Document 45vQndYDmEevdnXOGGrdG36G

i>> " J. L>. Ledbetter - B-2-N L. F. Steinbach - G-4-E R. J. Stratmeyer - B-2-N N. L. Sample - B-2-N A. H. Schwab - JFQ H. A. Partlow - JFQ X. D. McIntosh - JFQ J. R. Kellogg - JFQ H. L. Minckler - B-2-S T. M. Patrick - Res. 1 R. E. Keller - Res. 1 D. C. Reed - Res. 1 0. J. Marchand - Res. 1 MONSANTO COMPANY Organic Chemicals Division Vo s/2 To the General Manager Organic Chemicals Division Estimate No. 1908 Dept. No. 76001-0000922 Plant - RSD Laboratories f^cocXurv''- W.d2f &<- V---- Pvft t-Kl. htx.M< . t '- X. /Lf-w'C .* uj ,rtt -c*_ f>'": < 1C. ax*si a* t.`ift. / o-'Om i&fcit: t' l vCo VO J-"** - ^-vr F f' f.' r|AF , PURCHASE BIOMEDICAL GAS CHROMATOGRAPH Capital Addition $7,000 DESCRIPTION Purchase biomedical gas chromatograph with all-glass system and multiple flame ionization and electron oapture detectors for the analysis of thermally sensitive and polar materials. APPROVAL General Manager - H. L. Mlnctuer Date HONS 034702 Estimate No. 1908 Page 2 NEED FOR THE PROJECT Late in 1966 Swedish researchers reported the presence of poly chlorinated biphenyls in a variety of biological samples. Since that time the Organic Chemicals Division has received a number of requests for Aroclor samples from active pesticide research groups. We also know that the U. S. Public Health authorities have initiated studies to evaluate the significance of this environmental contamination. To assess the validity of these findings, the impact they may have on our Aroclor business, and to avoid restrictive legislation, the Functional Fluids Business Group has begun its own study. The Applied Sciences Section has been requested to develop the necessary analytical methodology for this project. To do this and to do it correctly, we need to purchase a biomedical gas chromato graph . This instrument is designed specifically for this type of analysis and is used by most pesticide researchers, including the Publio Health authorities. Any analytical information we generate will be judged in terms of the techniques and equipment used. By using the tools most familiar to these people, we feel any information we provide will be more effective. The biomedical-type chromatograph provides an all-glass system with direct injection into a U-shaped glass column which is attached directly to the base of the flame ionization or electron capture detector. This allows high efficiency analyses to be made on pesti cides, steroids, organo metallics and polyfunctional organic chemicals which are thermally or catalytically unstable or have polar functional groups that, in the environment of the ordinary gas chromatograph, cause them to decompose or become irreversibly adsorbed. The KSD Labs do not at present have such instrumentation. Therefore, we recommend purchase of such a chromatograph for initial use on the environmental Aroclor project and to broaden the capability of the Applied Sciences Section in the gas chromatographic analysis of unstable organic systems. HONS 03A703 Estimate No. 1308 Page 3 STATUS OF THE PROJECT No commitments will be made until this project is approved. RECOMMENDATION It is recommended that this project be approved. Submitted by E. M. Emery Group Leader K. E. Keller Research Section Manager T. M. Patrickj Manager RED Laboratories mw 8/28/68 HONS 03A10A