Document 44Dv4maEXxD6Oag31V6KQ55oe

, IM 2pp. Katherine E. Reed. PhD. IM Emironmentl, Heath sn SEHR 0Fo4 - 1S659 900 Bush Avenue, Buidng 425-2 So PNal aNN $5133.33 DH FA coin . August 27, 2004 AR226-1862 1 remiss IIE DEoPcAumEeasntt--PrRoocoesmsi6n4g2C8enAtttenr: Section 8() Office of Pollution Prevention and Toxics U12S00EPPeAnnsylvaniaAvenueNW. TT 1 = - 5 RE: TSCA 8(E) SUBSTANTIAL RISK NOTICE ON: Methyl perfluoroisobutyrate (CFs)-CF-CO:CHy Coo, = Zh nNG= oo SBI Dear Sirs i3nMathsascornecdeuicvteeddpornelmiemtihnyalrypedraftlaufoorroiasnobauctuytreatien.haAltatainonerxapnogseurfeinddoesretolxeivceliotyfs3tu0d0y0 plopwmctohnecernattsrasthioowneidmpculreiatrysiingnas3ofMnepurroodtuocxti.ciTthye. cMoentcheynltrpaetrifolnuoofrtohiisosbuitmypruartietyisian the product is controlled to assure product safety. "STphreasgtuuedDyawwalsecyornadtuscwteerdebiync3lMu.deTdhrineethteessttugdryo.ups, each consisting of three male 1) tWhheotleestbmoadteyrieaxlpo(sMuertehytlo apneraftlumoorsopihseorbeuotyfraatpep)rofxoirm4atheoluys.3000 ppm (v/v) of 2) tWehstolmaetebroidayl (exMpeotshuyrlepteorfalnuoartomiossobpuhteyrreatoef)apfoprro4xhiomuartse.ly 300 ppm (v/v)ofthe 3) Whole body exposure to an atmosphereof approximately 3000 ppm (/4) of Rats tretahteedcownittrholMemattheyrliaple.rfluoroisobutyrate at 3000 ppm showed clear signs of wneeuarko,totxhiocuigtyh (tthreeymsoresemaendd tseoirzuerceosv)e.rAatftterheaeppnrdooxfiemxaptoesluyr3e0, mainniumtaelss.aAplpleaanriemdavlesry appeared normal the next day. No lethality was observed at this exposure level aRdavtesrtsreeaetfefdecwtistahsMceotmhpyalrpeedrftloutohreoicsoonbturtoylrgartoeupa.t 300 ppm showed no signs of Gross necropsy was conducted 14 days post exposure on all rats. No abnormalities or other significant findings were noted. A185910 `sTahmeplsteusdcyiolslneocttecdofmrpolmetteheatexthpiossteidmer.atsA.naAlyftiincaallrewpoorrkt wiislblebiengfocrownadrudcetdedtoonEPurAinary `when received. Please contact Paul Lieder (651-737-2678) provide additional information. ifyou have any questions or ifwe can Sincerely, Katherine E. Reed Staff Vice President, Environmental Health and Safety Operations