Document 4QpyajzpQ96X6mbXnpBa204xG

CONFERENCE TO REEVALUATE- THE TOXICITY OF VINYL CHLORIDE, POLYVINYL CHLORIDE AND STRUCTURAL ANALOGUES March 20-21, 1980 . National Institutes of Health " Masur.Auditorium Building 10 Clinical Center Bethesda, Maryland Cosponsors . National- Institutes of Environmental Health Sciences National Institute for Occupational Safety and Health Occupational Safety and Health Administration see i-1329 Program Planning Committee Dr. Richard B. Everson NXEHS, Research Triangle Park, North Carolina Dr. Peter F. Infante OSHA, Washington, D.C. Dr. Philip J- L'andrigan NIOSE, Cincinnati, Ohio Dr. Raymond E. Shapiro NIEHS, Research Triangle Park, North Carolina Dr. Richard J- Waxweiler NIOSH, Cincinnati, Ohio I itv i see 1-1330 Thursday, March 20, lV80 8:00 A.M. REGISTRATION 8:30 A.M. INTRODUCTORY REMARKS Dr. David Rail, NIEHS SESSION I - CARCINOGENESIS BIOASSAYS OF VINYL CHLORIDE MONOMER Chairperson: Dr. Umberto Saffiotti, NCI 8:45 A.M. 1. Carcinogenesis Bioassay of Vinyl Chloride Monomer with Particular Reference to Multiple Sites and Dosage Review Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna 9:45 A.M. `2. Experimentally Induced Pulmonary Cancer Dr. Y. Suzuki, Mt. Sinai Medical School 10:00 A.M. Discussion 10:15 A.M. Break 10:45 A.M. 3. The Role of Aging on Vinyl Chloride Monomer - Induced Cancer Dr. David Groth, NIOSH 11:00 A.M. 4- Carcinogenic Effects of Exposure to Vinyl Chloride Monomer and Ethyl Alcohol on Rats Dr. Martha Radike, University of Cincinnati 11:15 A.M. 5. Cancer Induction Following Single and Multiple Exposures to a Constant Amount of Vinyl Chloride Monomer Dr. Robert Hehir, CPSC SESSION II -- TOXICOLOGY STUDIES OF POLYVINYL CHLORIDE Chairperson:- Dr. Peter Infante, OSEA 11:30 A.M. 6. Pneumoconiosis in Animals Exposed to Polyvinyl Chloride Dust Dr. David Groth, NIOSH 11:45 A.M. 7. Results of Carcinogenesis Bioassay of Polyvinyl Chloride Dr. Chris Wagner, BMRC, Penarth, Wales see 1-1331 Thursday, March 20, 1980 V SESSION III-SPUTUM CYTOLOGY OF VINYL CHLORIDE WORKERS Chairperson: D'r. Peter Infante, OSHA 12:00 P.M. 12:15 P.M. 8. Results of Sputum Cytology Among Vinyl Chloride Polymerization and Polyvinyl Chloride Fabrication Workers Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna Discussion 12:30 P.M. LUNCH SESSION XV'- MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE Chairperson: Dr. Philip Landrigan, NIOSH 2:00 P.M. 9. Multiple Site Risk Analysis of Vinyl Chloride Related Cancer in Workers - Review Dr. Peter Infante, OSHA 2:15 P.M. 10. Cohort Mortality Study of Vinyl Chloride Workers Dr. H. Weber, Der Staatliche Geverbearzt, Fed. Deutch Republic 2:30 P.M. 11. Epidemiological Study of Vinyl Chloride Workers Dr. Clark Cooper, Consultant 2:45 P.M. 12. Power Considerations in Epidemiologic Studies of Vinyl Chloride Workers Dr. Jay Beaumont, NIOSH 3:00 P.M. Discussion 3:15 P.M. Break SESSION V -- LIVER AND BIOCHEMICAL CHANGES ASSOCIATED WITH VINYL CHLORIDE Chairperson: Dr. David Groth, NIOSH 3:45 P.M. 13. Epidemiologic Review of Hepatic Ancjiosarcoma in the United States Dr. Henry Falk, CDC see 1-1332 Thursday, March 20, 1980 4:00 P.M. 14. United Kingdom Angiosarcoma Registry Dr. Peter Baxter, CDC 4:15 P.M. 15. Pathology of Vinyl Chloride Induced Liver Lesions Dr. Hans Popper, Mt. Sinai Medical School 4:30 .P.M. 16. Liver Screening Tests for Vinyl Chloride Exposed Workers Dr. Carlo Tambero, University of Louisville SESSION VI - INDUSTRIAL HYGIENE MEASUREMENTS OF POLYVINYL CHLORIDE OPERATIONS -Chairperson: Mr. James Gideon, NIOSH 4:45 P.M. 17. Polyvinyl Chloride Processes and Products Dr- R. Nick Wheeler, Union Carbide 5:00 P.M. 18. Characterization of Polyvinyl Chloride Homopolymers, Copolymers and--Additives Mr. Jay Jones, NIOSH 5:15 P.M. Discussion see -1-1333 Friday, March 21, 1980 SESSION VII - MORBIDITY AND MORTALITY STUDIES OF POLYVINYL CHLORIDE EXPOSED WORKERS Chairperson: Dr. R. Greenberg-, University of Louisville 8:30 A.M. 19. Mortality Among Polyvinyl Chloride Fabricators Dr. Leonard Chiazze, Georgetown' University 8:45 A.M. 20. Heart Disease in the Swedish Polyvinyl Chloride Fabricating Industry Dr. Gustavo Molina, Colombia 9:00 A.M. -21. An Epidemiological Study of Respiratory Disease in United Kingdom Workers Exposed to Polyvinyl Chloride Dust Dr. Anthony Seaton, University of Edinberg 9:15 A.M. 22. Polyvinyl Chloride Dust Induced Pneumoconiosis Dr. A. Amaud, Marseille, France 9:30 A.M. 23. An Epidemiologic Study of Pneumoconiosis in the Italian Polyvinyl Chloride Industry Dr. Guisepoe Mastrangelo, Padova, Italy 9:45 A.M. 24. A Case-Control Study of Lung Cancer Among Vinyl Chloride-Polyvinyl Chloride Workers Dr. Richard Waxweiler, NIOSH 10:00 A.M. 25. Review of Pulmonary Effects of Polyvinyl Chloride Exposure Dr. Ruth Lili's, Mt- Sinai Medical School 10:15 A.M. Discussion 10:30 A.M. Break 'V Friday, March 21, 1980 SESSION VXIX - REPRODUCTIVE EFFECTS OF VINYL CHLORIDE Chairperson: Dr, James Wilson, University of Cincinnati 11:00 A.M1. 26. Transplacental Teratogenic Effects of Vinyl Chloride in Experimental Animals Dr. Jackie John, DOW Midland 11:15 A.M. 27. Transplacental Carcinogenic Effects Dr- Jerry Rice, NCI 11:30 A.M. 28. Mutagenic Effects of Vinyl Chloride Dr. Jill Fabricant, University of Texas, Galveston 11:45' A.M. 29. Power Considerations in Studies*of Reproductive Effects Associated with Vinyl Chloride and Some Structural Analogues ^ Ms. Maureen Hatch, Columbia University 12:00 P.M. Discussion 12:30 P.M. LUNCH SESSION IX - ENVIRONMENTAL EXPOSURE TO VINYL CHLORIDEPOLYVINYL CHLORIDE AND LIVER ANGIOSARCOMA Chairperson: Dr. Pier Bertazzi, Institute of Occupational Health, Milan 2:00 P.M. 30. Fugitive Emissions of Vinyl ChloridePolyvinyl Chloride Speaker to be Announced 2:15 P.M. 31. Case--Control Study of Liver Angiosarcoma Among Residents in New York Dr. Nicholas Vianna, N.Y.S. Department of Health see 1-1335 Friday, March 21, 1980 SESSION X - CARCINOGENICITY OF SOME STRUCTURAL ANALOGUES OF VINYL CHLORIDE Chairperson: Dr. Kim Hooper, University of California, Berkeley 2:30 P.M. 32. Comparative Pathology of Vinyl Chloride and Vinyl Bromide Induced Liver Pathology in Animals' Dr- William Busey, Experimental Pathology Laboratories 2:45 P.M. 33. Review of Experimental Carcinogenesis of Vinyl Chloride Related Compounds Dr. Ken Chu, NCI 3:00 P.M. 34. Review of Epidemiologic Study Results of Vinyl Chloride Related Compounds Ms. Rosanne Apfeldorf, OSHA 3:15 P.M. Discussion 3:30 P.M. Break SESSION XI - RESEARCH NEEDS AND PUBLIC HEALTH INTERVENTION Chairperson: Dr. Anthony Robbins, NIOSH Panel Discussion: 4:00 P.M. 35. Dr. Dale-Haddis, Center for Policy Alternatives, MIT 4:15 P.M. 36. Mr. Steve Wodka, OCAW 4:30 P.M. 37. Dr. Maurice Johnson, B.F . Goodrich 4:45 P.M. 38. Dr- Irving Selikoff, Mt. Sinai Medical School 5:00 P.M. 39- Dr. Joseph Wagoner, EDF 5:15 P.M. Discussion Proceedings from the Conference will be published. see 1-1336 ess ZtrZ.Zv"..