Document 4J3ManMqdLE7R9BDqk21man0p

FEB 29 1968 UNITED STATES DEPARTMENT OF AGRICULTURE AGRICULTURAL RESEARCH SERVICE Pesticides Regulation Division 101 South Laboratory Building, A,R,C. Beltsvllla, Maryland 20705 To 'jxneft February 21, 1968 Monsanto Chemical Company Organics Division 800 N. Lindbergh Blvd. St, Louis, Missouri 63141 Gentlemen: Vs would appreciate receiving samples of your various Arochlors (chlorinated polyphenyls) to be used in our laboratory in the enforcement of the Federal Insecticide, Fungicide and Rodentlclde Act (as amended). In addition we would also like to have any literature you may have concerning these materials as well as Analytical methods if they are available. If there is a charge for any or all of these, please submit the bill with the msterlal end wa will initiata payment Immediately on receipt of the shipment. Thank you for your attantion to this matter. Sincerely youra. W. N. Bllckn,tCf '* Chemist in charge EXHIBIT WBP M-24 MON-MT-008577 ir r LEXOLDMONOOOQ94 beet W. R. Richard - WRICH C. Ptton - CPATO February 29, 1968 Mr. H. N. Bliokenataff U. s. Dept, of Agriculture Pesticides Regulation Divlaion 101 South Laboratory Bldg, A.R.C. Beltsville, Maryland 20705 Dear Mr. Blickenstaff> X enoloae our technical bulletin 0/PL-306. This describes the physical and chemical characteristics of our 12 Aroclors. Do you want samples of all of them and what else sample are you desirous of obtaining? X presume what you want is the technical Aroclor material as sold. Could you explain to me your intereet in Aroclors. Especially in relationship to the enforcement of the Federal Insecticide* Fungicide and Rodentioide Act. Are Aroclors used in appli es tiona that come under this act? Sincerely, REK/ln enc. R. Emmet Kelly, M. D Medical Director MON-MT-008578 ir r LEXOLDMONOOOQ95 ' --Q MAft fi ^'350 UNITED STATES DEPARTMENT OF AGRICULTURE . AGRICULTURAL RESEARCH SERVICE PCSTicioaa nboulation oivmion -WMMMtffMAfieaeMff 101 South Laboratory Building, A.R.C. Beltsville, Maryland 20705 March 6, 1968 Or* R. Basnet Kelly, Medical Director Monsanto Company Medical Department, Mail Zone 001 800 North Lindbergh Boulevard St. Louie, Missouri 63166 Dear Dr. Kelly; This vili acknowledge receipt of your technical bulletin 0/PL-306 and your letter of February 29, 1968. ` '-- Our interest in Arochlors atoms from recommendations made on page 36 of the above named technical bulletin. Since our organisation is directly responsible for the analysis of pesticide formulations under the FIFRA, wa desire samples of the various arochlors to use in identity testa and comparison testa when such formulations are analysed. You are correct In assuming that we would be interested in the meterial as it is sold commercially. We ara intaxested in obtaining about 3 ounces of ail of tha available arochlors. If ttaare la any charge for thaae, please bill ua at tha time of shipment and we will initiate payment upon receipt of samples. Thank you for your consideration. Sincerely yours. W. N* Blickanstaff Chemist in Charge EXHIBIT W BP M-24.2 MON-MT-008579 March 12, 1968 Mr. W. H. Bllckanstaff United States Dept, of Agriculture Pesticides Regulation Division 101 South Laboratory Building, A.R.C. Baltsvilla, Maryland 20705 Dear Mr. Bllckanstaff: Z have forwarded your latter to Hr. Xsn Walls, of our Organic Division, and J an sura you will be hearing from him shortly. It is true that at quite soma time in the past one of the Arochlors was used as a volatilisation retarder for soma insectioides. Lindane was the only one and I am really not sure how widespread this use was. For all I know, it may not be used anymorei although, certainly, it could be used without our knowledge. We do not, however, have any direct knowledge of its use. Sincerely, R. Emmet Kelly, M. D. Medical Director RBK/ln '' beet Mr. K. A. Wells - Will you send samples of our Arochlors to Mr. Bllckanstaff. REK t \ EXHIBIT WBP M-24.3 MON-MT-008580 ir r LEXOLDMONOOOQ97 I 4C A LOCATION) Cumming Paton - General Offlcea April 26, 1968 c, AROCLORS/ USDA INVESTIGATION Dr. R. Eraraet Kelly Medical W. R. Richard I refer to your letter of March 6 to Mr. Bllckenstaff of USDA in Beltevllle, Maryland. It Is Interesting to note that his Interest in Aroclors stems on recommend ations on page 36 of our technical bulletin 0/PL-306. I am sure he is referring to our recommendations on vapor suppression. In fact, our recommendations are based on those of the USDA scientists at Beltsville, Md, Our bulletin CS-6, issued in March, 1961, gives full details of the researches and recommendations given by the USDA workers whioh appeared to have been oarried out for a period of years starting as early as 1954. I wonder if a new breed has arisen at Beltsville which is unfamiliar with the work of their predecessors. Do you think it would be worthwhile sending bulletin CS-6 to Mr. Bllckenstaff. Cumming Paton dbw EXHIBIT \VBP M-24.4 MON-MT-008581 St. Louis April 29, 1968 AROCLORS/USDA INVESTIGATION Mr. Cumming Paton CPATO Mr. W. R. Richard - WRICH f iV f Thank you for your note of April 26 on subject matter. Will you send me Bulletin CS-6, as I think it would be worthwhile to send it along to Mr. Blickenstaff. If your files show the names of anyone at Beltsville with whom we have communicated, I would include that in my letter. RSK/ln R, Emmet Kelly, M. D. EXHIBIT I WBPM-24,5 I MON-MT-008582 ir r LEXOLDMONOOOQ99 May 2, 1968 Mr. W, N. alickenstaff United States Dept, of Agriculture Pesticides Regulation Division 101 South Laboratory Bldg., A.R.C. Doltsville, Maryland 20705 Dear Mr. alickenstafft it appears that the use of Monsanto Aroclor resin as an ingredient in insecticide formulations was based on U.S.D.A. work, I had not realized this when 1 wrote you earlier. I am sending you a copy of our data sheet that refers more specifically to it. I hope by now you have received the samples and if you have not, please let me know. Sincerely, REK/ln R. Emmet Kelly, M. D. Medical Director MON-MT-008583 ir r LEXOLDMONOOOI00 ifiwiouniv ^namivui wnipvii] wiyvim vnonivui iriviaiv 800 Nrth lindbargli llvd. St. loais 66, Missour CHEMICAL SPEC1ALT I E S DATA REPORT Ttic infontuUion in thin report was compiled to assist you in your cvatunlion and development of special uses for Monsanto products. Kvery effort Has been made to include pertinent material bearing on the subject. This information is intended to guide your development work, but Monsanto cannot take part in the specific formulation or evaluation of any finished product... since knowledge of such should bo reserved to yourself and is often your most valuable trade secret. No. Date CS-6 March, 1961 MONSANTO AROCLOR* RESINS FOR INSECTICIDE FORMULATIONS A Discovery A simple method of increasing the service life of expensive lindane sprays was developed several years ago by U. S. Depart ment of Agriculture scientists at their Beltsville, Maryland, testing station. The technique was to incorporate Monsanto*s "Aroclor" 5^60, a resinous chlorinated terphenyl in the lindane solution. This pale yellow solid reduces volatility of the' lindane -- slows it down to an effective, but not wasteful, evaporation rate. The result is an insecticide deposit on treated surfaces that lasts up to ten times longer than that left by straight lindane solutions. Normally, simple solutions of lindane leave a crystalline residue that dissipates within a few weeks. On hard surfaces such as glass, metal or painted areas, the residues last only about a week. Because lindane is a well established and effec tive pesticide, U.S.D.A. researchers sought a way to improve the lasting qualities of lindane residues. Of numerous com pounds tested, "Aroclor" 5460 gave the best results at lowest cost. Test Work A major objective of these studies was to develop a suitable formulation for application to crops and other plants. Al though results under carefully controlled conditions were quite promising, subsequent tests by other agricultural ex perimenters gave only moderate success. Consequently, interest has been slow to develop in agricultural circles. Apparently, the vagaries of sunlight, weather, and plant growth represent too many variables for effective study of the formu lation residues by direct application to exposed plants. * Aroclor: Reg. U. S. Pat. Off. MON-MT-008584 Th information in thin bulletin 1*. to our beat knowledge, two and aocurate. but U recommendation* or ugfwttionn are mad* without guarantee, xlnce the eonditioiw of um are beyond our control. The Momanto Chemical Company dtaclaime any liability locurred in connection with the une of these data or aufgealiona. Furthermore, nothing contained herein ahull be oonairued aa a recom mendation to uae any product in conflict with existing patent* covering any material or it* uae. ad te LEXOLDMONOOOI01 A New Idea But another posalbllity for putting the U.S.D.A. discovery to work has lain dormant until recently! this i3 the possibility of using to good advantage the ability of "Aroclor" resins to make the lindane adhere to smooth hard surfaces like metal, glass, painted areas, etc. This would consist of painting or spraying "Aroclor"/lindane formulations on such areas as the inside of garbage can lids, on window screens, doorallls, the painted walls of outbuildings, dairy plants, storage areas, etc., in order to obtain lasting control of flies, ants, roaohes, silverfish and other troublesome pests. Suitable formulations can be readily packaged in shoe-polish type "dauber" bottles, aerosol spray cans, and bulk packages for meohanical spray application. Development of this idea is baBed on the following: Advantages of Using "Aroclor" Resins in Insecticide Formulations * A suitable "Aroclor" (Monsanto makes seven) can remarkably extend the effective life of lindane and other chlorinated insecticides as much as ten times (up to 2 and 3 months). * "Aroclor" resins are very low in cost (around 20^/lb.). * Small quantities are sufficient (5 tc> 25 parts per hundred, by weight). * Formulation is extremely simple --- the resin is dissolved in a suitable solvent compatible with the insecticide. * Stable in inventory and in insecticide formulation. "Aroclor" resins are fire-resistant, non-oxidisable, non-corrosive, withstand weather extremely well. * Non-staining "Aroclor"/insecticide films formed when the solutions dry are practically invisible. "Aroclor" 5^60 has a pale yellow color as supplied. Other suitable "Aroclor" products are nearly colorless. , * "Aroclor" resins are odorleBS -- won't impart "chemical" odors. * "Aroclor" resins are safe to handle as long as they are not volatilized and inhaled. They are practically non-volatile at ordinary temperatures, do not irritate or sensitize normal skin. * The nature of the residue can be varied. Monsanto supplies a variety of "Aroclor" resins. These are chlorinated to various degrees and vary in physical properties as follows: Monsanto Chemical Specialties Data Report CS-6, ....Page 2 MON-MT-008585 LEXOLDMONOOOI02 Chlorinated Terphenyls Aroclor 5460 - Yellow, transparent, friable solid (drieB hard) Aroolor 5442 - Yellow, transparent, sticky semi-solid (dries tacky) Aroclor 4465 - Yellow, transparent, brittle reBin (dries sticky) Chlorinated Biphenyls Aroclor 1262 - Light yellow, sticky, viscous semi-solid (dries stick Aroclor 1260 - Pale yellow, soft, sticky semi-solid (dries sticky) Aroclor 1254 - Pale yellow, viscous oil (dries "wet") Experiments1 Work and Formulations The following information wa3 derived from preliminary reports on work done by U.S.D.A. research groups. These data are not to be construed as recommendations by either the U.S.D.A. or Monsanto, but rather are intended to serve as a guide or starting point for the development of private formulations. Fifty to 200 milligrams of lindane per aqxiare foot of surface has given good insect control on nonporous surfaces. The ratio of lindane to "Aroclor" 5460 has been varied from 1;1 to It4. For most purposes a 1:1 or a ls2 mixture is satisfactory. Formulations as used in the U.S.D.A. experiments ares 1) For application as a solution. Lindane "Aroclor" 5460 Carbon Tetrachloride 5 parts by weight 5 parts by weight 750 parts by weight (Carbon tetrachloride is toxic and should be handled with extreme caution. Less toxic solvents are easily obtained.) 2) For application as an emulsion. Lindane "Aroclor" 5460 Xylene "Triton" X-100 (available from Rohm & Haas) 20 parts by weight 20 parts by weight 100 parts by weight 3 parts by weight To obtain a stable 1# lindane emulsion, mix 1 part by weight of the above concentrate to 13 parts by weight of water. Monsanto Chemical Specialties Data Report CS-6, ......... Page 3 MON-MT-008586 LEXOLDMONOOOI03 3) For use as a pressurized (aerosol type) spray. a) Lindane "Aroclor" 5460 Methylene chloride "Freon" 12 (DuPont) 5 porta by weight 5 parts by weight 40 parts by weight 50 parts by weight b) Lindane "Aroclor" 5460 Cyclohexanone Ortho-dichlorobenzene "Freon" 12 (DuPont) 5 parts by weight 5 parts by weight 10 parts by weight 35 parts by weight 45 parts by weight Experimental Results - American Roaches Using Formula 3a or 3b, the toxicant was applied onto a painted wall, depositing about 200 mg./oq. ft. of lindane and a like amount of "Aroclor" 5460. When the toxicant coat was one month old, it gave 90-100# kill of Amerioan roaches when the roaches contained in a petrl dish were placed againBt the surface of the treated Wall for two hours. The U.S.D.A. research team found that the lindane-"Aroclor" 5460 mixture (used at the rate of 50 mg. of actual lindane per sq. ft.) would kill 80# of all cockroaches exposed for 2 hours to a 60-dayold treated surface. It remained lethal to 66# of the .roaches after 90 days. Regular lindane sprays used at the same rate killed only 4# of the roaches after 60 days. Results with Houseflies Deposits of 25 mg. of lindane plus 25 mg. of "Aroclor" 5460 applied from carbon tetrachloride onto glass and aluminum (hard surfaces) gave 100# kill of normal houseflies exposed for 2 hours to these treated surfaces after they had aged 18 weeks, the duration of the test. Without the "Aroclor" the hard surfaces treated with lindane alone were effective only about a week. A lindane plus "Aroclor" mixture sprayed as an aerosol onto leaves of a willow tree continued to kill houseflies after 2 months of outdoor weathering. Careful inspection of the treated leaves showed that the toxicant was held firmly to the surface and notwithstanding rain and weather, the coating re mained in good condition. Also, within limits of a preliminary inspection there seemed to be no injury to the willow leaves. Monsanto Chemical Specialties Data Report CS-6, .....Page 4 MON-MT-008587 LEXOLDMONOOOI04 (Note: The primary purpose of this report is to provide In formation for the development- of suitable insecticide formula tions for application to "nonsenai Live" suirfacoB such as metals, glasB, palntB, and other materials that will not be damaged by the application. Development of formulations for living plants requires sufficient test work to Insure that the formulations will not be Injurious to the plants or their products.) Another Formulation Reportsd A more recent development in these experiments is the following simple formulation: "Aroclor" 5460 25$ Lindane 25$ Methylethyl Ketone (MEK) 50$ Work on this was reported in the August 14, .1954 issue of Chemical Week magazine. This simple formulation appears to be most suitable for "painted on" formulations packaged in bottles but should be used with caution in mechanical spray equipment since the MEK solvent will soften rubber and certain plastics. The formulation could also be modified easily for aerosol packaging. Since MEK evaporates rapidly, it sboxild riot seriously affect painted areas unless too heavy applications are made. The package label should include a caution to this effect. Also, MEK is flammable. Possible substitutes that are less flammable are methylchloroform or a mixture of methylchloroform and methylene chloride. Formulating Other Insecticides The beneficial effects of "Aroclor" 5460 apply generally to other chlorinated insecticides including ohlordane, aldrln and dieldrin, but do not apply to phosphate type insecticides such as TEPP, parathlcn, methylparathion, malathion and chlorothion. ' For samples of the "Aroclor" products mentioned in this report, contact the nearest branch office (see attached list) or write to: MONSANTO CHEMICAL COMPANY Organic Chemicals Division PlasticizerB Department 800 North Lindbergh Boulevard St. Louis 66, Missouri Monsanto Chemical Specialties Data Report CS-6, ....page 5 A^/"XXT \ -T-T* An nr no LEXOLDMONOOOI05 MONSANTO CHEMICAL COMPANY Organic Chemioals Division District Sales Offices ATLANTA: 1401 Peachtree St. N.E., Atlanta 5, Georgia BOSTON: Everett Station, Boston 49, Massachusetts CHICAOO: McGraw-Hill Building, 520 N. Michigan Ave., Chicago 11, 111. CINCINNATI: 2330 Victory Parkway, Cincinnati 6, Ohio CLEVELAND: 427 Hanna Building, Cleveland 15, Ohio DETROIT: 18230 Grand River Avenue, Detroit 23, Michigan HOUSTON: 2472 Bolsover St., P. 0. Box 6863, Houston, Texas LOS ANGELES: 6670 E. Flotilla St., Los Angeles 22, California MINNEAPOLIS: Foshay Tower, Room 515, Minneapolis 2, Minnesota NEW YORK: 445 Park Avenue, New York 22, New York PITTSBURGH: 20 Cedar Boulevard, Pittsburgh 28, Pennsylvania SAN FRANCISCO: 111 Sutter Street, San Francisco 4, California SEATTLE: 911 Western Avenue, Seattle 4, Washington SYRACUSE: 731 James Street, Syracuse 3, New York WILMINGTON: 20Q5 Conoord Pike, Fairfax, Wilmington 3, Delaware ***## LONDON: Monsanto House, 10-18 Victoria St., London S.W. 1, England MELBOURNE: 256 Flinders Street, Adelaide, Australia MONTREAL: P. 0. Box 900, Montreal 3, Canada TORONTO 183 Front St. East, Toronto 2, Ont., Canada VANCOUVER: 1550 Rand Avenue, Vancouver 14, B. C., Canada MON-MT-008589 LEXOLDMONOOOI06 UNITED STATES DEPARTMENT OF AGRICULTURE AGRICULTURAL RESEARCH SERVICE Pesticides Regulation Division . 101 South Laboratory Building, A.R.C, Beltsville, Maryland 20705 May 10, 1968 R. Emmet Kelly, M. D. Medical Director, Monsanto Co. $00 N. Lindbergh Boulevard St, Louis, Missouri 63166 , * Dear Dr. Kelly: ' Thank you for your letter of May 2, 1968 which contained a data sheet concerning the use of Monsanto Arochlor resins in pesticide formulations. He did indeed receive sample* of Arochlors 1254 and 1260 and wish to extend our thanks for these samples. In order for us to have as complete references for our analytical laboratory, would it be possible for us to get similar samples of the other 9 Monsanto Arochlors. Again, if there is any charge for these samples, please forward the bill with the samples. _ Sincerely yours. W. n. Biickenstaff Chemist in Charge EXHIBIT WBP M-24,8 MON-MT-008590 St. Louis May 16, 1968 Mr. K. A. Wells The attached letter is self-explanatory. Can you send 3 ounces of the other 9 Aroolors to Mr. Blickenstaff. I ! REK/ln att. R. Emmet Kelly, M. D. MON-MT-008591 ir r LEXOLDMONOOOI08 UNITED STATES DEPARTMENT-OF AGRICULTURE AGRICULTURAL RESEARCH SERVICE Pesticides Regulation Division 101 South'Laboratory Building, A.R.C, Beltsville, Maryland 20705 June 3, 1968 Dr. Will lain R* Richard, Manager Research and Development Organic Chemicals Division Monsanto Company 800 K Lindbergh Boulevard St. Louis, Missouri 63166 _ ' - Dear Dr. Richard: . On Friday, May 24, 1968, Mr. Ronald Thomas of our laboratory spoke with Dr, Early of your Washington office. At that time Dr. Early indicated that he had contacted you concerning a request from our laboratory for samples of the various arochlors. Vie would be interested in receiving samples of all of the arochlors except 1254 and 1260. If there is a charge for these samples please enclose the bill with the samples and we will see that payment is made Thank you for your consideration in this matter. ' Sincerely yours. W. N. BlickenstafC Chemist in charge EXHIBIT WBP M-24.10 \ MON-MT-008592 June 18, I960 1 1 Kr. W, N. Blickenutaff Ohsmlot in charge U. S. Bapt. of Agriculture Pestlcideo Regulation Blv, 101 South Lab. Bldg,, A.R.C. Boltsvllle, lid, 20705 . Boar Mr, Blickencfcaffj 0 aro enoloDing, per your request, camples of tho following Aroclorai . Aroclor 1221 " 1252 " 12H2 " 1248 " 1262 " 4465 5ljJ}2 " . 5460. I hope they arrive in good condition, .' Sincerely, WRJUmo Ehca. W, R. Richard Manager R & B EXHIBIT WBPM44.il ' MON-MT-008593 1 i . ; ir r LEXOLDMONOOO110