be liquified by refrigeration or
Odor: Faint, sweet, ether-like.
Minimum tfete&ifeVe by fldefe.
Behavior in Hater: Slightly soluble.
Evaporation: Rapid
't<3
HEALTH HAZARD INFOWHIM
OSHA Standard: Average 8 hour exposure -- 1 ppm.
NIOSH Recownended limit: None detectable by rec ACGIH Recownended Limit: Average 8 hour expOSgjhi'/-^.5
Short Term Exposure:
i
Inhalation: Exposure at iU0b6lpli. for & minuted
intoxication, tiredness, drowsiness, abdominal in fingers and toes, pains InjOints, coughing, loss of appetite and we1g^;^>!
Skin: Contact
cause
cause irritation and fi$h. absorption Is pose:
Eyes: Can cause severe and immediate 1rrJ||J|
Ingestion: None found, '
Long Term Exposure:
May cause club-like swelling and shortening of become thickened and stiff with co*r; whi
joints of arms and legs may suffer dam$e^ L occur. Not all symptoms disappear after
Vinyl chloride has caused liver cancer In tifecu
Prepared by the Bureau of Toxic Substance Assessment (For an explanation of the terms and abbreviations is Toxic" available from the New York State epartme
Vinyl chloride
EMERGENCY AND FIRST AID INSTRUCTIONS
Inhalation: Move victim to fresh air, Give artificial respiration or oxygen as required. Seek medical attention.
Skin: Remove soaked clothing. Wash affected area with soap and water for at least 5 minutes, Seek medical attention If necessary.
Eyes: Wash with running water for at least 15 minutes. Seek medical attention.
Ingestion: Seek immediate medical attention.
FIRE AMD EXPLOSION INFORMATION General: Flammable. Fumes may travel long distances and flash back. Ignites at -108F <-78C).
Explosive limits: Upper -- 33%, Lower -- 3%.
Extinguisher: Stop flow of gas. Use water to keep fire exposed containers cool.
REACTIVITY
Cond1t1ons to Avold: High temperatures may cause breakdown to phosgene and hydrochleedc
of Ignition.
J
Materials to Avoid: Long contact with air may result in formation of unstable peroxides which are Corrosive to Iron at high temperatures In the presence of wetar,.
PROTECTIVE MEASURES
Storage and Handling: Protect against physical damage. Outside or storeTrTa cool. dry. well ventilated area away from sources pf
Englneerlnq Controls: Provide ventilation or process enclosures, should be readlly available.
Protective Clothing (Should not be substituted for proper handlInq and impervious clothing should be worn if contactwith vlnyi
Protective Equipment: For levels up to 10 ppm use a combination Ty* with auxiliary self-contained air supply and half faceplaca. demand type, with half facepiece, or a chemical cartridge providing a service life of at least 1 hour at 10 ppm. For ._ purifying respirator with hood, helne^ full or half facepiece, life at 25 ppm, or a gas mask with cNgst dr back mounted can' levels up to 100 ppm, use a Type 6 suppTNid-tlr respirator wttb facepiece, or open-circuit self-contalnedbreathlng apparatus up to 1,000 ppm, use a combination Type C supplled-alr resplra half facepiece and auxiliary self-contained air supply, or Type half facepiece, helmet or hood In continuous flow mode. For 1 Type C supplled-alr respirator, dttmnd tfh*, with full or half air supply. At unknown levels or above b,SOO pom use an open apparatus, pressure demand type, with fuii facepiece.
PROCEDURES FOR SPILLS AND L
Get all workers out of the spill area. Put on respirator and other latlon to keep levels below explosive limit. Remove possible sources to safe place in open air. For final disposal contact your regional of Environmental Conservation.
For more information:
.*
Contact the Industrial Hygienist or Safety Officer at your
of Health, Bureau of Toxic Substance Assessmuat, Empire Sia
Albany, New York 12237.
SC 520-8Q
Vinyl Chloride Monomer
Safety Notice
Shell Chemical Company
A Division of Shell Oil Company Houston Texas
For 24 hour emergency assistance only, call SHELL 713-473-9461 or CHEMTREC 800-424-9300
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Safety Notice - Vinyl Chloride Monomer
DANGER: VINYL CHLORIDE MONOMER IS A TOXIC, EXTREMELY FLAMMABLE liquefied compressed gas. Skin contact with the liquid can cause frostbite. Exposure to very high concentrations of the gas may cause asphyxiation, persistent irregular heart beat, narcosis, nausea or dizziness. Long-term exposure may cause permanent liver injury and cancer.
DANGER: VINYL CHLORIDE MONOMER IS A CANCER CAUSING AGENT (ACGIH). Long-term exposure to vinyl chloride vapor has caused cancer, including a rare form of liver cancer in animals. Some production workers exposed for many years to much higher concentrations of vinyl chloride monomer vapor than encountered in plants operat ing today have developed the same type of liver cancer. In addition, there are reports that vinyl chloride monomer may cause cancer at other sites as well. Degeneration of the ends
of the fingerbones has also been observed in some workers after prolonged exposure to high concentrations of vinyl chloride monomer.
Access to areas in which vinyl chloride monomer is manufactured, stored, handled or used must be restricted to authorized personnel.
Vinyl chloride monomer is flammable and highly reactive. It can be explosive under certain conditions.
The following guidelines must be observed when working with vinyl chloride monomer:
Poison
Do not breathe vapor. Avoid liquid contact.
YOU MUST HAVE GOOD VENTILATION WHEN WORKING WITH VINYL CHLORIDE MONOMER. Exposure to very high concentrations of vinyl chloride mono mer gas may cause asphyxiation, persistent irregular heartbeat, narcosis, nausea or dizziness. Long-term exposure may cause permanent liver injury and cancer.
The Occupational Safety and Health Administration (OSHA) regulations (21 CFR 1910.1017)do not permit employee exposure to concentrations exceeding 1 part per million (1 ppm) averaged over an 8-hour work-shift or exposure to concentrations exceed ing 5 ppm averaged over a fifteen minute period. These low concentrations are not detectable by smell. Workplace air monitoring is therefore required to ensure that concen trations are below the permissible level. If concentration exceeds the Action Level (See personal hygiene section), immediate steps must be taken to reduce concentration and avoid exposure. Leave the area immediately. Notify your supervisor at once.
NIOSH approved respiratory equipment must be available for immediate use when it is necessary to work in areas where the vinyl chloride monomer concentration may exceed the permissible exposure limit.
The Occupational Safety and Health Administration (OSHA) regulations (21 CFR 1910.1017) do not permit any employee to be exposed to direct contact with liquid vinyl chloride monomer.
Do not smoke, eat, drink or store food or beverages in the immediate area where vinyl chloride monomer is handled, processed or stored.
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Containers
Hazardous when emptied
Air should never be allowed to enter a vinyl chloride monomer container. Always leave at least 10 psig of vinyl chloride monomer vapor pressure in an empty container.
Empty containers which contain residual vinyl chloride monomer vapor are dan gerous. All safety precautions given for full containers must be observed for empty containers.
Containers for vinyl chloride monomer are dedicated. They should not be used for any other service unless they have been decontaminated under conditions approved by a safety engineer or other qualified person familiar with the hazards involved.
Practice good personal hygiene
Do not eat or smoke in the immediate area where vinyl chloride monomer is handled, processed or stored. Wash your hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities.
REMEMBER
Exposure to very high concentrations of vinyl chloride monomer may cause uncon sciousness or death. Long-term exposure may cause permanent liver injury and cancer.
Notify your supervisor and get medical attention at once if you have been exposed to vapor concentrations exceeding the OSHA limit (See PEL beiow) or if skin contact has occurred. PEL (OSHA) 1 ppm (8 hour period); 5 ppm (15 minute period). Action level (OSHA) 0.5 ppm (8 hour period). When monitoring indicates employee exposure in excess of the action level, a program of individual employee monitoring in accordance with 29 CFR 1910.1017 must be initiated.
If you have any questions about vinyl chloride monomer, ask your supervisor before transporting or working with it.
t
In case of accident or exposure, notify your supervisor immediately
In Case of Fire
Evacuate the area.
All unauthorized personnel should be kept at a distance of at least 2000 feet from fire area, due to the danger of exploding vessels (BLEVE'S). In addition, downwind areas should be evacuated if there is danger of exposure to toxic combustion gases or vinyl chloride monomer above the action level. (See personal hygiene section.)
Allow only authorized and properly protected personnel into the area. Personnel must be trained for fire fighting and wear full protective clothing and self-contained breath ing apparatus when entering the fire area. The combustion products are irritating, harmful and potentially lethal at high concentrations.
Use water spray or fog, foam, C02 or dry chemical extinguishing media on small fires. No entirely satisfactory extinguishing media is known for large fires. If possible, and without personal risk, shut off source of supply. If source is not closed off, do not attempt to extinguish a large fire, as vinyl chloride monomer vapor can be reignited by hot metal. Cool nearby storage containers with water spray or fog to keep fire from spreading if this can be done without danger to personnel, and let fire burn itself out.
In Case of Spills or Leaks
Evacuate the area.
Eliminate all sources of ignition (heat, sparks and flames of any son). No smoking. Only authorized personnel with full protective clothing and self-contained breathing apparatus should be allowed in the area. If possible, and without danger to personnel, shut off the source of supply. When vinyl chloride monomer vapor concentrations reach the flammable limits, entry into the area should be made only for purposes of rescue. Downwind areas may have to be evacuated if concentrations exceed the action level. (See persona! hygiene section.) Dike and contain the spill. Allow to evaporate. Notify fire department. Disperse vapor cloud with high sustained flow of water spray or fog. Vinyl chloride monomer vapors are heavier than air and can travel long distances along the ground to an Ignition source. They may also concentrate in low areas unless dispersed. Be prepared for fire. Keep out of sewers due to danger of explosion. Keep out of water systems. Notify authorities if this happens or is threatened. EPA and Coast Guard number for spill notifica tion is 800-424-8802.
For 24 hour emergency assistance only, call
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SHELL 713-473-9461 or CHEMTREC 800-424-9300
In Case of Exposure
Get medical attention at once.
If someone is overcome, remove to fresh air at once. If not breathing, administer artificial respiration. If respiration is difficult, administer oxygen.
In case of liquid contact, remove contaminated clothing and shoes immediately. If vinyl chloride monomer gets on skin, wash immediately with soap and water; thaw frosted parts of the body with water at body temperature or slightly above; flush eyes with clean, low pressure water for at least fifteen minutes.
Flammable
Eliminate all sources of ignition.
Keep away from heat, sparks, and flames of any sort. No smoking. Vinyl chloride monomer has a flash point of -108F (TOC). It forms flammable mixtures with air at concentrations between 3.6 and 33 volume percent. Vapors are heavier than air and may travel long distances along the ground to an ignition source. They may also concentrate in low areas unless dispersed by wind or water spray. When transferring vinyl chloride monomer, the entire transfer system must be electri cally grounded. On burning, highly irritating and toxic hydrogen chloride is formed. If combustion is incomplete, highly toxic carbon monoxide and phosgene may also form.
Reactive
Prevent contamination and contact with polymerization initiators
VEV-200530
Hazardous, exothermic polymerization of vinyl chloride monomer may occur on exposure to heat, oxidizing agents, oxygen, air, sunlight, and other polymerization cata
lysts. Contact with aluminum, copper, metal alkyls and alkali metals, such as sodium, potassium, and their alloys, must be avoided.
On exposure to air, shock sensitive peroxides can form. On decomposition, these may initiate explosive polymerization of the bulk vinyl chloride monomer.
Vinyl Chloride Monomer
CH2 = CH - Cl
Typical properties
Flash point (Tag Open Cup)
Flammable limits in air, %V Lower Upper
-108 F
3.6 33
Vapor pressure
2580
Specific gravity
0.91
Vapor density Solubility in water, %W
2.15 0.25
mm Hg @ 68 F 20/20 C (Air = 1) @ 20 C
Shell Chemical Company
If you have any questions on the use of vinyl chloride monomer and would like further information, call us at the sales offices listed below. Do not use emergency number except for emergencies.
Chemical Sales Offices
Anaheim, California 92903 511 N. Brookhurst PO Box 4648 Phone (714) 991-9200 (213)589-6661
Si. Ann, Missouri 63074 500 Northwest Plaza Phone (314) 291-5700
Atlanta, Georgia 30339 320 Interstate North Parkway (404) 955-4600
San Ramon, California 94583 2401 Crow Canyon Rd. P O. Box 241 Phone (415) 820-7004
Cleveland, Ohio 44130 7123 Pearl Rd. Phone (216) 642-4000
Stamford, Connecticut 06904 600 Summer Street Phone (203) 327-3600
VEV-200531
Houston, Texas 77019 2001 Kirby Drive Phone (713)526-4631
Waal Orange, New Jersey 07052 100 Executive Drive P.O. Box 600 Phone (201)325-5200
Oak Brook, Illinois 60521 1415 West 22nd St.
Phone (312) 887-5500
SC 520-80
A
Vinyl Chloride Monomer
Safety Notice
Shell Chemical Company
A Division of Shell Oil Company Houston Texas
gE^-200532
For 24 hour emergency assistance only, call SHELL 713-473-9461 or CHEMTREC 800-424-9300
Safety Notice - Vinyl Chloride Monomer
DANGER: VINYL CHLORIDE MONOMER IS A TOXIC, EXTREMELY FLAMMABLE liquefied compressed gas. Skin contact with the liquid can cause frostbite. Exposure to very high concentrations of the gas may cause asphyxiation, persistent irregular heart beat, narcosis, nausea or dizziness. Long-term exposure may cause permanent liver injury and cancer.
DANGER: VINYL CHLORIDE MONOMER IS A CANCER CAUSING AGENT (ACGIH). Long-term exposure to vinyl chloride vapor has caused cancer, including a rare form of liver cancer in animals. Some production workers exposed for many years to much higher concentrations of vinyl chloride monomer vapor than encountered in plants operat ing today have developed the same type of liver cancer. In addition, there are reports that vinyl chloride monomer may cause cancer at other sites as well. Degeneration of the ends of the fingerbones has also been observed in some workers after prolonged exposure to high concentrations of vinyl chloride monomer.
Access to areas in which vinyl chioriae monomer is manufactured, stored, handled or used must be restricted to authorized personnel.
Vinyl chloride monomer is flammable and highly reactive. It can be explosive under certain conditions.
The following guidelines must be observed when working with vinyl chloride monomer:
Poison
Do not breathe vapor. Avoid liquid contact.
YOU MUST HAVE GOOD VENTILATION WHEN WORKING WITH VINYL CHLORIDE MONOMER. Exposure to very high concentrations of vinyl chloride mono mer gas may cause asphyxiation, persistent irregular heartbeat, narcosis, nausea or dizziness. Long-term exposure may cause permanent liver injury and cancer.
The Occupational Safety and Health Administration (OSHA) regulations (21 CFR 1910.1017)do not permit employee exposure to concentrations exceeding 1 part per million (1 ppm) averaged over an 8-hour work-shift or exposure to concentrations exceed ing 5 ppm averaged over a fifteen minute period. These low concentrations are not detectable by smell. Workplace air monitoring is therefore required to ensure that concen trations are below the permissible level. If concentration exceeds the Action Level (See personal hygiene section), immediate steps must be taken to reduce concentration and avoid exposure. Leave the area immediately. Notify your supervisor at once.
NIOSH approved respiratory equipment must be available for immediate use when it is necessary to work in areas where the vinyl chloride monomer concentration may exceed the permissible exposure limit.
The Occupational Safety and Health Administration (OSHA) regulations (21 CFR 1910.1017) do not permit any employee to be exposed to direct contact with liquid vinyl chloride monomer.
Do not smoke, eat, drink or store food or beverages in the immediate area where vinyl chloride monomer is handled, processed or stored.
UEU-200533
Containers
Hazardous when emptied
Air should never be allowed to enter a vinyl chloride monomer container. Always leave at least 10 psig of vinyl chloride monomer vapor pressure in an empty container.
Empty containers which contain residual vinyl chloride monomer vapor are dan gerous. All safety precautions given for full containers must be observed for empty containers.
Containers for vinyl chloride monomer are dedicated. They should not be used for any other service unless they have been decontaminated under conditions approved by a safety engineer or other qualified person familiar with the hazards involved.
Practice good personal hygiene
Do not eat or smoke in the immediate area where vinyl chloride monomer is handled, processed or stored. Wash your hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities.
REMEMBER
Exposure to very high concentrations of vinyl chloride monomer may cause uncon sciousness or death. Long-term exposure may cause permanent liver injury and cancer.
Notify your supervisor and get medical attention at once if you have been exposed to vapor concentrations exceeding the OSHA limit (See PEL below) or if skin contact has occurred. PEL (OSHA) 1 ppm (8 hour period); 5 ppm (15 minute period). Action level (OSHA) 0.5 ppm (8 hour period). When monitoring indicates employee exposure in excess of the action level, a program of individual employee monitoring in accordance with 29 CFR 1910.1017 must be initiated.
If you have any questions about vinyl chloride monomer, ask your supervisor before transporting or working with it.
yEJ-200534
In case of accident or exposure, notify your supervisor immediately
InCase of Fire
Evacuate the area.
All unauthorized personnel should be kept at a distance of at least 2000 feet from fire area, due to the danger of exploding vessels (BLEVE'S). In addition, downwind areas should be evacuated if there is danger of exposure to toxic combustion gases or vinyl chloride monomer above the action level. (See personal hygiene section.)
Allow only authorized and properly protected personnel into the area. Personnel must be trained for fire fighting and wear full protective clothing and self-contained breath ing apparatus when entering the fire area. The combustion products are irritating, harmful and potentially lethal at high concentrations.
Use water spray or fog, foam, CO? or dry chemical extinguishing media on small fires. No entirely satisfactory extinguishing media is known for large fires. If possible, and without personal risk, shut off source of supply. If source is not closed off, do not attempt to extinguish a large fire, as vinyl chloride monomer vapor can be reignited by hot metal. Cool nearby storage containers with water spray or fog to keep fire from spreading if this can be done without danger to personnel, and let fire burn itself out.
In Case of Spills or Leaks
Evacuate the area.
Eliminate all sources of ignition (heat, sparks and flames of any sort). No smoking. Only authorized personnel with full protective clothing and self-contained breathing apparatus should be allowed in the area. If possible, and without danger to personnel, shut off the source of supply. When vinyl chloride monomer vapor concentrations reach the flammable limits, entry into the area should ha made only for purposes of rescue. Downwind areas may have to be evacuated if concentrations exceed the action level. (See personal hygiene section.) Dike and contain the spill. Allow to evaporate. Notify fire department. Disperse vapor cloud with high sustained flow of water spray or fog. Vinyl chloride monomer vapors are heavier than air and can travel long distances along the ground to an ignition source. They may also concentrate in low areas unless dispersed. Be prepared for fire. Keep out of sewers due to danger of explosion. Keep out of water systems. Notify authorities if this happens or is threatened. EPAand Coast Guard number for spill notifica tion is 800-424-8802.
VEV-2Q0535
For 24 hour emergency assistance only, call SHELL 713-473-9461 or CHEMTREC 800-424-9300
In Case of Exposure
Get medical attention at once.
If someone is overcome, remove to fresh air at once. If not breathing, administer artificial respiration. If respiration is difficult, administer oxygen.
In case of liquid contact, remove contaminated clothing and shoes immediately. If vinyl chloride monomer gets on skin, wash immediately with soap and water; thaw frosted parts of the body with water at body temperature or slightly above; flush eyes with clean, low pressure water for at least fifteen minutes.
Flammable
Eliminate all sources of ignition.
Keep away from heat, sparks, and flames of any sort. No smoking. Vinyl chloride monomer has a flash point of -108F (TOC). It forms flammable mixtures with air at concentrations between 3.6 and 33 volume percent. Vapors are heavier than air and may travel long distances along the ground to an ignition source. They may also concentrate in low areas unless dispersed by wind or water spray. When transferring vinyl chloride monomer, the entire transfer system must be electri cally grounded. On burning, highly irritating and toxic hydrogen chloride is formed. If combustion is incomplete, highly toxic carbon monoxide and phosgene may also form.
Reactive
Prevent contamination and contact with polymerization initiators
Hazardous, exothermic polymerization of vinyl chloride monomer may occur on exposure to heat, oxidizing agents, oxygen, air, sunlight, and other polymerization cata lysts. Contact with aluminum, copper, metal alkyls and alkali metals, such as sodium, potassium, and their alloys, must be avoided.
On exposure to air, shock sensitive peroxides can form. On decomposition, these may initiate explosive polymerization of the bulk vinyl chloride monomer.
VEV-200536
Vinyl Chloride Monomer
ch2 = CH - Cl
Typical properties
Flash point (Tag Open Cup)
Flammable limits in air, %V Lower Upper
-108 F
3.6 33
Vapor pressure
2580
Specific gravity
0.91
Vapor density Solubility in water, %W
2.15 0.25
mm Hg @ 68 F 20/20 C (Air = 1) fa 20 C
Shell Chemical Company
If you have any questions on the use of vinyl chloride monomer and would like further information, call us at the sales offices listed below. Do not use emergency number except for emergencies.
Chemical Sales Offices
Anaheim, California 92803 511 N. Brookhurst P.O. Box 4848 Phone (714) 991-9200 (213) 589-6661
St. Ann, Miasourl 63074 500 Northwest Plaza Phone (314)291-5700
Atlanta, Oaorgla 30339 320 Interstate North Parkway (404) 955-4600
San Ramon, California 94583 2401 Crow Canyon Rd. P.O Box 241 Phone (415) 820-7004
Cleveland, Ohio 44130 7123 Pearl Rd. Phone (216) 842-4000
Stamford, Connecticut 06904 600 Summer Street Phone (203) 327-3600
Houston, Texas 77019 2001 Kirby Drive Phone (713) 526-4631
West Orange, New Jersey 07052 100 Executive Drive P.O. Box 600 Phone (201)325-5200
Oak Brook, Illinois 80521 1415 West 22nd St. Phone (312)887-5500
VEM-200537
VEV-200539
--626 VINYL CHLORIDE/ANGIO REG. 1987 ----- ;
^mmd
CONFIDENTIAL
World Register of Cases of
ANGIOSARCOMA OF THE LIVER (ASL)
due to VCM
REVIEW DATE
1st JANUARY 1990 *********
Collated by:
Dr Brian Bennett
Occupational Health
ICI Chemicala and Polymers Ltd
Hi1Ihouse Site
PO Box 4
Thornton-Cleveleys
(Telephone
Blackpool PY3 400
(Telex
England
(Fax
0S53 861638 ) 67483IC1PLH6)
0853 961861 1
VEV-200540
A
liver angiosarcoma cases
CIRCULATION OF REGISTER
CONFIDENTIAL
FEBRUARY 1990
BAGSHAW Dr I M M BAND Dr P R
BARRAT Dr G BAXTER Dr P BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTA2ZI Dr P
BERTUZZI M BEYNON D W S BISHOP Dr C BORRELLI F E BRAUN Dr C L J BROGDEN K E BROWN Dr M G BYREN Dr David CAMPION Dr Catherine CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard
DOHBROWSKI S L S DOORNBOS Dr N DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W
EVANS Dr A E J FALK Dr H
FARMERY Dr K FAVRE Dr FIELDING Miss C
Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vacouver, Canada AECRP, Conroentry, France University of Cambridge UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium ICI Runcorn, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands ICI Runcorn, UK Shell, An Den Haag, The Netherlands Nobel Industrier, Sundsvall, Sweden Health & Safety Executive, Bootle, UK EMAS, London, UK EVC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France EVC, Brussels, Belgium Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, UK Dow Chemical, Midland, Michigan, USA DSM, Beek, The Netherlands Vista Chemical, Houston, Texas, USA APKE, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centers for Disease Control, Atlanta, Georgia, USA ICI Hillhouse, UK Atochem, Montluel, France ICI Millbank, London, UK
VEV-200541
<4
2
fillinger j
FINCHAM Ms Shirley
Solvay, Brussels, Belgium Alberta Cancer Board, Edmonton, Canada
FOA Prof V
Inst Industrial Medicine, Milan, Italy
FORMAN Dr D
Imperial Cancer Research Fund, Oxford
University, UK
frase r w
DiversiTech General, Akron, Ohio, USA
FREIESLEBEN Dr W
ECVM, Brussels, Belgium
FRIEDEL Dr H P
Berufsgenossenschaft der Chemischen Industries,
Heidelberg, Germany
GAFFEY Dr W
Monsanto Co, St Louis, Missouri, USA
GIUDICE Dr S
Montedipe, Venice, Italy
i GOTTESMAN Dr R T
! GROISMAN D
The Vinyl Institute, Wayne, NJ, USA Electrochemical Industries, Acre, Israel
HILLMAN Dr D W
Diamond Shamrock Corp, Dallas, Texas, USA
HOWARD Dr J K
University of Otago School of Medicine,
Wellington, New Zealand
HOWE Dr W
ICI Runcorn, UK
HUMPHRY Dr N F
ICI Australia, Melbourne, Australia
JOHNSON Dr C A
Goodyear Tire and Rubber, Akron, Ohio, USA
JOHNSON Roy N
GenCorp, Fairlawn, Ohio, USA
KAIPERT Dr J H
Dow Chemical Europe, Horgen, Switzerland
KALNAS Dr J
Imperial Oil, Sarnia, Ontario, Canada
KLEIN Dr H
Dynamit Nobel, Troisdorf, Germany
LAGAST Dr H
Solvay, Brussels, Belgium
LANHAM Dr John
Dow Chemical, Midland, Michigan, USA
LANOUZIERE Dr Claudine
Solvay, Tavaux, France
LAWRENCE-JONES Sir C
Chief Medical Officer, ICI, London, UK
LEE Dr F I
Victoria Hospital, Blackpool, Lancs, UK
LEESER Dr Jenny
ICI Runcorn, UK
LELBACH Prof Dr WK
University of Bonn, West Germany
LEVEQUE Dr G
CDF Chimie, AZF, Bully-les-Mines, France
LEVISON Prof Dr D A
Guy's Hospital, London, UK
LEWIS Dr P
Chemical Industries Association, London, UK
LIGO Dr R N
Dupont, Wilmington, Delaware, USA
LO MARTIRE Prof N
EniChem, Milan, Italy
LUSS R D
Occidental Chemical, Pottstown, Pennsylvania,
USA
LUSSATO Dr Josette
Atochem, Port de Bouc, France
MALTONI Prof C
Institute di Oncologia, Bologna, Italy
MATTIUSSI Dr R
Montedison, Milan, Italy
MELTON B
Formosa Plastics, Delaware City, USA
MIDDLETON D
Hydro Polymers Ltd, Newton Aycliffe, UK
MCKKA Mr
Neste Oy, Espoo, Finland
MONTESANO Dr R
IARC, Lyon, France
MOTTI Dr A A
ICI Duperial, Buenos Aires, Argentina
MUNOZ MOUTON Dr M
Rio Rodano, Madrid, Spain
MacSWEEN Prof RNM
Western Infirmary, Glasgow, Scotland
NAKAMURA Dr S
Japanese PVC Association, Tokyo, Japan
OSMAN Dr J
Health & Safety Executive, Bootle, UK
PADDLE Dr G M
ICI Central Medical Group, Alderley Park, UK
VEV-200542
A
3-
PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J rAMBAUD Dr J RICHARD Dr A ROBSON Mrs D ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr TACHECI Dr H TAMBURRO Prof CH TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr Gilles THUS-EVENSEN Dr E THOMSON Dr D H
TOMATIS Dr L TONER H P
VAN DER MERWE Dr H J WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R
YORK J ZOBER Dr M A
Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimica, Salvador, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France University of California, Berkeley, USA Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada IARC, Lyon, France Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium BASF, Ludwigshafen, Germany
From:
Dr B Bennett, Occupational Health, ICI Chemicals & Polymers, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD England
UEU-200543
CONFIDENTIAL
A
register of cases of angiosarcoma of the liver due to exposure to vinyl chloride
- REVIEW DATE 1 JANUARY 1990
PREFACE : ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS
1 The 14 new cases in this Register are: France 26, 27, 28; Germany 33, 34, 35, 36, 37, 38, 39; Spain 01; UK17, US 42,43. The Spanish case is the first notified from that country.
2 The following 2 cases have been deleted from the Register: Germany 26 (Alcoholic Cirrhosis), US24 (Cholangiosarcoroa).
3 There are amendments from the previous Register against cases: France 22, 23, 24; Germany 31, 32; US33, 34.
4 I thank the following for information about new cases: Drs Lagast, Contassot, Friedel, Tenkhoff, Lee, Hamill and Mr Roy N Johnson. For information about other cases I thank Drs Dietz, Fendel, Smith and Williams.
5 So far as I know the following are still alive: France 15 and 28; US33 and 36. I am grateful for information on this subject in the past year, and urgently need to be kept up-to-date, please.
6 In Table 3 I have now treated a 'cluster' as 3 cases instead of 2, due to the passage of time and the increased number of cases in the world.
7 Tables 4E to 4H have been amended, as the number of cases per factory has altered.
8 A new Table 16 has been introduced showing the number of PVC factories in the world so far as known to me. Please keep me informed of any alterations in ownership, openings, re-openings or closures (see Tables 8 to 15).
9 The initials of case UK05 have been amended to RX (not JK). It will be
seen that certain cases have no initials against them. Can anyone please
help with this? Some of the countries concerned are Belgium,
Czechoslovakia, France, Sweden, the US and Yugoslavia.
'JEU-2GG544
10 CHOLANGIOSARCOMA As stated above I have deleted US24 which was a Cholangiosarcoma, not an Angiosarcoma. I have heard of another case of Cholangiosarcoma but the significance of these cases is not apparent in connection with VCM. I should be grateful if anyone who knows of any other case where the patient does develop Cholangiosarcoma with VCM exposure, would inform me about it.
11 RESEARCH Please keep me informed of all relevant research and if possible send roe copies of Reports. Would recipients of the Register please pass on this request.
12 Please also notify me of all changes relevant to the Register and especially new cases, for which a blank sheet is provided at the back of the Register.
FROM:
Dr Brian Bennett, Occupational Health, ICI Chemicals and Polymers Limited, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool,
T*vc
INDEX Table Sequence
Belgium
Canada
Czechoslovakia
France
Germany
Italy
Japan
Norway Spain
'
Sweden
UK
USA Yugoslavia
Incidence of Cases per annum (Table I)
Distribution of Cases
by Country
(Table 2)
Pattern of Cases by
Factory
(Table .1)
Latency Periods (Table 4A)
Distribution of Latency Periods (Tables 4B-4H)
Annua 1 Geograph ica 1 I nc iderice (Table 5)
yHW-200545
1.1 vi:i< ANGIOSARCOMA CASKS (KKVIKW OATK - JANUARY
1 1
91 1
\
2-1
4
1 ASL Cose Numbers by year of Death 1 (Table 6)
1 1 ASL Case Numbers by year of first exposure 1 (Table 7) 1
5-10 1 Western Europe PVC Producers - Start-up Dates vs ASL Cases
1 (Table 8)
11-18
1
1 USA PVC Producers - Start-up Dates vs ASL Cases
19-20
I |
(Table 9)
21 1 Canadian PVC Producers - Start-up Dates vs ASL. Cases
1 (Table 10)
22 1
1 East European PVC Producers - Start-up Dates vs ASL Cases
23 1 I
(Table 11)
24 1 Japanese PVC Producers - Start-up Dates vs ASL Cases
I (Table 12)
25-29
1
1 South & Central American PVC Producers - Start-up Dates
30-38
1 I
(Table 13)
39 1 Australasian PVC Producers - Start-up Dates 1 (Table 14)
40 1 1 Middle Eastern PVC Producers - Start-up Dates 1 (Table 15)
4I l I Number of PVC Factories in the World l (Table lb)
42 1 I 1 Blank form for notifying new cases
41 1
1
44-50
1
1 |
51 1 1
Page 52 53 54-55 56-57 58 59 60 61 62 63 64
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1r---------------- 1 2
country am> REFERENCE
NAME OR INITIALS
31 1 1
DATE OF
BIRTH
NO
4 COMPANY
CANADA
10 16.05.IS
11 Ui 13.10.25 Golf
12 K 14.09.20 Gulf
LIVER Anqioaercona Cases - (Review Hate: I Jan 1990)
pay - nmm> - year Mil <UIps uhp IK afslt
1--------------------
56
I
1_____________ ______________ 1
8
9 10 II 12 13
_____________1 ___________ (
1
14
FACTORY
FIRST VC EXPOSURE
DATE OF
AGE AT
YEANS OF
YEANS OF DATE OF HISTOLOGICAL ESTIMATED
DIAGNOSIS DIAGNOSIS EXPOSURE 10 EXPOSURE
DEATH
CONFIRMATION EXPOSURE OCCUPATION
DIAGNOSIS 1 ______________ 1 ________________ 1 ____________ I ___________ I
LEVEL 1I
15
OTHER CANCER HIGHLIGHTS
| 1 1 |
|
| 1 1 1 I
lb
OTHER CONORS
Shawinigan 1953
1976
61
23
14 00.04.77
Yes
Reactor
Furnace np. | Ex-anter
cleaner
Maintenance, {
packaging
|
1 1
Shawinigan
1943
i
Nov 85
60
42
______________ 1
5 05.04.86
Yes
1 ___________ 1
Hi^t
1943-47 Operator 6 Supervisor VC Plt
--------------------------- 1-----------------------------
1
Retired 1972 |Letters frcn
(Age 47}
|Dr Fernand
(Oeloree,
(Pathologist b
|N 6ibeau, BFG --------------------------- 11-----------------------------
Shawinigan 1945
Mar 82
61
37
Tl 31.03.82
Yes
High
1945-55
Retired 1972 (Letters frca
Autoclave
(Age 52)
|Dr Fernand
Operator.
(Delorme,
PVC Resina
(Pathologist A
|H Bibaau, BFG
Law 1955-65
1
VC 1
Manufacture
1
Untilib
1965-72 Aulurlave Operator, PVC Resins
1 1 1 1
--------------------------- 1-----------------------------
1 1
13 ss 10.06.26 BFG
Niagara
1957
1967
60
30
23 26.1.87 Yea 1957-70
Retired I960 |lnfiir**tion
ye 1 land
High A Operator (Age 54)
|fron
1970 60 Supervisor
(Dr H W Dietz, (BFG, 19BB
!!!!!!!
! !!
Law
!
1
1--------------------------- ----------------------------J
C
m
tooo
cn CD
p.p*
CZECHOSLOVAK i A
COUNTRY AMD REFERENCE NO
NAME OK INITIALS
DATE OF BIRTH
OWANY
I.IVFR AngiosarroM Cases - (Revive Dale: I Jan 911)
n is
FIRST VC EXPOSURE
DATE Of DIAGNOSIS
ACE AT DIAGNOSIS
YEARS Of EXPOSURE TO
DIAGNOSIS
YEARS Of EXPOSURE
DATE Of DEATH
HISTOLOGICAL COHfIRNATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER CONCRTS
1
f7.FCHOSI.Q-
mi*
01
45 162tt.06.28 State Co
Nuvaky
01.07.S7 24.12.73
16 24.12.73
Yes
Autoclave Cleaner
I ARC latter of 1-4-82 giving details frt Prof A David of Centre Ind Hygiene and Occ dir
(12 06.07.27 Slate Co NovaJry 01.II.SO 27.11.64
14
IS 26.11.64
Yes
Autoclave Cleaner
IARC letter of I-4-82 gave
vaewhat
altered dates for this case. I have accepted the changes since the dates olwb froa prof A David of the Cent re of Industrial Hygiene and Occupst ional Diseases, tty <Utes came originally froa NIOSH.
ormCoi c
o
jcsn.
'Cl
Jh
Page l-
LIVER Angioearcna Cw - (Review Date: 1 Jwi 10)
1------------ -------------------------
1
12
l1
T------------------- 1j------------------
COUNTRY AK> | KAHE OR | DATE OP lErauct j DflTIALS ( BIRTH
01 |H
1 t ? Il5.04.24
1
1
1
02 (SOI
l 1 1
(03.06.11
1
1
1
1
T-----------------4 16
1 1 i
COMPANY | FACTORY
1 J
1 ftp (Rouaa-
| 11Ion
1
1
PCUK
1 l I luriipoud
i
i
i
i
6 FIRST VC EXPOSURE 00.01.46
06.07.59
7 DATE OF 01RGMSIS 18.02.67
15.01.75
B AGE AT DIAGNOSIS
43
63
9 YEARS OF EXPOSURE TO DIAGNOSIS
21
16
10 n
YEARS OF EXPOSURE
DATE OP MATH
19 19.02.67
12 24.01.75
12
.
HISTOLOGICAL CONFDHITION
I
13 i 14 1
--------------------- -----------------------
ESTIMATED
|
EXPOSURE ( OCCUPATION j
LEVEL 1
|
1 1
Tas M* |Autoclav*
n----------------------------is | 16
OTHER CAREER
n----------------------------( OTHER
I UMNBITu
HIGHLIGHTS 1 11
(Ref. Ravlar at
(wrfcer and
|al Arch. Ml.
|cleaner
(Prof. 1 30 n'
(19 yra
(3 tov 75
Yea (HIOSH no
COMBOt )
Hi*
1 i 1 (2 yra ao |infer
|10 yra on
(Italian (origin
|p 171-177 1 "f-----------------------------
(Ref.
|G Boonetoo et jal "Muwvelle
(polyner-
jpreane
|iaatloo
|aadlcalan
5 Nov 1977
p 735
03 MV
06.01.20 HP
St Fana 00.00.46 15.01.75
55
29
29 29.06.76
High
(Pnlyworker: |10 Tra aa |autoclave (cleaner, (ffpmwftinq |1 yra
V(JI production Ref. Rely et
16 in.
1 Arch. Hal.
Italian POU. Prof. I 37 n'
Shefdntd,
6 June 7?
Surer, Hmoo p 551*655
04 WR
77.01.77 PCOK
frigioud 19.10.49 16.01.76
49
26
26 04.01.76
Tea
High I
(productloa
I writer
|e yra.
|PVC
(filtration
110 yra
PCI*05
29.01.30
RrIgnoud LO.OL.65 13.05.76
30
mC OTcOi oaconi
13.05.76
Tea
High
(Polfworfear
III Tra
1 )Tboreootny Ref. P Coudare 9th Feh 19/6 At a) "Sanalna
coatal
daa hoepltem
engineercna 10 5iapt a*re
2)Sctatlgr^hy 1976
found ASL
Previaualy had
3)Heenorrhage bamm
fran ASL
angtonarooM*
4)Rlght
ilao
Mepatectany
PillchowMi et
a! "La Houvelle
Preaaa Hadicale"
/th July 1979
page 2405.
>
/aw (>
UEU-200552
Page . FRANCE - Sheet J
LIVER Angltiaarivae Case* - (Review Date: I Jan 199(1)
country mo
REFERENCE NO
KANE OR INITIALS
DATE Of BIRTH
10 VP
24.05.19
CtWANY St Font
IS.02.12 HP
St Fans
FIRST VC EXPOSURE
DATE Or DIAGNOSIS
AGE AT DIAGNOSIS
YEARS Of EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE Of DEATH
HISTOLOGICAL CONFIRMTlON
ESTIMATED EXPOSURE
LEVEL
OTHER CAREER HIGHLIGHTS
OTHER OCMRIS
00.12.56 10.01.78
SO
21
10.01.78
Tea
Hi^i
(Aulocle* (cleaner
10 fra In
ectoanical engineer Lng
Industry
im-iTss
Died of pulamary
(Nulla S
di;i after
urgery
00.01.41 12.08.78
66
13.11.78
High
|miim
Ipolyiar-
|Isatloo (general Ipurpose
|worker. 11946-1972
|vot
(synthesis I(HC1 A
|Acetylene |
Ifonwfl
|(agent
|de net trie* 11972
retlred
16.08.14 PCUt
Brifpwud 09.02.49 00.OS. 79
65
27 23.06.79
Yea
High
Mmrmr (product l(m (and polfner
laatliai operator
19.01.31 Solvaf
Tavaux
23.09.63 26.06.79
40
13 22.08.79
Yes
(Autoclearer I? fra. |Aulo(operator |9 yrs. |Copol yimra |4 yra
2 fra a* cycle|Ctgar*tte
echanic.
|ianki r until
10 fra aa
(1974. Ill all
enaaellar in (of 1977 due to
unitary ware [Oeicphagaai
aaaufacture (vuioes.
{Surgical
| Intervent Ion l2S.0S.79 height
|hepatectoar)
HJ OS-04-24 ChUie Chiaie
(F..merlT RP)
1943
00.07.81
29.07.81
Very High {I94V19/5 [19/5-1979 194V1975 (All types nfjaalnw
and
| )nhs n
fuurk
Ini emit l - laanuicM'l urv
enl If
|i Ml<ileiianti>
19/5-19/9 | in VOt Poly
Ik.
t'S S O O S -A B A
Page 9
FRANCE Sheet 5
------------------- 1
2
-------------------------1 ------------------- 1 i
1
COUNTRY AMD NAME OR | DATE OF
REFERENCE
INITIALS
BIRTH
HO 1
-------------------------1 ------------------- 1
4 COUPAMT
FRANCE
19 HAZ IS.I2.J2 Atochee
LIVER Angiosarccee Cmm - (Review Dale: I Jan 19%)
1 --------------------- ---------------------- 1------------------------- 1------------------- 1 11
1 ---------------------------r 1
7a
9
J______________ 1 ______________ | ________________ I 1
10 11 12 13 1 ___________ 1__________________1______________ |
14
FIRST VC FACTORY | EXPOSURE
DATE OF 0IAGK6IS
AGE AT D1AGN06IS
YEARS OF EXPOSURE TO
YEARS OF EXPOSURE
DATE Of DEATH
HISTOLOGICAL continuation
ESTIMATED EXPOSURE | OCCUPATION
IS
OTHER CAREER
1 16 1 1 1 i OTHER
I cm--arm
j_1 n
DIAGNOSIS | 1
1
1 LEVEL
HIGHLIOfTS
U. .. jj J______________ i_______________ |
1
1 |Myocardial
11 11
| Autoclave Ioperator wd
infarct loo 1980.Coronary
Brlgnoud 07.04.S9 26.10.84
52
25
25 06.11.65
Yes
High
cleaner
|brpass 1981.
1 11
(Letter frost
1 11
Dr Cootasaot
5.4.86
20
H 02.03.23 Atochee Bri^Mud 1951 27.12.as
63
1
34
22 26.12.85
Yes
11
11
11
11
11
!1
1i
11
11
High
Portal
Autoclave
In other parta|fibroals (na
operator and of factory
26.04.74. Tbe
cleaner
since 1946
i1 loess was
jdlai^wewd as
Ipreswablf
(work related
on 20.04.74.
Letter fna
Dr Contassol
05.04.86
21
Pa Ok.10.40 R?
SEP
19S9
03.06.86
45
(Huntlucon
t
22
AL 13.08.28 Atochn St Auban 0I.O9.S8 OS.11.87
59
_____________I
23 DO 07.02.27 Atnchee St Fun* l 1
1944
1988
61
27
4 20.06.86
Yes
1
11
1I
11 1I
11
11
High
Autocleaner Maintenance
4 fears
worker
HepetIc teat Hey 84 iwm]. Hepatic test Nay 86 showed doonallllu. Isitter Ins Or Barret 18.07.86.
29
26 U8.09.6S
Yes
11
High 1958-70
12 rears Autoclave
letters Fire Dr Contas*>t,
11
worker.
Atochta
11
2.12.87,
1 1 U*. >4 iwb In 29 / 86.
1
1970-84 ("<m1rol Noon
24.Ul 89
--------------------------- 1
44
20 21.09.69
Yes
High
Autoclave
Partial
l
(leaner 6
iHepetwct'wy, Apr
11 11 11
| ||
.ill YVC
8ft, dmntherspy
|product ion
Inf(treat i<* trim
|nhs
|lJr .1 r (.nlisaot
____|jj|*i.-.-Tw. vmn/ti'*
J
pv to
francs
Sheet 6
LIVER Angknsarms Cases - (Review Oats: 1 Jwtuary 1990)
1 1 I S I6
12 13
16
cowmtv aw REFERENCE NO
NAME OR [ DATE Of f
INITIALS! BIRTH j
CTWAHY
l [FIRST VC I FACTORY (EXPOSURE
YEARS OF
DATE OP AGE IT
EXPOSURE YEARS OF
DIAOHSJS oiionsis TO
EXPOSURE
DIAGNOSIS
DATE OF DEATH
HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION
LEVEL
OTHER CAREER HIGHLIGHTS
OTHER ONWUffS
24
KA 08.12.26 Atochen
Brl^mud I 1443
1968
62
4S 36 01.12.66 Yu
High PVC Production
| j-2 riri |
Liver transplant Nay 1966.
Inforul Ion Ira Or J C Contasnol,
| JMCY Detect loo
I I' 1 T-*r. |
Atocbw, 1966/99
| |PVC Production
| jaaintenancej j I - lo Tears |
26 B6 02.03.30 Solvar
Tavau*
1962
1966
66
26
23 07.06.86 |
Yea 111 years)[Polycleaner|
II
Ii
1 High))- S fears j
| |Polyfloor |
j |- 6 yaars j
| 12 years!Coot rol Roan
I Low ) - 12 years|
Prknary Liver Twir (tetastasas lung, brain, booe, spleen,
k litany.
inforantion fro* Or H Lagast, Solvay, HuvnaAmr 1968
26
MG 29.11.40 Solvay
Tavaux
16.04.63 26.10.68
46
26
02.11.86 Yu
High 12 years Low 3 years
Autoclave Cleaner for lb years
Died by honor ragic nature of the ttsajur. No surgery. Letter fran Dr H Isgut, Solvay, 28.4.69.
27
| RC
1929 Alochw
St Fans j 1964
I960
69
34 30 00.01.69
1964-74 High 1974-64 Low
Autoclave Cleaner and all PVC product Ian )ohs
Notified by Dr Owitessot, Atocfau, DwnAiiir 1969
28
oor5oI
cu
JG
1926 lAtochu
St Foos
1942
I
I
I
I
1
1969
63
47 20 Alive Yu 20 years 10 years High arulysis (labs) 10 years product inn PVC
Notified by Dr Contaaaot, Hocbaa, Deis^wi 1999
rv* j i
GERMANY
I.IVKR Angiosarcoma Csm - (Review Date: 1 Jwi 1990)
Sheet 1
)2
country i REFERENCE
HUE OR mums
MU |
QttMfff
i------------------- 1 1
3
DATS Of Brirm
--------------------- 1 <
______________ 1
COMPANY
5 FACTORY
--------------------1 --------------------- 1 ----------------------1 ------------------------- 1 --------------------1 ------------------,--------------------------- ,--------------------- 1
618
*
10
U1
12
n
- 1 ______________ 1 ______________ _1------------------------- 1 _____________I
|1 I
|
FIRST YC
DATE OF
AGE AT
YEARS OF
YEARS OF DATE OF | HISTOLOGICAL ESTMATED
EXPOSURE oi Mans is DIAGNOSIS EXPOSURE TO EXPOSURE
DEATH | CONFIRMATION | EXPOSURE
DIAGNOSIS ____________ 1 ______________ 1 ______________ _ ________________ 1 _____________1
1 j
LEVEL _-_._________i___I
I i
14 15
OCCUPATION
OTHER CAREER HIGHLIGHTS
1---------------------------1 1
1
m
00.00.30
4
4 01.10.56 19.09.68
48
12 12 2S.0I.69 |Ye* (RUSH)
h>l|wriwr
16
OTHER CCWOTTS
02
00.00.41
4
------------------- 1------------------ 1 !
04 1
j00.00.30
12
1 I
1
1
1
1
1
1
i
1 1 1
1
1 1
4 14.10.57 2S.09.70
49
13
| ______________ 1 ________________ I
12 09.06.52 00.04.73
44
21
___________ 1
--1
04 |
1
1
1
1
1
1
1
1
C
mc
ro
O-- cn
|
1 ! *
i>.
00.00.40
8
6 16.04.57 26.11.74
44
l ___________ 1______________ 1
17
U 14.12.71 |Tas (NIOGN) 1 j ___________ 1 1 1
Polfworker
16 10.10.73 |Tes (KTOSH)
Filling
Reported tmter
1
pesticide (
non polgwnr-
1
aerosol cans|
isatIon
1
with VC
|
workers In
1 1 NI05M list of
1 1 31.4.77.
1 1 This of course
1 1 ! is strict If
1 1 1 correct.
l 1 |Howeer 1
I 1 wonder
1 1 whether this
1 1 laan tad high
1 1 exposure to
1 1 |VCM in his
1 1 ran filling
1 1 operat iun?
1 1
------------------------1 --r~-------------------------
11
17
25.11.74 (Yes (N10SH)
200-500 pfm Potpnrfcer 6 1958 was
(Clinical
1
but high
tNnrn
autoc leaner
details In
1
during 1 f sutocleaner for 1 jt
paper bf
(
eutoc leaner
1
|Gokel et al
1 1 Ylrchow* Arch
1 1 A Path 1976
1 1 472 p 195 204 1 11
1 11
1 J|
11
1 11 l 1 1__________________
^SS00e-h3A
Pgp I.
GERKANY Sheet 2
COUNTRY AMD NEFFSDICE NO
NMC ON INITIALS
DATE OF
birth
GERMANY
OS
00.00.36
(NIOSH give* as Caa# 06)
06
(NIOSH give* a* Cut 06)
07
00.00.32 00.00.26
08 00.00.1/
COMPANY
LIVER Angioserccua Cases - (Review Dale: I Jan 1940)
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
02.0460 10.12.73
16.12.6? 00.00.75 15.04.54 12.11.75
19.07.S4 06.04.76
AGE AT DIAGNOSIS
38
43 49
58
--------------------- t------------------r
1--------------------
9 1 >0 1 <i 1 12 ( 13 1 K
_| i -- _ i 1 1l
11 11
YEARS OF | YEARS OF 1 DATE OF | HIST0U1GICAL | ESTIMATED 1
EXPOSURE TO j EXPOSURE j DEATH j CONFIRMATION j EXPOSURE ( OCCUPATION
DIAGNOSIS 1 J
\1 11
( LEVEL 1 J _|_|
1 11 I 11
11 |
1------------------------IS 1 >6
_j1----------------------------
OTHER CAREEN HIGtfl.1 GIFTS
| OTHER
| ON--3WJ
1 1 1 (Confined
13 1 OS 116.12.74 \Us (NIOSH) 1
{BG Chnit
ll
1 |ar*
1 Ii
1 |"cJmi*try
1 Ii 1 tI
1 |labnrttori*o 1 jin the
1 li
1 (Techno-
1 lI
1 |logical
1 li
1 (Research
1 ii
1 (DepartaentM
1 li
i ({NIOSH says
1 iI
1 (assistant
1 ii
1 (factor}
1 Ii
1 |rbaaist
1 Ii
1 |uhich Hf be
1 il
1 | wrong
1 Ii
1 Ii
1 (translation) (1
1 ll
_l JL I 11
13
1 12 (09.01.75 f
Ye*
1
1 1
1
1 jpVC - Mama-
11
1 (lecture
( 11
1 |s*Uft Leader
1 11
J JL 1I
21
i 21 |13.I1.75 |
Ye*
1 1 1 1
1 1 1 |PVC Hum-
j(NIOSH
1
I
1 |facture and
1 sere 1?) 1
1
1 (all uorlt
1 11
1 |Inel auto-
1 11
1 (cleaning
1 11
1 |I2 Tr.
1 11
1 ((1954 66)
1 11
1 (FortMn Tech
1 11
1 |le B }rs
1 11
1 1(1967-1975)
J 11 11
11 11
20
1 70 |2S.12.75 1
Yes
\ ? l Pol porker
(Reported under jnon-polfaer|isat Ion
(uorkera in (NIOSH list of (31.3.77 and (1.78. 1 don't |thiok this is |a correct (ciaasiflcatloo |bf NIOSH. The (aan nay have (haen involved (in VCM (polymerisation |in pilot plant |or In aain jplaol.
1 t 1 1 1 1 _|1----------------------------
1 1 1 1 1 1 1 1 1
J
-j---------------------------J 1
>
Pv* /.'
GERMANY
LIVER Ang.iearcone Cases - (Review Dele: 1 Jan 1990)
Sheet 3
"1---------------------- T
~\---------------- ~r
TT
T
T
T
T T---------------- T
l-------------------- t-----------------------r~
1 2 1 1 6 8 10 1 11 12 1 '1 14 1| | 3 4 5
7
9
1 1 IS
1 4 -1 -1l i
. 4. J 4-
-------------------- j---------------------1--
r 1 1 1------------------------
1 1courrsY aw \ NAIC OR | DATE OF i
FIRST VC DATE Of
AGE AT
YEARS Of
YEARS OP | DATE Of HISTOLOGICAL | CSTJYUTED i
OTHER
----------------------------16
( OTHER
1 1reference I INITIALS | BIRTH
COWANY
FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE TO EXPOSURE | DEATH
CONTINUnON 1 EXPOSURE | OCCUPATION |
CAREER
j cwans
NO |
r-------------------------
germany
I
11 1i
---------------- *r
1I
1 1j
1
1
DIAGNOSIS
1 J1 1
j LEVEL
4
I
J1L_
11
1 HIGH.IGHTS ( 1 _i1 I1
1i
1
1|
|)
|
00 00 1 2 1 209 |
( . . 34
20.02.61 16.06.76
41
IS
13 j 24.03.78
Tee (High peaks j12 yrs polY-j
|10/78
1 l1
I if
1 1
1 1 (worker incl (
ICmfiraari
1 1 |l7\aulo- |
|Average
1 I1
1
1 1 (clave
|
1 I1
1
1 1 (cleaning |
1 i1
1
1 1 |Control rtxa|
1 i1
1
1
1
(1 Yr
1
1 i1
1
1
11
1
1 1 1 1 11 11 11- r 10 2 1 2 10 (10|
i j
H---------------- T-
|00,00.36
j "T
T
01.01.61 00.01.77
40
16
J 4. |07.03.7?
Yee
4
Iwitfl pMfcl
yre polrl
|exposure first
(9 jrra ISO ppn.
|<kc 1000 ppn.
(Next 3 fra av.
|7Sppn. Lest.
(rr av 35 {*
1
J (Average
(MlOSH glvns|
s Use U)|
1
11 1 1
1 1 1
1 1 |worker incl |
|exposure first
1 1 11A auto- |
|9 Trs 150 pin.
1
1 (clave
|
(occ 1000 Pen.
1 11 1 1) 1 11
1 1
i
1 1 (cleaning )
(Last yr av
1 1 1i (75 ppn. CW 1 1 1t flatter of
--------------H
ii |
1i
i
ji
1 8 1 8T---------------- + 100.00.29
"T
10.10.55 2fl.06.77
47
21
1 J1 4. 22 128.06.77
Tee
i i1 1 Hi*.
111
1 t1
(3 yre auto- |
(21.04.78
11 1
(MlOSH gives)
11
1
1
1 (clave
|
1
as Use 10)|
1I
1
1 1 1|cleaner
(
1 I1 1 11
1 1
1
1 (14 Tre
|
1
1
1 (llltar
|
1
1 --------------r
12 |
11
1
1 1"
1100.00.38
4
111 14
00.00.61 00.10.77
39
16
1 41 4.
1 41
(operator
|
11- --__| 1
6 (07.10.77
Yes ( ? |PC fitftu- |
111 1
1 11
1
11
1 |ract ure
|
1
1 I
a Ic )
11 11 |1 11
1 1 1
1
1 1 1 11
1 (Autoclave |
1 (worker for |
1
(6 rrs
(
11
1
1 1
t
1
fO 1
O
11 1|
1
|
lI
|I
11
I|
1
j
1
{
cn l c.n |
11
1 1
l1
1
I
|
11
I
I
co l j
1
I|
1
11
I
11
1
1I |
1
I
1
L
11
11
_X J.
_L _L
1
1
J J.
11
(
j JL-
1
_J
Page \U
GUMMY
Sheet 4
1 23
COUNTRY UK) REFERENCE NO
KMC OR WIDALS
DATE OP Biirm
13 00.00.lt
04)
IS
(MIOSH git Lhla as
Cm* 13)
00.00.29
C
4 corANY
7
8
LIVER Anglosarcon* Cmn - (*nlw Dale: 1 Jan 1990)
s FACTORY
7
8
6 FIRST VC EXPOSURE
00.00.60
7 DATE OF DIAGNOSIS
08.04.78
8 ACE AT DIAGNOSIS
61
I--------------------1----- -------- 1--------------------------- r
T
9
| 10
11
t
>2
t n i >4 l
IS
16
l 1L 1l
I
1. 1
YEARS OP
YEARS OP | DATE OP | HISTOLOGICAL | ESTIMATED
1 OTICR I OTHER
EIP060U TO EXPOSURE | DEATH | COMPIRMTION j EXPOSURE | OCCUPATION 1
CAREER I CORCNTS
DIAGNOSIS
11
1 LEVEL
HIGHJGMTS |
1 1L 11
1
18
14 |19.0S.78 |
Yes
|
1 P W tost
11 11
1 I
latter of JOth Jura 1980
11 11
1 1
onelosing data
frae
11
1
Nr H P Frieda I
______________ I ______________I
I1 11L
1
of K Cheat!e 4.
1
(Hot an
|
r U Brat
1 |Angiosaroara |
latter of
i |ln his letter |
30th June I960
1 |nf 21 12 81, |
enclosing dots
i
|Kr Frkedel
|
fra
i (raid this waa j
1 H P Frieda) of
i |a "Plattenepl-I
l BG Cbestie
i (thelkarzinca f
l |Dr
|
l |SpelsernhreM (
l |(a carcloora |
l
(of iba
j
l jnraophsgus) j
1 {
I 1 1
( 1 1
withdrawing this csss
I (not ettrlbut- |
(
i (able to VCN 6 |
1
(not raongniaad]
I |as an tndust- (
1
i (rial disease j
1
i 1L ^i
r
r
19.10.SI 09.10.76
49
25
25 (21.10.78 |
Yes
( 7 (Autoclave 1
11
1 (cleaner and 1
Angloswcras conf lrrad
(1
1
| worker.
1
09/79. Sow
1(
1
(Drier
1
datsl) of this
I1
1 (operator. 1
t also cases
11 11 11
1 (Later shift 1
J
| leader
1
11
9, 11, IS, IS A 17 gives la MU Report for 1978
<
'"TV 4 > A H|| '* /R VH 1 l| j. J..||.|| M-w-m -U| |
----------------------------b 1
______L 1
tUJ*
i||rj|IV.|oip*M| *sa>ijva|
IBtfAevdiviHil
!*** H'| C*a!p|
pi JO|l|.l| M1A -S(l*|p|
IPV1 **|6| (/(-/W
8/61 )jo)xdau| |
lMHW|
umn| Ml-*0* Mil J| IKMtej [mny|
-p|juoa|
KJMU|6uv| ___________________l_
U> < 1861>j
<V
1
i
1-------------
--------- 1
11
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1 1
1 JMT-'uml qf'Mi
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bi `WOO | K OI Rl
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ll \ I1
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1 j ***
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1
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s
f
1 i
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1
1 11
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ipj|| SKIISj
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ll"J'
1 V%!j
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1 ll'l
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MujvcoifNiyj ---------------------------1_
1 A|n>i)ny| fill
1
**A
I1 1 1 i--------------------------i
1 KAHOrMDIH 1
1 mvi 1
siifMru |
3iiv.>
1 MUllVdA-IJO | 3anattt3
NflLLil | __________________L
imuii
1 1 irumiis:* | 'iv.iim/vosiH
1
1 -------------------r
T'
1
1 ________________l_
M
1 VI _L
|
i1 J
Cl
8/ *80*/.0
K
17
HiVW! ,*i ;uvn
------------------ T SI90NPVK1
JHnSOdJ.4 ui aanauxa
.) SUTJA
.40 SMV4A
-- n Ill
6
1 | | 1 | 1 1 1 1 ( iBI)JVlt| |
s/bl q.4| lB 'ISVl
ss 8/80/0 | ss lo ot
-------------------r
51 SOMOV Ml
1 SISOR9VIO | iMnso.fxi
IV 19V
.) UVD | JA ISM 1.4
-------------------- h
R / 1 '( L
V ANIU.IV.4
<OhM *r I
!#) - '<*. oteui-ilw* IT-tAI' I
V | VOU'UO
s | (i 'rvrm j
M
Rl
O in o CM
S
V | ifOOOO 1
(SI "WJ TM **!& HSOIN)
41
V | won ivi
91
ANVJMO | HIM IN | .VI 34.VO
simuii 80 WN
ON 3JN383438 on MUM/MX)
j\ J1
(
t
S )""IS
IAHV-HrfM--O,l
I9S00Z--A3A
i
t1
UFJ4MANY
I.IVER knqiiiseraam Can*] ( Review Date: I Jan 1990)
Sheet G
-------------- 1-------------1
1 2 t1
67
1--------------------1 1
rummw mid
NAME OR date or
FIRST VC
REFERENCE
INITIALS
BIRTH ClMPANY FACTORY EXPOSURE
NO I 1
-------------------------1------------------ 1 ------------------1 -------------- 1 ------------- 1
to |
00.00.IS
4
4
14,02.61
DATE OF DIAGNOSIS
oo.o4.no
1 1 !
1
-------------------------1------------------ 1
21 i
00,00.1j
1
1
1
1 ------------------------- 11--------------------1 ------------------ 1
22 1
00.00.21
1
4 4
4 01.01.62 00.09.79 pronounced clinical liver *yag>tnas)
4 IS.10.61 28.08.80
8 AGE AT DIAGNOSIS
6S
66
S9
9 YEARS OF EXPOSURE TO DIAGNOSIS
19
18
19
------------------1
10
12 1 I
___________ 1___________ 1
14
IS
t III STD
YEARS OF
ESTIMATED
EXPOSURE
DCimi
C0NF1M- EXPOSURE
OCCUPATION
ATION
LEVEL
___________ 1___________ 1______________ I
OTHER CARETS HIGM.IGMTS
n 19.10.80 |Yes
High
Autoclave
Hawwnglo
t*rker
IEikMIipIhsm
Jot liver with
iMetastams ___________ 1__________________________ 1
13 19.06.80 |Tes
High
Autoclave
|Hanunglo
l*>rker and
|Enckitheli<
worked in
nf liver with
drying shop
Jpielastases ___________ 1___________ 1______________ 1
11 06.12.81 jvee
High
Autoclave
Chargehand,
|HpI aliasing
Worker
SUhSM|Ueol iy
ASL f orwan
16
OTHER (THORS
Dr Beache letter of 11-04-82 to Ur W C r Adaae
Dr teiclK letter of 13-04-82 to Dr W C. F Adana
Ur Besche letter of 11-04-82 to Ur W C F Ad
21 OU.UO.27
1 1
1
1
1 1 -------------------------1-------------------1
?\ !
00.00.28
1
1 ----------- ;----------- 1i
|
26 l
00.00.23
1 1
1 -------------------------l!------------------- 1
(26)
|
1 J 1
27 l
1)0.00.28
1
l 1
8 8 8
4
o I9SS
26.03.79
S2
24
21 29.09.81 Yes
High Chasislry
(>30(i ppa) Market
8 19G*>
11.10.82
S4
11
12 78.OS.81 Ye*
High
Autoclave
(>W0 pp) Cleaner
______________ 1 ______________ 1 ________________ I
8 1*160
28.09.81
`>8
71
13
14.01.83
Yes
High
Polfclave
Worker and
Autoclave
1 ______________ 1 ________________ _
Cleaner
ITT
I
Deleted on advice of Dr Tcnkhoff Uiiwttr 1989:
Alcoholic Cirrhosis not VCR associated. 1i
4 19SS
18.01.83
SS
28
18 02.03.84 Yes
High
Alat(H-|>ive
CU-ana-i till
1972
Priaary hepalucal lar rarcimsH; pr*>l (feral ion of the sinusiodal cells with sinusoidal ectasia. Friedel letter 23.12.86. |---------- -----------------------------------Prof Eder (Munich) letter 22.08.81. Friedel letter I9.04.8S. t-------------------------------------------------Prof Selaair (Munich) letter 22.08.83. Friedel letter 19.04.8S
r1 -----------------------------------------------1
(-----------------------------------------------\*> 1 bach. Fi icdel letter 19.IM.8S
l
GERMANY Sheet /
1 2 54
------------------------- 1------------------1
COUNTRY AND MAKE OR
REFERDICE
INITIALS
MO |
DATE OF BIRTH
rrnrurv FACTORY
FIRST VC EXPOSURE
ni
21.11.23
1
1 1
l
1
1
1
1
1
1
1
2y j
00.00.22
1 -------------------------i1------------------- 1
X) !
oo.oo.i;
1 -------------------------ij-------------------1 ------------------1
3i 1
00.00.23
1
t -------------------------i1-------------------1 ------------- --1
32 1
00.00.30
1
1
/
4 8 8
7 01.10.60
2 1962 4 19SI 8 I9S3
' i'.S
LIVER
Cattes ( Review Hole: I Jan 1990)
/ DATE OF DIAGNOSIS
it.oa.as
IS.02.83 07.01.80 30.06.8S
00.04.as
------------------ 1
--------------------------- r
8
9 10 M ) 12 1 I 14
IS 1
16
___________ 1
1 1
| msTu
1
AGE AT
YEARS OF
YEARS OF DATE OF LOGICAL ESTIMATED
OTHER
|
DIAGNOSIS EXPOSURE TO EXPOSURE DEATH | CONFIRM- EXPOSURE OCCUPATION
CAREER
1
OTHER ClWIIl)
DIAGNOSIS
ATION
lVEI.
HIGHLIGHTS !
___________ 1
1 1
61
2S
2S 2S.08.8S Yes
ttiijh
Process
1 Annual WR screening
hotIter
24.04.6S: no oc^laint.
1974-84
(no ahnunwlily detected.
1970 two-thirda
01.10.60 -
|ga*lrecta*r for ulcer*.
II.03.84
19/1 Coranerr tlwanboei*
PVC 1963 Tmal
product ion.
| i^ilantat ion
agitator
1984 Pulmary atolla
area
land pleurmxmttoola.
(landers letters I8.09.8S
and 04.02.87.
--
61
21
19 IS. 02.84 Ye*
Nigh Chemistry
Il>i--ngiosMiwa.
____________| ___________ j
worker
62
29
2b 2S.OS-83 Ye*
High
Polrworker
(Friedel letter 23.12.86.
rI ----------------------------------------| Heeaangi oevkuse
________________ |
(Shift leader ___________ j ___________ j ______________ 1_______________ 1
61
32
20 31.01.86 Yes
High Autoclave
(Friedel letter 23.12.86. I 1 | llaenang toaarluaa.
(cleaner
(Friedel letters 23.12.86,
________________ 1
SS
30
21
IS.07.86
Yes
High
Polywortcer
IS.11.89 6 Fendel 16.2.89.
--------------------------- 1---------------------------- ---------------------(HaeaanginearknM. Alsu
Autoclave
(Developed CbolangiaearctM*
cleaner
Friedel letters 23.12.86,
IS.11.89 and Feocfel lb.2.8
33
00.00.1/
8
8 19S3
19.08.83
67
30
21
2S.03.8S
Yes
High Autoclave
dewier,
rheaistry
Worker
Letter fn* Dr Friedel IS.11.89
Z9SOOZ-A3A
VI
00.00. w
4
4 I9S6
I3.0S.8S
SI
29
16 J/.09.8S Vm
High Shift
leader
sIS
DO.llO.24
4
4 1968
18.2.ti
49
1
16.1U.84
Yps
High
Autoclave
ll.ancr
fitter /roe Dr Friedel IS.II.89
I97S disease of liver parenchyae; at last 8UV lo-tler Ina l>r FrinNfl IS.11.89
r.w
GERMANY
LIVER AixjGisiarcien Cane* ( Review (talc, i .1an 1490)
She*! 8
------------------------ ,--------------------J------------------ 1
----------------------1
1
2 11
1
s
/
-------------------------1--------------------1------------------ 1--------------- 1--------------1-------------------1-------------------- 1
1 t1
8
------------------------- ,--------------------1------------------,---------------- 1----------------------1
9
HI n
17 M I
I___________ 1______________ 1
i1
1
Hism
14
country AND
MADE OR DATE OF 1
|
| FIRST VC
HATE OF
AGE AT
YEARS OF
YEARS Of DATE OF LOGICAL ESTIMATED
REFERENCE NO
INITIALS
BIRTH| O HPANY | FACTORY | EXPOSURE I 1f
DIAGNOSIS
DIAGNOSIS
EXrOSWE TO OC/WNUSfS
EXPOSURE
DEATH
CONFIRM ATION
EXPOSURE LEVEL
OCCUPATION
--------------------------- 1
is l __________________1
OTHER CAREFJt HIGHLIGHTS
1
16 OTHER COfKNTS
16
00.00.18 4
4 1951 19.01.7b
5/
21
21 14.02.86 Yes
8(96
Autoclave
Marker
letter frn Dr Friedel 16.11.89 and information (r<* Dr Tmkhoff Dec 89
17
00.00.* 4
4 1969 09.08.85
59
16
6 05.09.86 Yes
i^buralorr
letter frua Dr Friedel
Assistant
16.11.89
ib
00.00.22 4
4 1954 16.05.88
66
M
19 16.09.86 Yes
High Shift keadei
letter fraa Dr Friedel
at the
15.11.89
autoclaves;
later lo at
the tiMfcler
19
00.00.42 4
4 1968 00.10.86
44
18
S 01.11.86 Vos
High
Autoclave
Cleaner
Pension fr. 1974-64 804 later on 10U\. letter frca br Friedel 15. II. 89 and inforsMtion IroM Dr Tenklvtff Dec 89
e?S0CE-rt3fl
* See Heltoai Had di I^voro p44S, 1974. Further details in letter free Dr Rontesano of IAHC on April 1st 1962. * Also see Rallcmi an) He m>lln> I id in <lj mu-oloqira V<>! I l-<tV I |wp-s IS 4').
toga zo
ITALY Slagl 2
LIVER AngioMrncen Curt - (Review tote: I Jan 1990)
YEARS OF
10
12 13 14
+
II
15
i COUNTRY AMD KAK OR DATE OF
FIRST VC DATE OF ACC AT
EXPOSURE TEARS OF DATE OF histologicil|estikted|
OTHER
urnaKE INITIALS Bomi
COMPANY
FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS TO
EXP06URI DEATH
CONPimmONlEXPOSORE jOCCUPATION CAREER
m DIAGNOSIS
(level
j
H1GM.IGHTS
------------ 1---------1-----------
OTHER
06 2bGZ 21.06.36 Montediaoo Porto 01.10.60 06.12.65
49
25 13.02.66
Yen
|High
|PVC
1
Narghere,
|1960-71 (eaufecturel
Venice
(Media (11 feere en|
j1971-74 |Autoclave j
(Leu
(cleener
|
(1975-65 |1960-71. | 1 |l4 revs Inj
( [Control |
(
!
|
1 |1971-85 | tR
| letters fra Dr Chlotslni, Venice, j 22.09.67 and 11.01.86
I 1 1 1 1 1 1 1
21.01.6607
AP 09.02.25 Noplefan Temi
1956
60
26
22 05.04.66
Yes
1958-74 [Maintained [
High |vc Machinerr
|(not
|
[operating |
[or cieaningl
| |eutucleve*)|
(1974-60 |VC levele |
| Media |reduced fra
| 1973/74
| Inforat ion frae to eediciM del | levoro, Italy, tfol 79 Ro.t I Jaa-Feh 66, and Dr Benetta, j EniOw.
1
Cm cTOaiO
I I
cn J___________ L
CK
cn
i
JAPAN
LIVER AngloMTcow Cmm - (ftevtev tot*: 1 Jan 1990)
------- 1------------- 1--------------------T--------------
1 11
1
1
I2
|3|
A
|b
1 11
1
1----------------1-------------- 1
1
111
1
coumiv m> | MIC Oft | DATE OF I
1
RIPERENCt
DflTULS j turn | COWANY | FACTORY
NO 1
1J
1 . _ .1
1-------------------- 1
1
1 11
1 1 1
1
01
(Tcmji
|01.0a.22 InitMi
|Nagoya
|Horl
1
|ltal(u
1
1 1I
1
1 11
1
1 1(
1
1 11
1
1 1l
1
1 11
1
( 11
1
1 11
1
11 i ---------1 T----------
11
1 J T
(
1 J 1 1
02 isc
102.06.39 |XwjafmAl |o*ak
1 1 | Qmical 1
1 j1 1 11
1
i
1 11 l1
f---------- ---------1---------------- 1
1 11
i
i
03 I vs
(01.09.30 lllitsui
(Nagoya
1
1
|Toatau
1
1 (1
1
1 11
1
1 J______
1 i
1 J
1 J
67 6
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
00.04.53 24.10.75
53
______________ 1
00.11.58 10.08.76
37
00.07.65 26.06.85
54
9 TEARS OF
1---------------1
1
10 II
12
___________ |_________
YEARS Of DATE OR HISTOLOGICAL
T------------------ T"
11
13 1 >4 1 ^JL_1
11
ESTIMATED |
|
15 OTHER
1-----------------------1
1 16 1 1 1
| OTHER
EIF06IIRI TO EXPOSURE DEATH COftrUMATIOR EXPOSURE | OCCUPATION (
CAREER
| COMMENTS
DIAGNOSIS
LEVEL
1 1 1
1
1 HIGHLIGHTS 1 1i I1
11
22 13 24.10.75 Yea PVC Aaaoc |13 yra auto-|
(Japan Tlnna
ays not (clave
|
(25.10.75 6
know.
(claanar
|
|japanam PVC
Japan
(1964 -
(
(Aaaoc lettara
Tlnaa
| assisted to |
(of 31.03.78 A
indicated (dlffaraot |
(30.11.87
on 25.I0.75|anrt eiooe |
1
cipoiuru (had 111
(
1
of Ian at (health
|
1
WW
4>l
1
1
to 1974
1I _J_______________ 1
11 11
17 13 10.08.76 Ye* Not know (la polynar- |
|laatton Mork|
1 1 1 1
(Japanese PVC
(Asaociatian
(including |
(lettara of
|autoclave (
(31.03.78 A
______
20
5 14.09.85
Yea
HI*
(cleaniag l 1 1 (5 yaara
| Autoclave
(claanar
( t I I
|
j j
(30.11.87 l -t 1 (latter free
(Dr Naftaawre,
(japeneaa PVC
1I
(Aaaocletion
11 _Jl_
(30.11.87 _i
?90GZ-A3ft
>
/**
c>n-
>
LIVED fc a jlo u rc o M C i-- - (Rh I m D a te : I Jan 1990)
^-200549
SWEDEN
LIVER Angiosarcaaa Cases - (Review lisle: I Jan l*WO)
T "1------------------ 1
1
i2
|3
-f------------------1
COUflflV A | NM OR i DATE OF
REFERENCE I INITIALS 1 Burra
4 COMPANY
t------------------r
|5
6
1 i------------------r
1 FIRST VC
| FACTORY OPOSURE
7
DATE OF DIAGNOSIS
NO I
oi (nu
02 |BL
1 H------------------1
1 |23.06.27 Ko--nurd _|----------------1
1/7.11.11 E--ur.ii d |
1 t 11
1
(Sundtvali 1 f jSundsvall
14.06.51 00.01.45
1
20.10.70
00.06.72*
|(
11
11 !l
11
11
11
11
11
11
1 H------------------1
1
i 1-----------------
1------------------1
03 ME
|10.06.10 ItMiwrd (Suodavall 00.05.47 16.03.76
H------------------1
1------------------1
04 AL
Il6.ll.14 Kenenord |Suodavall 00.00.46 12.05.77
11
11
i1
11
11
I1
11
11
\1
11
11
l1
_|1----------------
l 1
05 (12.03.19 (moord |Suftdffvall 11.05.64 22.11.80
1l
11
il
11
I1 _J J
6 AGE AT DIAGNOSIS
43 61
65 62
61
T---------------- T
9 10
12
1___________J 1
4-
YEARS OF
YEARS or l OATE or HISTOLOGICAL
EXPOSURE TO EXPOSURE j MAIN
CONFIRMATION
DIAGNOSIS
1 J 4. 1 1
19
18 (20.10.70
Ye
J---------------- 4-
27
27 (16.06.72
Yes
1
1
1
I l
1
1
1
1
1
1
J 1
21 (19,03.76
Ym
J 1
31
31 (12.05.77
Yes
1
11
1
11
11
11
11 1 11 1l 11 11 14
16
16 (22.11.80 1
Yea
11
11
11
11
11 1 11
l 13 1
4
ESTIMATED 1
1~ 16 1
15
1 1 OTHER
EXPOSURE I OCCUPATION 1
CAREER
LEVEL
1
I 1 1
1 HIGHUMTS 1 1 1
|Palywrinr 1 4---------------------- 4-
High
(VCM (production 1 1
1 1 1 1
T-----------------------------1 15 I-- l ( OTHER
| a--NiA
1
1 1
1
11 ... |% SJanlln'a
.
| letter of
(26 March 1976 I confirm 6L
11 1 1 1 1 1 1 1 J
High High
(Polymarker -I- ____
I (1946-1956
IpoljBBT|lastlan |worker (12 (yrs) 6 1956 -1 (1977 forMil l(19 yr.)
1 1 1 1 11 1 J
High * 6 Years Um 10 Years
(1964-1970
Icwilrtfuge |<>prrator (1970-1980 |dr ier I'lprrator l
1 1 1
|worker who wna
(heevlly
(exponed.
Iprobehly even
(wore no than
(a normal
| reactor
(cleaner
l 1 1 l 1 (in firat
12
(yra of
je^iloynent bed
(been heavily
(expound. In jl974, liver
jahoormlity
(and necroeia Idiegnoned. (Oeta conf lrned
(in Dr D Byren | letter 16.8.77
|to CEFIC 1 1------------------------------(Letter of
(2nd Nov 1961 (True |Ur Oevid Syren 1 | J
In his teller ul 1st April 19(12, Dr ftmlesanu <>f IARC says Sweden's National Board of OS Health gives 20-02-70 as date of diagnosis for Case 01 and 15 05-72 for Case 02.
UK Sheet 1
COUNTRY AID REFERENCE NO
2
HAW OR INITIALS
~r 3
4
DATE OP BIRTH
CON*ANY
1 ---------- r |5|6
L1
1 l
1 1 FIRST VC
( FACTORY | EXPOSURE
11
LIVER Anglnaarmea Cases - (Review Oele: 1 Jan 1990)
7
DATE Of oiAonsis
8
AGE AT DIAGNOSIS
9 10 II 12 13
________ 1L__________ | ___________ 1
YEARS Of EXPOSURE TO
DIAGNOSIS
YEARS OP EXPOSURE
MTT Of DEATH
HISTOLOGICAL C0NPUMTICM
ESTIMATED EXPOSURE
LEVEL
M i 15 1
OCCUPATION j
OTHER CAREER H1GM.IGHTS
|
j
14
OTHER CUWNTO
UK
01
UJ
20.04.01 JC1
Hillhouae 04.04.44
03.12.72 (Poa 6 Collier WW sir* 23.12.72)
28
22 03.12.72
Tea
500 r. 1944-7 V<7t
(Poa *
1947-8 Drier
Collier
1948-61
paper
"T
Autoclave operator
23.12.72)
1961-66
Drier
Lee and Herrf Laoael 29-06-74
1316-8
(02)
Dubious fabrication
03 &jy
02.06.37 BP
Barry
00.02.66 00.12.74
37
04 JS8
23.06.20 1CI
Hi llhouae 26.04.54 00.06.79
59
orcom/c
09
3.5 24.12.74
Tea
High
Autoclave
Eapoeur* liauted to 2.66 - 9.69
25
18 12.10.79
Yes
fhdlw- 1954-5
(pre-war fish
high
ftaggtog
| packer
Plwit
(1939-45 aivy
1955-6
(vehicle
Drier Pint (nintenaoce
1956-8
(1945-54
Autoclave |fieh packer
worker
1
195861
1
CWgeband 1
Drier
1
Plant
I
1961-72
1
foreaan
1
C If3 Plant 1
05?o
1 COUNTRY REFERENCE
MO
05
17
J t1
1
T * TM> | HATE OF 1---------
[ INITIALS | mimi | OHPANY
| 11 1
t----------------- i--------------- 1
|U | 30.03.14 | UP
1 11
I 11
1 11
| 11 1 11 1 11
1 11
1 11 I 11 1 11 1 1t 1 11
1 11
1 11
1,1 vKA Auglnuari'.ata laaes (lU-vifU Dale: I Ion l`MO>
16 1 7 r
9 HI II
T FIRST VC. 1 DATE Of | age at
j FACTORY EXPOSURE | DIAGNOSIS DIAGNOSIS
YEARS OF EXPOSURE TO
YEARS Or EXPOSURE
DATE OF DEATH
f 1 1 |Harry
1 J| 1 08.01.51 | 00.10.79
65
DIAGNOSIS 26
21
11 11
11
1l
11
11
!1
11 11
11 11
11
11 11
06
1931
(tarry
1962
09.01.60
96/9
12 09.01.80
07 RGB
26.04.20
Barry
1963
00.00.60
60
06
08.06.24 BP
Barry
19.09.50 77.11.91
6.2 13.06.60 24 25.12.61
C
5tooOl
CJ\ -sj
*6 50
12 HISTOLOGICAL
11 1 ESTIMATED 1
r. t/niER
l 11. | OTHER
CONFIRMATION EXPOSURE | orrupATioN
CAREFJI
I oworts
IRVEI. 1
HIGHLIGHTS 1
J______________ 1
i T
Yes |1951-52
|Fur1 her
|Polycleaner j|9S2-5S
linfonHlion ||969 (run
(Ulex
|nr P N Salih
|1955-60
(ami llrOAJ
|Polyfloor
Iwimim
(1960-64
1
(Poly
1
(Chargehaod
1
(1964- 70 (Charging
1 1
(operator
1
(1970-72
1
|0rier
1
(operator
-|-----------
1
I7 rr*
Further
(poly PI.Of
information
(llperstor
I* fr.
1969 fra Or P H Sailh
|Gr*r on
and Dr 0 N J
Fee 1
|Pol? Floor
+
Polfcinaoer
WiUkM |Further infora-
1 1963 5
(ation 1969 fr<*
1 Recovery
(Dr P N Sailh 6
1 j1950-1956
l%5-197| 1950 51
11918-1946
|l>r D X J Hill la 1 Furl her
|SO0 ppa
Autoclave (Motor (techanic|inforaet Ion
(1966-1974 operator
(1946-1950
(1989 (rca
1 Mi Vfm
1951 1957 |Operator on |Dr P M Saltb
I
IChargoun [Acetylene
land DrORJ
|
{autoclave (Product list
|Uil Haas
|
Ibuilding
iPlanl
I
I ||957-I974
l
1 (Shift
1
| (nigiervisor | |aut<x: lava | (buiIdiog | (never
1 1 1 1
1 cleaned | (autoclaves 1 (hot 1 supervisor'
1 1 1 1
1 j"h entailerij | |.filer log
1 autix- lawts 1 |l" trurpi'i:l 1 I"-
1 1 1 1 i
UK
Sleet j
I.IVtJt AngloaarccMa Owi - (lv>ln tate; I Jan 1990)
T-----------
-------1------------------- "1---------- -------1------------------- 1 --------------------- 1
1 | 2 | 1 1 4 | s 1 <>
11 1-------------------- 1----------------- 1------------------- 1
1 1
7
country and | NAME UR | DATE Of |
1
j FIRST VC
DATE Of
fl
AGE AT
REFERENCE 1 INITIALS | BIRTH [ COMPANY | FACTORY f EXPOSURE DIAGNOSIS DIAGNOSIS
9
YEARS OF EXPOSURE TO
1--------------------T--------------------- 1
l
in 1 >1
12 1 n 1 4
IS 1 lb
J1 |_________________
J____________ T
_1_______________
1 1
--t T-----------------------------
YEARS OF | DATE OF HISTOLOGICAL | ESTIMATED
OTHER
| OTHER
EXPOSURE j DEATH
CONFIRMATION | EXPOSURE | OCCUPATION
CAREER
j COMCMTS
NO 1
11
1 ---------r--------------- 11
09 Ieigp
|07.OS.2b I BP
1 1 1
jnarrf
l 1 1 | IS.02.SO
02.03.83
S8
U1AGNUS IS 33
|
____________ J|_________________ 1
29 |24.02.83
Ye* |
LEVEL Nedlui
1 HIGHLIGHTS 1
_J_______________ 1L_____________ 1 I 1-------------------------- 1
| Pulyvorker |2 year* m
1
1 11
11
| (Acrylonitrile 1
1 \1 1 11
11 11
1 (Resin Plan!. 1 1 Alee prior to (
1 ii
11
1 I9S0. 4 years|
1 11
11
1 RAF (
1 11
11
1 Maintenance. 1
1 11 1 11
11 ll
1 3 year* Motor 1 1 car pekntsbop 1
1 11
11
1
?. years in
1
1 11
11
T--------------------11-----.-..------_-_--_-_--L1-------------------
1 1
1 1
10 |gjt
{04.04.47 | BP
|Barry
| 27.04.66 01 OS 84
37
______ J
_________
| (Graving Onck. 1 _J______________ 1 ______________ 1
1
IB
4.2 |16.OS.84
Yes (High - 11 |PolycleM>- Heavy goods (loforMtioo
1 1l
11
jwnlh* (SOOj 1966-67.
vehicle driver(given in
1 11 1 11
1i 11
!) Luv-(spray-drier tartil final 118 annth* (bagger 1967-|i1Inea.
{letter j18.06.84 fro*
1 11
11
1(90 ppi). (68.
(Dr D N J
1 11 \ 11
11 11
|Hediue - |fl low-down )2I aonth* | at r i ppcr
(Nilliw 1
1 11
11
j<200 ppM) [operator
1
1 11
11
(1968-70.
1
( 11
11
1 1 ________. ..1...
i--------------------1------------------1
1
1 I
11 |gu>
jO8.0S.2B j BP
(Barry
| 19.I2.6S 02.06.8S
1 11
11
1 11
t1
57
______ 1 1
1 1 1
19
16 (02.06.85
Yea (High
iPolycleaoer
| I96S -69 jI96S-60.
|ltod 69-79 (Service
1 1 t' -
(letter of
(04.06.8S jpr Paul Saith
1 11
11
(Low 79-82 (operator
(and letter of
1 11
11
(68-69.
(04.06.8S
C1 m C1 l1
1I 11 11
11 11 11
|pnlT (Operator (69-79.
(Dr D M I) Evans (Oesophageal (hasMorrhag*
Ol
1!
1l
(Leading Kami
(due to
cn 1 1
11 11
11 11
(79-82. 1
(ueaophegeal (varices due to
1 11
11
l 1 Anq inearocMa
1 11
i-----------
1 1
i 1
u |JT
|24.0I 17 | 1CI
11 1 11 II
|HI 1Ihouaej I6.09.S7 03.06.8S
_________
48 28 28 |06.I2.8S
1
1 ------------------------1 Yea |U 19S7-S9|Stwre mi,
(of liver 1-----------------------------
(Latter
1 11
l1
(High S9-/4 (bagging
|26.06.HS
11
11
|Lm 74-BS (floor
|0r F 1 Lee
1 11
11
(I9S7 S9.
1
1 11
11
(Autoclave
1
1 11
11
(operator
1
| J_______
I
1 1
1 J_______
1 1
i
11
Jl'W-NS i
[ i_________________
'v UK Sheet 4
------- 1---------------- r
3I
4I
LIVER Anui'iSdUTM Caws - (Review Hate:
---------- ,----------------------|----------------------|----------------------
s I7
l January tT)
10 it
T-------- 1-----
I 12 I 13
lb
country juo (name oh REFERENCE | INITIALS NO I
DATE OF BIRTH
COMPANY
FACTORY
YEARS OF FIRST VC |DATE Of ACE AT EXPOSURE EXPOSURE lt>IAGM1S DIAGNOSIS TO
YEARS or EXPOSURE
diagnosis
(H1STO- |
)
DATE OF |LOGICAL |ESTIMATED| bEATM jCONFIRM- (EXPOSURE j
(ATION (LEVEL
j
OCCUPATION
13 I
02.03.46 BP
Barry
1968
Jan 86
17
02.06.06 | Vet
HI* |Pol ye leaner j1960-69
| Low (Central 1 Depot 11964-70
High |Polyfloor |1970 1971
|OTHER |CAREER HIGHLIGtfTS
OTHER CnfMEWTS
|lkmd to
ftenained well, vorklny
|Acrylonitrile actively, until Jan 1906
|Plant until
(left BP 1981.
(Manager or 1C 6
(SS Ltd at
|Cardiff Airport
1963-06
14 (GS
lb.06.4 BP
lb BCP 23.00.2 BP
Barry
07.07.66 27.06.67
4b
Barry
I9b6
1900
66
01.12.60 Yu
10 Months Polycleaner
Hi*
(1966-67
10 years (Polyfloor
constant (worker at tises
letters fra Or flfD Evans, Pathologist, Mouth, titles wd Dr DU Millions, BP, Barry
Mndiun (between
|but on 11968-1962
|inter-
|ni(tent
hob#
\--
32 16 oi.os.00 Tea (9 years (Poly cleaner 6
Information froe
I Hi* |b mr.
| Nedlw
(Operet or
Exposure
(Blow A Recovery
(operator
periods
Dr 0 N J Willina, BP, d Or Paul Snilh, Palinlog1st 1400.
|2 years jutliity
intermittent
( Low
(Operator
SZ002-A3f*i
RT 2b.0b.2 ICI
milhouse 1963
1986
14.01.31 ICI
Hillhouse 06.04.63 1969
b0
26
12.11.88
|l year ) (Packer
l U>tf ) 1 Ii
|9 Tears! |
| High ) |Autoclave
12 years) (operator
Low )
17.09.09 Yes
1963-63
Uw
l%3- 74
Packer
) moths
I
High
) Autoclave
(II yeara)) Operator 19M-66 I) 2S years
Dm j)
t 14 years)) ___________ i_____________
Hepatic fibrnaia 1974 Oesophageal variru Portacaval shunt 197b
Information lr Dr B Bennett, ICI, and itr F I Lee, Blackpool Victoria Hospital 1968.
Information frrm Or 6 Bennett ICI, and Dr f 1 Lee, Blackpool Victoria Hospital, 1969.
;n
UK >f9ta nt dales
us*
I.IVKR Angiusaret** Canes - {Review bale: l .Ian 1990)
MV - KWH - TEAR
Sheet 1
1
_1-----------------
1-----------------1--------------------
1
1
TT
T t------------------r~
T-------------------- I
i
|2 |3| 4 15 15 | 7
a
9
10 1 n l
12 1 13 i H
II
1
1------------------ l----------------- 1------------------- 1
commit nt) | MMC 00 | DATE OF |
1
J1 I1 | FIRST VC | DATE OF
AGE AT
YEARS OF
ji-- 1
Jl 1
YEARS OF | DATE OF | HISTOLOGICAL | ESTIMATED 1
1
REFERDIC j INITIALS | birth | cca&un ( FACTORY | EXPOSURE | DIAGNOSIS DIAGNOSIS EXPOSORE TO EXPOSURE ( DEATH | CONFIRMATION ( EXPOSURE | OCCUPATION
15
OTHER CAREER
1 1 16 f|
1 OTHER
1 oomfTS
MO 1
i1
1
1 T------------------ (-----------------1-------------------- 1
1 11
1
1 1 1
1
1 1 1
1
1 11
11
1
01 (Earl
(17.10.23 | BTC
(Louis' | 09.12.46 | 03.03.73
49
DIAGNOSIS 24
11 JL_ l1
11
11
21 (03.03.73 |
Yes
| LEVEL 1 J J1
1 1f
HIGHLIGHTS 1
11 (History given (Rolling Stone
11
in Annals NY Art
1 |Pot Cleaner (ACAD SCIENCES (Ref 1 MY Acad
|Parks
1
1
| vllle 1
1
(1
1 ((Block Jh |Vol 329 (1979)|of Sc Sy^i
1 1I
11
1
11
1
I 1974) p 53 page 190 in
1974
1 l1
11
1
11
1(
1Paper by
Also Block
1 11
11
1
11
II
|B A Cotline o r|jna 1.7.74
1 11
11
1
11
11
USHA
P 53
11
11
1
J _||
1------------------ 1
1
I1
I
11
i
02 1
(19.06.33 | BPG
(Louis- | 15.11.55 | 00.05.70
37
14
13 |27.09.71 (
Tea
1
(Pot Cleaner
J___________________ j Ref 1
1 11
j vllle (
i
((MIOSH |
l |(Cf Block)
|ilao Block
1 11
11
1
jseys
|
11
(JAMA 1.7.74
1 11
11
1
|28.09.7I)|
11
1
(p w
11
1
T------------------ T------------------1------------------- 1
1 1
1 1
_1L_ II
_i _l1 1
1 1
0)
(Eiteard
(25.05.IS ( BTC
(Louis- 1 28.11.45 | 19.12.73
56
28
28 119.12.73 |
Yes
1
(Pot Cleeoer Louisville
(Ref I
lOlnslddie 1
1
| vllle (
i
11
1
|(Cr Block) Courier
Also Block
| 11
1
i1
11
Journal
1 11
11
1
1
------------------T1------------------11-------------------
1 1
1 I
1 1
04 1
115.01.24 | RFC
lUniis- ( 06.01.52 | 19.06.67 1
43
l
15
11
1
JJ
15 (07.01.66 |
Ves
1
1 02-09-80 J1
|Pot Clewer
Ref 1
1 11
| vllle i
1
l
il
111
|
T------------------ 1------------------1------------------ 1
1
1
1
1
OS 1
(25.01.12 | BfG
(loo is
( 19.06.44 | 09.04.64 I
52
1
20
11
1| 20 109.04.64 |
Yes
( I 1 1
j(Cf Block) 1 1 (Pot Cleaner
Alan Block Ref 1
1 t1
( vllle 1
1
1
1
lJ
11
1
1
i-------------------1----------------- 1------------------- 1
1
1
1
1
06 |flaT
(23.11.28 | BFG
(UmIs* | 17.01.62 | 00.02.74 1
45
I
12
iI _ii_
ii 12 (24.07.75 |
Yks
1 1 1
1
((Cf Block) 1 r (US Air Force
A Iso Block
1----------------------------Ref 1 *
|Au*tIn
I
1
j vllle 1
1
1
1
1 11
11
Loulsvt1)*
(Junes?
1
1
11
1
1
1
1 11
1 (Put Cleaner
Tines 23.7.75
1 11
1i
1
1
1
1 1l
1 |(Cf Block)
RetIred April
1 11
l1
1
1
1
1 11
((
1974
1 11 l1
1 11
07 |chir) (OJ.OS.22 | UCC
11
1
1
l
1 J1
i
11
1
1
|S Charle | X) .06.44 I U0.00.b8 1
45
1
24
1 11 1 _|1_
11 1 17 (23.03.68 |
Y*s
1 1 1 t
1 1 1 1
Also Block |------------------- ----------
Ref 1
|T Seart 1
1
{ Rlim I
i
1
1
1
11
_J _i____________ _____________ j
.j
T--------------- 1
1
oa 1
(06.05.20 | Goodyear I Mi agar* | (1/10.46 1 no.OB.61 1
41
1
IS
1 11
_1 J|_1
1 15 129.08.61 |
Tea
1 1 1
1
1 _l___ ___
1
1------------------- "1 -- ( Ref 1
1 1I
l1
1
1
1
1 i(
!
1 11
11
1
1
1
1 ii
11
1
l 11 J _11
1i
1
1
_J J1_________________________ _L
1 _L
1 Ii _L -JL_
11
1
j J1.
b^QOQZ
Pag*
I
USA ShegU
LIVFJt Angtnsarcona Cases - (Review date: I Jan 1990)
UK syslea of dates MV - MONTH - YEAR
10 n IS It.
COUNTRY RID REFERENCE MO
NAME OR INITIALS
DATE OF BIRTH
COIfAMY
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOUXICAi. CONTIRMTION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
Iijsmd 08.11.1109
BFG
Louis
28.OS.tS 01.03.74
43
29
24 11.03.7S
Yes
2000 VV
Gel tie
ville
Finger?
OTHER CAREER HiGM.iorrs
| | |
OTHER UJWJffj
|Ref 1 has |wrong figures |re first (enponure. |Louisville {Tiass |29.10.74, (12.3.7S,
110.3.70
10
16.08.13 Goodyear Niagara
12.06.SI OO.OS.68
SS
17
I0.0S.68
Ten
|Ref 1
27.0S.09 Goodraar Niagara
14.10.46 00.03.70
23
23 16.03.70
Yes
|Ref 1
12
Francis A 17.11.18 Flrastone Pottsto
13.07.49 02.0S.69
SO
20
19 02.0S.69
Yen
High 10 frs 10 yrs aa
Utility 6
|Raf 1 Utter
Fa reactor op Servlae op. I of 26 April
(not c|
Mwr
11978 fra
- separate Dryer qp.
itusnell A Part
crew cleaned Stripping op. I to J T Saawell
autoclaves) 3 frs prior lor RCA
service in tyre pleat
I I
13 Richard 01.12.21 ucc
S Charle- 1.12.42 00.OS.74
S2
32
26 07.04.74 Yes 2000
Ethwd
stan
4-----------
| Char Ieatcs>
lOelly Mil
Cleadenin
|21-7.7S
(14)
(IS) c-cOONs5oniij
I
| Never diagInosed as angiluaarocaa of [liver. Inforw[ation given in I letter 22 Itoy (1984 fron |j A Salg.
Accountant; ASL - No evidenoe of VW exposure.
>
>
200576
USA - Sheet 4
LIVER AnglnaarcoM Cams - (Revise Date: 1 Jot 1990)
IK vystHK ill dates MV - mm - YEAR
10 12 i)
IS I 16
cnwnv DC UTEUKE
HO
HkfC OR INITIALS
DATE OP BIRTH
COWART
FACTORY
FIRST VC UFQGflU
MTS Of D1BOI06IS
AGE AT Duonsis
TEARS Of ED06UU TO
DIAGNOSIS
YEARS OP EXPOSURE
MIC OP MATH
HISTOLOGICAL
conannoM
ESTIMATED EXPOSURE
LEVEL
OCCWATIOR
2622
02.10.23 BFG
Loula-
11.07.47 00.01.74
S2
29
04.12.76
Tee
ville
5023
00.00.23 Great
Fitchburg 06.09.SB 06.04.73
IS
14 06.04.73
Tee
torlcto Naee.
Chemical
CfKI
OTHER CAREER HIGHLIGHTS
OTWR
jLouisville
ItLmm 26.1.76 I wid he mb |the 10th AS jvictto at
(Bella Lew of | whoa B had (died by (36.1.76 jlo hie letter |oi 16.09.81 (Or H N Johnson foonf irne this (is the (cnee described (by Oannaher (TmAwito 6 Vm | in fto 1900 |to J Nadicine jvol 70 p200
(24)
Deleted 1990 by b Bennett: Bot angiasarcna, but confiraed Cholangloaarc
*2S)
mMOOccin
--j -si
I
II
I
II
Renovel fron register conflrvd in R KMinsfcl letter of S Boweter 1900
I
II
I
II
I
II
I
II
___I_______ I______1______ I_______ 1_______ 1______
A B Mieeler
|let tar of
(20/2/79 end
|Itnee XMlneki
(letters of
126/2/79 and
IVM/00
_L
A
P&jm
LIVER tniu(ci
|llvln Ukta: I Jb 1MO)
atw 4(ln - Ml - MJMTW- UM
USA - Sheet 5
1 2 3 4 S6 7 8
9 10 11 12 13 14
15
16
COWTRV AID REraaci 0
MIC Oft nrrruLS
date or
birth
comunr
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS (IT EXPOSURE TO
ouonsis
YEARS OF EXPOSURE
DATE Of DEATH
HISTOLOGICAL coaruMTicM
ESTIMATED dposnc
LEVEL
OCCWATIOR
OMR CAREER HIGHLIGHTS
OMR ecu--its
26 Join terry 07.07.23 BFG
Louie* vllle
03.10.47
00.00.77 (up to 2 Tears after death)
S2 (<Wh>
28 (death)
18 11.02.7S Yea Exposed Ln Various jobs anee degree to pvc
to 22
plants fne
chadcall cold rota to
but nain peste
' exposure reemry to um to vat. PVC charging
prdublf operator to
high
paste
charging.
Ill August
1965.
Terminated
mylnymeot Jm 1966
R r--InMt latter of 28/2/79 and Prof. Tsdiifin letter of 9/1/79
27 J L
It.OS.16 UCC
forreet
S Charle 01.07.41 ston
30.11.78
62
37
20 2S.I1.78
Yes
(KIOSK
I ZT and C
Dally Neil 2S)
'
High
Operator to Exposure Is H N Nbaelar
10.10.76
bulk end
ltr of 4 Jao
dfaperalon PVC 1979 nd
manufacture Char laston
Daily Hail
30.11.78 Md
R KaMnski
26/2/79
28
U.W.17 ucc
S Charie 00.08.44 03.11.78
61
34
33 03.11.78
Yes
ston
K iMiiukl latter of 6/4/79
29
30 UVM
c
c 1
K o o
cn -o
I
12.10.07 UCC
S Charie 00.OS.42 00.03.80
72
38
16 01.03.80
Vee
ston
1
tainnki . Lattera of ' 19lh June 1980
6 616 Hov 1980
22.07.22
l 1 1
______
Temteco Chemicals
Flaming! on 11.06.64 | 30.12.80
11 11 11 11 11 11
______ 1______ 1_______
S8 1
_______
17 16 30.12.80
_________ ____________
Yes 6 - (Jnknoun Haintenaocm
9 - Rinimnl Mechanic
'
6 yre
Elseuhere
li yre
Boiler house
Operator
9 yre
________________ _______
_________
rage
UK aysten of dates
USA ' Sheet 6
LIVER Angioearccaa (um - (Review Date: 1 Ji 1990)
DRY - MONTH - YEAR
------------------,-------------- -- ---------------------r-
r
i
1 2 3 4 |S | 6 7 11 11
i s
9
1 r--:----------------|------------------------ 1
10 11
12
13 |
14
IS
16
lr______________ 1
1 1
------------------- --------j
COWRY AMD NAM OR DATE OF
urooct
INITIALS
birth
CONANY
NO 1 --------------------11------------------1
SI |03.11.23 UCC
| { FIRST VC
[ FACTORY | EXPOSURE
11 (1 11 |S Charla-| I2.0S.46
Dm OF DIAGNOSIS
01.06.01
Me at DIAGNOSIS
57
VURS OF EXPOSURE TO
DIAGNOSIS
3S
YEARS OF EXPOSURE
13
DATE OF HISTOLOGICAL KITH CONFIRMATION 1
ESTIMATED | EXPQSORA j OCCDPinON
LEVEL j
OTHER CAREER HIGHLIGHTS
<
OTHER cotarrs
J1 I--------------------- 1----------------------- 1----------------------- -I-----------------------------
02.04.62
Yae
(High (But (Cheaical
Fran ISM to |Dr Oncer
1 ) aton ( l | (not a blqb(oparwtar la (1976 Aliphatic| letter
1 I1
1
1
as raactor {charge
(GMicels
16.10.61 ant)
1 11
1
1
Iciinf
(reactor
(operator and R 6 kfceeler
1 !1
1
1
would
|
Iran July 1976(letter of
1 11
1
|
(experience) |
|totale
(9.11.61.
J j1 1 1
1
Worked aa |
fnrnsi
(Also Dr Oeaey
1 11
1
1
labourer |
(Aliphatic
(letter of
I 11
1
1
fc
|
(Chanicai
(07.03.63 re
1 11
1
(
(June 1941 |
(operation
(data of death.
1 i 1 1 | (to Her 1946|
j1 1 1 I i (end nay
1 1j
1
1
Iheve
|
I 11
1
|
(cleaned
|
(
1 11 11
1 reactors io| that tin j
I
32 C fi Gireev 22-02-06 IfcONOto Springfield IS-10-S1 00-07-79
1
i Aw
|
(
71
1
1 1 1
1
rn 1 <: 1
1 o o1 cn 1
o 1 1 1
1 1 1 ........ ...... _J1
1I
(
11
1
j1
11
I
i1
11
i1
11
1
I1
1l
11
1
11
11
11
1!
11
_____________________ JI ____________ 1
13 S Ferguson 06-10-77 BTC Jnr 1 1 i
(Louisville 09-09-S4 11 1I 11 11
IJ-OS-02 | 1
S4
28
14
17-OS-60 to eutepsj
The death |l940lttl
((In PVC
wei done and certlftcalejvarloue )aba
lofornatlon given lo
1Autoclave
lanediete
gave
(in polyanr
letter of 24
1 area)
cause of
Hr Glrous' (naoufacture
February 1962
1
death given usual
(BUTVAR
Iren Dr
1
1 as (occiRMtlon (LUSTRE]
(Uniter C
1
1 "AagianarooM* aa 1wUie(l9Sl-1964
Bernes of
1
( (operator* (Various Jobe
Iffcannoto
1
1 in (in and
(Springfield to
1
1 wHndcals (aimnd PVC
(Dr A flan of
1
1 industry". (autoclaves
Noneanto
I
(
(1964-1973
I Europe.
1 1 (Various
i 1 J (clerical
1 1 (jobs in PVC
1 1 (polinerlaatlon
! 1 (facilllf/
1
1 ii_________
1 (Retired
1 (OJ-03-71. l_--_--_-_--_-_--_-_--_-_--_-_--_--_-_---_1_-_--_-_-_--_-_--_-_-_--_--J----11---------------------j ------------------- ?--------------------- ---------
26 {
28 Alive
Yea
1
j I9S4-74 (High
(fAiitiple (jobs
[Prof TMtmi iu letter of
1
1
(l9/*>-82
(including
1 12 Aug 1967 *
1 I Dr H N Jnhneue
1
i 1 (Opeialor '
1 letter of
PolfcInener.
78 Feb IS81.
I'
I'M frai | 1955-19561
36
27-06-32|n GeoareUebt^ele 11-06-56 21-06-03
SO
77
Tire and
ftidfcar Co
37 J Payton(29.06.29 IPG
Louiavlllt
1953 06.06.64
M
77 Alive fee 22 06.00.64
toferate {1956-56 |labourer (1956-57 (prod helper |1957-70 (operator [1970-75 [eiectrlclaD |1975|operator
Hlb
[Uorkad |regularIf | Id PVC re |In the |earlr daja
36
21.06.22 ir
Calvert 00.02.63 19.01.64
Pnxkicti CltT
m c
i ro o o
ui CO o
20 20 26.10.63
| reactor [cleaner 11953-75.
Hl^i | Boreal 1963-1962{progreaa1on
| frta helper | to amlor |operator, [cleaned | reactore, (stripping * |recovery [area* aa [eel 1 ae [charging |operator.
I U Lauadrle letter of 17 S^t 1963: votttd at aedlcal Her 1963. Tfeet tag coMoed hr 1963
iDfomtln gives In letter 09.06.64 fro* Or R I Jotaaoa
ftirato cftopenla
leuk^enia
since 1978. Gold traatnant for arthritis
1976. Under Dr'e care about 6 aoatha
before deetb, had passed standard [dtyelcal nalnilIan 3 nonthe earlier. J Barr
letters of 22.10.84 td 23.01.65.
Kage Z>7
USA Sheet 6
LIVER Angioeerccan Cun - (Review Oete: I January 1990)
UK Sfaiea of dates MV - ram - YEAR
2 3 4 5 |6
---------------- 1
7
a9
10 11
12 13
14 ( 15
16
---------------------- 1---------------
1
' T................ 1 --------------1-----------------1 ----------------
11 1
1r t YEARS OF |
__________ 1 ti | HISTO-
-_____I _________________________ | 1 I
courntY and MIC 0B MR OP
REfttOICE
OflTULS Burnt
COMPANY
or{first vc mte AGE AT
EXPOSURE YEARS OP DATE OP LOGICAL esttkatcdI
(otwa
TOFACTORY (EXPOSURE DIAGNOSIS DIAOIOSIS
EXPOSURE DEATH CdTlIM- EXPOSURE {OCCUPATIOi (CAREER
OTHER OARRJTj
i
1
t ---------------------- 1---------------1 ---------------1------------------ 1
1 t i---------------- 1
diagnosis)
1
ATIOR
1it-- --| 1
LEVEL
Ihiqughts
__________ | ____________ 1___________ 1
1I
1 1 11
Newer in hn^ital for uf chronic or
39 J Keuice 27.06.16 Pantaaote Paaaaic | 1960 Kerch
65
24
23 29.06.64
Yaa
Low 29.09.60 - Worked
acute Medical problau. Death certificate
t 1 1 i 1964
11
|Na, 66
before
atataa cauaa of death caniio-pulanaarT
I 1 1 1 1 11
(Vinyl
1960
nrreat secondary to angloMrooun of
1t
1 J 11
{Kabrlcetlonfvith US
liver.
1 ( t1
1 11
(plant
Air
Letter of 15.07.66 frts Jala E Ertei
1 1 i1
1 11
Nigh (Nay 66 -
force.
of Paotanote with lettar of 24.02.66
1 I < 1 1 11
|Aug 70
United
free Or Auerbach, Petbologlet.
1 1 I 1 1 11
{Utility {Uool
| I 1 1 1 11
Rea in
(Uyera
|I
1 J 11
{Operator (and
11
1 1 11
I ( 1i
11
|(toe JmI 66{akanlte - Sep 67
I1
1
11
(Reactor (
|t
1
11
(Operator)
|1
!
11
Low |saf> 70-62 |
|1
I
11
Ihnonr
11
i
11
{Operator
| 1 I1
11
Low 1962-63
|1
1
11
lull I
I1
1
11
|0peretor.
1 I 11
11
|Calendar
l1
1
Shop, wit A1
1 retf remit
40 - P P
26.10.14 IPG
Louia- |22.05.42
1967
Glluar
villa |
cmc
* (
11 11
I
to o
o
u\ co
41
R Buckler 2.02. IS Goody*
alegar* Kalla
1949
1967
72 72
45 34 03.01.67 Tea High Cbeulcal
1942-1974 Mortar
1i
(1942-45
11
Low
1975-l9?6|Po
11945-76
Letter freu Dr Dints, APG, 10.3.67
38
27 20.06.87 Tea
High |1949-6S
| Retired latter* fn* Prof T^hmiii
fauMlcal Op/ 1977
IhiJveralty of Luuiavilla, 1967
{Shift Sup/ J (Age 62) and Dr C 1 Johnaca, Goodyear, 1966
{Knreaan,
|PYC Rea in
{Productioo
Itediw
1965-/7 RF Plant
(Left PVC area for 6 aoothe in l%b| IiI
ication
Cconoco)
4
rafjt of what I thought Ies of the neighborhood
"*5
t our
comnents you may have, but I'd specifically like the following:
too much detail or not enough? ss
"SJ l
the question of mutagenlcity/teratogenicity?
possible, but I need your input at least by
'
.ehmkuhl >st
A1 Arasden Jphn Friend
--11 Broddle
^M-2020 78