Document 4MvyM7dODo5rObVgGNGvr6RN

\: DuPont DCFuOoramntamyran Sirgen mans Aezze- 662 October 3. 1994 DFirr.stJaBcrkanAd. sMaCcoPrphoerrastoino,n Group Leader 7201 Adams Street `Willowbrook, IL 60521 Dear Dr. MacPherson: plannintgou`sYeourTe9f/l2o/n94K-p2h0oPnTeFcEalflliuncdriocpatoeldymtehratdFiirsspt eBrrasnaidsosanis dweedruestcionngcaegrennedtobneccaluasyepatrhteicMlateeswrihailcShaafreteytDoabteasoSlhedaets(cMaStDlSit)teirn.diYcoautes that K-20 contains <0.2% of ammonium perfluorooctanoate (APFO), and tNhoetiecxepoofsIunrteelnidmeidt sCehcatnigonesof(t1h9e93M-S19D9S4)inwdililcactaersrythaant Ath3edAeCsiGgInHatTioLnV., As noted inthe ACGIH definition thaIt faxed to you, A3 . indicates the following: "aAn3im-aAlnsiamtaal rCealractiivneolgyehni:ghThdoesea.gebnytriosuctae(rsc)inoofgaednmiicniisnterxapteiroinm.eanttasilte(s). of histologic type(s), or by mechanism(s) that are not considered relevant titonhcawtroetrahkseeerdagerexinsptkosoiusfrcneoa.tncAleivrkaeiillnyatbeolxepcoaespueisddeehmciuaonmlcaoengrisc.ianlhAsvutamuidalianebssledeexovcnieodptetncuconendfseiurrgmgeasnts `uncommon or unlikely routes or levels of exposure." In deciding whether or not to use K-20 in your proposed application, you need to consider the potential risks to: 1. FyiorsutrBprraondudcst.employees who manufacture 2. Cdaetfsecwahtioonu.se the litter for urination and 3. Cat owners who may handle the litter. industrial eTmphleoyDeuePsownhtMoShaDnSdlfeorKK--2200ainndditcealltsesthteheprheaczaaurtdisofnsacwehdibcyh EIDO78812 1 armament RN 000176 @ never FDri.rstJaBcrkanA.dsMaCcoPrhpoerrastoino.nGroup Leader OPcAtGoEbeTrW3,O1994 s`mhoosutldPTbFeEtadkiesnp.ersTihoensAwPhFiOchcoanrceewnitdrealtyiounsiendKc-o2m0meirscsiiamlillya.r to that tn owners face TInhepefroslpleocwtiinvgemaasyyoheulepvyaoluuapteutthteheporsissikbsltehuatsecaotfsKo-r2c0aftor this application. 01..Y0o5u%rPpTrFoEpoosnedthuescelaoyf.1 Ib (dry weight) PTFE per ton of clay, would give 2. Using K-20 as your source of PTFE, this would give less than 2 ppm APFO on the clay 3is. sKo-a2k0ed1suspolbdyasthae3cl3a-y3.4A%PdFiOspeisrswiaotnerinswolautbelre., Yaonud tshaeyretfhoartetshheowualtdebre asomaokuendtuopf AbyPFthOeopnortehse isnurtfhaececloafytahleoncglawyisthhotuhledwbaetemr.ucThhelreesfsotrheatnhe2 ppm. . c4.arTchienoOgeSnHicAcHoamzpaorndeCnotmsmounniacMatSiDoSnifStthanedcaorndcednotersatniootnriesquliersse tlihsatning 0.1% (i... <1.000 ppm). 5. The OSHA Hazard Communication Standard does not consider ACGIH class A3 as establishing that a substance is a carcinogen. 6. A 2-year feeding study in rats at doses of30 and 300 ppm APFO in the d3i0etppprmodgurcoeudp eavniddetnhceeoIfncliidveenrcienjoufryt.umLairvserwtausmsolrisghwtleyreinncorteasseeedniinn tthhee 300 ppm group. While no toxicity data are avatlable for cats, rodents are gpernoedruaclleydcboynstihidserceldastsoobfecmheomriecaslustcheaptnihbluematonsth,edtoygpse oorf minojnukreyys. You eshxopuolsdurbeefaorbeeitttheerrjcuadtgseotrhhaunmwaenso.f whether ingestion isa likely route of 7. The purpose of the K-20 is to minimize dust formation. Potential `emxeptohsoudreoftocaAlcPuFlaOtiboyn,inuhsailnagtiyoonucraanctbuealesmteiamsatuerdembeyntthse offolclaotwilintgter dust TinWAth)efaoirrPwahretirceulIahtaevseNoutseOdth1e0rwmigs/emC3l,aswsihfiicehd (iTshtihseisACaGfIaiHrlTyLhVig(h8-dhurst concentration): (a) (b) TAhheuremains b1r.e7 aptphmesAP1F0Omo3onftahierctantalintt8e-r.hr day. : EIDO7S813 000177 DFirr.sJtaBcrkaAn.dsMaCcorPphoerrastoino.nGroup Leader OPcAtGoEbeTrH3R, E1E994 If concentration of cat litter calculated amountofAPFO dinuhsatliend tihneaanir8w-ehroeur1d0amygw/omual,d tbeh:en the The cu1r0remntg/AmCG3IxH 1.7x10-x6 10 TLY for APFO m3 = Is 0,1 1.7x10-4 mg mg/m3 (6-hr TWA) but the Uinstienngdtehdischlaatntgerenfuormb1e9r9.3-t1n9a9n48i-sharTdLaVy oaf p0e.r0s1onmgco/uml3d i(n8h-ahlreTWA). which 0".r0e1prmegse/nmt3coxnd1i0timon3s = 0.1 mgAPFO under which it is believed that nearly all wefofrekctesr"s(mquaoytebefrroempeAaCtGedIlHy deexfpionsiteidondoafyTaLfVt)e.r dTahyiswiitsh5o9u0t atdivmeersstehheealth ccaolnccuelnattreadtiaomnooufnctatthliatttewroduulsdtboef 1in0hmalge/dimf3faoprearsnon8-ihnohuarleddaya. a8.bsTohrebemdosbtyltihkeelbyordoyuttehorfouegxhposskuirneciosntsakcitn.coEnxtpaocts.urAePbFyOthciasnrboeute : tdheepecnodncsenotnraatmioounnotfAofPtFiOmeotnhtehseksiunrIfsacien coofntthaectliwttietrh(stehee#c2atalnidtte#r,3and above). - deciding whe1thheorpeorthneotabtoovueseinTfeofrlmoantioKn-w2i0llibneyousuerfpulrotpooFsierdst Brands in application. Sincerely. Wayne H. Martin FRelguuolraotporroyduAcftfasirs cc: WD2i.0i6Bm.iWneJgloldnoienns,,BDiDdEegl.a.1w39a8r41e10MaSirikveirnsigdeSeRrovaidces WWHHMMS3jk-s94 bee: DR.ILL.. PReiettchey DoLHN.. VKaismhburn R3.0 Valentine F. Dickey 000178 EID0783)4