Document 4QR77E0j8ax1vRyMLDoMng1qp

July 23, 1953 D r . N o r m a n AS'. K a r r D irecto r, Ch em ical R esearch St ik e r L a b o r a t o r i e s , In c. p . O. Bo x 3157 T e r m in a l A n n ex L og A n ge le s hi, C a lifo r n ia D ear Doctor Karr: I r o g r e : v er y m u ch to h ave to t e ll you , even a ft e r t h is lon g c lo y in r e p ly in g go y o u r le c t o r o ' Ju n o i , t h at w e h iv e n ot b e e n a b le , o r y e t , to obtain the In form tien on th e c a se s of t e tr ae th y l le ad poison in g t r e at e d by D r . K it sm llle r in P an am a. Th e r e p o r t s h ave been p r o m ise d r ep eated ly out th ey h ave n ot been d e liv er e d . I a m & u :r t h at you kn ow t h at th e .supply of c a lc iu m d i s od iu m ED TA w h ich you;; people t r ied to got to Dr. Kit.sm aller at m y r e q u e st , w as no; r e c e i v e d b y h im w h ile h e w as in P a n a m a , an d t h e r e fo r e h e h u d on ly a. sm a ll Quan tity v/h ich h e took w ith h im fr o m th e La b o r a t o r y . We sh ou ld h ave ad eou ate in form ation ca how th e su pply w h ich you fu r n ish ed w ac u se d w h en it ciih a r r i v e , b a t w e h a v e n 't it y e t . T h is fa c t m e r e l y iliu =t r e toe the ir u st r e t io n c th at con fron t th e experim en tal, o b se r v e r when he attem pt-.5 to w ork o u t sid e of hir. ow n fie ld c f co m p le t e c o n t r o l. 1 su sp e c t , t h e r e fo r e , th at th e m o st w e sh all le ar n fr o m tidy' exp er ien ce is th at th is a ge n t w ?.s w ell t o le r a t e d b y v e r y si c k m e n , an d t h a t t h e r e w a s so m e e x c r e t o r y r e sc o n s o {in cr e ase .", in u r i n a r y le a d c o n c e n t r a t io n ) to i t s a d m i n i st r a t i o n . VJe sh e ll im p r o v e on t h is a s m u ch a s w e can w ith d e t a ils, when wo can . W> sh e ll do so e v e n t u ally , if on e of u s h as to retu rn to P an am a to get th e case r e c o r d s. We car r ie d out sc o r e s of a n a ly se s, an d I don 't in ten d to lo se t h e ir valu e en tir ely . On th e oth er h an d, I am m u ch m o r e in t e r e st e d in b ein g able, to m ak e so m e o b se r v at io n s of a m o r e d e t aile d type in c a se s of in or gan ic lead p oison in g, th an I am in th e P an am a r e su lt s, sin c e a t b e st thv la t t e r can n ot t e ll u s m uch abou t th e tilin gs I m o st w ish to know ~ th at i s, (I ) w h eth er c r net the ad m in istration of the produ ct in du ces sign ifican t clin ical im p rove m en t in in o r ga n ic le a d p o iso n in g, (which h a s n ot b een p r o v e d oy th e r e p o r t s w h ich I h ave se e n a s y e t ), an d (2) w h at ch an ge o c c u r s in th e d istr ib u tio n of lead in th e body, follow in g it s ad m in ist r at io n . At la st we h ave o v e r co m e the h u r d le w h ich d evelop ed h e r e in th e u se of th e p r od u ct in th e tr e at m e n t of ch ild r en . T h is is th e poin t at w hich a good 0008330 N9773 V