Document 4JjJ0yk44MVp7dyDgnXaLe2G1

Industrial Hygiene Digest June, 1957 744 Toxicity ot m-Aminophenol. H. Ozawa and others. Ann, Kept. G. Tanabe Co., Ltd. l^, 35-43 (1956). The acute and chronic toxicltlea of m-aminophenol were studied. When it Is administered intravenously, Its LJDjq Is 500 rag. per kg, (or rabbit and 340. 7 mg. per kg. (or mice, and below 100 mg. per kg. no toxic effect could be observed. Daily 20 mg. per subcutaneous injections (or two months caused no noticeable symptoms in rats. p-Amioo- sslicylic acid is said to be contaminated with m-aminophenol at a level of not more than 0. C3?, but (rora the above results, it is thought that PAS injection would cause no harm(ul effect due to m-amlnophenot, even i( administered daily to man. -- Chem. Absts. 745 Toxic Hazards oi Pesticides to Man. Report of a Study Group. World Health Organisation Technical Report Series No. 114. 51 pp. (June 1956). Obtainable (rom World Health Organisation, 1501 New Hampshire Ave., H. W., Washington 8, C, C. 60 cents. Recommendations are made to enable more toxic Insecticides of all types to be used safely in public health work. Subjects included in the report are: toxic properties o( pesticides, incidence and nature o( poisoning, measures (or the protection o( operators handling pesticides, contamination of food and water, effects on domestic animals and (ish, control of pesticide hazards by means of regulations, laboratories carrying out investiga tions on the vertebrate toxicology of pesticides, the degree of exposure of workers to in secticides and the relation of this exposure to the toxic dosage, and respirators and dust masks suitable lor pesticide operators. -. Public Health Eng. Absts. 746 Tolerance for Residues of Monuron (3-(p-Chlorophenyl)-l, 1-dimethylurea). Anon. Federal Register 22, 786 (Feb. 8, 19&7). The tolerance previously established (or asparagus is revised to 7 ppm. The tolerance for citrus citron, cottonseed, grapefruit, grapes, kumquats, lemons, limes, onions (dry bulbs only), oranges, pineapple, spinach, sugarcane, tangelos, and tangerines is 1 ppm. -- Chem. Absts. 747 An Outbreak of Tri-ortho-cresyl Phosphate (TOCP) Poisoning in Durban. M. Susser and Zena Stein. Brit. J. lad. Med. 14, 111-120 (Apr. 1957). An outbreak of TOCP poisoning in 11 African patients in Durban, South Africa, in 1955, is described. From the epidemiology of this outbreak it is suggested that water, as well as the previously reported solvents such as lipids and alcohol, may be a vehicle for the poison, either in solution or suspension or both. The clinical picture, which in cludes a delayed flaccid paralysis with subsequent upper motor neurone signs, is empha sized as an important and reliable guide to diagnosis. The pathology and etiology ot the nervous lesions are discussed. Swelling of the parotid glands is reported in this outbreak for the first time. Family, social, and occupational factors are shown to be Important in diagnosis. A follow-up after 18 years on four patients poisoned in 1937-38 shows that dis ability may be profound and permanent. The necessity (or precautions in Industry is stressed. .. Cond. (rom authors' summary 748 Tolerance (or Residues of Mineral Oil in or on Shelled Corn and Crain Sorghum. Anon. Federal Register Zl, 10274 (Dec. 21, 1956). A tolerance of ZOO ppm for residues of mineral oil in or on shelled corn and grain sorghum from postharvest application is established under the Federal Food, Drug, and Cosmetic Act. -- Chem. Absts. 749 Environmental Aspects in the Etiology ot Occupational Cancer. A. J. Vorwald. CA (Am, Cancer Soc. ) 7, 21-26 (Jan. 1957). The literature on environmental and occupational (actors in cancer is reviewed. A table lists environmental agents in the etiology of malignant tumors, with an appraisal of current evidence having possible relation to occupation. Both in the experimental and 13. 11 206 1040