Document 4JaQE7gYM0o8mOm6rrVLbDp2e

i Ju n e 2 , 1937 Dr* J . Howard Bear d Health. Se r vice St a t io n Ur b an a, I lli n o is Dear Do ct o r Bear ds I h a ste n -to r ep ly to your l e t t e r o f May 2 8 t h co n ce r n in g t h e e xp e r im e n t a l ad m in istr ation o f lea d and a r se n ic r esid u es to human sub je c t s * I am q u it e s ym p a t h e t ic w it h t h is type o f exp er im en tation sin ce I th in k i t is v ir t u a lly the o n ly s a t is fa c t o r y means o f a n sw e r in g some o f th e q u e s t io n s a s s o c ia t e d w it h t h e s p r a y r e s id u e p r i&lem * On th o t h e r hand I can b e s t t e l l you w hether o m o t I co n s id e r t h e e xp e r im e n t a l program s a fe by d e s cr ib in g t o you what I would fe e l t o be n e ce s s a r y s a fe gu a r d s in ca r r y in g ou t su ch work* I would n o t w ish t o do th is type o f exp er im en tation an d, a s a m atter o f fa c t , I w ou ld 'n ot do i t under any cir cu m sta n ce s u n ie ss r had the f a c i l i t i e s , both c lin ic a l and a n a ly t ic a l* to fo llo w c a r e fu lly t h e s u b je c t s and t o know p r e c is e ly what was happening in th e m a tte r o f le a d a b so r p tio n and le a d e xcr e t io n * `To be p r e c is e , e xp e r im e n t a l s u b je c t s u n der t h is r egim e sh ou ld be give n a p h y s ica l exam in ation n ot le s s than once a week, in clu d in g a r a t h e r ca r e fu l and th or ou gh -goin g study o f the blood * In a d d it io n t h e ir fe c a l and u r in a v e xcr e t io n should be fo llo w e d in su ch a way a s t o en ab le one t o b e su r e t h a t th ey were main t a in in g a b a la n ce between in t a k e and ou t p u t * 'The r e s u lt s h e r e a r e in some d e gr e e p r e d ic t a b le fr om th e a v a ila b le in fo r m a t io n , b u t I do n ot b e lie v e one co u ld escape a very ju s t c r it icis m fo r b ein g in cau tiou s i f he d id not m ain tain such a degree o f co n t r o l in t h is t yp e o f e xp e r im e n t a l w o r k. The q u a n t it ie s o f le a d in volve d h er e a r e in t h e neighbor hood o f two and a t h ir d m illigr a m s per day* I should su sp e ct t h a t the g r e a t e r p o r t io n o f t h is would p ass t h r ou gh t h e a lim e n t a r y t r a c t u n absor b ed * On t h e o t h e r h a n d , t h e fig u r is s u f fi c i e n t ly clo s e t o t h e acne o f r e co gn ize d dnger in occu p a tion a l exposure t h a t I do n ot r egar d th r e s u lt s as w h olly p r e d ict a b le . I t seems q u it e p r obable t h a t I have had ab ou t a s much e xp e r ie n ce i n t h is f i e l d ;as a n yo n e , and y e t a t the p r e s e n t tim e I am m akin g some o b se r va tio n s in which I do n ot p er m it th e d a ily In t a k e t o e xce e d one m illigr a m * Even u n d er t h is co n d it io n I am m a in t a in in g th e typ e o f e xp e r im e n t a l c o n t r o l w h ich I e 0019378 N2 0 0 4 0 - 2- d escr ibed above. In as much a s you have n ot o u t lin e d t h e m anner o f exp er im en tafcIon * I am go in g somewhat beyond your r e q u e s t in m aking an a d d it io n a l comment* However I t h in k I am ju s t i fi e d in m aking the statem ent th a t t h is type of exp er im en tation is not lik e ly to be u s e fu l in s o lvin g the q u estion a t Issue u n le ss a very a ccu r a te and ca r e fu l determ in a- . t io n o f th e le a d in t a k e and o u t p u t is c a r r ie d on as p a r t o f the e xp e r im e n t a l p r oced u r e* In making t h is comment I t r u s t you w i ll r e a lis e t h a t I am. n ot d is cu s s in g t h is m a t t e r p r im a r ily from t h e p o in t o f view o f an e xp e r im e n t a l man; r a t h e r I am s p e a k in g t o you as one p h y s icia n to an oth er * I s h o u ld be gla d t o see the experim ents ca r r ie d out bu t fr a n k ly Ijr iou ld not do i t m ys e lf e xce p t un der th e co n d it io n s I have ou t lin e d ,, n or would I co n s id e r t h e r is k ju s t i fi e d by a n yt h in g ot h e r th an com p lete d e t a ile d knowledge o f the b eh avior o f lea d under such co n d itio n s* Go r d ia lly yo u r s, RAKs is . Ro b e r t "A* Ke h o e , Il.'D* KE 0019879 0 8 8 6 10 0 3 X