Document 4JmEd2KO2GdyrD73v9B9x85K1

Principal Dr . Jo s e p h F. Ca l l a h a n CHATHAM JUNIOR HIGH SCHOOL CHATHAM, NEW JERSEY Te l e p h o n e Mer c u r y 5-9100 January 15, 1962 Roc-art A. Kehos, K.D., Director Kettering Laboratory, Eden and Be the s da Cincinnati, Ohio Dear Dr. Kehoe: Vfhile reading an article about lead, noisoning in the Jan uary, 1962, issue of the magazine, Today*s Health, I came across several references to the work done at Kettering Laboratory to analytically detect traces of lead in the body. The author of the article, a Dr. John E. Allen, particularly praised your con tributions in this area. The aforementioned article was brought to my attention by . an inquisitive fourteen-year old science student of mine who was stimulated to do an experiment on mice to note some of the effects of lead poisoning.- Since I am not well grounded'in this specific area, we jointly decided to learn more about the topic to deter mine the feasibility of pursuing this experiment, keeping.foremost in mind that the lives of the experimental animals must not be jeopardised. I would very much appreciate your advice. Listed below under column A are some considerations we wish to investigate. Column B lists the means by which we hope to obtain the needed information. If you will be so kind as to evaluate these steps and add suggestions, you would be most helpful. Column A 1. how to detect the presence and amount of Pb nigment in paint 2. find out the amount of Pb which, if administered to mice in the form of paint scrapings.in their food would be sub-lethal Column B 1. write to the Rational Paint, Varnish, and Lacquer Association, Inc., 1500 Rhode Island Ave. , IT.'Y. , Washington 5, D.C. . 2. ? : perhaps this infor mation can be obtained from Ciba.Pharmaceutical Products, Inc. Principal Da, Jo s e p h F. Ca l l a h a n CHATHAM JUNIOR HIGH SCHOOL CHATHAM, NEW JERSEY (2) Te l e p h o n e Mer c u r y - 5-9100 Column A 5. how to perform, laboratory 0. tests on blood and/or urine to obtain evidence (other than external symptoms) of ab normal concentrations, of Pb a.- what;Is the test agent used In the, sample screening test, and where can It be obtained? b. is the ether used (CgHvj-)pO or another ether? c. wbat volume of urine is required? 4. learn :tde-leading" techniques 4. a. what specific compounds and In what quantity can be used as cleansing enemas to 'de-load' the mi. c e b. can the drug, edaths.mil calcI urn d I s o d iun (S.D?A} be obtained for In lection? If so, where can it be obtained, what quantity need be purchased., v/hat is the cost involved, and will specific directions be Included to explain how to inject the animals (subcutaneous. Intravenous, or in muscle}? Column B r- -- -- - - cognizant of our lack of suitable equipment and techniques, we hope to duplicate the sample screening test which, do c tor s cs n n er form by adding a few drops of a test agent into a urine specimen, add some ClhCOOH and HpOp , and then and a small 'amount of other a. perhaps the local b. physicians can c. swcm ly this Informatic ? : perhaps this information can be obtained from Ciba Fharaac eu tic a1 Products,Inc. As you can .gather from the above listings, at present we lack much information needed before undertaking the experiment. The student Is anxious and I might add, quite able, to tackle this project. } Any information that you can forward to us will be gratefully received. Very tru1y yours. 0020268 y/S.../"/ 1 Gertrude Ih Clarke (- iss) 9th. Grade Science Teacher