Document 44bJ77rkRB2jqxoY12xEj4Xx1

FILE NAME: General Motors (GM) DATE: 1963 DOC#: GM019 DOCUMENT DESCRIPTION: Book Excerpt - Potential Exposures in Industry Industrial Hygiene and Toxicology a Uni>*:*{& '*8i&B&&~---.: tS1ea m i l INDUSTRIAL HYGIEANNED ( TOXICOLOGY Second Revised Edition ( FRANK A. PATTY, Editor \9 G ^ > f V O L U M E II TOXICOLOGY David W. Fassett and Don D. Irish, Editors Index by M rs. K athleen K umi.f.r Authors W. B. Deichmann F. W. H eyrotii V. K. Rowe D. W. Fassett C. H. Hine H. E. Stokinger H. W. Gerarde D. D. Irish W. L. Sutton C. L. H ake R. A. K ehoe J. F. T reon D. 0 . H amblin M. L. K eplinoer R. J. Weir I' L. W. H azleton F. A. P atty M. A. Wolf INTERSCIENCE PUBLISHERS a division of John Wiley & Sons, Inc., New York London Sydney U d AUTHORS of Volume II William SBc.hoDoleiocfhmMaendinc,ineP,hU.Dn.i,vePrrsoitfyesosof rMaianmd i,CChoariraml aGna,blDese,pFarlotmridena.t of Pharmacology, David WC. oFmapsatneyn,,RMoc.hDe.s,teDr,irNeecwtorY, oLrka.boratory oj Industrial Medicine, Eastman Kodak Horace WE.ssGo eRreasredaer,chMa.nDd.,EnPghi.nDee.,rinSgenCioormRpeasneya,rLcihndAesns,oNcieawte,JeMrseedyi.cal Research Division, C. L. HDakivei,sioPnho.Dj .T, hHe eDadow, CChheemmiisctarly CRoemspeaanrcyh, InDdeiapnaartpmoelins,t,InPdiitamnaan. -Moore Company, Donald OY.oHrka,mNbelwin,YoMrk.D. ., Formerly Medical Director, American Cyanamid Company, New Lloyd W. Hazleton, PhJ)., President, Hazleton Laboratories, Falls Church, Virginia. Francis FP.hHyseiyorloogthy,, CMo.lDle.g,e(oDfeMceeadsiecdin),e,AUssniisvtaernstitDy iorjecCtoinrc,iKnneatttei,rCinigncLinanbaotri,aOtohriyo.of Applied Charles HS.chHoionleo, jMM.Ded.,icAisnseo,cUianteiveCrlsinitiycaolfPCraolfiefsosronriao,jSOanccFurpaantcioisncaol, MCaeldifiocrinniea.and Toxicology, Don D. MIriidslha,ndP,hM.Dic.h, igBaino.chemical Research Laboratory, The Dow Chemical Company, Robert A.CKolelehgoeeo, jMM.Ded.,icDiniree,cUtonri,vDerespitayrotmf eCnitncoinj nPartei,veCninticviennMateid, iOchinioe. and Industrial Health, M. L. KeWpillimnginegrt,onP,hD.Del.a,wTaroex.icologist, Medical Department, Hercules Powder Company, Frank A.MPoattotyrs, FCoorrmpoerralytioDni,rDecettorro,itI,nMduicsthriigaalnH. ygiene Department, Personnel Staff, General V. K. RowMei,chMig.Sa.n,.Biochemical Research Laboratory, The Dow Chemical Company, Midland, Herbert EU.niStetodkSitnagteers,PPubhl.iDc.H, eCahlitehf,SeTrovixciec,olCoignycinSneacttiio, nO,hiDo.ivision of Occupational Health, William RLo. cSheusttteorn,,NMew.DY.,orLka. boratory of Industrial Medicine, Eastman Kodak Company, Joseph FA.tTlarseoCnh,ePmhic.Dal.,InMdaunstargieesr,, BWioillmoginicgatloSnc,ieDnecleaswSaercet.ion, Chemical Research Department, Robert J. Weir, Ph.D., Toxicologist, Hazleton Laboratories, Falls Church, Virginia. M. A. WolMf, iMch.iSg.a,nB. iochemical Research Laboratory, The Dow Chemical Company, Midland, ifc'ft,'' .. 2145 .. 2145 ...2146 .. 2146 .. 2147 .. 2147 .. 2148 .. 2148 .. 2149 .. 2149 .. 2150 .. 2150 .. 2151 .. 2151 .. 2152 .. 2152 .. 2153 ..2153 .. 2154 ..2154 .. 2154 .. 2155 .. 2155 .. 2157 .. 22117711 .. 22117712 .. 22117756 .. 22117788 .. 22117789 .. 22118719 .. 22118811 .. 22119819 . 2192 .. 22119963 .. 22119988 . 2199 . 2200 . 2201 . 2202 -r- / M M ti94kaL*'.it>JtiM n* '- iw iwiii'iiiVtjinltfrM fJ Mu i -*f> ., :.h^> iBSyMtiMgfl^'iii l CONTENTS xxtx NH-eSxuabmsetitthuyteledneMteotrrapmhoinleines................................................................................................................................................................ 22220046 1 AzQidueisnol.i.n...e........................................................................................................................................................................................................................... 22202807 | 1 GSoednieurmal ACzoindseid.e..r.a..t.i..o..n..s.............................................................................................................................................................................. 22221008 j ', DiaHzyodmraezthoaicneA c..i..d.......................................................................................................................................................................................................... 22221123 j DNiimtroesthoymlneitthryolsuarmetihnaene........................................................................................................................................................................................ 22221156 i HyGdreanzeirnaels C.o..n..s..i.d..e..r..a..t.i.o..n..s.............................................................................................................................................................................. 22221188 H1,y1d-Draizmineethy..l.h..y...d..r.a..z..i.n..e.................................................................................................................................................................................. 22222225 Phenylhydrazine.................................................................................................. 2227 , -Chloroethylamines.............................................................................................. 2230 General Considerations ..................................................................................... 2230 Methyl-bis(p-chloroethyl)amine ...................................................................... 2233 f DTimriest(h0y-cl-hpl-ocrholeotrhoye]t)haymlaimneine........................................................................................................................................................ 22223333 . Diethyl-jS-chloroethylamine ............................................................................. 2234 ! XLIX. FProatennktiAal. PEaxtptoysu.r..e......i.n.....I..n..d...u..s..t.r..y..:......T...h...e.i..r...R....e..c..o..g..n..i..t.i.o...n....a..n...d....C...o..n..t..r..o..l.......B...y 2235 > AAbbrraassiivveesBMlaasntuinfagc.t..u..r.e....a..n..d....U...s..e...................................................................................................................................................... 22223365 21.. ASarntidficiAalbrAasbivraessive..s..................................................................................................................................................................................... 22223376 AAcciedtyMlenaneuMfacatnuurfeacatnudreRe..c..o...v..e..r..y.................................................................................................................................................... 22223387 21.. HNyitdrircochAlcoirdic ..A...c..i.d...................................................................................................................................................................................... 22223389 < A3ir.cSraufltfuMriacnuAfacicdtur.e..,..M....a..i.n..t..e..n..a..n..c..e..,..a..n..d....R...e..p...a..i..r............................................................................................... 22223399 AAmlummionnuima MMaannuufafcatcutruerianngd...U...s..e............................................'......................................................................................................... 22224410 Aniline Manufacture, Distillation, and H andling............................................. 2242 Anodizing ................................................................................................................. 2242 AArrmt-Matuetrael WCaosrtkinegrs.................................................................................................................................................................................................... 22224433 ' AAssbpehsatlots (WMoinrekrearlsP...i.t.c..h..).................................................................................................................................................................................. 22224443 i BAautttoemryobMileanMufaancutufarcet..u..r..e............................................................................................................................................................................... 22224446 BBleeearcVhiantgC.o...a..t.i..n..g.......................................................................................................................................................................................................... 22224488 BBreircyklliaunmd TPrioleceMssiannguOfapceturareti.o...n..s..................................................................................................................................................... 22224498 BCraoropmentMryan..u..f..a..c..t.u..r..e..................................................................................................................................... 22224499 Carroting................................................................................................................... 2250 A POTENTIAL EXPOSURES IN INDUSTRY 2243 Armature Workers ture Icdoenattiro"ltsi,nmnianyg"nboat tphrsesaenndt lseeardioupsotlse,awdheexnpossmuarells.anHdoweqeuvieprp, etdhewliatrhgetermoppeerraa tWiohnesr,eevseprecthiaelrlye wishaennynoquteemstipoenraotufreexcpoonsutrroel, itshienoupseer,actaionnofsfheorusledrioeiutsheerxpboesuprreos. vbiedfeodre wthiethy cmaencbheaninichaallleyd,inodrueclesde aaiirr, bflloowod,toorruemrinoevesaomrpldeislustheouthlde bleeacdolfleucmteeds and aWnaaltyezrperdofoofr vleaardnitsoheess,tabeslipsehciwalhlyeththerosveenmtialadteionfroismneccaesshseawry.nutshell liquidfthoermwaeldtevhayrdneishre,sfinrosm, mthaey vcaarunsieshdedrumstatditiissp.erTshedis imn agyrinredsinuglt afrrmomatucroens,taocrt fwroitmh sskoilnvecnotnbtaactthwsihthoudldirtnyostoblveenpterbmatihttsedfortodipbepcinogmeanbdacdlleyancionngtaomldinaarmtedatuarneds. sTkhine nceosnstaicstamn uesftfebcetivaveopidreevde.nItnivtehemceaasseuroef, wanetdovradrnryishvadrnuissths,hgoouoldd pbeerscoonnatrlocllleedanbliy ipnrsotcaenscsesv. entilation. Protective creams and clothing may be useful in some Art-Metal Casting fromAwrth-miteetamlectaalstsorfobrridtiasnpnlaiays,mterotaplh, iewsh,imchedaarles, aalnlodystheoflitkien,araentuimsuoanllyy, caansdt caorspepneirc,. oTfhteen ahllaovyisngarseommeelzteindc inanpdotbsi,smteumthp,eroactucraessionraalrleylyleeaxdc,eeadnidngpo3s0s0ibolyr 4tr0o0lleCd., Bsiugrnriinfigc,anfitlienxgp,obseulrtes"staondminegch,"anaincdallbyufgfienngemraateydbme edtoanl eduanstds, munalyessrecsuolnt. Atotmtheetatlefmumpeersa, thuorewsevoerrd.inWahrielrye eumncpelorytaeidnttihesereexiisst,lietxtlpeosliukreelsihsohoodulodfbaenevexapluoastuerde iannvdo,lvwehepnlatfionugndbaetxhcsesasnivde,cycoannitdroelldeidp.s.OSthoeldreprionsgsibolpeereaxtipoonssuraerseinustuhaellyinadtusltorwy tceomndpuecriavteurteosthtoe faovromidatfiounsinogf mtheetallofwu-mmees.lting-point alloys, and therefore are not Asbestos Workers of 5 Dmuilsltiionnespsaartrioculensdpaesrbecsutboiscwfooorkt.erPseirshsaopms emtiimniensgaobfofveersththeepgrorepaotseesdt setxapnodsaurrde otorddeursot,fadnudstiinnefsasb, raicrea:tioscnrepelnainntgs, tphieckoipnegr,asttiaocnksi,nlgis,teadndinwtihlleowpriongbaibnlet,hedepcrreepasairnag tsiaowninrgo,omfil;incga,rddrinilgli,ngd,ryanwdegavriinndgi,nsgpoinfnbinragk, etwliinsitninggs,iws ionrddiinnga,rialyndwewllarcpoinntgr.olTlehde. Gsarwinindgingo,r mbeixvienlgin,ganodf absabgegsitnogs basobaerdst,oasrecedmuesntyt aonpderiantsiounlastiunnglemssatperroiaple,rlayndentghie neered. The asbestos content of these dusts frequently is not high but diatomaceous 2244 FRANK A. PATTY earth in considerable quantities may accompany it, thus complicating the exposure with free silica. I t is desirable in asbestos exposures to keep the dust count down to 5 million particles, or less, per cubic foot of air. Asphalt (Mineral Pitch) t withTbhiteumnaemn ean"dastpohaalrte"siadpupeliefrsomto cbeirttuaminenpeotrrolteoumeasr,thcoaolr traorc, klsignimiteprteagrn,aetetcd. o(afrtoirfgicainailcasmpahtatelrt).. IItt iissacbolmacpkosseodlidchfoierfmlyedoifnhthyedreoacratrhbofrnosmaslloonwg dwecitohmpvoasryitiinogn amouAnstpshoaflot xisyguesne,dnpitrriongceipna,lalyndfosrulwfuartecro-emxpcoluudnidnsg. coatings upon roads, floors, or rtooopfsr.otIetcitsmemetapllsoyferodmascoarrroussitvpere(avceindt)ivleiqiuniddsucatnsd, cgoalsleesc.toFrso,rtsaunckhs,apanpdlicsaotiofonrtiht is commonly dissolved in benzene. amonVgapoothrserancdomgpaoseusndfsrosmomheeahteyddroagspenhasltulafirdee.obDneorxmioautsitiasndfrotomxicc,oncotancttaiwniinthg Saskpinhaclat nhcaesr bheaesnarlesopobrteeedn arespcoormtemd,onb,utwistthatitshteicesnatirree lbaocdkyings.omSoemtime easutahffoercitteieds. saottlrviebnuttseemmpolsotyoefdtwheithpoitis(obneinnzgenthe,apt hheansolo,cectucr.)r.ed from the use of asphalt to the PersoGnrailndclienagnlionpeesrsaitsiotnhse haenadrt ohfoat npyropcroesgsreasmsfhooruplrdevheanvtiengesxkhinaudsitsevaseen.tilation. Automobile Manufacture indusTthrye. mTahneurefacatrueremoafnyauteoxmpoosbuirleess haansd fepwoteonpteiaraltieoxnpsosthuraetsarceompmecounliatro tooththeer industries. BlastTinhge,seAnaoredizdiinsgc,usBseadtteerlysewMhaenreufaucntduerer, sEpelecciftircophleaatidnign,gsFosuunchdryasO: pAerbartaiosinvse, IFnodrugisntrgiaal nXd-RIraoyn, WLeoardkinWg,orGkearrsa,geMs,etGalriCndleinanginagn,dMPeotalilsihziinngg,, MHeoatot rTTreeasttiinngg,, PRaeipnatiirn,gWaenlddinDge,ceotcr.ating, Pickling, Plastics and Resins, Radio Manufacture and moreBoordylespsoplieschuinligarbtyo tthhee pursoeduocftitorinpoolfi hpigohlilsyhipnoglischoemdpoauutnodms oibsilaenboodpieersa.tiNono harairsminfgulfroemffecthtse hpaovlieshibnege,nanadsseoscpiaetceidallywiftrhomthcisomoppreersasteiodn-a.irHbolwowevoeffr,opaenryatidonuss,t and from the cleaning of the brushes should be controlled. There seems no logical epxecrucsuebficorfocootnodfonaiinr.gSsiuncche tdhuesttriinpocloi npcoelinsthraitsioanpsploiefdmaosrea tshluanrry5, mduilsltiocnonptarrotlichleass not been a difficult problem. soldeAr.nTo)til. myeeatrasl pbaysti bcllooosudreosr ua. ecxicpnotsluyrebsig atarkeeacdaerqeu;o pcileiendt-aaiirr eh>. froemreoivnatolxoifc with lead 0c.o0u8pmlegd. lwe<i: encoCunotnetam tbhilaetmaraenuinf-; tact Awisthtattli tehxepohsiegdhepset stictriesw---monacthl "soluSbolemoeilsc eparicmh aorfythient namitrionpesh,enaonlc, objecIttioinsabi;i sdteesriirlaizbaleti.oInr wtehuerirzeatthioeny ! that certain odorsTwheithmooi i effective wa i I ' . ' : >\<*W. - / . v ..