Document 44b7kpdKYE9rEd4Rj3RrQ2akG

INDUSTRIAL HYGIENE FOUNDATION OF AMERICA, INC MXLLON lN*TiTUTC. 4400 FlPTM AVf.NU PlTYftSUftOH, Pa. tSS!9 April 15, 1955 Mr, Leon Horowits Mr, C. L. hec*ier Mr. F. H. Edwards vr. Lee E. Grant Dr. J. H. Wotfsie Cartain-ieed Product* Corporation Johne-M&nvill* Ccrporaticn Ovrene-Corniag Fiber;?!* Corporation Fittebur^h Plate Gl** Company U. S. Rubber Company o <r Attached is an industrial Hygiene Foundation aibeatca and fibre* iip* throe~year research project proposal incorporating suggestions made y those listed above who attended a research planning meeting in n>y of&ice a April 12, 19 Si. Also *r.cloaftd \ ? contractual. agrsin an original r:*.s cc in ths ivan; that sponsorship c; this p r c; e c '. i: sc proved, been :h.>uid j s the carbon returned and the original retamea for the ponor'u iil *y ^ -V y .** e 1v' y o u'N i ^ idyizsCf Itda Hobsrt *T. P, cfeTreville, M.D, -Kt.'ii.i DiveciCA de.:c;; .-Jr. closer.** cc: Sir, Mi'ihiU Burch, 0*.ven5~Ccvrninr .r'iberj;!:-* Cur.-'orati:,!-. Dr. G. 5. Znehcp# Cwti:e-C.onurv] j'ibtrglca Co.';--t-.on ...*.-** T-*. >aT*Ci** ><M>^*T>C* /T T.C ,C>vAHriNC*T Of Ht/.i THrui wC-S*f0 0. < .'irmu&vmAL s/aiEKS ^unoatiom or ^ERa,iNC MesLM iwa?:wr# fin** ^ Pimsu^M, Pa. issis A$?U 1 1966. ?ff(9St5HC^t3 fo? Aa lawatiigailoa eft & Th* j*efcfllfcv $f Aabeattes 31odi* iiji hi *!:* isioAejie J&SfecS* ci !StiiC9 C<2.ht*&z*t r..d~e^U':^a &U3h 2urysei& JtcfeosS-if), -*r s??ir>r5UCT20?T <n `y itetaiasi ifea* nfetwl $&$ $ tba ?ee?l* a& b*t<& Al#4 ia L21 ;-d^: $36 <gJfc<PSm'iT<?l aw-i5*->J>ia*3 S-t>^ ' 7'5'j ^ >.*,,? >>;t v'v?.-us *.>?-*'v te*& * sSt./,.',*.* .`'yE-C-US'" 2 'sab-jete* o-*:i**wr`` .viTjv.-iT v; ,,; 17.:; is S<Ci;*cal yieri&a, C&tua-a, 7:;si *si :-(*.: " ' .r ;-'^;-.', '.'.ii* -.v^*;>t; (?>j t j5 &S?.^vA*`J*\ .';&i. / *T '-} vsi; V-S^-c?-' '.v>':.. '..;<v^. t js.ftA S^isis^c U!iS M '>:'* .*<3 -. ,,. v :;ja; is i'-ii.'.-J, ia 'ti'ab si**?''"*' 3-aiw-iiiy a 61 vy ViA-V.-. ; . '._ ^>`. ;'/. 1. .; :< .:'> .;.' J. 'Zs.S'Sv i`i> Sv \-\;j ^ t.cui'l 7'u.t ,:* v`r.,wr;r-', tC<lJ.SfiiJ STS . -i.y* -. '-..'' i/,;..:! `v^'i r.i-U^is.-tvv. <r^ -.; >,' <5. . .ch ? -c .'.:? o htvs *>i; is ??*s.'.vxj> . ui-.j *T.r^l-Sy* *rVs*. Qu/ i.K'r.z K-t%r. cs-Uai '..z* '-ic.-.y.c. *-aty& l>v? i * *j **' Dzvt<L'~f &&-S. - ^ i`- !i * ,V.ua tCxsJivu^F i-l -\m.:.-rci- ^ts .-rr.r.j -- . ^ ^->o\.-.-a.'*;: Lj ***.; v..\i .<* CV wr^Vw.-w v * \* xrrx >>> MVaitHl fOUMOAVIOM kMSRK' < ill. , Atl>*toa ccupUs aa ttuounaicnaa position la tie ability to produe* taa$ &amag*, causing 4lus* lb*8ls a* wall ao tba protraction ct luag c*ac? U it ^uccatlo\i5 laaemueh a* a tbar silicate baa fe* ihtfa to posoaaa tble ability* T3 flbrocitf &cauateff*4 is toleosle ia limited to to* tramollte variety. ^MvsSi is aet*s*tc>8&llM* Ca tho -ihoff ba&i, a<s gaacuraseonteel* associated cl^s ths jstd::i <*A swtes oiUe&te} k** ocH *#a iawstigated ettpsyiiwsetoUy,. as-4 tbs libre^&ia activity & fcJbi gusto eaasUtiag with the mica has act baa* vAiuntodo $&* silicate* may sveko sltfeor twiaia&al 7 #tktivily sli.jkt is^laatrvi&tc-i'y fc4ag*6# aaa caa-teiaiy or* i&captfeto protuciag ls&$ $*ecs? aw{u*a as mU j^iycycite feycrscarbooa ad trace meteis fc&ata to >5 s^te-cs ..fe;ac62>e'j>7^5U4;la^ c^asa 3tav V>sa gstrtOAOSratod la fcabcetofti* ? rtlcv-.i*?;.? i-.oCi'OA &ad "2`SEao,Or,;?aay>> $L-s poisisLUty iisistii fcljAt -i. %?%* : '^.i /:..?./ ;- jxuyeysile :, 1:3 ' **v* * y * -ac;; -* alftity .atvA/ Ss isu.l\*;W *;.*;? v?.* 'Jhls 7'^:'. f*E.t`UiW li av^Sirisa. by tit- /LiaiUf..3S .-, .7*1^ <;i ws-sw i-~v, ^rj2-s:.b bL'.i^&tag tl-its tba ..*u.c* -2 c *&</ i/c&aag Cvj.a**u&a fcs&ftftox s&iavvs v;a sc $*$$*:? '-ii c-?i4 ^r::x\`,.Jiocav ' ''Tl-.ir- *7'?.s ia ''? ty>v.`v*; f *l ^U^11 -'S:.c';. ':' HcOs** a fj3wi\tiy !:.*? tficb cl' i'*.u* caav.ay j.::U; :.b v.'o ^\zi \..v: a-'.i-.w evi-t hU.s ,'j',^.';`.;':^ *.Lo ct, 2, **s y^c.'Viit ?-t.:v:.*A to it^&ratovy ^aiv^tri^ H.ytlv:.^ yev.^^i/ 'or.. caaccr* ?/sl".s :'!&*.^ la sate tr-jpoaxO. !^v li o>o^tSc to hlgia ,:'T'5Ci;'.- iCorc.t'/.?.* s*tii o*roo^i*d to cbryaotUa ^.v.-r. -i. - :--.'-:xi;:ri ;.*. :,vr:.vp lvi:^ .`ti,;**; >-*:.' ;.v i. .*^wi y;z\T-.\: IHOUfcTmAi. MYOltKK. rOUMOATIOfS . AKCftiUA.lMQ. 3 that the chry*iU duet Out produced lung ccacer wr el^&UicnaUy different from that vhlch did not have this effect* It Ifi i&eiy Out this difference U etueed by a setting of nickel steel Alloy Applied to the asbestos dust partieiee during the continuous Homme? mllitag precoec ueed for rendering the duet respirable. This method Has not bees used by previous iarsflil.yatcrfl. Nickel bee '&*** capebl* of producing iWi3f cancer is trace asaouate. Aithoa^h fttbeirw end ff.ro both silicates* the ke&uctrial health sswiri^nce ^rhere of theoa two matsri&ia haa bs* vi.-;uy ^fffsreat. SCo pu-raoiias*** Ha beoa reported la ^rkere ssrpesed b* jhsi duct* -Jev^-rta^tp^ee, .the dues etf ftlAscaentoue glee ha* boea labeled a* highly \n fkc .Ur pre<?e by Asas-ciatisau with tcbe***5e J id . fact that i.i >v- v*J* S-.J ;;-4i.Ue giiwfij dvwt on ode voi/js ex V^s bees tep^rsA-A, i.':'i' Jc?.'I.V>.r ; I-y IvO-lf c>^v>(3 &&%.*. !~?Z txVi *U2.C$ i '-: , v*'f.'.-A^ JiV'/.r, j'j> S'Ji*TM* . V%5> 'vda / tV A. . v* 0%a ee-s^<:>:)v- w S'.uimJ * * -V?-. ^ aLiiia,<JS& ? -...i- . ;; *-^*..',51 csi vt*: resting cj.^jicv. J.iv1-*:.!;-*.? s-:-i fc``^U/.c?U.\ . tj. :. .> *> It ii 'IPhase S. tc< iivvc'.j.t'cS-t-t the iafi'icncj ci >i'*cir cr.insrtl p.viy A .iir. -'.-*v. (1, 3, ? hw.^-v^rece) - s^oc*. vi-s-A tnth aeceeic*-/ ore or cwC.-.; \; j r,,z?,i. jiz,^ =rj. u...> io:r.*ji v <* : liv-.j tv- >** ',t<-.V VO I IMOWITfrIAk MYOICWC SOUNOATtON (. AMKHIOA.IMQ. Another objective of ihl* phase is to obtain infinitive data cm the long term effect of duet derived from filamentous gl&ac upon the tangs. Three varieties of such glass dust wiU he Investigated! 1. with the phenol"formaidehyde^typ* of binder 2, with the hinder used In textiles 3 without hinder. *. MATSRT.A13 AND MSTKOP Phase 1. The following fibrous mats riels will he reduced to respirable particle else (<3^r) and will he injected in amounts of 2.5 rag. to 30 tag. at* aqueous euspcsiftiea*: 1. chrysalis dust (prepared by milling in H'right mill and MSh dcmcn- stratod carcinogenic potential) 2. chryrotiie dvat {unmil led synthetic.)* S., aluminum nitride *4. tricelcium phosphate (filamentous) / S flhrour class a. with phenol-formaldehyde''type b'-nder b with binder used frr teazle? e without binder 6. taagnertam kydroxioj (orucite) 7. mineral */ool $, sine* orids (fi'.azncnfcous) These materials will he injected intra;;r%*<heiuiy iz\to K.T^ar s-sher &neib:*i*. Previous cxpeniuce Jar demonstrated that nsb-esu.o bodies will form in resfonse to chryijtU* cut si rruhia five tucnlhs. The ani.r.t.to wtU there Mrs he held /or six vr.ontn* aad theu kttitd. The Ivn^s will h 3>->ci*t.nd with buffered formalia uude7 a he*-ft Ul -.0 cr.i. vMo'\ Vi".r.* ,;ve5 f:,vi.n thes-; I will be r*ecto./*f * Syothitlr: chfy*clil> hac been prepirad at Mellon Institute by C*r. 'V'lil'.ais Grai.^vlslu ~l;.t**rt>Q r*. ;ou-iicr>^TJ).`as Jt.uv (he char*cta\l'jVic twh*\t>r r*yA\r.l** SVOtrfct yO'JNOATtOH AMCMlCA.IttO. 5 fcJtcr p%cLtiift imvrr.ti{loti. Thais stations will b* eialasd by difisrsni Tzvsthode ar.J photographed sequentially to provide means for studying mots completely the tissue reaction to these various materials* Search for tbs 8C"Cfcil-6<i atbedos bodies will he made using routinely stain*4 sections, euad x4Cii-n* for Ir&n, is xidition, unst&i&ad cisar+.i sections will be ^xJ.r^.izvsd u-^.zy ccadlSioaQ foff asbestos fetdi(de, S`he letter glovr 4 is. reaction defcvrs'jiuu tbs .RynlhetU; chryeotUe ic45 v..--5 is icaawn *$ be f\brogic as *?ar-9U to carcinogenic will ,.-> c.&- r ^vii-'ibui^a to **&:* 3nicity 'cia&o Vp-sn or me*** of in* various /.>*4,:-^:; wr.ich &.*? b fecto-ulated rilh ^hryicti:. j asbestos dust as a Jr r..1 '.. # -!" \..'* :s--v .'.Ki'i .VI1;.- .:'>).is+\<s, bv.`.f, v i.tt:a ;,?.** ItLa b;-diits , <, -r.-'.ip ,sb*>te# would p>v* *r- the non*>*-p*",\fii*/,. f-s . = :r,;l':?^ `iv :jiM of grv.V.iC k\- * `T'.r.f ;Vr* Kv; 1 .v.:vr.ic, . ia tyjc.n7 t tr.b;*'Ct them ?& r,*v.:--r/a;Cc3> it.* ;*w jt-wa regard to &* chemical ci the nu,st --'.-i.c `ri-- , ' iho ;, ^ ' t+ .'';vl P'ite.s 2, 7^ to wjjeoicrs the oi the vrncua cotta mir.tc ct cJiryioiiiaj vch.j.*,rc* tis preovziloa of Ixa-* iibrc.is And ci-ic:*.!', sin i.mhi of j'tu. o-Ui b* injsst&c. r.t?s. :bc Ally with '.>*. foliowbjj: /* rr r.-ct v- c.*.:-: 2. /i-.s i lNOU*TfUAU HTOICNC rOUNOATlC f A* <ICA.,IH0. 3. synthetic chrysotile plus nickel 4. synthetic chrysotile plue nickel, plus benzopyrene 5. nickel alone or with carbon as carrier 6. benzopyrene with carbon as carrier. 6 These rats will be held for two years and then killed. The lungs will be prepared for examination and sections cut in the same manner as in Phase 1. Throe other series of rats will be injected intratrachsally with the following dusts: 1, filamentous glass with phrnoi-formaldehyde-type binder 2, filamentous glass with the binder used for textiles 3, filamentous glass without binder* These animals will also be held for two years and then killed. The lungs will be prepared and studies as in the preceding groups. The number of animals per series will be such that there will be no doubt regarding the statistical significance of the resultr. ' process p,r:ro7iT5 A progress report giving the results of Phase 1 will be submitted at the end of 12 menthe, ' An interim report on Phase i will be submitted at the end of 24 months, and a final report will bo submitted at the end of the third year. COST The cost of this investigation is $10, 000 per year for throe years, or $30, 000 for each ci the five participating companies. IfcOUdTRIAl KYeiCNC>FVUKP*TtOM AMCTMOA.IMO. 7# SUPERVISION Research wilt be performed under the direct supervision of Dr. Paul G/o<a, Director of the Foundation's Research Laboratory, The Foundation's studies oa asbestos presently ara being conducted under partial su#pport of the US, Government through a National Institutes of Health grant and a contract with the U,S, Public Health Servlee, Division "of Occupational Health (Dr, JLewis 3* Cralley), A list of Dr, Cress' publications in the pathology of pulmonary diseases, and a membership information booklet describing laboratory projects presently in progress, are attached. UrniAt HYatEKC rOUHCATtC r AJ4**OA,MC. I -^K RSrERgWCgg 1. Thomson, J. O. Kaschul*, A. O. C. and MacDonald, R. R. AiUltOI if Modern Urban Hasard. 3. Afr. Md. J. 3_6;759, 1962. 2. Thomson* J. O. Asbastos &ad the Urban Dwallar in 31o2c,t*c Direct* of Asbestos. Anaala tfotv York Academy </ ScU-cs 1961* .3. Caurai, D. Totten* R. and Gross, 2P. Asbestos Bobirs In Langs at Awtcpay. J.A.2kA. 1_>2t371 1963. 4. V/bt?r, I. ar.ci Caattrldaki*. ``Incidence o/ Asbestos Sbrsorare** 24*2$ Annual Report on Medical Research 1963*1964. C5l Special Report* Pretoria, . Africa* 1963. * 5. Dario, J. 1A. O. Electron Microscopic Studios of A-sbestocis in Maa *ad Animals in Biolcffic HXiecta ol Asbestos* Annals of Now York Acaficsny o Sr.iunca> IDy/ifl* 1963. 6. CeUct, A., ^orsoaal cor^oowucstien to Dr. Crons, 1964. T ?trrva D. C. jtr/i Trttsja, 7. Dc * PVlrU?:iiiO:leai Study of Vsjzfi. Cotter in Asbestos 4iacrs, Arch. Xao^nt* Health 1J71V:>3 /- . .Ooil, Dl. Ltortaiity from Xs&{ C&s&sv ici Asbeafot V'orkoro. J3?> t J, -I3.i .( 9* Grose, P. <SeTrrvil2o, Vi* ** t to W *r.VU#b*4 ]. A \t