Document 44D6mjj1LrVnjbe8NmjOwVROx

1 T:r, r u.s DEfARTMEN' OF COMMERCE National ' 'echnicai Information SefMce ringtieid, Va. 22161 \ SPI-00267 BIBLIOGRAPHIC data sheet 4. T u If ) nd SuOt U I* H f port ''o. Toxicity of Vinyl Chloride (A Bibliography with Abstracts) reditor: Pernell W. Crockett 9. Performing Organization Name and Address National Technical Information Service 5285 Port Royal Road Springfield, Virginia 22161 12. Sponsoring Organization Name and Address Same 15. Supplementary Notes Supersedes NT1S/PS -77/0365 and NTlS/PS-76/0197 3. ' c r <> nr'. A c r *. s , r>r) sn NTIS/PS-78/ 0445 5. Hr pot t i) u r Mav, 1978 8. Performing Organization Rept. No. 10. Project. Task/Tork Unit No. 11. Contract/Grant No. 13. Tvpe of Report St Period Covered 1969 - Apr. , 1978 14. Lb. Abstract: Research is cited on the health haza rds from exposure to vinyl chloride and vinyl chloride resins. Studies are included on the epidemiology of industrial and public exposures to the compou r d and its degradation and combustion products. (TTiis updated bibliograpl y contains 79 abstracts, 10 of which are new entries to the previous edition Copyright Warning Portions of this publication bearing 1 copyright notice are copyrighted. lntrnai>of>*l Copyright. T National unat' me oroviSiona o' me Uni Stales copyright IJ not assfrieo Law. Tma IT. jmiec States Cod* Tecnmc3i i n f c t. a t o n Serv.ce '978 a< Copvngni ^o'-.ennon 0-n'eC unoer me U"iic States Ccoyg'M NATIONAL TECHNICAL 17 NT! 5 r :cld ('roup 5 / Y, 68 IS. A ra i i b t i i; y $t a i e me ni ' C u y I 1 V H C '"'i' -:.'.rx'RSir bt wji i\c tsf <o INFORMATION SERVICE US ct :i \>| NT nf t-VMt RCl s? n[lo :::sj 19. Mcutiiv CtJSS (This K r pof t ) t icqticn W Liiss i i nis Page sn fccjctf.-n 121. No. oi Pages ?2. Pr.ce S2S. 00 7HIS FO R '1 MAI Dt RF?RODLCSD 5C , 3. SPI-00268 ! V I C h f- r i c a 1 s rr. 1 "xpariren*-*! ?^:cir.oc;r;:s ' ding West Fclycvclic H ye! r cr 3 rbcr.s nitrcso Cem dc ur.d s ) j 1 Career Inst., Eetherda, !",d. International Career Research : - \ ir.k. listir.q. ' -12 Fid: 6E, 6 J, 510*, 571} ;( \-v 11 Ulp* : F c : NCI/ICECE/SL-76/F7 IB G? AI78CS t: The Special Listing of Current Cancer Research Projects is a rvree of the I r f er n e t j c ra 1 Career Research Data rank (ICEE3) program *he National Cancer Institu* ~ach list in a contains descriptions ? r co in a projects in cr.e seise4 ed cancer research area. This listir.q :rclud?s research areas in: Cant r risk asscciated with cccupa*icr.al ^rrrsure to specific organic chemicals; carcir.cger.ic effec*s and ^atclisir cf aze dyes, arvlac ir.es and other isccyclic arcnatic hydrocarbon derivatives ^nim.al mcdels; ca rci.n ege r.ici t y and r-tilclisir cf aliphatic hydrcca: bon derivatives in animal models; carrir. ogenicity testing- of etl vler.e halides ar. d oth=r saturated aliphatic hal ch yd iccar hor derive* ive.e; car cinc ger. ici* v a r.d metabolism cf heterocyclic ccmpcunds in an: ira 1 medals; ar. i broad programs, and cth.= r studies cn chemical ca rci reqe ne s i s in animal models. Irscriptors: malignant nespl? srs, -a cog rch d* :s, Industrial ridicir.e, `Organic compounds, Cai cir.cgens, Metabolism, Vinyl chicrii-, Ihlrrchvdrccarfccrs, Aromatic yd roca rbcr.s , izo d y<=s , Ar y 1 .am in c s , . 1 d h a 11 hyd:c:arhors, Halid's, Ethyl1 n a 1 c h y d rccarbcr. s. h~*erccvclic com rounds Identifiers: I i s t i r. ]s, `Cancer, -dical research, "Carcinogenesis, Health risks, Et h er/C h ler ciret hy 1 NTISNIHIC? NTISLE/C/296-00u Nils Prices: 1C A0 3/`F API SPI-00269 a Cr^ss-Sect icr al " p i >3 e m i c 1 cc ic Furv-y cr vinyl Chlcrida wcri Nat icr. 11 I r. s T.. for Cccupat ioral Safety.and Health, ' i -c i rna ti , Cb io . E i v. cf Surveillance, Ha: a rd r va 1 u - ic r. and ?i eId : udi e s , '* 2ur e au c f "tidFiiclcqy, Atlanta, . Cancer ard 3irth Defects Eiv.**North Carolina tlr.iv. at C hapsl JH il 1, N. C. Occupational Health Studies G roup, **Mcnt*>fici H o s p i * a 1, Pitts burgh, pa. Dept, of .tad ic ire. A i; ~ H C F axvei:e: Piclard J .: Fa Ik, Henry; ."c .rich a si, Anther, v; dallcv, Joseph s.; Grivas A. Scett ~r32u F2 Fid: 6j, 570, 'UD, 6 EG G? AI76CU Jur 77 cr,D h c r i * c: DHES/Pt'B/NI CSH-7-'/l77 Freparsd ir. cooperation w th Bureau of zpidemiolegy, :1 an ta , Ga . Cancer and Eirth Effects Div., North Carolina EJriv. Chapel Hill, M,C. Occupational Health Studies Group-, and Sonteficre Hospital, Pittsburgh, Fa. Eept. cf edicire. Abstract: The extent tc hich vinyl chloride monomer induces clinical detectable abnormalities a .none workers cccuoa t io.na llv a x CO F. ' w* s ir v- s* i cat e d during a tress- sectional medical survey at a chemical plan* which hed a pclyvityl chloride pclymericaticn pe ra ti cr. , a oolyvinyl chloride fabric itior. eperatier, ar.d a rubber tire production operation. The survey of h23 predominantly whi'e rale employees, divided into four vinyl c Hcride axpcsuia groups (never, lioht, heavy, former), determined the crevaler.ee cf illnesses ar.d abr.crmalities based cr. data gathered by interview, radical examination., blood a' pulmonary function tests, liver scans, ar.d hand ar.d chest x-ray::, Aae-aagusted analyses rdicated tha* he pa "o me ga 1 v , central nervci. system symptoms, d i a s t c 1 ic hypertension and spcus = r1 fetal wastac. (th" latter twc statist: cally s i g r. i f i c a r. * ) were "ere prevalent amor-* past cr present vinyl chi crice excc.eed workers than among controls, ' e c t- was re excess o f respiratory system problems, acroosteolvs is , Faynaud's phe no me nen, enld chrcmosomc aberrations as compared wi- . industrial worker controls. Dcsc rioters: Cccuoat io r.al diseases, * Industrial medicine, *Viry. chloride, '"Chemical irdi stry, *Pubber industry, Pclyvin.vl chlorid-. I ridtmicleay, L:v=r dise ses, Nervous system disorders, hypertersior Frgrancy complications. Abortion, Toxicity, Chlorchvcrocar ions Identifiers: Health surveys, Cccupaticnal safety and health Environmental health, NIISHEVrSH PE-27U 193/2 5T MIS Fr res: PC A' 3/1F ACT SPI-00270 ( -=:* h Hazard Ivalua*icr/Tc* ic y pc `'rvir.?. *ior "cnort 76-66-34P, 5 h 1 ]f r-Gl cb? Ccrpcra*icn, 'ir.ion I i t / , Indiana. Hardv Division : a * i c r.a 1 Ins*, for Occupational (390 76 6) ;,'7H C F: Salisbury, Star, lay A. lr252-u Fid: 6 J, 6T, i7U, 57K D^c 76 9p Fepr ko : NIOSH-TF-HHE- 76- 65-3U8 r. c r i ` c r : 18 a f e*y 9u, a r. d H = a 1 * h , 63G, *8A GPM7813 Chic . O ' 4-1 Abstract: A heal`h hazard avalue tier, deterirination performed by NICSH or July 12 ard 13, 1976, at th Hardy rivisior cf `he Sheller Glebe CcrDcraticr, ir. t'nion City, 1 r d iar.a revealed `hat emulcyeos vorkin v i * h cr near the polyvinyl chlor de injection molding process are r.o exposed to detecfatla level s cf vinyl chloride vapers. The dete i rr i raticn was based cr. dir cf measureme.o-s and collected air 3 Mnlfs taker. during bcth r. c rjmal ana purgir.c operations of an injecting mcldir.c machine. Hydrcg en chloride, a thermal dacempesition product cf polyvinyl chloride, was alsc r.ot detcced during the injection melding operation . descriptors: `Thermoplastic resir s, `Hazardous materials, `Industrial medicine, *Er.vircr. mental surveys, `Vinyl chloride, `Hydrcger .chloride, `Fclwinyl chloride, `Plastics it dustrv, Tcxicity, industrial hygier.c. Toxicclcqv, Evaluation, Ir.sp^cti Air pollution, 5econtend atic ns , Criteria, Vapers, holding techni cu 7 n C r V i? V 5 C h ler ch vd rocar bor.s. V i r. v 1 resins I a n. 11 tiers: Environnen + al real h. Air samolin.g. Toxic substances, C,'cu rational safety an- dj health *Air tell u tier. effects (Humans), Shelier-Glcbe Ccrpcratior., Ur. icr. :ity (Indiana) , N'TISHr^SH PF-273 - 25/8ST >,,TIS Prices: FC A C 2/hr AC 1 3 V SPI-00271 ( - L r m a 1 Statili *: y * n c Tcxici4. y c f Fclysi*rs: Pol yphcrrhiz *r? ri*tsburgh n r i v F ? C p t of " e iallurgica] and .".a *? ria Is Ingirc? ring ur22ui) tester's thesis ACTHCF: Seta'a. X . ; K a a i 1 ], j H.; 5 C22 5 hu Fid: 111, 61, 71C, 5 7T u Sc v 77 U6c = nt No: SETfC-M.rr-77-109 , 7? -1 Contract: f.'OOC lu-7 7-C-d 8 1C ter. iter: 18 A1 a r i e , Y. uFAI78C2 Abstract: The toxicity of thermal deccirpcsition products ( in air) of pclyaryloxyphcsphezsr.a and pc lv f lucrcalkcxyphosphazsr.e was evaluated ir. tarns cf their sensory irritation stress index (S. I.s .I.) using aic to ascertain certain tree physicicaical effects. T hr results are compared with sem-* o+ her polymeric materials (cf ccmrercial interest) tha* have already Ifeen investigated elsewhere. A ccm pa risen o' all these data shows hat th* hazard ratir.q icr tha thermal d eco rposi4- ior. products of PT 7, PVC-A (PVC resin; US.S',, ph"halite clasticisar; 325, filler (CACC3): 2A.5r-, FVC-C IFVC r esin: 92', 2 5), pel y f lu or ca 1 kc x4 phespha ze r.s , pcla rylc xypho s ph azer. hared or. `M S.J.S.I. was foujd tc b? FT 5 7 greater than ?vc ( A), PVC-C, gra*sr than pci y f 1 uo r a 1 k cr y chesrhazen* creaner than cclyar yloxyphosp- hezene. Thermoaravimetric a i;d differential thermcqravirerr ic ana1lyVsF's were made cr these two pclypl-.es phazar. e sms in a nitregan atmosph=re different heating rates, The pclvfluc c a 1 ko x y pho sp h a z * ne decor rose 1 with a single activation en i-roy oe 39 . 9 k ca1/xc1 e leaving nc residue, whereas the pc 1 v al ko xv p hcsjrhlaa?zene xhibittf twe rrcce ? s.e e with activation energies of 37.7 ca 1/mcl- : 3 7 r 'TsI/tcIt re suec'ivelv. The latter also left a sahstantial residue which car. te associate-; wi*h its improved behavior ever the flucrc-mat r r i a 1. (A u h c "escrintors : r hes n hd n? '-e , decomposition, P h t h a 1 a t e s., hi tr cqer. * Flastics, Senses (F h ys Thermal s * a b Plasticizers Thermal degradation, "Te-xic hazards, legy). Irritation, hi ca, Polymers, liny, Flammatili'y, Polyvinyl chloric-. Fillers, Thermc-mravimet ric analysis. Identifiers: *Pcly(arylcxypljo sphere re) , *Fcly(flucroel.koxyphosph azer. e) , NT.'SCCTXA A. L - A r li 6 776/777 N'TIS Prices: FC AC3/FF AC 1 SPI-00272 1 I i' e a 1 * h H;:ard Fvolu5*nr/*c*ic r v r e *. = r m 1 na - i or r=port 'Mich Plastics and v 3 r, u f a ct ur i r, g Company, C^lurt-us, Ohio 7 6 - 2r* - 3 3 2 , National I n.st. fcr Ccc up a ti on a 1 Safety ap.d Health, Cincinnati, (39r 7hh) MIT HOP: ijsiss^rt , J. 0.; Herbert J. D3161.;u rid: 6 J , 61, P7TJ, 57 K PHD, esc CPAI7720 Fen 7 6 25d ?ect No: STC5H-TF-7S-28-332 Monitor: 18 Chio. Abstract: Exposures c ample Vees tc chemical agents af a melding operation cf the welch Plastics: end Manufacturing Company in Cclumbus, Ohio, were ret found to te `cxi under the conditions observed by the National Institute for 0 ecu pat i cr.al Safety and Health (NICSH) hazard svalu4tiop. personnel. Wcrker FX posures tc benzene, bis-chlorcmsthyl ofher, 2,6-ditert-butyl-p-cresc 1, carbon monoxide, formaldehyde, hydrogen chloride, hydrogen cyar ide, particulates, phthalat.ee, stvrar.e ar.d vir.yl chloride v=re determir gd by tsrscnal and area air sampling, "he workers experienced up: er respiratory and eve irrigation associated with the use of recrcur.d polvvinyl chloride ar. d acrv]cnitrile-fcuiadiene-pclys*yre r.e material. The use of this material has been discontinued. escriD*ors: `Hazardous materia] s, `Industrial medicine. Particles, 1l1 ydrcosr cyanide, Toxicity, Criteria, Inspection, Standards, P-co mm 3n d at ions, Industrial hycie r.e, industrial atmospheres. Exposure, 'cso:rjtc:y system, T y s (A ra t cm y) , Fesoiratcry infections. Personnel, Per. zer.e, Cresols, Carton morexit = , Fcrma 1 deh yd3 , Hydrogen chloric, rhthelates, s * y r e r e , vir. yl cMc:: d e per. ___ _lastics industry, 0 c cu ca t icr.a 1 Safety and Health Act of 19 70 Toxic substances, Columbus (Chic), Air samolir.o. Threshold limit ralufs, Maximum peraissible xdosu:= level, Ether/ch lorom=thyl, 17 IS hiVOSF PB-2 6 S 111/ISi MIS Frices: PC A02/M.F .Ml 5 SPI-00273 (I i . ci*y of Plastic Comb us* itr. Products. -cxicoloaical " = tl-cifr>iccis \ r s i s 3 -vr pelativ? Mtardp r.c Thtrmal Eecomcos itfcr Frcduc*s from : vr-ric M. at srials c tu r ch Er i v. , r 2. Graduate School ct PuMio Ha a It h. `Nat icr.1 : >au of Standards, Washir.a+ r., 7 . c. (28u 1 5 <") reef. 'hcf: Alari=, Y.; Barrow, I -;'9mu Fid: 61, 57Y, 68 G t 77 3 1 3p Erart: NBS-5-9CC5 rri*cr : NES-GCS-77-8? C. GFA 17716 Abstract: Sensory and pulLtoorary irritation. effects of thermal J*cradaticr. products from r. at ur al and synthetic materials were studied ic rice. rice were us^d tc develop a sensory irritation stress t.dex based or. char.aes ir. respiratory rate. In addition, acu` hality was oIf aired. E cs e-re sncr.se curves wer generated fer 1 * c o it pc si ti or. products from F uglas Fir, F7C, flexible cclyurerbar*, eflon, and fiberclas reir.for:cec polyester. Similar data were obtained for CC, CC2, lev C2, acrcleir.:, Fci and C12. Fre 1 iirir.ary studies on *be cclmrr,ary effects of ccmbusticr. products using rabbits are also :-corted. F^scricTcrs: `Plastics, *Tox: ci*y, `Hazardous materials, `Combustion pro due* s. In h a 1 a * icr., Chi crirel Hydrogen chloride, Tcxicolccy, = *. Hcdclcgy, nice. Laboratory animals, Experimental data. Pyrolysis, "xrosu: = , m a tl es (E a* a) , Polymers, Lethal dosage, Pioassay, =abbi*r, Folvvinvl chloride, Pclyuret b a rt resins, T =*. r a f 1 uo r c-* h y 1 e r e resi*s Fiherolass reinforced plast ics, Fclyes*er resins, Ca r ton me r.c xi i e , Carbcr d.icxide, Oxygen, Acrol cir.s, Ecuglas fir wood Identifiers: Toxic substances , Animal models, NTT S CCH. KPS PF-267 2 3 3 /5 T MTS Frices: PC Aiu/HF AM SPI-00274 i racist: y or 'cxic Effects of Che ical Substanc-" s. 1976 cd is ior. Tracer Jitcc, Ire., Pockviile, .w d . *i a t i c r. a 1 Inst. for occupational Safary an d Health, Pockvilla, r.c (u C8 825) \ r r u 2 1 r e F t. ur HCF : Chr ist e r.s e~ , Herbar* : Eriora .; Lewis, "ichard J. Sr C265u*^ Fid: 67, 6 J, 57Y*, 5 7*. , Ju.n 7f 135F* Contract: CFEB-2 1C-7=-CC3 teniter: Kir SH-76/ig 1 Supersedes PE-2U6 S57. Fairchild, rdvard J.: 68G* , UUG, 9 ^ D* GFAI7715 Carroll, Abstract: Ifce 1976 edition. c f -.he Fegistry of Toxic Effects cf Chemical Substances, formerly r ferred tc as the Tcxic Substances List, is prepared annually by tr e Naticnal Institute for Occupational Saie*y and Health (KIOSK) it ecu pliar.ee with the Occupational Safety and health Act cf 1970. Tbs 197* EEGISTPY contains c-om 82,908 listings cf chemical substances; 5,228 mere than the 197 5 edition. Its purocse is tc provide basic i rlformaticr cn the known toxic ar.d brcicgical effects of chemical substances for us cf employers, employees, physician s, ir.du ^trial hygiar.ists, toxicologists, researchers, ar.d in general, all concerned with safe handling cf chemicals. The absence cf a sut arcs frem the FEGISIFY does r.ct indicate that it is net toxic. Drugs cr therapeutic chemicals ir tj-o FEGI5TFY have teen included if t Jjey have been reported tc produce a r.cxicus affect. Descriptors: *Tox icolonv, * Che mi cal compounds, Trdixc; (Toc'Jjer.tc'.i'T) , Public h a 11 h, D c s ? g , h yoic re , S*ar. cards, Chemical properties. Pesticides, Carcircoens, Vinyl c Hloride, Aguatic `Hazardous materials, Toxicity, Industrial Exposure, Asbestos, biology, peculations I de r. t i f ie r s: *7cxic substances, `Occupa*icna1 safety and health, raxiruo permissible exposure lev 1, Occupational Safety ar.d Health Act Cf 197 9 , ` N7ISHEKOSH ?E-2*6 295/5S7 N^IS Prices: PC A 9 9 / H F A r 1 7 SPI-00275 I Hazard "vsl'ia4 :on/ Toncitv rcrrnin a t c r. : = d o r t 75-i e-3C, iite: veil Erill: re Companies, 'li.starr. Turners :i;p h <= r :* i or. %1 Its*. for Occupation al Safe*'/ { 3?C 756) 'UTHCF: Gilles, E.; Hatch, L. C2C32K2 Fid: 6J, 61, 57U, 57 Y, 9UC, Jol 76 e p t So : Ninsh - IR- 7 5- 1 6 6- 20 9 M cri ter: is and Health, Cincinnati, fiflG, UUG GPAI77 11 Chic. A bst r act: Or. the basis of ne d ica 1 and anvircnm?n*al dat a collected at t he va t er Well Crillers in rr Tr. nesse, the use cf rclyvir. vl c h 1 o ride (FVC) cement is r.ot f c u r. d to constitute a heal* h hazard urder xistinq condition s cf us< r. viror. mortal samples show only low level of t etrahydro f uran and ro detectable levels cf cyclohexanone. ?Dtrs?s to medical oues*ior r.a ir: indica 7= no symptoms associated with exposure tc the chemicals. redicin, Veils, rrillino, Ct hygiene, Irvircrmer. tal surveys, Cyclchexarcnes, lexicology "Hazardous mater i * Is , "Industrial Industrial a t mos chere s , Ind us* rial 5*. aplir.q , :hlor ohydrocarhens, Identifiers: "Toxic substances, Occupa ticr.sl Safety ar.J Health Act of 197C, NTTSPEJiCSH FF-2*2 850/15" ;:~IS Prrces PC AC2/HF AC1 8 T SPI-00276 (\ - 'c 3 : c h E r r o r 2 m cr Vizard Trier t y Tan hire of "arufactnred chemicals (Chemicals 21-UC) S-ar ford :5'?rch Inst., r. ?rl Park, Calif. `National Science F r u r r a t: o r., e s h i r. 51 c r., D. C . Fes arch Applied to f.'aricn.al "-eds. ( 332 ErC) Final rspt. cn Phase 2 3 MH r : Brcvr., S. L. ; Char., F. Y. Jor.es, J. K. E. C1F55I2 Fid: 7A, 6T, H", 6, 993*, 7 Y * Acr Vi 1?5p" Project: SFI-FCU-3386 "cr i * or : n S F /F A. / E - 190? See also FP-263 16 1 ar.d PE-263 16A L.: Liu, D. G P AI 7 7 C 8 h. ; bcCaleb, Ahst rac` : Ir. Phase II cf this t vc-chase effort, sr chemicals having " he n neatest potential for eni :ronmztal effects were studied, Ir. fo nation, was collected cn he extent of the exposure of the e r v i ten. it er.t to t h e se chemicals id tjrir.g manufacture ar.d use) and or. the c css i'rle environmental effects cf this exposure (chemical, physical, ? r d biological properties, per sis ercc, and toxicity). The chemicals stud led ir. this vclume are as follows: 3er.Z"re (chemical uses) , Sil i core fluids. Nitrobenzene, c lue n ad i i see van a te (7PI), Xylenes - t i x a d total, Aniline, Cimethyi teq eph*hslat <=, Trichlcroflucrcmethan , P-Vi ch 1 cr c fcer.zen e, Eithicbis fcer.7 c t hia zcle ) , c-Eichioro tor. zer. e, rabrenee thane , .".ethylene (his ) - 2-chloroaniline, Poly halo 3erated high er.yls (Arcclcr 7 2 5 ti) , Tricres; 1 phosphate. Fluorescent brightening a oe n ts (nc. 28), Polyvinyl chloride, .# ethylene chloride, Ti el 1 crc? rcn=r. a, Cichlcroprrpans mixture, and Ethyl chloride, der tiers cf this document are r.ct fully legible.) Tescrifters: "Hazardous materials, Chemical industry, "Environmental ircac-s, "Oceanic compounds, "a rjufacturirg , Utilization, Chemical properties. Physical properties, I oxicclogv, 3ioassay, Puolic h = a 1 * h , 72tlre (par a), Releasing, Air pc 1 u t i c n , viarer pollution, Chemical analysis. Soil analysis. Fnzer.e, Silicones, `iitrcber.zsr.es, Xvler.es, 'nil ire, Eiphsryl, Pclvvinyl c h. It ride, Chlcroethan-zs, Fl core seer. cr, Optical briahtaners. Industrial we s, Halo car. ornaric ccnrcur. ds Identifiers: net har. =/tr ic hi or c- flilore, 3sr. zena/dichlcrc, Ethar.e/tetra- brcm<*, Arcclcr 12 5u, Prcpar.-e/di qhloro, Hcthylere/chlcrc, Isccyar. ic acid / (,Mer. hylcher.ylene-ester) , ererhitalic acid/ (Dime*:hyl-ester), E^r.zrthiazcle thiols, Anilire/N-F bis(Chlcrcmsthyl) , Phospr.a: e/'ricr-2- syl, MISNSFEA., h1 T IS 5 P I P F-2 ^3 16 2/rF7 MIS Prices: PC C 9 /," F : C 1 9 T SPI-00277 :eseerch Frcim cn Hazard ricrity Far. king of "s: u fact u rad Chemicals (ChCTicals 1- 2r) 3 * anfcrd =?hj:c!i ne nlo Pari?, Ca 1 i f . * `Ht i c n 1 Science r<~ur> at ior,, Washington, D.C. research Applied to National Needs. ( 332 CCC) Final :di. cr. Phase 2 ACTHCF: Ercwr, S. L. ; Chan, *. E . 11 6 5 5 11 Fid: 7A, FT, 66H* Apr 75 196c* "reject: SPI-ECU-3396 monitor: *SF/PA/E-75/ 1 SCA See alsc EB-263 162. Y.; Jones, J. L. : Liu, D. F. ; 66, 990*, 57Y* GSAI77C8 !*. cCaleh, Abstract: Ir. Fhase II of t is twe-phass effort, 9C ch erica Is havir.a `he oreitest potential fo environmental effects v ere studied, Ir f o r bi* ior. was collected or. the ei*sr.t of the e xcosure of the * r. v i ten n e rt * c these chemica|l (durina manufacture and u s?) ar.d or. *`he possible environmental sffec s cf this exposure (cfcemica 1, physical, ar.d biological preparties, pfe rsist^nce, and toxici*y). A questionr. a: re survey cf industry was condji cted to determine * he am cur. t ar.i typ*s cf lessrs in th nar.ufscturirg arts. Ir-fcrmatier. from th is survey is -abuleted. 7h following sui ry rrperts are submitted f cr each cf tb* 9r chemicals: (11 A fl 3w diagram shewing ir.dustri el data or. * h? amounts used for various app icaticns; (2) A cne-paqe assessasrt cf th* data gathered cr. rcxicol gy and envirermen*al r=rsis t e r. c 3 ; ( 3) A r('pDii*->: nrirtcut cf a tubulfe r summary cf th* important data a a1- b *r e d ; > r> J (uj Copies cf the 25 rose. csrtinert abstract* found in Th* area c f tcnicclcgy. 'he report is divided in"o five volumes: in eluded in this v o I u m * ar chera;cals 1-20. (Fcrticr.s cf this locum *n.` are r.ot fully leoible) Eescriptors: "Hazardous mat3 rials, "Cherical industry, * :t vrrerm er.t el i ir pacts, *Crgar.ic corn-pound ?, manufacturing, utilization, Chemical prepertias, Eb.ysiral prepert ies, Tcxicclcgy, Bioassa7, Public health, Air rcllutior, Table= (Pat a) , re Is as inc, vinyl chloride, Crescls, Ethvl her. z *r. - , Vinyliden e chlorid , Toluene, Carbon *-attach. leride, Water pollution, Scil analysis, Ch ?mic*l analysis, D ich lor edi lu creme t har. , T c ` r ae t h y 1 lead. Chlorine aliphatic compounds. Industrial wastes, Fh*r.c2s , balccen ccmpcunds Identifiers: Sonar.als, Benzopyrenes, B r.ta r.e/h-n-?. ch. lort>, Ithyl = r. e / r richlorc, Ether, /trichlcrc, 7. th. yl*r.-/chlcro , Fhos ph.cr inm chlciide/tetraxis (livdrcxyme vl), Eii-a di an c/bsx ac h lor c, Ethyler.e/dihr- ore, I* hvler.e/dichlorc, Ph espb. ate/trie (Pibromcprcpyl) , NT IS US F r A, '11 LS.E ? I In 1/2ST TIS Prices ?C Q' / m r I0 SPI-00278 V "inarch Program or. Hazard an deals 2 1-aC) ( rionty Parking o: danufarturec C.-.emiciis jnford ?. e s e a r c h I r. at. , ":indation, Washington, D. )2 50C) denlo Park, Calif. `National Scier. ce Research Applied to National Needs. ( r.nal rept. on Phase 2 ':a<r., S. L. , Chan, F. Y., Jo nes, J. L., Liu, D. H., dcCaiao, X. Z. 3 i d 5512 fid: 7 A, 6T, 68H, 63 , 99 B`, 57Y* OR AI77C8 spr 75 195?* : o jact: SSI-SCU-3336 on it or: N3F/RA/E-1 903 3 ee also P3-263 161 and PB-26 3 163. ibs trad Ir. Phase II of t is t wo-phase effort, 30 ch enic a 1 s r a v i ng the greatest potantial environmental effects were st u iie d . Information was collacted on the extent of the expos a r a of t he environment to these chemical (during manufacture and use) a nd or t ne possible environmental effe cts of this exposure (chertcal, phy sica 1, an i biological properties persistence, and toxicity). The che mica 1 5 studied in this volume ar as follows: 3er.zer.e (c.nem cal uses ), 511 icon a fluids, Nitrober.ze ne, Tcluenediisocyanate (TDI) , Xvl eras mixed total. Aniline, Dime t hy 1 terephthalate, Tricnleror iuo rone t n a r p-Dichlorobenzene, Dithiobi s (ber.zothiazoie) , o-Dicrio r ooe r.zer. - t Tetraoroaoethane, Methylene (bus) -2-chloroar.: line , ?c 1 yh alog e n a t bipnenyls (Aroclor 1 254), Tri crssyJ. pros p hate. Fluorescent b rig r agents (r.o. 28), Polyv in yl chloride, Met h yla re chi or id e, Diohloropropers, Diehloropr ooar.e mixture, ar.d chi or id z, (Portions of this document are not 'ulJ lecibie. :e scriot ors: : r. a z a r l o u: rla Is , `Chemical industry, `Environmental impacts, `Organic compounds da.nu f act ur ir. g, Utilization, Chemical properties. Physical propert ies, Toxicology, Bioassay, puolic heal*, n, Tables (Data), releasing, Ai : pollution, water pollution, Chemical analysis. Soil analysis. Be izer.e, Silicones, N'ltro terrenes, Xylenes, Aniline, Biphenyl, Polyvicjyl chloride, Chioroethar.es, Fluorescence, Optical btighteners, Ir.du a1 wastes, Halogen organic compounds Identifiers: d at h a.re/hr i c hi or o-fluoro. Be r.zer.e/dichi ore, Bthar.e/t etr a- Droio, Aroclor 1254, Propa :e/dichloro, dethyler.r/cnlcro, Isocyar.ic acid/ (dethylphenyier.e-ester) , Terephthalic acid /(Line t r. yl-es ter) , 3enzothiazoie thiols. Aniline XM-N-bis(Chloromethyl) , Pr.ospr.ate/tncre- syl, NTISNSFRA, NTIS5RI PS- 263 1 6 2/0 S T N TI 5 Price ?C AC 9/dF AC 1 SPI-00279 ( Research ?:oj:ci or. Hazard Priority Ranking cf h ar. u : act u r ei Ch-oroi (J.nemicals 1-2 v) Stanford Research I .jst., Menlo Park, Cal i: . * N at: or.a 1 :?ci*n foundation, Washington D.C. Research Applied to National Neels. 332 SCO) Final rapt, on Phase 2 3.. own, 5. i,., Chan, F. If., Jones, J. L. , Liu, D. H. , McCaieb, K. . D 16 5511 Fid: 7A, 6T, 68 H *, 68, 99B, 577* G?kill 0 6 Apr 75 196 p* Project: SRI-lCU-3386 monitor: NSF/3A/I-75/1 9 A See also PB-263 162. Abstract: In Phase of this two-phase effort, 8C chemicals havi the greatest potenti: 1 for environmental effects were stu.iie Infornation was colle dted on the extent of the exposure of t env ironir. er.t to these ch emicals (during manufacture and use) and on t possible environmental effects of this exposure (chemical, pnysica and biological properti s, persistence, and toxicity). A questionnai survey of industry was conducted to determine the amount and *yp-s losses in the manufa turing plants. Information from this survav tabulated. The following summary reports are submitted for each o: t 83 chemicals: (1) A flow diagram showing industrial lata on t amounts used for var ous applications; (2) A one-page assessment the data gathered on toxicology and environmental persistence: (J) computer printout of a ubulac summary of the important lata gatnerr and (4) Copies of the 21 most pertinent abstracts found in the area toxicology. The report is divided into five volumes; included ir. tn volume are chemicals 1-20. (Portions of this document are r.c: :'ul legible.) Descriptors: "liazardou materials, "Chemical industry, Ir.vi: cr. j :. t impacts, "Organic com iounds, Manufacturing, Utilization, Cnemic properties. Physical ? goperties, Toxicology, 3ioassay, public h ?a11 Air pollution, Tables (Da ta), Releasing, vinyl chloride, Crescls, rtn benzene, Vinylidene ci lorida. Toluene, Carbon t e t r3c nlor ide , ': pollution, Soil analys: s, Chemical analysis, Dichlor odi: luor or a t na.t Tetraethyl lead, Chloi ine aliphatic compounds. Industrial waste. Phenols, Halogen compounds Identifiers: Nonan a s, 3er. zopy r enes, Ser.ne .te/h ex a c h 1 or > Ithylene/trichloro, har.e/trichloro, Eth y lene/ch Io ro , ?h os-l.ont: chi oride/tetraKis(Hydro) /methyl) , Sutadier. e/hexachloro, Ethvler.o/lm; omo, Ethylene/dichlore Phosphate/tris (Fibre meproryl) , NI li N'i FT. N TI S 3 P. I ?3-26 3 1 6 1/2ST ices: PC AC9/I1F ACT SPI-00280 I "oxicoiogy of Plastics H a v Hr ogr ess ; r. t a c t w: . ood, o: Program Travenol Labs., Inc., .'lore : > n G r o v a, 111.`National Heart, L un g, and Blood Inst., Bethesda, Md. Annual rapt. Josephson, A. M. D1503CU Fid: 67, 6L, 57Y, I5C GHAI7707 hay 75 22? Contract: NO 1-H3-2-2990, PHS- '2-2990 Monitor: NIH-NO1-H3-2-2S90 Abstract: Di-2-ethylhexyl pnthalate (DSH?) was extracted fr oi polyvinyl chloride (PVC) . his material was diluted m sterile r a t plasma and used to uj set, IV, groups or rats with a 3 . 7 mg/xg/ir. ject ion , which is e guivalent to the DEHP dose that a patie would receive from a tota exchange transfusion of blood. Grow t h rates, gross reactions rol Rowing injections, hematology and ser ua chemistry parameters, gross organ pathology, absolute and relati v e organ weights, histopathoiegy , and residual DEHP levels m plasma a r.d tissues were similar f all groups, including plasma control group No toxicology significant chan ges were observed. Descriptors: `Toxicology, *?l*s ticizers, `Polyvinyl chloride. Toxicity , ?la sties, Medical supplies, Medical equipment, 3lcod, Bioassay, Hats , Laboratory animals Identifiers: `Phthalic acid,' bis (Ethylhexyl-ester) , 'Si cod ccnoa * - H = materials, diomaierials, NTIS:tIHMLI ?5- 262 260/3ST NTIS Prices: A02/MF AO 1 SPI-00281 f Special Listing or Current Cancer research cn Ca : c i r. og = r.ic Suns*, i: .- in Food ar. 3 Drugs (Along with related epidemiology) Smithsonian Science Ir. or wa tior. Exchange, Ire., Washington, l.C. Current Cancer P.esearcii Project Analysis Cer te r . * n'a t ion a 1 Cinc-r Inst., 3etnesda, fld. International Cancer Research Data ran:-;. D1U92F3 Fid: 6H, 60, E, 98H*, 57'2, 57E, 68(i* GPAI7707 2 Nov 76 28p Monitor: NCI/ICRDB/SL-76j/25 See also PB-261 670. Abstract: ; Contents: Afllatoxins ana other organic naturally occurring carcinogens ; Oncogenic food additives, residues, a r.j environmental contaminants; Zpidemiolo jy cf cancer in relation to diet; Influence of dietary factors on susceptibility to chemical carcinogens m experimental animals; On :ogemc side-effects of drugs. Descriptors: *flalignar. neoplasms, `Carcinogens, `"cods, Drugs, Etiology, Diet, Food additives, Pollution, Environments, MNi itr os compounds. Amines, Vin yl chloride. Esophageal carcinomas, Breast neoplasms. Chemical co mpounds, Tolerances(Physiology), Zpidem10I0jy, Antineoplastic agents, Sleserpine Identitiers: Aflatoxins, fly cotoxins, Biotoxir.s, Nitroscamir.e s, Cir.cer , Environmental health, ST1SNIHNCI P3-26 1 6 7 1/2 ST NTIS Pr ices: PC A03/MF A01 ! 4- r- SPl-00282 Problems of 0 coper ior. al / ji ^e and the State of Health : : v o rs : s Tap loved .'la nu : a ot ur i r.g Latex Polyvinyl Chloride (Vcprcsv 9i;i-r. / Truda i Soetoyar.ee ZJorov a ?. aooc.nikh, Z c n y a t v k h r. a Proizveistve . I Lat eksnovo Nolivimlkhlorida) Environmental Protection Agency, Research Triangle Park, `i, C. Translation Services Section. Filatova, V. S. , Gronsberg, I. Sh., Smirnova, ". A., Stulova, 1. A., Oreshkevich, I. V. D13U5G3 Fid: 6J, 6T d77C| 6 1965 10d ?ept No: SPA-TS-76-366 Monitor: 18 Trans. of Gigiena Truda i Pro fess iona Inye Zabolevaniya (USSR) v9 r.b p9-14 1965. Abstract: Pollution of the air with vinyl chloride and resin dus t is possible during the manufa cture of latex polyvinyl chloride, Such O 1 pollution is caused by di sruption of the seal of equipment an a by -I *I carrying out certain opera tior.s manually. During the study of * H 5 state of health of the orkers, some of them were :ou.t t o h iV<; changes characteristic for tlhe r.itial forms of chronic vinyl chic ride intoxication: slightly pronou need disorders of the vegetative-vasc ui a r regulation, symptoms of veq etative polyneuritis and thernoreguia tc r y disorders. An improvement in the conditions of labor of vor ke r s employed in manufacturing la tex polyvinyl chloride car. oa attair.e d b y means of sealing the eguipmer. improving technological operations a r.d improving the function of ven tilatior.. Descriptors: "Polyvinyl chi oride, "Industrial hygiene, "Toxicity, Hazardous materials, h status, Toxic diseases, r.ar. of act ur i.t g , Industrial medicine, Tran lations, USSR, Toxicology, Industrial atmospheres, Recommendations, Pathology Identifiers: Occupational afety and health. Toxic substances, "Air pollution effects (Humans) , NT ISEPAISD ?3- 26 1 76U-T/3T NTIS Prices : PC AC2/MF A01 I1 wr' r SPI-00283 Ocoupat iona 1 vir.y! :h1 oriie :ii*.0K5ina`.sii Vir. ilk! . or.. -o~) ! nt ox r ca t io: P: oreesror a * r o: Environmental ?:ot =c:i :>n Agency, Translstior. Services Sec . i o n i research Triangle Par*, Antonyuzhenko, V. A. D1345G2 ?ld: 6J, 6T d7 706 1958 6 p Sept No: EPA-TP-76-.165 Monitor: 18 Trans, of Gigiena Trud;, i Prof essionalnye Taoole va n.iya ('J>5R) v12 p50-52 1 9od. r.? Abstract: Cases of ac its vir.yl chloride intoxication ir. workers ar extremely rare and nr usually due to massive exposure to the substance during work i closed areas and during accidents. Under tr.s indicated condition s e '' an short-term breathing c: vinyl chloride car. cause sudden loss of co nsciousness and a state cr narcosis. Ir. those cases when the patient : s not immediately removed fret -.he gas-filled room, a coma may devel ip that is lethal as the result of respiratory arrest. with timely ren qer ir. g of first aid, patients -con emerge fro? the comatose condition but consciousness may remain clouded for a short time. Over the next few days, headache, dizziness, general weakness and an incline tier, to bradycardia and arterial nyootony are observed. The oatiant or ctically recovers in 5-7 days. Descriptors: Vinyl ghloride, *Industrial hygiene, Hazardous mat eriaIs, Toxic diseases, Chemical c on po ur.: s , Translations, Chlorine organic compounds. Industrial Industrial atmosoheres, l)SS R, Respiration, Gases, Toxicology Identifiers: Cccupatior al safety and health, ?ffeexs(Huaans) , Toxic s dbstar.cas, NTI3EPAISD ut i or ?5- 26 1 76 J-I/ST NTIS P ices: PC AC2/MF A01 I6 SPI-00284 A /a : ;npss vice Peport Number 2. Par *i z z nr Toxic Suostir. ces (C 3 T *.) . u m 11 a i v L i 111 e (Arthur D.) , : r. c. Agency, U ashi.ngt on. D.C. Of ' a c b r i d : ? , : a s s . * iv i: o : it il Pro*.actio: :e of Toxi' Substances. (i J n 3 5 0) Annual rept. D12u132 Fid: 133, 67, 6 3 57 y I ?. A I 7 7 0 5 Nov 7 o 36 4 p* Pent .Vo : ADL-C-77355 -Pt-2 Convict: ZPA-69-01-2694 Monitor: EPA/56G/7-76/OG2a See also report dated Dec 75, P5-25C C 75 and Part 1, P3-26C J60. Abstract: The scanning topics included in this two part series are the chemicals and subject areas as follows: Acetonitrile, acrylonitrile, arsenic, aryl phosphates |(pher.y 1, cresy 1, mixed phenyl-cresyi) , asbestos, benzidine, and kalts (hydrochloride, sulfate), boron, broainated oipher.yls, aichlcr pbenzidim.e, dicxane, ethyls r. eimir.e, flame retardants, fluorocarbcn haloethers, hexachlcrocenzer. hexachlorobutadiene, hydrazi e, derivatives, ar.d salts (sym i.td msy diaethyl, aonomethy1), i$ ocyar.atas (organic), iituefaction ar.d gasification of coal, met'ny er.ebis (cn lcroa ni line) , model ecosystems (environmental fate testing. microecosystems), naphthylamir.es (alpr.a, beta, N-phenyl cerivat s) , r. it r i lot r ia ce t ic acid, optical bn ghteners (fluorescent yhiter. ing agents, fluorescent lyes), perchlorcethylene, phtha ates (dioctyl, di-2-etr. ylhe xy_ ) , polyurethanes, propiolactcne trichloroethylene, sr.ale oil extraction and refining, vinyl chloride, vi r. v liden e chloride, ethylene d : and nitrosaaines Descriptors: 'Toxicity, *Ch mica s. chloride resits, Acetonitri e. Acrylonitriles, Arsenic, Phosphates, Cresols, Phe.nois, Asoestos, itrosamnes, Lactones, Sen zidi r.a, Sornr., 3iphenyl, Dioxar.es, A zi:| idines, Eire resistant materials, Fluorohydrocarbons, Ethers Ha 1 oge no r gar. ic compounds. Coal gasification, hydrazines, I ocyanates, Zcosjsters, Amines, Optical brighteners, Phthalates, Poly rethar.e resins, .Naphthalenes, Shale oil, Extraction, .defining. Vinyl c ioride Identifiers: Diphenyl/bromo, 3er.zidi.ne/dich loro, Ccal 11 y u e : a cm o r., Benze.ne/hexacnloro, 3uta diene/ hexachloro, An illne/V-N-ris (Ch1 orore tny1), Naphthylamir.es, Acetri c ac id/n i tri lc-1 r i, It h yler.e/chl or o, Ethylem.e/trichloro, Ethylene/d ibrono, NTISIPAOTS P3-26D 361/157 Prices: PC A 1 6 / M.? A 0 1 (7 SPI-00285 r Current Awareness Servi ? e d o r t "umber 2 . Part I tor -0X1 c stances (TATS) umuia-i /e Little (Arthur D. ) , In|c Cambridge, 3ass."En vir: n c e r. * a 1 ? r o t e Agency, Washington, 0. C. Office of Toxic Substances. (20 3 8 5C) Annual r Dt . 0124131 Fid 133, 6T, 68 *, Nov 7 6 UQ 7 o * ?ep: No: ADL-C-77355-Pt-1 Con tr act ZPA-68-01-269U ;ion itor : SPA/56C/7-76/002 also Part 2, PS-260 331. 57 T* GPAI77C5 Abstract: This cumulative report contains 26 current awareness documents prepared biweecly from 25 August 1575 througn 9 August 197c during the second year c a two year project. The purpose of this project was to provide the Office of Toxic Substances (OTS) , 'J.S. Zn v ir or.m e.nt al 'rot ection Agency with information or. r. e w uses or existing chanical produt s and with information f obvious potential environmental concern for both new and existing chemical p-rroodduct each biweeicly document a core list of approximately 8C journals was scanned for information of interest to OTS on mere than 30 topics (compounds, classes of compounds, and subject areas, e.g., model ecosystems) . Abstracts wfe re prepared all 11 e ms seir c t e d and .n1, o abstracts ware presented b i we e hi y u r. c r t he a ss::r. addition, a 'General I.i formation' sec ion was a idea to accor abstracts for topics np included ir. the original or scar..tin topics. 3iweekly subjec indexes were cumulated this annua. compilation, and an autho :: index was added Descriptors: "Toxicity, uticn, Vm ylider. e chloride resins, Acetonitrile, Acrylonitr les, Arsenic, Pnospheres, cresois, Phenols, Asbestos, Nitrosamines, L ^cto.nes, 3er.zidine, 3oror., 3ipr.er.yl, Dicxa.tec , Aziridines, Fire res stant materials, Fluorohyd rccaroor. s. Triers, iial ogenor gan ic compounds Coal gasification. Hydrazines, Isocyanates, Ecosystems, Amines, Opt:, cal brighteners, Pfcthalates, Pol y ur e t na r. a resins. Naphthalenes, Sha e oil, Extraction, Hefining, vir.yl chloride Identifiers: 3ipher. y 1/b r<p mo, 3enzidine/dichloro, Coal liguefactior., 3enzane/hexachloro, 3utaa ene/hexac hlcr o, A r. i lir.e/N - hi s (Ch lor one tr. y 1) , N'aphthylamines, Ac: e trie acid/r. itrilo-tn, Ztr.yler. e/chior c Sthylene/trichlcro, Ethyl cn e/dibromo, N'TISZPAOTS P3- 260 3 60/3 ST N TI S ? r i c: e s: PC A13/MF A C1 I8 SPI-00286 ;o-Cal. i ; r. v i V i r. y 1 c h 1 o r i i - < z i r* * n e 11) oriie Disease (','eoer ! 1 ; 3 o je.t a r.:: t< Environmental Projection Translation Services Section Juehe, 5., La .17=, C. -I., St DO 3 ^ 5 3 1 FI 1: 6J, 6T, 57'J, 19 7 5 1 5 p ?9pt No: EPA-TS-75-6 Monitor: 19 Trans. of Deutscae Medizi d2034-2037 n.J. Agency, ? e s ea r c h Tr 1 a r ; 1 e in, G. , V e 11 m a r., G . 57 Y, 6 d G GP.A17 702 ische v oc n er. sc hr i f t (West Part, Germany) v98 Abstract: Since the first r por ts cn impairments of health c r v or Xr r s jS in the vinyl chloride (VC) ind ustry appeared m 19 58 , ar.d o f w or x e r s 76 in the polyvinyl chloride PVC ) industry m 1963, atter.tio 1 ha s be C. *"> .s repeatedly directed at this ran ch of the chemical industry :y f u r t i reports. A syndrome was bse rvea which was similar m it ; s < m a r.d , f bone changes to scleroder: a, while its etiology and pa : hcg er.es is 1 retained unresolved. Its pri: cip al symptom was the ?.aynaud s d r 0.1 ? nodose or surface hard skin chi r.ges and band-shaped csteoly ;es 0: : n e . s finger er. d-pnaianges. The i 1 r s t ODServaticns of this disea ;e p : S was reported in Germany r. 1 972. The authors nave recent .y m a u e a r. ,,, ** exhaustive report on the res alts obtained through the er. . of 197 2 30 which reveal new aspects : n t he assessment of the disease e mo important features are s umm a: ize d. * Descriptors: "Occupational diseases, "Vinyl chloride, "Industrial n il medicine, "Integumentary dis eases, "Toxicology, Dermatology, Dhemi industry, Skin diseases. Signs ar.d symptoms, Gases, Pat hole Pathophysiology, Histology, e s t Germany, Translations -f 5 / Identifiers: Air pollution effects (Huans) , Ir.vircr.i- r.t al r. e a ^ t h, Occupational safety and healt h, NTISZPAISD ?3- 258 838-T/ST NTI5 Prices : PC A02/MF AO 1 I9 SPI-00287 / V Standard Support and in viro.t rent a 1 Impact S' Promulgated Emission Stan arc for vir.vl Chloride V o 1m } : n v 1 r o r. m e r. t a 1 Protection Agency, Pasearch Triangle Park, :i.C. Oc'ficf of Air Quality Planning a n d 31 a r. J a r d s. D03JUL3 rid: 133, 6J, Sr, 7A, o3n, 6 5, 6dA, 57 U, 57-i S' A 17 7 u 2 Sap 76 13 5 d Sept No: Z?A/u50/2-75/009^ Monitor: 13 See also P9-2U9 703. Abstract: A national amis sior. standard for vmvl chlonce emitter fr or ethylene dichlor ids-vm yl chloride and polyvinyl chloride plants is being promulgated under the authority of section 112 of the Clean Ai: Act. Vinyl chloride h a|s been implicated as the causal agent of angiosarcoma and other serious disorders, both carcinogenic am: noncarcinogenic, in people with occupational exposure and m animal; with experimental xposure to vinyl chloride. Peasonaui- extrapolations from the|se findings cause concern that vinyl cnloni- may cause or contribut to the same or similar disorders at present ambient air levels. The purpose of the standard is to minimize vmy. chloride emissions froa all known process and fugitive r i s s i r sources in ethylene die hicride-vinyl chloride and polyvinyl cniarrdr plants to the level attai natle with best available control technology, This would have the a ffect of furthering the protection of pubii.. health by minimizing he health risks to the people living atm vicinity of these plants and. to any additional people vhc are expos as a result of new cons ruction. This is estimated to have tne e::eoof reducing emissions from a typical ethylene dichlor ids-v i:. , . chloride plant by a??: oximately 9 ^ percent and rrom a *.y; i c a. polyvinyl chloride plan by approximately 95 percent. T.-.is dooum ?- contains a summary of the public comments or. the proposed star.car: :~ IPA's responses tc the comments. It also contains upd- concerning the environme tal and inflationary impacts or Descriptors: "Air polluti cn control, "Environmental impact 3tat = rr.tr "Vinyl chloride, "Hazardc us materials, Chemical plants, Cos* analyst.-, Economics, Public healtl , Industrial wastes, Combustion products, 11 enforcement. Standards, Industrial hygiene. Particles, waste water Water pollution, Pestici es, Aerosols, Testing, Toxicity Identifiers: Fugitive emissions, Air quality, NTI5E?AAWh P3-258 527/53 T15 ?r: ces: PC A07/M? AC 1 : SP/-00288 Evaluation o f California C h 1 o r i d Emissions in the Long reach National C7 6 9 4 A 3 day 7 u F.ept Mo: .Ion iter: Fis 1J Ir.vastiga110r.s "13: 1J 3, 66A, 6bD i7d EPA/3 30/2-7U/CC2 18 te r t = r , Denver, GPAI7625 Colo, Abstract: A survey of viny chloride emissions from the Amer: Chemical Corporation and 3. . Goodrich Chemical Company shewai ; vinyl chloride monomer was 1 ea vir.g the plants via ;a-;r, slung a, and air as veil as in the fi dal product, polyvinyl chloride. I: i s estimated that about 2.3 icy ( lb)/day of PVC leave the 3.F. Cool: i cn plant, and 10 kg (22 lb)/day aave the American Chemical plant in t ne wastewater effluents. Smaller Quantities were found in the sludge, The report presents a plant evaluai ion and a sampling program. Descriptors: `Pollution, `Vinyl chtiiec r i d 'Polyvinyl u: v? ys , Water pollution, Sludge, .mi pollution, Ir. f ra rc-o spec*, reset er s, Evaluation, Industrial plants, Toxicity, Environmental impacts, Sa f e t v , Public health. Assessments, S a mpling, California Identifiers: Long 3each (Califor r.ia) , NTISEPAO P3-257 6U2/9ST NTIS Prices CS4.C0/dF53.C0 2I SPI-00289 Toxicity of the Pyrolysis Products of Spacecraft Materials T-jn.T assae 'Jr.iv. , Mem phis . Annual Report, 1 Aug. 197U - 31 Jan. La wrenca, *. H. C6915C3 Fid: 06T, 223, > 7 Y, 6 u A 29 Mar 76 79 Pept No: NASA-CR-1U7563, Aji 2 Contract: NAS9-13617 Monitor: 18 1976. STAR 1U13 Abstract: Data is presen ed which provides guides to (1) approximate temperature necessary to initiate therm odegraJa tio r. of the polymeric materials tested, (2) tli e relative toxicity of t her nod eara da ti or. products from the varioi s materials, (3) the relative importance of carbon monoxide as the primary cause of death (as contrasted to cyanide cr other toxic g;. ses), and () whether or not the hazards of the fates are confine:: to the tine of exposure, or whether post-exposure death is lik ly. Two differ1 experiment o e t h c d: were employed. (Author) Descriptors: `Combustion products, `Pyrolysis, construction material: , `Toxicology, Carbon Car boxy h emog iobir., Nylon Tradenark), Polyimides, Polyv: Rats, Thermograviaetry, 'Jr thanes * 5 pac ecr art nor. oxide, tyl chloride. Identifiers: NTISNASA N76-22b87/3ST NTIS Priced PCS 5.00/MRS 2.25 22 SPI-00290 [ r.e : ic . or. of to of i ft i ?i C 3 a m pi in q :arl Jr. iI/sls or Chloride, Secondary 5cu:ces . 0 X 1 C a j . :ar.c=i . i 3 <____ Midwest research ir.st, , :< a n s a s City, m o . * Z r. v i r o r. m e r. t a 1 ? : o t - o r i o r. Agency, Wasnington, D.C. off ice of Toxic Substances. (23c 35U) Final rept. 1 'Jov-31 Dec 75 Going, John I. C68 2UL2 F1J: 06T, 06?, 13(3, 57Y, 57H, 68A, Apr 7 30p Contract: EPA-6B-01-2646 Monitor: Z?A/56C/6-76/002 See also reoort dated Se o 75, PS-246 213. 6 3'J, 99A i ? A I 7 5 In Abstract: A sampling and a :alysis program was cor. cue tad to determine whether and to what extent vinyl chloride was present in ambient *. ir due to the presence of polyvinyl chloride products. Sampling environments .were chosen to represent real 1 if -, out r.on wo rx situations where a signifies t exposure to polyvinyl chloride products mijnt occur. A sampling c od analysis protocol was developed with a recovery efficiency of gre a ter than 9 0^ and a detection limit of 11 IX | ppb (v/v) . The two genera 1 categories of environments sanpli-i w;r vehicles and commercial orodicts. The interior ambient air w as sample from r.ev and used domest automobiles, rcreign :omobiles and domestic mobile hemes. Uc evidence of vir.yl chloride was found. The following commercial vinyl products, when sampler i.t their normal environment, did not produc e a measurable quantity of vir.yl chloride ic the ambient air: vir.vl v all covering; vir.yl swimming pool liners; and vinyl nursery products A room being painter with a heavily pijmentec red pai was found to contain a verv eve. v i r. v . chloride. Descriptors: `Toxicology, Ca ci r.og e ns , Vir.vl chloride. Air pollution Automotive industry, Sampling, Exha us :ombusti: products. Public health, Vehi les. Paints, Fabrics, Gas enrornategra?ny , Gas analysis, Charcoal, Adsorbents, Sites, Sources Identifiers: `Air pollution sampling, Car.cer, Environment al health, Secondary sources, N7ISZPA0TS P3-252 966/7ST NTIS Prices: ?CS4. 00/.1F52.25 23 T SPI-00291 Toxicity or .opponents o Piastre r.a v rr. g contact with :.cd: Travenol Labs., Inc,, fleeter. Grove, 111.`National He Inst., Bethesda, .13. Div of Blood Diseases and Pesources. and Lit Pinal technical progress rent. tiripol, J. E. , Garvin, P. J., C65 73C3 Fid: 06T, 06 L , 5 7 Y, Sap 75 34C p Contract: NO 1-H3-2299C flor.it or: NIH-NO 1 - H 3- 2 29 9 Jun 7 2 - M a r 75 Stern, I. J. , Wallin, 95C, 9 5 A G? AI7 6 1 3 P, Abstract: Method of soluoilization, dosage form and route : administration are fact ors which are critical in tne distrioution a: excretion of di-(2-eth ylhexyl) ph the late (DZHP), one of the mo: widely used components employed in the formulation of flexib. polyvinyl chloride { ?VC). Changes in the apparent volume distribution of DEHP o bserved when aguecus suspensions were used f; injection of the plasfc letter indicated that differences in systemic disposition a id distribution of DEH? were ceper.dent on - : physical state of the dosage form. Valid studies cr tne biologic: effects of parenterall|y administered DEHP must be performed with dosage form of the pL asticrzer which is luxe that encountered : clinical situations. Wh ole body autoradiographic studies performed : mice infused with serum containing Iwc-DEHP showed rapid accur.ulatt: of labeled carbon in he kidney and live: with rapid excretion t urine, bile and irtes tin e.- Essent ial 1 y all the labeled compound . excreted within 2 4 hou s. Pats infused * wice weehlv ror o 1 u a v 3 rat plasma containing DEH? extract; f rem PVC exhibited * o x ico lo g ica 11 y signifi :ar. t changes when compared to c residue studies m na sealed no relationship b-twee:rn. t r as f u u. nistory and tissue co w T - of DEHP. Copyright Natrona 'ecu:,:: Information Service 1976 Descriptors: `Plastics `Toxicology, -Polyvinyl chloride, 31??: Phthalates, Medical supp ies. Plasticizers, Toxicity, Toxic tolerar. , Dosage, 3ioassa , Pats, Mice, Laboratory animals Absorption (Biology) , Sxcr et ion Identifiers: `Blood com patible materials, acid/bis (etnylhexyl-esteif) NTI5NIHHLI Bio.materials, ` ? h t h a 1 P3-251 742/33T UTIS Prices: PCS10.CD/M?52.25 2* "T SPI-00292 / "oxicology of Plastic ;jv:c n a v i - u <- o r. t a c t 3,oo: Utah 'J r. i v . , 5 a 1 - L a k a c 11 y . Dept., of A p u 11e jaercss. *:iat ional Heart and L u r g Inst., 5 e t h e s d a , v d, n a r ~ a c u * real Final r e p t. 2 u Aug 7 2-2.3 Aug 7 5 Petersen, P.obert V., Lyman, Do A. C6232K3 Fid: 06T, 06L, 57 Y, 9 5 A , 9 5C 3 5M76 1C 23 Aug 75 2 u 8 p Contract: PHS-73-29C8 Monitor: NIK/NKLI-72-6-F Sea also report dated 1 May 75 P3-2U4 753. Abstract: The project was primarily concern ed v 11 n toxicological evaluation of polyvinyl chlor d = and, o ore specifically, the com or. 1 v used plasticizer, di(2-ethyl e xy1) p h t h a1 a t e (DIH P) . evaluations are primarily concerned with long range, subtle toxicity potential, although aany basic acute ard subacute studies -ere also conducted, The project is divided into valve tasKs including an organizational phase, plastic composition Studies, acute toxicity studies, tissue culture studies, subacute toxic itv studies, metabolite identification, jratoger, ic studies, neurolcgic studies, larger S Vj ' 1 ? 5 y analyses of human blood exposed to plastics :ur mg hospital procedures, and possible sta tistical analysis of human o a 119 r. s following extensive exposure of blood tc olastics. Descriptors: `Polyvinyl chloride, '?la stici `Toxicology, Patients, Tissue culture, Bicassav, Laboratory animals, Pathology, Pats, Heart, Phthalates, B od v 'luids , :.'t urology. Mice, reproduction (Biology) , Medica: lies, : h a 11 c a 1 organs, .-.utars, Slood Identifiers: *31ood compatible materials. Biomater: acii/bis(ethylhexyl-ester), Mat abolites, NTISNIHHLI ut n a i: ? 3-250 1C 2/1 ST NT IS Prices: ?C36 . G 9/.MF 5 2. 2 5 25 SPI-00293 f Standi i: 1 Support ar.i Envir or. a anta 1 1 n p a c t Statement: Emms tor. 3 - a r d, r; for Vinyl Chloride Environmental Protection of Air Quality Planning a C6195KU rid: 113, 06J, Oct 75 53 6 p * Rapt No: EPA/U5C/2-75/009 lonitor: 13 Agency, ~e search Triangle Par*, . C. Sta r.iarls. 06F, 63A*, 63, 57 U, 57 H GFAI7609 Office Abstract: A national emis non standard for vinyl chlor ^ o -- n * tted from ethylene dichloride-vinyl chloride and polyvinyl ch loride plants is being proposed under thi authority of section 112 of t h a Clean Air Act. Vinyl chloride has been implicated as the causal agent of angiosarcoma and other serious disorders, both c arcinog er.ic and r. on carcinog enic, in peop e with occupational exposur e and l n animals with experimental ex}> osure to vinyl chic:: d e . ? easonaule extrapolations from thes findings cause concern t ha t vmyl c h 1 o r i 1 e may cause or contribute to the same or similar disc riers a t present aaoient air levels. The purpose of the proposed ari is to minimize vinyl chloride en issior. s from all known prec ess and :ugitive emission sources in ethy er.e dichioride-vir. yl chiczi n e and pol yvir. yi chloride plants to the evel attainable with best a vaila o 1 e contro. technology. This would navfc the effect of furthering t he prot action of public health by minimiz ng the health risxs to t r. e people living in the vicinity of these plants and to any additicr.a 1 peopl e wno .re exposed as a result of new construction. This is estim at e 1 to h a v ? the effect of reducing emssi s from a typical ethylene d i c h 1 c r i d e - v i r v. chloride plant by appro: imately 9u percent and from typ: 'il polyvinyl chloride plant by approximately 95 perc-n t. ~ r. v i ror.m en* si Impact and Inflation In pat t Statements o u a r. t i f / 11 o t e mpac ts of : e proposed standard and ai inciuu ec in : doc unset. Descriptors: *Air pollut cn control, "Hazardous materials, "7i:.y. chloride, "Environmental impact statements. Cost analysis, Piolic health. Combustion p: cducts, Law enforcement, Standards, Polymerization, Industrial hygiene, Particles, ril*ers, Incinerators, Absorbers (Materials) , was te water, Water pollution, Solid is t * treatment, Noise reductip n. ;ermal pollution, Pesticides, Aerosols, Chemical industry. Combust cn products, amission j.aen timers: NTI5ZPAO?. D Air t y Fabric filters, Fugi*ive > o i d r. s FB-2U9 7G3/CST ITIS Pric s: PCS 1 3.0 0/h ?S2.2 5 26 SPI-00294 r Scientific and Technical As Polyvinyl Chloride ;sse r. V 1V 1 C h 1 c r i : e ltd environmental Pro lection A g e n c y, Research Triangle ? a r x , N. C. Final rapt. Cb 1 05G3 rid: 06T, 06J, 133, Dec 75 12 5 p" Sept No: i?A/600/6-75/00u .Monitor: Id Sea also P3-246 320 . 57 7*, 57 U, 68 G*, 65 A, 6bD GF. AI760H Abstract: V inyl chloride (VC) is a chemical of widespread irdustr r a 1 and commercial use. Occupatio la 1 experience ar.d experimental evide r. c e strongly indicate that i is a carcinogen. Additionally, there is experimental evidence t ha indicates that it may be a teratogen a n d nutagen. An increased inciderc a cf liver angiosarcoma, excessive li v e r damage, and acroosteolysis has been reported among VC workers, and frequency and severity of the liver pathology is related to the let of exposure. The principal route of exposure is thought to re air inhalation. Sources of i.ncreas d importance fcr the general popular i or. include rood and water. Tumors at multiple anc diverse sites nave o e e n observed in all species of e x oe r ime r. ta 1 animals tasted carcinogenicity by inhalation and inge.stion of VC, addition to health effects of VC, this document also considers tr.e sources, iistrinution, and control technology. Descriptors: "Polyvinyl ch oride, 'Vir.yl chloride, "Toxicology, Industrial medicine. Air do lution. Public health, liver, F a 11 g r. a r t neoplasms, Carci noger.s, ."iutacefl e, Water pollution, rcod main s, Hu mans :tal data, Chemical c cm no ur.is , Chemical ir.d ustrv Tdantifisrs Ter atog er.s, !TI 5 2 ? A 0 r.D Air pollution ef facts (H umars) , "Er.virc . n e a 11 n, Air pollution co n trol, water pollution e : meet: (iiumats), F3-2U9 U61/5SC NTIS Prices: PCS 5.50/MF32.25 27 SPI-00295 r Health Hazard v >1u a c Lon/7oxicity 2 e t 5 : m i r, a 11 o r. Paport il.M.I. 7u-94-253, Armstrong Cork Company, Jackson, .11 s 31 s s r p p i National (39C 766) for Occu )at tonal Safety and Health, Car. c t.n.t a 11, Sato. Final rapt. Dec 74-jul 75 Flesch, Jaroaa P. , Sostanji, Fobert A. C610ul3 Fid: 06J, 06? , 5 7U, ?uD, 6 3 G Dac 75 16p Rent No: NIOSH-TR-HHZ-74- fcu-253 '1or.it or: 13 Sea also PB-2U9 432. I? AI76D8 Aosiract: An environmen :a 1- tied ical evaluation was conducted by NICSH at a plant manufacturing inyl asbestos floor tiles. In v iron m er. - al air samples were obtained, medical records were reviewed, and r.on-dir act ed medical interviews were dministered. It was determined that exposure to airborne chrysotile asbestcs was in excess of the proposed D3HA standard and that theri was a potential for exposure to trace concentrations of airborne vinyl chloride monomer, worker exposures tc ot.ner toxic materials nare below levels believed to he potentially toxic. aeviev of medical records revealed no findings suggestive cf lung cancer (noting that Malignant manifestations of asbestos exposure may take 1C-40 years to develop after the exposure has ceased. Descriptors: *H azaraous '.aterials, `Industrial medicine, *'.'ir. y. chloride, `Asbestos, `Silicon dioxide, `Limestone, Toxicity, Cnt.-ria, Inspection, Standards, 5 eoo mme nd a t ion s, Industrial hygiene, I must n il atmospheres, exposure, ct.rium. Lead (Metal), Chromium, I me, Titamu: Carcinogens, Interviews Identifiers: `Occupational Safety and Health Act of 1971, 7ox; hazards. Air sampling, St hane/trichloro, NCISHZVOSK P3-249 U33/UST NT IS Pric:es: ?CS3 . oO/.M ?5 2 . 2 5 23 SPI-00296 Health Hizar 1 Zv;iua::cn/T3 i c 11 y De`.-:::r.it:or. ? ; p c r t :t. : 75--d 1 -- 252, Art ex "jnufacturmg ca?ar,y, Inc., Overland Part, Fan si: Nat ion.al (J 90 766) for Occupation <il Safety and Health, C: r. c i r. r. a t i , Dhi o . Final rent. .1 a y - J u r 75 Hervin, Raymond L. C610UL2 Fid: 06J, 06T, 57U, 9|uD, Dec 75 lip Rept Nc: Nl65H-TR-HHI-75-81-252 .'Ion it or: 18 See also ?3-2*9 u 31. 53G IPAI7608 Abstract: A health hazard evaluation was conducted by NIOSH at a plant involved in the silk screen dyeing cf decals onto various textile garments. It was determined tha employees in the two mam production areas were not ex,posed to toxilc concer. t ration s of vmyl chloride and organic solvents, including 1i,1,1-tnch loro ethane, toluene, xyier. e, and petroleum naphtha. It was further determined that the clear, room operator was exposed to pc ten tally toxic concentrations of organic solvents from cleaning silk sere ins witn an organic solvent cor.t '.mg primarily naphtha. Descriptors: "Hazardous mate rials, "Industrial medicine. "Vinyl chloride, "Toluene, "Xylenes Toxicity, Criteria, Inspection, Standards, 3"commendations, Ind u lal hygiene. Industrial atmospheres , Fumes, Organic solvents, uposure, Chloroform, Naphthas, Textile industry Identifiers: "Occupational Safety hazaius, NTISHZViOSH 1 j 7 Q, : . OX 1C PB-2U9 432/6ST NTIS Prices: PC43 . 50/:iF52.2 5 9 SPI-00297 0( Health Hazard Z V 2 1 U : tion/Tox i c i t y Determination eucrt H..!. 74-24,92, 9 5- 2 4 6 , 'J n c 1 e Bl 11 ' S ? i o k - N - Pay M a r x e t, No. 1r. , M i u d 1 e n u Heights, Ohio, Madsen' 3 / <3 1 U Center, Mankato, Minnesota, ar. J Xro- ) Company, Logan, *'9st vir gin i a National Inst. for Occ upa tiona 1 Safety and Health, Cincinnati, Or.: (390 765) Final r`pt, Vandervort, Robert, Broc k s, Stuart. M. C6104JU Fid: C 6J, 061 , 57U, 9 4 D, 68G GHAI7608 Dec 7 5 31 p Rapt No: NIOSH-TS-HHE-74 -24 -246, N 105 H-TP-ilfiZ-74-92-246 Monitor: 18 Also availabla as repo rt no. N I0S H-7.R-H HZ-7 4-5 5- 24 6 . See 925 . also P3--2 Abstract: At the request of employees from several supermarkets, N 10 conducted health hazar d surveys to evaluate exposures to suost emitted by hot-wire cur ting of polyvinyl chloride meat-wrapping and thermal activation of meat package price labels. Meat depar employees were inrerv iewed and given physical examinations pulmonary function t ests. Blood samples vere also obta Environmental air samp ling was also conducted. Based upon medical and environ men tal data and upon other information rega meat wrapping and labeli no operations, it was determined that ho* cutting of ?VC meat wrapping films and thermal activation of laoels can release irr itant substances into tne vorx er.vironmer. health hazard exists fro m vinyl chloride monomer however. Descriptors : 'Harardou . a is, chloride, * Hydrogen chlo ide, 'Polyvinyl ch 1 o Inspection, Standards, R ecomraendaticns, Ird us atmospheres , Exposure, C ompcsite wrapping -A > f la 1 medicine, '7ir. oxici.ty, Britan ygier.e, Ir.dustrt Identifiers 'Occupational Safety and Health Act or 1e70, hazards, Ai sampling, Phthalic anhydrides, N7ISHZWOSH A pa-249 426/9ST N7IS P ces: PC34.00/MFS2.25 \ t\ [ . a--`ut - I - - . . 30 SPI-00298 T i 3 ( 2 u9 SH I es I as j r.t nd d. r se -ng .E . Cc VO 1 a/ . d* 1C Health Hazard 2 v a 1 u a t1 o r. IxToxicity Determination Prior*. H.H.E. 73-173-2uu, Barden Chemical pnpany, Leominster, M a s s a c r. v 5 s t a s National Inst. far Occupat anal Safety ar.d Health, C i.tcir. r. a ti, Drio. (3 9 C 76 6) Final rept. PolaAorf, Phillip Lee I 26104J2 Fid: 06J, 06T, 5 7'}, 9uD, Dec 7 5 14 p Sept Vo: NI03H-??-HHZ-73-173H2HU Monitor: 19 63G ;?A17 60S Abstract: NIOSH investigated! an alleged health hazard ::oi trypsin, a proteolytic enzyme, and M ?<al i-78, surract ant. o i a; manufacturing polyvinyl chi'pride resins. Employees were administered r,on-directed medical question!pares, sic in tests and pulmonary function tests. It was determined |that a number of employees had developed allergic sensitization to trypsin, resulting m respiratory impairment. Some employees who have not been sensitize! have still developed mild upper resnif: at ory tract irritation. It was also determined that several en bloyees who handled the surfactant a x * 1 3-73 had periodically exp-e pieneed upper airway irritation, gagging, and shortness of breath. Th s problem was judged to re the result of poor work practices and nij> serious health consequences from tens exposure were observed or act ici pa t ed . Descriptors: `Hazardous natfria.s, `Industrial meiirir.e, `Polyvinyl chloride, `Trypsin, `Surfac ants. Toxicity, Criteria, Ir.spaction, Standards, 3 acoemendations. Id custnal hygiene, industrial atmospheres , Exposure, 2 aspiratory system, Chemical industry. Allergic Ji ^ c i :? r i Identifiers: `Occupational ^ afety and Health Act or 1970, `Toxic hazards, NCI SHEWOSH P3-2U9 U2U/3ST NTIS prices: PC S3,50/MFS2.25 SPI-00299 H e a1t h Hazard ivj.'ja' on/Toxicitv Fe no r t H . H . I. 75-9C-236, Russell Corporation Alexander City, Alabc.ua o National Inst. for Occupational Safety and Health, iir.cir.r.j Dm o. (39 0 766) Final re pt. Geissert, Jack 0. Col 0H2 Fid: 06J, C6T, 5 7U, 9 4 D, Nov 75 1 2p Pept No: ;j:0SH-TR-HH-75- &C-236 donitor: 13 Sea also P3-249 415. 63G GRAI7608 Abstract: Air sandina fir vinvl chloride and medical interviews we;; conducted by NI05H to determine if a health hazard existed iron the use of polyvinyl chlo .de-based inks in the scrstr.-urmtin] of garments. The potential health hazard of literal spirits used i:. cleaning the screens as also evaluated based noon environmental data and information collected during confidential employee interviews, `.'t health hazard was found to exist from vinyl chloride, however, miners, spirits was found to cause skin problems following worker contact. Descriptors: *Hazardous natenais. 'Incustna. rr,e :i ci r. e , v i n v: chloride, :Polyvinyl cilonae, inks, `Printing Criteria, Inspection, 5t ancards, Recca a and a t ion s , .r.oustnai .tygiene, Industrial atmospheres, Textile 'industry, Interviews, Solvents, Rxi: diseases Identifiers: *Cccuration Safety and Health n: hazards. Air sampling, *" 61 il 3 oi,r its , c: 1 P3-249 416/95? NTIS Prices: PC33.5C/*?S2.25 32 SPI-00300 ! ( Health Hazard "v a 1 uj t io.-./to* i c: 74-6 1- 23 2, 'lates Sjbber Co; na; y, Denver, Color--aad^ot National Ir.s: (390 76 6) for Occuoaticna 1 Safety and Health, - -jo ; i. !. :, rir.al r e d z. Jon 7 u - ;i a y 75 Gunter, Bobby j., Lucas, Janes 3 . C6104G2 rid: 06j, C6T, 57'J, 9 4 D, Nov 75 15p Pept No: Nlb5H-TR-HH-7U-61- 232 .'lonitor: 16 See also PB-249 413. 680 GRAI76C8 Abstract; A plant manufactup ing extruded hose, principally from t n e extrusion of polyvinyl chlond , was investigated cy .VIC3H to evaiua a employee exposures to cycloh exanor.e, 7 DI, trichloroethylene, 1st a r a thermoplastic polyurethane, mje thylene chloride, Nigrosine, Di-2-etr. yi hexyl phthalite (DO? oil), dus , and vinyl chicride. It was determir. c d that a potential health hazard may exist from exposure cyclohexanone, and that seve al cases cf primary irritant derm,atit had occurred following rscei m e d exposure to solvents. A11 h ou g r. or. i V one of 38 vinyl chloride $a '.pies was found to exceed the Fedar a i Standard action level, it was ecoamer.ded that airborne concer.tratio ns be reduced to levels not etected by the recom. r. d e d analytic al techniques. Descriptors: `Hazardous na erials, **naustrlaj * 71 r. y 1 chloride resins, "Cyclohex 4nor.es, "Solvents, Organic sc 1 vest s, Polyvinyl chloride, Isocya ates, Polyurethane resins, PI alo; . - 3 f Toxicity, Criteria, Inspection hygiene. Industrial atmosphere , C h 1 c r o m e t h a r. e s , Hoses, i n u ; a c Dermatitis, Carcinogens Identifiers: "Occupational 3a fety and Health Ac hazards. Air sampling, NIISHSwqS H 1971, "Toxic P3-249 4 1 2/8 ST NILS Prices: PCS 3.50/hFS2 . 25 l> o SPI-00301 rI Health Hazard .vdi'jat ::r,/ .ox i c 11 v tic r. ~ e r> o : t H . H. 75-12C-22C, S'.ori ? r o d u c :s Company, Palo Alto, Calif c r r i a Ha*, ior.al Ins:, (J 9 0 76 6) for Oc: unational Safety and Health, Ci:.cir.r. a 11 , Oni final reot. Cxava, delvir. T. C610UD2 Fid: 06J, 06T , 5 7U, 9 4 D, Sep 75 5p Rapt No: NIOSH-TR-HHS-75 -120-220 Monitor: 13 Sea also PB-249 401. bdG GRAI7608 Abstract: N XOSH conduct ed a health hazard survey at a plant product finished cables. A sm ail extruder is used to coat wire with ? plastic or other coat ing materials. Environter. ta 1 air samples we col 1ect ed fez vinyl ch lor id e analysis and no detec taole amounts v found on any of the s a m pie s. It was cor. eluded that a potential heal hazard f roi vinyl chlo r id e gas does not exist unde r cor. ditto ns rot d uring t h is evaluation. Descriptor s: *Hazardous chloride, "Vinyl chiorid , Toxici ty. Criteria Industrial hygiene, Indus materials, "Industrie resins, Plastic coatir. Inspection, Standa rial atmospheres x. e d i c i r. e , * P o 1 y v i r. Gas-s, Carcmoge d s, ? e c o m m e r. d a 11 o t Identifiers: "Occupational Safety and Health Ac hazards. Air sampling, MTISHEWOSH ci 1 9 70, To* ? 3-24 9 4 C 0/3 51 NTIS ices: PCS 3. 5 0 / M F J 2.2 5 3A SPl-00302 Health Hazard I v a 1 u a i o r./ .0X1 75-94-219, Proto Production ? i Deetteerr:i r a 11 o n r. c . , Sou : > v. c: ora : o I.'at ion a I . r. s t. (390 766) for Occuds t. onai Safety. and Health, Cincinnati, Dmc, Final rept. F.uhe, Saymond L. C6104D1 rid: OoJ, 06X, 57U, 94D, Sep 75 6o Hept Nc: NIOSH-T ?, -H HI-75-94-219 Monitor: 13 See also PB-249 400. 68G G=AI76C3 Abstract: A plant manufacturi ng polyvinyl chloride telephone switchoox covers by means of an in ge tior. molding process was investigated ov NIOSH to evaluate exposure of employees to vinyl chloride. Air samples were obtained for vinyl chlor ide analysis and there ware no ietectaole amounts of vinyl chloride found. Nor.-d irected medical questionnaires were also administered and on the basis of medical and environmental data, it was determined that a health hazard did not exist at the time of this evaluation. 1 .s Descriptors: * Hazardous mat rials, `Industrial medicine, *?ciyvinyl chloride, Vinyl chloride rest s, Plastics industry, Carcinogens, Eases , Exposure, Toxicity, Criten , Inspection, Standards, I ecom m end a 110 r. s , Industrial hygier. e, Indus" Lai atmosoheres .c Identifiers: `Occupational Safety and Health of 197J, `Toxin hazards. Air sampling, NTISHZ OS H ?3- 24 9 3 99/7 ST iTIS Prices: PCS3.59/njS2.25 35 SPI-00303 Health Hazard I v a 1 u a ion/Toxicity Determination ? ; port H.H . 7 4-113-213, General. Tir and .Rubber Company, Manor., I r. liana ve:iona1 .nst, (J90 7*6) for Occ ipa tior.dl Safety and Health, .c i n n . , 7h i Final rapt. Dec 7u-Jan 7|3 Poper, C. Paul, Corner, John v. Jr C&IOucu Fid: 06J, 06T , 5 7U, 9 4 D, Aug 7 5 2 0 p Hept No: NI0SH-7R-HHS-74 -118-218 Monitor: 13 See also P3-249 399. 6 3G IP. AI76C8 Abstract : A plant whi manufactured molded urethane cushions automobi le seats and sulk urethane foam for a variety of roomer: pur poses was mvestiga ed by NIOSH to evaluate employee exocsur: toluene 2,4-diisocyana r , polyvinly chloride resir.s, and mold rel: wax . Zn v iron mental measu remer.ts were performed, medical interviews pu1 sonar *fun nrct-ionn t9S ts were administered, and work practices c obs er ved It was H a f ^ mined that airborne co r.cen t ra 11 on.s of tol Jr 2,4-diis ocyanate are potentially toxic to employees at the foam 1 . in the Slab De par ta an but not in the Molded Foam Departm Particle s of mold rele ase wax were found to cause temporary irn sym proms i r. some work rs. Exposure to polyvinyl chloride r=sins nor bei leved to pose any nealth hazard under conditions onee Z v during t his evaluation. Descriotors: Ha za r dous materials, *Ir.d us trial medicine ?c_yvir chloride, `hold relea se agents, Plastics industry. ; ocv \n at- Urethanes, Waxes, Exp p Criteria, Inspection, S andards, Recommendations, Industrial hy ;ieu Industrial atmospheres, arcinogens, vinyl chloride resins Identifiers: *Occupatio al Safety and Health Act of 1470, 'To* hazards, *Isocyanic a id/(methylphenylene-ester)di, Air sam^lir NT I SHEW OSH P3- 24 9 3 98/9 ST N'TIS ?r 1 ces: PC53.50/MF32.25 36 SPI-00304 I Health Hazard lvalue tio.n/7 oxicity C ete r m ia* : c r. e p< 7u-59-217, JooJyM: !iri and brer Company, Sr. h.a:vs, Chi; a r io n a 1 Inst. { 3 9 C 7 6 5) for Occupational Safety and Health, C ic i r. r. a r i, Dnio, ;ai :eot. Jul 7 4 - h r 75 Van darvort, Sobert C610ac3 ?ld: 06J, 06T, 57U, Aug 75 6p 3e?t No: N "l OSH- 7 ?. - H HI-74-59-2 1 Honitor: 13 See also P3-249 393. 9 4 D, 63G GRAI76C3 Abstract: NIOSH evaluated empl cyee exposures to vinyl chloride monomer in the' nixing and film cast ing processes during the manufacture of clear plastic films by the = olvent casting method. Air samples -are obtained and no detectable leve Is of vir. yl chloride '-era found. It was determined that a health ha zard did not exist at the time of tms evaluation. Descriptors: "Hazardous mat erials, "Industrial medicine, * 71 r. v 1 chloride, "Polyvinyl chlori|de, Pla sties usury, Carcinogens, Toxicity, Criteria, Inspection, Standards, recommendations. Industrial hygiene, Industrial atmospheres .ers: "Occupational Sa f e t v an c hazards. Air sampling, NTISHSw;03 H Health Act of 19 7 C, . o x: PB-2U9 397/1S7 7715 Prices: ? IS3.50/MFS2.25 37 SPI-00305 (' r Health Hazard v a Iu a or./Tox ici: y Determination 74- 125-2 1 5, tonaghan Compk n y, Denver, Colorado * e :>c r t H. H. I, )i/' Nat lor .ns: for Occu m tiona1 Safety and Health, Cincinnati, Dhio. (390 766) Final rept. Dec 74-May 75 Gunter, Bobby J., Butler, George, Lucas, C6104C1 Fid: C6J, 06T, 5 7 U, 9 4 D , 68G Jul 75 8? Rept No: NIOSH-TR-HHE-74 12 5-215 monitor: 18 See also P3-249 396. Jaies 3. GRAI76C8 Abstract: A health haze d survey was conducted by HIOSH to evaluate worker exposure to vi n/l chloride in a plant utilizing powdered, pelletized, and film. 0 JC . 3ased on the results of enviroom antai measurements, employee interviews, limited physical examinations, observation of work pra it ices, and a review of literature pertaining to the toxicity of vi :iyl chloride, it was determined that a health hazard did not exist at t le time of this investigation. Descriptors: 'Hazardous materials, `Industrial medicine, `Vinyl chloride resins, `PolvviJ: yl chloride, Plastics industry. Carcinogens, Gases, Toxicity, Crite :.a , Inspection, Standards, Recommendations, Industrial hygiene, Indus irial atmospheres Identifiers: `Cccupation il Safety and Health Act of 1970, `Toxic hazards. Air sampling, NT "S HEWOS H ?3- 249 3 95/55T NTIS ?n :es: ?CS3. 50/MF52.25 30 SPI-00306 Health Hazard Evaluation/? o x t c 11 y Determination 75-20-209, ?. ichcel Corporation Carson :ity, Nevada ? n o :' a t i o .n a 1 (390 76 6) for 0 ecu ratio na Safety and Health, .mcmnati. '.10, Sinai r e ? t. H a r - A p r 75 Ok a va, Helvin T. C610UA3 Sid: C6J, 06T, 57U, 9ud, J ul 7 5 8p Sept No: NIOSH-13-HHZ-75-20-20$ Monitor: 18 Sea also P3-2U9 390. 68G GSAI76C8 U Cl. Abstract: A regrinding opera tion in a plant manufacturing mol clastic valves was studied bv NIOSH. 3ased udoh environmental sampling measurements, analysis of work practices, and on availaole information regarding th toxicity of vinyl chloride, was determined that a ootential hea 1th hazard does exist. Descriof ors: Hazardous ma erials, Industrial medicine. v iv: chloride, `Carcinogens, Toxicity, Criteria, Recommendations, Industrial hyt iene. Industrial atmospheres, Plastics, Valves, .Holdings Identifiers Cccu national S a fety and Heart! Act hazards. Air sampling, NTISHZNCSH 197 0 , Toxin ?3- 249 369/6ST NTIS Prices: PC53.50/M?32.25 39 SPI-00307 Health Hazard Zv;l jatior./ .oxicitv _et.er.Tiir.?. tic: 7u-134-193, ? HC r.-.dust:;^, n c , C a ti j e n , N e * Jersey . e uo r t National I:st (39 0 766) for Dccupatiana1 Safety and Health, C me tr.r. a i, Ohio, Final rapt, uilles, Dawn C6103I3 Fld: C6J , 067, 57U , 940, Say 75 6p ?. apt No: NIOSH-TR-HHE-74-134- 193 Hon it or: 13 See also P3-249 374. 63G 3nAI76C8 Abstract: NlOSil conducted a lan uf act ur ed handles from sampling conducted at the determined that a health monomer did not exist at the lealth hazard evaluation at a plant vhrch 'VC resins. Or. -the basis c: environmental molding ar.d extrusion processes, it -as |azard from exposure tr vinyl chloride ime of this evaluation. Descriptors: `Hazardous r, t a rials, "Industrial medicine, "Vinyl chloride, `Polyvinyl chi or de, "Carcinogens, Toxicity, Criteria, Inspection, Standards, Eecoame ndatiocs. Industrial hygiene. Industrial atmospheres. Extrusion, Expose re, holdings. Polymers "Occupational safety and Health Act of 1? 7 C, hazards, Air sampling, UTISHE'.wos H x ic ?3- 249 373/257 N7I5 Prices: PCS 3. 5 0 / h F 3 2 .2 5 SPI-00308 VC-PVC Crisis: A S/sterna Approach to Tc :< i col og ica 1 ?r :bli.is California Ur.iv., 5ar ic<al(*/ K1 a n d , * . J . A72 65FJ Fid: C 6 ?, S7y Aug 7 5 3 u p Rapt No: CON F-75C673-3 Ccntract: W - 7 4 0 5 - Z N G - 4 8 dor it or: IS Lacer.ce ? A0 1 C4 Derfceley Lac. (1 1UNCC) Abstract: For abstract. see IRA G1 04, r.umber 0 58 29. Descriptors: (*PVC, *Hea :.th hazards), (`Vinyl ipnomars, Health hazar*. ), (`Carcinogens, Heal :h hazards), (`Organic chlorine compounds Health hazards), Biological effects, Carcinomas, Hunan populations Neoplasms, Reviews, Toxicity Identifiers: IPDA/560306J NOISE?. DA L3L-3275 NTIS Prices: PCSu.00/MFS2.25 :iu- r ' 42 SPI-00309 Epidemiology Studies. Task III. fir. y 1 Chloride American Public Health Associ tior., Washington, D.C. Environmental Protection Agency, Washington, 0 C. Office of Toxic Substances. Final cept. A :J T HO?.: Landau, inanuel, 3rink.ua C58 75H1 FLD: 06J, 57U*, 68G* Mov 75 10 6 p * CONTRACT: ZPA-63-C1-2U90 MONITOR: EPA/560/6-75/002 , Charles ?., USG3DR7605 Kanos, Nicholas Z. ABSTRACT: Using data from the the number of people living plants -producing 7inyl chlor prepared. Findings are reported pro vided. 970 Census of Population estimates of within a 5 mile radius of industrial de and vinyl chloride resins was The sex, and age characteristics are DESCRIPTORS: `Epidemiology, *v nyl chloride, Industrial medicine, Public health. Vinyl chlorid resins. Industrial plants. Exposure, Populations, Demography, Tables( data). Environments IDENTIFIERS: NTISEPAOTS PS-2U8 U26/9ST NTIS Prices: PC3 5.50/KFS2.25 SPl-00310 ! Health Hazard E va 1 uat i on/To xic i ty Det eriinat ion Report 74-151-131, Western Forge Corporation, Coiopado Springs, Colorado National Insl (390 766) for Occupational Safety and Health, Cincinnati, Ohio. Final rapt. AUTHOR: Butler, George J. C5793I1 FLD: 06J, C6T, 57U,/ 9d, Apr 75 7p ?.F?T NO: NIOSH-TP. - HHE-74-15 1- J 3 1 MONITOR: 18 68G USGRDR7604 ABSTRACT: NIOSH conducted! an environmental survey of a forge nan u act urirg har.d tools. Employees were exposed to vinyl chloride gas in the assembly and packing area arising from the vinyl chloride coating applied to packiag containers. It was determined that employees were exposed to potentially toxic levels of vinyl chloride at the tiae of this evaluation. Recommendations vere made regarding reduction of airborne concentrations and the use of respiratory protective equipsent. DESCRIPTORS: "Hazardous (materials, "Industrial medicine, "Vinyl chloride, "Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations,I Industrial hygiene. Industrial atsospneres , Protectors, Exposure,/ Porgina, Tares hoids (Perception), Toxic tolerances. Films, Packaging materials. Respirators IDENTIFIERS: "Occupational Safety and Health Act of 1970, "Toxic hazards, hetalvorxin-j industry, maximum permissible exposure. Air sampling, NTISHEWOSH ? 3- 2 4 6 4 97/2 ST NTIS Prides: PCS 3.50/riF $ 2.2 5 Spl-003li Health Hazard Evalja:i:r./T:xic i*: y De t e : i: r,a 11 on .leport 7u-l49-1d'J, Protecto Wrap Company, Denver, o 1 or a d o National Inst, (390 766) for Occupational Safety and Health, Cincinnati, Ohio. Final rept. AUTHOR: Butler, George J. C5793:-:U r LD: C 6 J , 06T, 5 7U , 9|4D, Apr 75 7p SEPT NO: NIOSH-TP,-HKZ-7U- in 9- 180 aONITOS: 18 66G USGBDE 7604 A3STEACT: The anvironiental urvey of a plant manufacturing a polyvinyl chloride bached mat rial by NIOSH investigators revealed potentially hazardous levels of 'inyl chloride gas. It was recommended that airborne concentrations of vinyl chloride be reduced to non-detectable levels and th; t respirators be worn by exposed employees until control measures are effective. DESCRIPTORS: 'Hazardous mate ials, `Industrial medicine, *7inyl chloride, 'Polyvinyl chloride , Toxicity, Criteria, Inspection, Standards, Recommendations, Indu trial hygiene. Industrial atmospheres , Exposure, Evaluation, Plastics industry. Respirators, Gases, Surveys IDENTIFIERS: *0 ecudationa1 Safe ty and Health Act of 1970, `Toxic hazards, Air sampling, NTI5HZW0SH PB-26 496/UST NTIS Prices: PC33.5C/M5S2.25 Sp\-00312 r Health Hazard va1uation/Toxicity Detera:naticn Report 7^-?6-17J, Fic hd e1 Corporation, Carson City, Nevada n Na* ion a 1 Ins: for Occuoa' onal Safety and Health, Cincinnati, Ohio. (39 0 766) Final rept. AUTHOR: Okava, he Ivin T. C5793H2 FID: 06J, 06T, 57jj, 9ud, Feb 73 8 o SEPT NO: N:OSH-TR-HH-74-96-(l73 IGNITOR: 18 63G USGEDR7604 A3STRACT: A plant involved n injection molding of polyvinyl chloride vas studied by NIOSH to ev a L uate employee exposures to vinyl chloride and trichloroethylene, which is used as a degreaser. It was determined that a potential health harard from exposure to vinyl chlouJa did exist in the ?.egrind Room and a potential hazard nay also exist in the injection melding are as. Trichloroethylene vas judged to be not toxic at the concentratio measured at the degreasing operation. DESCRIPTORS: "Injection me ldir.g, "Hazardous materials, "Industrial medicine, "Vinyl chloride, Polyvinyl chloride, "Chlorohydrocarbons. Degreasing, Toxicity Criteria, Inspect ion, S tar.dird s, Recomaen dations, Industrial h ygien e , Industrlal atmospneres, Respirators, Exposure, Prc tectors, Plastics industry. E valua tion , Toxic tolerances, Threshold:(Perception), Surveys, Gases IDENTIFIERS: "Occupational Safety and Health hazards, "Ethylene/trichloro, Ai sampling. exposure, NTISHS'WOSH Act of 1970, "Tcxic "aximum oeraissible PS-246 49U/9ST NTIS Price:;: PC S3.50/hF 32.25 <6 SPI-00313 Health Hazard I va 1 ua x or./T ox ;c; y Determination Report 74-39-169, New Yor k Telephone and Telegraph Cos :any. New Yc:k, N.Y National Ir.st. for Occuoa tiona Safety and Health, Cincinnati, Ohio. (390 766) Fin a1 rapt. AUTHOR: Straub, Wesley I. C5793H1 FLD: 06J, 06T, 57U, 9t D, Apr 7 5 7p DIPT NO: NIOSH-TR-HRI-74-89-189 MONITOR: 18 63G U3GRD?, 7604 ABSTRACT : NIOSH conducted an e nvironzenta1 survey to determine employee exposure to vinyl chloride, styrene, benzene, and hydrogen chloride during the application of heat shrinkable tape to telephone cables. It was determined that air concentration levels ware below detectable levels for all substances tested and therefore were judged to be not toxic under the conditinns noted during this evaluation. DSSCPIPT0P5: "Hazardous materials, "Industrial medicine, "Styrene, "Benzene, "Hydrogen chloride. vinyl chloride. Toxicity, Criteria, Inspection, Standards, Pecoramenda :ions. Industrial hygiene. Industrial atmospheres. Evaluation, Expos ire. Coatings, Polyvinyl chloride, 'hresholds(Perceptioc) , Toxic tolerances I OS NT IFIIPS: "Occupational Safe :y and Health Act of 1970, "Toxic hazards, Air sampling, Maximum pe imissiole exoosure, NTISHSWOSH P3-246 493/1ST NTIS Prices: PCS: . 50/SF 52.2 5 4?; SPI-00314 Health Hazard evaluation/ To <i city Oeteroir. ation Report 74-85-185, M , H. Gall Company, Lancaster, Pennsylvania National lost, (390 766) for Occuoa tional Safety and Health, Cincinnati, Ohio, Fir.ai rapt. AUTHOR: Straub, Vesley E C5793GU FLD: 06J, 06T, 5 7U , 94 D, Apr 75 10 p REPT NC: NIOSH-TR-KHE-74-85 195 MONITOR: 18 68G USGRDR7604 ABSTRACT: A health hazard s urvey was conducted by NIOSH to investigate a potential health hazar d at a company performing lamination of printed material on a job basis. The laminate is a polyvinyl chloride based product which is layered with the printed material, then the layers are heated for c uring. It was determined that a potential health hazard- exists at th e lamination press from vinyl chloride gas, based on environmental meas cements, observation of work Dractices and a review of past medical re orts. DESCRIPTORS: `Hazardous materials, `Industrial medicine, `Vinyl chloride, `Polyvinyl ch|l oride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Evaluation, Gases, Laminates, Carcinogens, Liver, 7 hr es hoi ds (P erce ption) , Tox|ic tolerances. Ventilation, Surveys IDENTIFIERS: `Occupational hazards. Lamination, Ai exDosure, N'TISHEWOSH Safety and HeaIt h sa mpling, Cancer, Act of 1970, `Toxic Maximum permissible P 3-246 492/33T N :s Price PCS3.50/MFS2.25 ^0 i SPI-00315 ft Health .Hazard Evilua:; :fi/7ox:ci: miration Report 74-71-142 C e 1 c o ? e m y Division, A n a r, e i 'r, California National Inst. for Occuoatioial Safety and Health, Cincinnati, Ohio. (190 766) Final re pt. AUTHOR: 6<awa, Melvin 7. C57 93 G1 FLD: 06J, 06T, 57U, 94D, Sep 74 5? PEPT NC: NI0SH-TR-HHE-74-71-14^ MONITOR: 19 68G 0SGSDP7604 A3STRACT: An operation in which polyvinyl chloride was being used to manufacture the separators usee in autcaoDile batteries was studied by NIOSH investigators. It was determined that vinyl chloride vapors were not toxic a the concentrations measured during normal operating conditions. This determination was cased upon the environmental levels of chloride, the conditions od use of polyvinyl chloride, and current information available on the tcxicity of vinyl chloride. DESCRIPTORS: "Hazardous raa arials, "Industrial medicine, "Vinyl chloride, "Battery separate rs. Toxicity, Criteria, Inspection, Standards, Recommendations, Ind ustnal hygiene, Industrial atmospheres , Vapors, Exposure, Evaluation, Electric batteries IDENTIFIERS: "Occupational 5a fety and Health Act of 197C, "Toxic hazards, 3attery industry. Air sampling, NTISHEVOSH PE-246 489/9ST NTIS Prices: P :S3.50/MF52.25 4S SPI-00316 I Health Hazard Z va 1 >ja t i or. / Vo x i c i t y Det 0 r n 1 r. a: 1 on report 74-29-161, Ethyl Visqaean Division of Zthyi Carp., Terre Haute, Indiana National Inst (390 766) for Occupat tonal Safety and Health, Cincinnati, Ohio. Final rest. A'JThOR: Sutler, Georg? J., Eodner, C5793Z2 FLD: C6J, 06T, 570, 94D, Nov 7 4 10 p ?. ZP T NO: NIOSH-TR-HHZ-7U-29 16 1 .10 NIC 0 R: 18 mold H. 68G USG3DR7604 1 l ABSTRACT: A manufacturer c f polyvinyl chloride pipe was investigated by HI03H to evaluate worker exposures to polyvinyl chloride. Crystals of polyvinyl chloride res in are nixed with other materials and then extruded into pipe. Air samples were collected, workers were given medical interviews, and tilood samples were taken to be analyzed for serum g1utamic-oxaloacetic transaminase. It was determined that a health hazard from vinyl chilioride lonoaer did not exist at the time of the survey but that a pote ial carcinogenic hazard did exist in the blending room areas of the clla nt . DESCRIPTORS: "Hazardous m a tenals, `Industrial medicine, `Polyvinyl chloride, `Vinyl chloride, oxicity. Criteria, Inspection, Standards, Recommendations, Industri al hygiene. Industrial atmospheres, Evaluation, Surveys, In erviews, 3iood analysis. Pipes (Tubes) , Carcinogens, Plastics ind u. stry> Dust, Statistical data, Chemical ind ustry | IDENTIFIERS: `Occupational Safety hazards. Air sampling, NTISH IEW0SH Health Act of 1970, `Toxic PS-246 48 2/4 ST NTIS Prices PC 33.50/MF $2.2 5 * 5n SPI-00317 T r Toxicology of Plastic Devices slaving Contact with Blood Children's !los oc r a 1 had ic al enter, Boston, .'lass. * Na tional .heart and Lung Inst., Bethesda, Hd. (062 790) Com pr e har.siv e rept. Sep 72-Sep |7 5 AUTHOR: Kavy, Shervin v., Butte , Lawrence N., C57 51 F1 FLD: C6T, 131, C6L, > 7 T *, 710, 9 5C Oct 75 112?* CONTRACT: PHS-72-2963 MONITOR: HIH/NKLI-72-2969-C 3 See also P3-2U4 7 53. Jacobson, lay U5GSDH7603 5. ABSTRACT: The objectives of this research were twofold: (1) the utilization of an animal mod; to evaluate the functional effect of Di-2-ethylhexylphthalate (DEHP) accumulation,- and (2) the development of an in vitro testing proc dure that could be correlated with the animal studies. The rate of ext: action of DEHP from polyvinyl chloride (PVC) is dependent upon both the temperature during storage and the lipid content cf the medium, DEH? so obtained is in true solution, with particle sizes less than 0.22 micron. Tissue culture studies demonstrate that solubilized HP in varying concentrations inhibits the growth and ultimately hi.11s human diploid fibroblasts. PVC and siliconized glass transfused rhesus had abnormalities in liver his topat hology and li-ver func ions for up to lu months following cessation of transfusions. DS HP or silicon persisted in the tissues for up to lu months post-tr in s fusion. Both the control rhesus and those transfused with platelet processed in polyethylene containers were nor mal. DESCRIPTORS: "Plastics, *Toxicb logy, *Polyvinyl chloride, Blood, In vitro analysis, In vivo analvs -s. Tissue culture. Body fluias, Blood plasma, 31ood serum, Blood 11s, Plasticizers, Polymers, Blood transfusion. Liver, Spleen, ssues(3iology), Histology, Patnologv, ."onheys. Experimental data, Accu uulation IDENTIFIERS: * iomateriaIs, *31oo d compatible materials, Animal models , "Phthalic acid/bis(ethylhexy1- ster), Histepathology, Bioaccuaulati- or., NTI3 NIHHLI P3- 247 1 68/8ST NTIS Prices: PC i5.50/MFS2.25 5f SPl-00318 ? ec 3is = e n d ed 5 t a r. d a r d i c r 'jccjpr. lona 1 Exposure to Vinyl Chloride National Inst, for Occur U07 192) C56 7 uJ 3 FLD: C6J, 06T, 197 5 ICp ICSITCS: 13 See also P3-246 692. tional Safety 570 , 9 u o , 58G and Health, Rockville, USCRDR7602 dd, A3S TRACT: T he report flcludes: Background (events and toxicoiogica1 finds) of the standard; cope and application; definitions of terms; requirements for regulal ed areas; routine operations; reactor and vessel entr y; maintenanc ar.d decontamination; hygiene measures; sig inf or mation and aining; environmental monitoring and record keeping; re ports; medic 41 surveillance. Despite the fact that animal experiments have shown o liver tumors at atmospheric concentrations of 50 ppm. the concept of an allowable working level is rejected, Since there is measura b] e concentrations of vinyl chloride personnel should wear ar. air-su Pjl ed respirator because chemical cartridge respirators do not affo id adequate protection against vinyl chloride vapors. DESCRIPTORS: 'Hazardous materials, 'Industrial medicine, *Vi:y. chloride. Toxicity, Critar ia, Inspection, Standards, Recommendations, Industrial hygiene, Ird ustrial atmospheres, Chloronydrocarbons, Chlorine a lapha tic con pounds. Protection, Safety, Requirements, Evaluation, Carcinogens IDENTIFIERS: 'Occupational Safety anc8 Health Ac- of 1 97 0, * Tox i: hazards, Air sampling, NT: SHSWOSH P2-2U6 691/C3T NTIS Pri das: ?C33.50/3FS2.25 51? SP1-00319 ( ,'is-.ry or . O X1C ' f f 2 c t s of Ch steal Substances. 1975 Edition National lost, for Occupational Safety and Health, Rockville, AOThCR: Chr i st a r.sen , H. E. , Luq nbyhl, T. T., Carroll, B C56 73 A 3 FLD: 0 6T , 06 J , 5 7y* , 57 0, 6 8 G * 0 3 G R D ?. 7 6 0 2 Jur. 75 1 3 9 9 p * ?E?7 DC: SICSH-TSL-75 CONTRACT: ?HS-CDC-99-7U-92 MONITOR: 18 Md A33 TRACT: The 1 975 Edition o|f the Registry of Toxic Effects of Chemical Substances, formerly known as the NI OS H Toxic Substances List, is the fifth Editio(n prepared in compliance with the requirements of the 0ecu patio nal Safety and Health Act of 1970 (PL-91-596). This Registry contains toxicity information on approximately 17,000 unique ch eoicai substances along with about 98,000 synonyms. Information s given cn route of entry, toxic dose and toxic effects including an indication of existing evidence of the substance may be carcinogen, mut qen, teratogen, etc. DESCRIPTORS: `Toxicity, `Chemi al compounds, `Hazardous materials, Indexes (Docuoentation) , Public health. Dosage, Industrial medicine, Standards, Chemical properti s. Exposure, Asbestos, Pesticides, Carcinogens, Vinyl chloride, Mut agens. Aquatic animals. Toxicology IDENTIFIERS: Occupational Safe permissible exposure, Teratoge i s NTISHEWOSH and Health Act of 1970, Maximum `Occupation al safe' v and health, P3-2U6 557/3ST NTIS Prices: PC191 . 7 5/M FS2 . 2 5 SPI-00320 V The Phy s io 1 o q ica 1 and Toxicologica 1 Aspects of S.iose Produced During the Combustion or Polymeric materials Utah U n i v . , Salt Lake City. Flammability Research Center.`National Science Foundation, vasf ington, D.C. Research Applied to National Nee ds. Annual rapt, 1972-73 AUTHOR: tinhorn, I. N., irky, fi. , Grunnet, M. L., Packham, S, Pet. ajan, J. H. C533UL3 ?LD: 06T, 06P, 5 7 T, 5 7 S, 71 USGRDH7524 24 Se? 7 3 1 60p ?E?T NO: FRC/UU-12, UT2C-7|3 -161 GRANT: NSF-GI-33650 MONITOR: NSF/P.A/E-73-196 ASST PACT: A study was un|d ertaken at the Flammability Research Center of the University of Utah to determine the physiological and t oxicologicai 1 effects of smoke. Four classes of materials were selected for study: cel l|ulosics, urethanes, polyvinyl chlorides, and Douglas fir. Smoke cha mbers and animal exposure chambers ware developed for the anal ys: s of smoke and its components and the observation of effects of combustion products on animals. The effects of combustion products on survival response in rats were measured, and toxicological studies otl rats under exposure to smoke were made. The effects of combustion n the eyes of the animals are the subject of continuing expenaentatio n. Small-scale laboratory fire experiments are being correlated vi th Yull-scale fire tests conducted at the National 3ureau of Standard s. Selected case histories of fire injuries are being studied to de t arsine the medical history of victims until r ecovery . DESCRIPTORS: `Toxicology Combustion products. Flammability, Materials, Smoke, Fu nes, Physiological effects. Responses, Experimental data. Labor atory animals, Rats, Polyvinyl chloride, Chemical analysis, Urethan ;s, Injuries, Cellulose, Fir wood IDENTIFIERS: NTIS NS FR A PB-244 876/9ST NTIS Pric ;s: PC56.25/MFS2.25 54 SPI-00321 Toxicology of Piastre Devices 3a vmg Contact with 31ood Utah Ur.iv., Salt Lake y. Dept. of Applied Pharmaceutical 5cie.nces . *) a t icnal Heart and LJi ng Inst., Bethesda, Md. Annual rept. 1 Hay 74-30 Apr 7:> AUTMOF.: Petersen, Robert v. Lyman, Donald J. , Roll, Swin yard, Ewart A. C5332D3 FLD: 06T, 06L, 57Y* 9 5 A *, 9 5 C USGEDR75 23 1 Hay 75 1 16 p CONTRACT: PH3-73-29C8 MONITOR: NIH/NHLI-72-6 See also P9-233 7C1. David 3., ABSTRACT: The project is corjc erned with toxicological evaluation of polyvinyl chlori.de (PVC) and more specifically, the commonly used plasticizer, di- {2-ethylhexy1) phthalate (DEHP). Selected findings indicate that (1) the acute and subacute LD50 of a metabolite of DEHP (nc.no- (2-ethy 1 hexyl) ph thal|a te) given intravenously or iDtraperitoreally in nice o rats is highly toxic and irritant. (2) Analysis of particle size distr ibution of DEHP dispersed in fetal calf serum by sonication indicates that the vast majority of particles are less than 2 microns diameter, (3) DEH? appears to have some effect on chromosomes in human leukocyt s and human fetal lung cells in tissue culture. (4) OEHP prolongs barbital sleep. Phthalate-con tammat ed sheets caused greater ad he sit? n and aggregation of platelets than methanol-cleansed PVC when exposed to sheep blood in sx-vivo experia ants. DESCRIPTORS: 'Polyvinyl 'Toxicology, lethal dosage, animals. Tissue culture, supplies. Mechanical organs ilonde, ?a holcgy, lo ass ay, * P la sties , 'Plasticizers, Body fluids, 31ood, Laboratory Humans, Phthalates, Medical IDENTIFIERS: 'Blood compatible aaterials, Biomaterials, Phthaiic acid/bis (et hylhexyl-ester) , MTU NIHHLI PB-244 753/03T NTIS Prices: PC 3 5.2 5/M F 5 2.2 5 53 SPI-00322 Three Week Intravenous Administration . n the Dog DI (2 - .hylhexyl) Phtha 1 a t e Hazleton labs. America, Inc., Vienna, Va.`National Heart and Lung Inst., Bethesda, Final rapt. 9 Jul 7u-28 Feb 75 AUTHDR : Rutter, Henry A. Jr C525UF1 FLD: 06T, 57Y USG3D R 7 52 2 9 Apr 75 55p CONTRACT: NO 1-HB-2-299 1 MONITOR: 13 Sponsored in part by Natio aal Heart and Lung Inst., Bethesda, Md. See also PS-224 376. ABSTRACT: A repeated dos e of approximately 0.50, 0.75, and 1.4 mg/kg/day of di(2-ethyl hexyl) phthalate in canine plasma was administered to beagles for 21 days. No consistent compound-related alterations were observed in animal behavior or hematological and clinical chemical paraaet ers. Terminal body weights, organ weights, and organ/body weight ra tios were acceptable normal limits and comparable to control values. Compound-related hist omorpholog ic alterations were not observ ed in dogs receiving various concentrations of di(2-ethylhexyl) phtha late leached from PVC blood bags during sto rage. DESCRIPTORS: "Toxicity, * Phthalates, `Plasticizers, Dogs, 3ioassay, Laboratory animals, Dosag e. Medical equipment, Medical supplies, Tables (Data) , Experiments 1 data. Animal behavior, Histology, Morphology, Polyvinyl chlor Lde, Pathology IDENTIFIERS: Biomaterials, H T15 N IH H LI PB-24U 2 62/2 ST NTIS Price : PC3U.25/MFS2. 25 56 SPI-00323 T \.' Ambient Air h ?asu : e .Tie n t s of vin y1 Chloride in the Niagara Falls Area National Environmental 3 9 sear rh Center, Research Triangle Par*, N.C, Chemistry and Physics Lab. Environ a? r. tal monitoring series AUTHOR: Gay, Bruce V. Jr, Noona :, Richard C. C5175A3 FID: 13B, 07a, 06F, 5 8 A, 993, 57 U hay 7 5 19p REP? SO: IPA/650/U-75/02 0 PROJECT: EPA-ROAP-21AKC f.ONITOR: 18 USGRD3752 1 ABSTRACT: A 6-day survey was conducted in the Niagara Falls area to determine the concentration <t>f vinyl chloride in the atmosphere, Samples were obtained in a re$ ider.tial area adjacent to the chemical plants where vinyl chloride em ssions were suspected, in areas around the plants, and in other a teas o: Niagara Falls. The highest concentration of vinyl chlor de measured was b 0 cob for a 5-hour integrated sample observed at - residential area two blocks east of a vinyl chloride polymerization plant. Grab samples taken downwind of chemical plants exhibited a hign of 28 ppb. Samples taken from downtown Niagara Falls and tip wind north of the chemical plants contained no detectable viny chloride. The areas surrounding the chemical plants, including th e adjacent residential areas, are also affected by emissions into tine atmosphere of chlorine and other halogen ated compounds as exh: bited by the deterioration of metal surfaces, particularly aluminum vind.ovs and doors. DESCRIPTORS: *Air pollution, Vinyl chloride, *Chemical plants. New York, Angiosarcomas, Chlorine organic compounds, Halohydrocarbons, Aluminum, Buildings, Corrosion, Sampling, Public health IDENTIFIERS: Air quality. Nila|gara Falls (New York), *.Air pollution sampling, Air pollution effacts (dateriaIs), Air pollution effects(Humans), NTISEPAORD PB-2b3 695/UST NTIS Prices: PC J3.25/J1FS2.25 SPI-00324 A Trane work for the Control of Toxic Substances (A Compilation of Speeches) E r.v irons er. ta 1 Protection Agency , Substances. AUTHOR: Schweitzer, Glenn E. C51CA1 FLD: OoT, 06J, 63C}, 63A, Apr 75 57 p F.EPT VO: EPA/56C/4-75-004 MONITOR: 13 Washington, D.C. 63D, 57Y, 57U, 99 Office of Toxic USGRDR7520 A3STRACT: This collection of speeches in large measure reflects the evolution of the inter est , policies, and programs of the Orfice of Toxic Substances from April ^97 3 to March 1975. The speeches deal with questions that are of broa d national concern: the identification of chemical hazards, the need f]or development of toxicological and other data on chemicals, the pendi ng Toxic Substances Control Act, and need for regulation to control tea ic chemicals. DESCRIPTORS: `Public healt , `Toxicology, `Environmental impacts, `Industrial medicine, Envir or.mental surveys, Government policies, National government, Le gilslat ion, :cono mic impacts. Inorganic compounds, Organic compound s, 7inyl chloride. Regulations, Decision making. Hazards IDENTIFIERS: `Hazardous mat erials. Toxic Substances Control Act, NTISEPA0T3 PB-243 U59/5ST NTIS Prices: PCS4.25/MFS2.25 58 SPI-00325 ( Evaluation of vinyl Cnlocide A sociated with -.eat sealing ?VC Products Environmental Health Lao hccle ljlan A P 3 Calif (u07509) ( ; Final rsot. AUTHOR: Smith, 3illy 3urnett, Ronald D. , Diamond, Philip, Greathouse, Jacx E. Cu7a5?3 FLD: 6J, 57U U3GRDIR7515 Dec 7u 70p RE ?T HO: EHL-7UH-17 PROJECT: HAF-351 MONITOR: 19 ABSTRACT: Potential vinyl chjl onde (VC) exposures were evaluated during meat packaging and during we 1 ding operations using heat to join polyvinyl chloride (PVC) sheets or f il.m. The potential for VC exposure was evaluated by analyzing he PVC materials for entrained or encapsulated VC and by analyzing a ir samples collected during the meat wrapping and welding ope rat tics f or VC. The results of all analyses are shown. The potential for eif osure to vinyl chloride monomer at the 0.1 ppm level was not found to exist in either of the two operations studied. No vinyl chloride monoo er was detected in the PVC materials. DESCRIPTORS: `Industrial hygiene, Exposure(Physiology), Polyvinyl chloride, processing `Packaging, `Welding, Gas analysis, Meat, Food IDENTIFIERS: `Vinyl chloride, ndoar air pollution, Gas sampling, Air pollution standards, NTISDODA? AD-A0C9 997/8 ST NTIS Prices: I C$H. 2 5/.NFS2. 25 5S SPI-00326 i I( ?:=lii:r.a cy Jss3ssa?nt o: the Environmental Problems Associated with Vinyl Chloride and Po 1 y v in;y|i Chloride Environsen t a 1 Protection Agency, Washington, D.C. Office of Toxic Su bst an c es . Interim rept. CU335Z4 FLD: 133, 68G* Sep 7U 10 6 p * REPT NO: EPA/560/U-74-C01 "ONITOR: 18 Report on the Activities Force. USGSDR 7509 and Findings of the Vinyl Chloride Task ABSTRACT: The report susaa rites the activities and findings of a taste force to assess the char acter and extent of the problems associated with the production, distri bution, use, and disposal of vinyl cnloride and polyvinyl chloride The first Section discusses the nature and magnitude of ' problems, he second discusses previous and planned activities within the deral Government of particular significance and the role of industry The report concludes with some specific recommendations. DESCRIPTORS: `Air pollute on, `Water pollution, `Toxicity, `Vinyl chloride, Polyvinyl chlo ride. Surveys, Problem solving. Health, Ecology, Tests, Industrial relations IDENTIFIERS: Air pollution ibatement, NTISEPAOTS P 3-239 1 10/0ST NTIS Price ;: PC35. 2 5/2FS 2.25 60 SPI-00327 Experimental Data Serving a s a basis for Seoarate Perm 3 31 ble Concentrations of 0ibutylphtha 1 National Institutes of Health, Uni t. * In v iro nment al Protection Agency, Translation Services Section. AUTHOR: Spasovski, Hincho CUO U5C2 FLD: 0 6J, 06T USOR DR750U Jul 73 8d REPT NC NIH-73-370C HON noa E P A -T R- 2 9- 7 4 Trans, of Khigiena, Zpidemio ogiya l p 33-u 4 196, Sethesda, Hd. Translation Research Triangle Park, N.C. Hikrobiologiya (Bulgaria) v7 ABSTRACT: Based on experiment: using animals subjected to single and multiple inhalatory, oral aru skincoating dosages, and which are supported by mathematical and analogical ' methods, the separate permissible standard for concent rations of industrial dibutylphthalate heated above 1UQC is 0.C01 ti'll':igraas per liter of atmosphere. The toxicity of dibutylphthalate depends upon the modality of its introduction to the organism. Host toxic are its fumes heated above mOC which penetrate and cons use the lungs. The substance is weakly toxic in oral application, It does not possess skin absorptive capability. Dibutylphthalate ossesses a highly cumulative effect in inhalation and ingestion. The c u mulative coefficient falls just short of one, which explains the hype r s e.nsitivity associated with it. DESCRIPTORS: *Phtha 11ates, Toxicology, *Plastics, "Industrial medicine. Industrial atmosphe res. Polyvinyl chloride, Bulgaria, Translations, Lung, Laboratory animals. Experimental data. Exposure, Permissible dosage. Fumes :0iNTIF. IRS : Phthallic acid/(d|ibut yl-ester) , Ir.door air pollution, NTISSPAISD, NTISNIH P3-237 8 8 6-T/ST NTIS Prices: P E33. 2 5/MFS2. 25 6I SPI-00328 The Effect of Dibutyl- and Di oct y Ip h t ha 1 a t es on Pa s vioh Oral Feeding during Prolonged Testing Part I. Application and Toxicological Properties of Dibutyl- and Dioctyl-Phihlates National Institutes of Health, Bethesda, Unit.*Znvironmental Protection Agency, Research Translation Services Section. A UT HOP: Piekacz, Hanna C399ULU FLD: 06T 0SGRDR7503 1974 19 p PEPT NO: NIH-73-37UC MONITOR: EPA-TR-29-7U Trans of Poczniki Pan st vowego Zaklada Higieny 197 1. Md. Translation Triangle Park, N. C. (Poland) v22 p55-61 ABSTRACT: The use of dib utyl- and dioctyl-phthalates is discussed a propos of legislation i n various countries, as veil as their toxicologica1 properties, This study serves as an introduction to research on hyperacute and extended toxicity of both ph thala tes. DESCRIPTORS: *Phthalates, Toxicology, Chemicals, Polyvinyl chloride, Manufacturing, Poland, Tran slations IDENTIFIERS: Pnthalic ac id/| (dioctyl-ester) , Phthalic acid/(d ibut y 1-e ster), NTISEPAISD, NTI3NIH PS-237 83 5-I/ST NTIS Pric e: PCS3.25/MFS2.25 62 T* SPI-00329 Accumulation of OI-.-Ethylhex 1 Phthalate (DEHrO Platelet Concentrates, and Plat let-Pcor Plasma in 'hole 31ood :;aval Blood Research Lab Chelsea "ass (387U81) AUT H05 : Cont rer as , J . , S heib ev, R. H. , Valeri, C. R. C3 6 1 11 1 FLD: 6L U3GPDS7U2U U S?p 73 15 D PROJECT: KROui.02 TASK: ".SOUI. 02. 01 .".ON CTOS: 19 Revision of report dated 30 la: 73. See also AD-766 55U. Availability: Pub. in Transfusic n, viu n 1 p34-U6 Jan/Feb 7U, ABSTRACT: The concentration or the plasticizer, di-2-ethylhexyl phthalate (DSHP) , in the ?la sma was measured after storage of the whole blood in polyvinyl chloric e plastic bags at uc for up to 38 days in either ACD or C?D. The plasma rom ACD-stored whole blood contained iiore DEH? than that from CPD- sjtored whole blood. The continuous-flow cen tri fugat ion washing procedulr es removed about 98 per cent of the DEHP from ACD whole blood stor ed for 33 days at UC. DEHP was assayed in the plat elet-rich plasma, pi atelet-poor plasma, supernatant of the platelet concentrate, washed platelets, and washed red blood cells prepared from CPD whole bloo d. Very little DEHP was found in the washed red blood cells and plat elets, a small amount was found m the platelet-poor plasma, and a large amount in the supernatant of the platelet concentrate. A great er amount of DEHP accumulated in the platelet concentrates that were stored at 22C than in those stored at UC. Vast platelet concentrates rom CFD whole blood were stored at 22C for 72 hours, the amount of D EH? was about four times that observed after uc storage for the same len gth of time. (Author) DESCRIPTORS: 31ood, -Phthalate s, -Plasticizers, -Polyvinyl chloride, Plastics, Bags, Blood plasma, Blood platelets. Accumulation, Blood banits. Storage, 3lood transfusio^ Toxicity IDENTIFIERS: Phthalic acid/bis(e thylhexy1-ester), NTISDODN AD- 786 2 53/5 S L NTIS Price: Bepfint 63 SPI-00330 V Toxicology of Plastic Devices Having Contact with Blood Chiliren's Hospital .Radical C met, Boston, .r ass . Annual rept. Sep 73-13 Jun 74 AUTHOR: Kevy, Shervin V., But on, C32Su;M FID: 6T, 6L, 57 Y, 95A, 21 Jun 74 52p* HOSTTOR: NIH/NHL 1-72-2969 Lawrence N. , Jacobson, 95C USG2DS7U19 day S, ABSTRACT: Continued stud . es are presented that evaluate the possible toxicological effect of 01 - 2-ethylhexyl phthalate (DEHP) extracted iron poly-vinyl chloride (P VC) plastic by blood and biologic fluids. Specific studies are outlined m four areas: The preparation of an antibody to phthalate in rabb|its for use in immuno-fluorescent studies and a radioimmunoassay for erection of phthalate; bi-weekly platelet transfusions after storage for 48 hours at 4 and 22C in PVC, polyethylene and siliconize d glass is a natural and clinically oriented method of phthala administration; evaluation of these animals for hepatic, spier ic and pulmonary functions by means of nuclear medicine techniques. liver function tests and comoaroaental 3SP analysis; tissue analysis of tranfused and n on-t rar.s fused patients for DEHP; and quantitative analysis of liver tissue for DEHP of multi-transfused Rhesus monkeys. DESCRIPTORS: `Plastics, Toxicology, chloride, Slocd, Tissue cul ure; Hedical Experimental data, Antibodie$ Phthlates, animals. Blood transfusion *Plasticizers, `Polyvinyl supplies, mechanical organs, 3ioassay, Humans, Laboratory IDENTIFIERS: `Blood coaDatible materia Is, acid/bis (ethylhexyl-ester), 3iomaterials, NTISHEHLI `Phtnalic PB-233 857/2 JTIS Prices: 'CS5.75/MFS1.45 64 SP/-00331 Toxicology of Plastic Devices vmg Contact with Blood Utah 'ln:v., Sait Lake City. Ccj> 11. of Phanacy. c Interim rept. 21* Aug 72-1 .lay 7 4 A O'? HO?.: Lyman, Donald J. , ?.oli David 3., 5vir,va:d, Dvart A. C32 83H FLD: 6T, 6L, 57 Y` 95 A * , 9 5C 7SG3DP7419 May 7 a 206 c* SHAN'T: PHS-7 3- 290 8 MONITOR: NIH/NHLI-73-2908-B ABSTRACT: The project is i.marily concerned with toxicological evaluation cf polyvinyl chlor ide and, more specifically, the commonly used plasticizer, di(2-ethyihexyl) phthalate (DEHP). Evaluations are concentrated on long range, sub tie toxicity potential, although basic acute and subacute studies are also utilized. Plastic composition studies, acute toxicity stu ies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger nimal studies, analyses of human blood exposed to plastics dur i jg hospital procedures, and possible statistical analysis of human atients following extensive exposure of blood to plastics are i nc 1 idded. Selected findings indicate that: Plastic components which c ofttair. DEHP as a plasticizer are toxic to L-929 cells in tissue culture; DEHP appears to prevent implantation of fertilized ova in rats and } ice; DEHP affects rate and amplitude of contractions in isolated rat hearts; DEHP is hydrolyzed in vitro by liver microsomes and aitochond la but not by cytosol. DESCRIPTORS: "Polyvinyl chloride, `Plasticizers, Blood, Medica supplies. organs. Experimental data, Ihthaiates, Sioassay, Neurology `Plastics, `Toxicology, Tissue culture. Mechanical Laboratory animals. Humans, IDENTIFIERS: *3lood clompatible materials, acid/bis (ethylhexyl-ester) , Bi omaterials, NTI53EWHLI Pathalic P3-233 701/2 NT IS Prices: PCS5.7 5/MFS1.45 :5 V SPI-00332 \f Dynamics of Hygenic 'Jork ir. g Conditions and Occupational Disease Incidence among Workers in Suspension Polyvinyl Chloride Production ever a Number of Years National Institutes of Health 3e t he sd a , Hd . Translation AUTHOR: Filatova, V. S., Anto ayuzher. ko, V. A, C32KA2 FLD: 6J, 6T USGR DR7U 1 8 Jul 7U 7 p RZPT NC: NIH-7U-352C .1CNIT0R: 18 Trans. of Gigiena Truda i P rof ess i ona In ye Zabolevaniya p32-3<4 1971. Unit. (USSR) v15 nu ABSTRACT: The occupational di ;ease incidence in workers resulting from vinyl chloride air pollutija n was studied over a period of 17 years (19 53- 1969). Although industr Lai conditions .have improved, there still occurs new cases of chronic occupational poisoning. Various clinical manifestations of chronic vl nyl chloride poisoning, as a function of environmental air pollution have been established. A series of measures designed to improve lir quality in work areas is suggested. DESCRIPTORS: `Industrial hygiene, `Occupational diseases, `Industrial atmospheres, `Polyvinyl chl|oride, Air pollution. Toxicity, Toxic diseases, USSR, Translations IDENTIFIERS: Air quality, NTIf NIB, NTI3HZWIHL P3-233 6 1 U-T NT IS Prices: ? CSU.CC/MFS1.U5 S SPI-00333 V Health Hazard Ival'jj:ior./"onc:t y Determination. Jonn Morrell Company, Sioux Falls, South Dakota National Ins* (39 C 766) for Occuoationa Safety ar.d Health, Cincinnati, Ohio, Final rept. Oct 72-Jan 73 AUTHOR: Polakoff, Phillip L., Va C306UE2 FLD: 6J, 6T, 570, 94D Oct 7 3 15 p KEPT NO: NIOSH-TH-039-74, HHE-71 MONITOR: 19 dervort , Robert 68 G USGRD27 416 29-39 ABSTRACT: In response to a req iest received from a representative of employees, the National Institji te for Occupational Safety and Health (NIOSH) conducted a health ha zard survey to evaluate exposure to thermal decomposition products of polyvinyl chloride meat packaging film at John Sorrell Company Sioux Falls, South Dakota. 3ased on medical evidence compiled dur r.g a limited study of meat wrapping employees it was determined hat air contaminants generated by the thermal cutting of polyvinyl cl loride packaging films in conjunction with the wrapping of meat are p cftentially toxic to some meat wrapping employees. Symptoms range from m Id eye, nose and throat irritation to more serious respiratory proble ms for meat wrappers who have an underlying predisposition to resiIt!ratory difficulties. Recommendations have been suggested to managemen regarding preemployment examinations and work practices. DESCP. IPTOPS: * Hazardous materia Is, `Industrial medicine, `Polyvinyl chloride, Toxicity, Criteria, I inspection, Standards, Recommendations, Industrial hygiene. Packaging, ? yrolysis, Respiratory infections IDENTIFI35: `Occurational Safe y ar.d Health Act of 197C, Packaging materials, `Meat packing indu sltry, `Toxic hazards. Air pollution effects(Humans), NTISNIOSH FB-232 579/5 NT IS Prices: ?CS4 00/MFS 1.45 67 SPI-00334 (, Health Hazard Eva luatzon/7c licit y jetermination Sea ttle , as mn it on National Inst. (390 766) o: Occuoa : ior.a 1 Safety and Health, Cincinnati, Ohio. Fir.al rapt. Aug 72-Jan 73 AUTHOR: Pola'x off, Phillip L , 7andervort, Robert C270 5IU FLO: 6J, 57U, 57 |r 94 D, 63G DSC RDR7 411 Sep 73 23p REPT NO: NIOSH-TH-070-74, H {5 E-72-53-7C MONITOR: 19 Also includes Rept. nos. HH 72- 54-7 1 thru HHE-72-53-75. A3S TRACT: In rsponse to a eceived from a representative of employees the National Institute f or Occupational Safety and Health (NIOSH) conducted a health hazard survey to evaluate exposure to thermal decomposit ion products a p olyvinyl chloride (PVC) meat packaging film at six retail grocery compa ies in the Seattle, Washington area. Based on medical e vid ence coop Lied during this limited study of meat wrapping employees it was determined that air contaminants generated by the thermal cutting :f polyvinyl chloride packaging films in conjunction with the w:a nping of meat are potentially toxic to meat wrapping employees. Sympt :ms range from mild eye, nose and throat irritation to more serious respiratory problems for meat wrappers who have an underlying prejJ isposition to respiratory difficulties, Recommendations have be an suggested to management regarding pre-employment examinations and work practices. DESCRIPTORS: `Hazardous terials, `Industrial medicine, `Polyvinyl chloride. Toxicity, Criteri. a. Inspection, Standards, Recommendations, Industrial hygiene, ?yr lysis. Packaging, Hazards Respiratory diseases. Air pollution IDENTIFIERS: `Occupational Safety and Health Act of 1970, NIOSH PB-229 709/1 NTIS Prices: PC34.25/nFS1.45 68 SPI-00335 Coal tine Coo oust ion Produces-: Id *tnt if icat ion and Analysis Ultrasysterns, Inc., Irvine, Calif. (07 617) Annual rapt. FY 1972-73 AUTHOR: Paciorek, K. L., Kratzer, C2J1UG2 FLD: 7D, 21B, 81, USG RDP7U06 Aug 73 16Cp RI ?T NO: SN-8220/A1 CONTRACT: HC13300U .HCMTOB: Eud ines-OFR- 3-74 R. H., Kaufman, J. , NaXahara, J. Ill, 11L, USA, 710, 99 P, 81 A, H. 71R ABSTRACT: T he toxic products formed during thermal oxidative degradation of neoprene and poly7 nyl chloride compositions, urethane foams and various untreated a nd treated woods were determined qua n tita ti ve 1 y on a g/g basis Quiescent and dynamic decomposition conditions w ere employed. Analy ses were performed using high vacuum sa pa ratiocs, gas chromatography, mass spectrometry, infrared spectroscopy, and wet chemical methods. The mam toxic species found were among ot ers CO, HC1, HCN, S02, anhydride, aniline, ar.d furfural, 7 he rno gr avime trie analyses were performed on all the compositions, and the data we re correlated to available formulating information and product forma t ion. DESCRIPTORS: `Combustion product Plastics, *7ood, *Coa! mining, ."ining equipment, Chloroprene resi :s. Polyvinyl chloride, Polyurethane resins. Carbon monoxide, Decoapoi itiqn reactions, H ydr ogee chloride, Sulfur dioxide. Hydrogen cyanide , Anhydrides, Anilines, Furfurals, Toxicity, Thermal analysis. Gas chromatography, hass spectroscopy, Chemical analysis, Oxidation, Safe: y. Organic compounds IDENTIFIERS: 2.1 P3-226 9UU/7 NTI3 Prices: PCS 11.CC/HFS1.45 69 SPl-00336 A Toxicological Evaluation of Comdexes ( ertain rle pa 2 ua ternary iajor.iua Sattelle Columbus Labs., Ohio (UC7 C8 0) Annual rept. 1 Oct 72-30 No 7 73 AUTHOR: Grode, G. A., Crowley, J. C2313K1 FLD: 6T, 6L, 7C, 5Ti*, 26 Dec 7 u 33p* CONTRACT: PHS-73-2913 .'l ON I TOR: 18 Falb, R. D., Leimnger, 95 A *, 99C USGRD37U06 E I. ABSTRACT: Physical and chem ical characterizations show that the heparin-quaternary aisonium salt complexes can be reproducim1y prepared from a given lot of a quaternary ammonium salt. Local toxicity studies also indict te that both the tndodecyl methyl ammonium chloride-heparin and tricapryl methy 1 am mom um chloride-heparin complexes e icit qualitatively similar responses, while quantitatively, the T AC-he par in complex produced a locally more severe response. Singl =-d ose toxicity studies of the heparin complexes, carried out in mice show that the TDMAC-hepann complex is the more toxic with an LD50 vaL ue of 3.3 mg/kg, as compared to an LD50 of 195 mg/kg for the TDMAC-he >ar in complex. This toxicity gradient is perhaps the reflection of iji creasing solubility of the complexes in the biological medium with the (C9) capryl-based heparin com pi ex (TCM AC-heparin) being the most soluble. Experimental evidence indicates that the toxicity of T DSAC-he parm treated poly (vinyl chloride) devices is very low. DESCRIPTORS: `Heparin, `Meehan cal organs, `Mechanical hearts. Surface properties. Toxicology, 31oo<. plasma. Plastic coatings, Ammonium compounds, Polyvinyl chloride In vitro analysis. Anticoagulants, Surface chemistry IDENTIFIERS: `Quaternary a mm or.ium salts, `Blood compatible materials, Ammoniaa/methyl-tridcdecyl, Am ionium/methyl-tridecanoyl, NHLI PB- 226 886/0 iJTIS Prices: PC: 3.25/MFS1 .45 70 SPl-00337 rf. Toxicology of Plastic Devices it: v ing Contact With Blood Utah Ur.iv., Salt Lake City. ( 126 9^0) Interim rept. for 26 Aug 72-15 ep 7 3 A JT HO D: Petersen, Rooert V. , Ly: an, David J., Roll, David 3., Svinard, Ewart A. C1901 C4 PLD: 67, 6L, 57 Y , 9f 9 5C USGPDR 7324 Sep 73 117p* CON TRACT: NIH-NHLI-73-2908-B .MONITOR: NIH/NHLI-7 2-6 ABSTRACT: The project is pri marily concerned with toxicological evaluation of polyvinyl chlorid a and, lore specifically, the commonly used plasticizer, di(2-ethylhe xyl) phtbalate (DZHP). The project is divided into twelve tasks inclluding an organizational phase. Plastic composition studies, acute toxcicity studies, tissue culture studies, subacute toxicity studies, leitabolite identification, teratogenic studies, neurologic studies, la :ger antral studies, analyses of human blood exposed to plastics i:mg hospital procedures, and possible statistical analysis of human pa :ien ts following extensive exposure of blood to Dlastics. Selected findings indicate that: DZHP is poorly absorbed from i.p. = intraper itonea1 administration of massive doses; the 3C-day subacute i.v. = intravenous LD50 of DZHP in mouse serum is 355 ag/kg in mice; DZHP accumulates in lungs of dogs for at least 2 weeks during daily i.v. = intravenous administration; an efficient method for analyzing DZH? by ga< chromatography utilizing an internal standard has been developed; and seme components of renal dialysis and cardiac bypass units are toxic to L929 cells by tissue culture mstnods. Portions of this documert are not fully legible. DESCRIPTORS; ("Plastics, *31c od), ("Toxicology, Plastics), ( "Plasticizers, Toxicology) , bed i cal supplies, Polyv*:^y^l chlo^rijd.-e=., Addition resins. Elastomers, heraoplastic resins. Tissue culture, Medical equipment, Mechanical or gacs. Experimental data, Phthalates, 3ioassay, Humans, Laboratory ani ma1lsc IDENTIFIERS: Phthalic acidb is (ethy lhexyl-ester) , materials, *31ood compatible mate rials, N H LI Biocompatinle PB-224 558/7 NTIS Prices: PC34. 2 5/MFS 1 . 45 7 SPl-00338 ( Incineration or Plastics roun l Municipal waste. Syracuse Un i v. Research Corp. N . {. (3 39 750) Final r e p t. AUTHOR: Heimburg, R qolella, A. R. , Jones, D. , Rausch, J. H., iac::na, M. C1725L1 FID: 13B, 68C*, 68A USGRDR7 322 Sep 73 246p* GRANT: EP-CG304 MONITOR: I?A-670/2-73-087 ABSTRACT: The purpose of tbi project was to determine the coaDustion efficiency of plastics whe burned in several types of laboratory inci ne ra tors . These laborata ry units were designed to simulate the primary flame zones of nun icipal incinerators. The parameters of efficiency considered vere: Pe rcent of material consumed, the chemical 'cleanliness' of the gaseo ijs effluent, the rate of production of flyash, and the more obvio us environmental effects of the gaseous effluent, flyash, and resi dlue-ash. Several pure resins vere burned individually in several laboratory incinerators. Also, several mixtures of plastics and a garbage recipe were burned. Results are presented here from analyses o f the effluent along with the effects of each effluent on rats and plan ts for 1- to 3-hour exposures. DESCRIPTORS: (`Plastics, Combustion), (`Solid vaste disposal, Plastics), (`Incinerators, Pla sties), Garbage, Fly ash. Air pollution, Combustion products, Polyet hylene. Polystyrene, Polyvinyl chloride. Acrylonitrile copolymers. Polypropylene, Polycarbonate resins, Polyurethane resins, Urea for maldehyde resins, Melamines, Toxicology, Pats, Pla nts (3otany) IDENTIFIERS: NERC P3-223 651/1 NT IS Prices: PCS5.75/MFS1.U5 72 SPI-00339 Combustion Products f*. .1 the Inc iteration or Plast. ricnigar. Dniv., Ann Arbor. Schoc 1 of Puolic Health. final r e p t. <L-/ A'JTHOP: 3oettr.er, Z. A., 3a 11, G . L. , Veiss, 3. C 150 1 A3 FLO: 133, 7C, 68C*, 6|8 A, 59H USGBDR7319 1 97 3 1 5 d* CCNTSACT : EP-00386 .NON IT 0 2 : 3PA-67C/2-73-0U9 ABSTRACT: Analysis of the ombustion products of plastics was ur.d er t ak en to provide scientists and engineers with information needed to design incinerators in or der to maximize their efficiency while miniaizing maintainance and pollution, to identify products of incomplete combustion potentially recoverable for their fuel or cruoe chemical ' 7alue; and to iden ify products of incomplete combustion which would bo acutely toxic i|r. an accidental fire. Plastics studied were polyvinyl chloride, polysul 'one, polyurethanes, polyimide, Lopac, Barex, phenol formaldehyde, urea formaldehyde, polyethylene, polypropylene, polystyrene, >olycarbonate, polyphenylene oxide, polyester, synthetic fabrics (Dacron, Orion, nylon), and natural products {wood and wool) . (Nodif :.ed author abstract) DESCRIPTORS: (`Plastics, `Corn tustion products), (`Air pollution, Combustion products) , (`Ir.cine ators. Air pollution), (`Solid waste disposal. Plastics), Decomposit on reactions. Incinerators, Chemical analysis. Gas chromatograph , Infrared spectroscopy, Nass spectrometers. Data, Polyvinyl chloride, Tneraogravise trie analysis, Pclyurethane resins, Polyimide resins, Urea formaldehyde resins, Polyethylene, Polypropylene, olystvrene, Polycarbonate resins. Polyester resins IDE NT I FI IP.S : NIP.C P3-222 C01/0 NTIS Prices: PCS8.00/MPS1.45 72 SPI-00340 Coal Mine Combustion products, Identification ar.d Anal vs is Ultrasystems, Inc., Irvi r,e, Ca ii t. (uc 7 6 17) Pinal r e ? t. 3 Jul 71-7 Jul 72 AUIHOP: Paciorek, K. L., Krat; CC 3 u 5E2 FLD: 111, 7C, 91, 710, Jul 72 165p* CONTRACT: H0122CG9 MONITOR: BuMines-OFR-1-73 71H, Kauf aan, 57H, 641 J. USGRD57 305 ABSTRACT: Little data is ava iL able on oxidative degrative behavior of materials used in coal lines under truly dynamic conditions approximating the mine envirojs meat. However, because of the possible danger involved with the forma ion of toxic gases, the authors studied the decomposition of variou materials. Tests were performed on: Polyvinyl chloride-containing materials; Neoprene compositions; Rigid foams (urethanes, isocyanate 5) Miscellaneous materials (including jute, fiber glass and pol ethylene) using a stagnation burner arrangement. It was found that the chlorine-containing materials evolved hydrogen chloride v-( ry readily, its rate of evolution being strongly temperature depended t. The fluorocarbon propellant and C02 were the main products fount, on decomposition of the foams, whereas among other products jute compc sitions liberated methyl chloride. The analyses were performed ns ng mass spectrometry and infrared spectroscopy. A review of the combustion products of various polymers is also included. DESCRIPTORS: {`Combustion orrcducts, `Polymers), (`Coal mines, safety), (`Polyvinyl chlcridli. Combustion products), (`Chloro resins. Combustion products), Cellular plastics, Combustion pro ), (`Jute, Combustion products;)), (`Polyurethane, CCoomm! bustion prod Glass fibers. Polyethylene, S; aJiaohe UHja7oa i-. ^`dnouucs ma aate; Infrared spectroscopy, Mass spectroossccooppyy, Decompos; ion, Rev Cellulose, Polyamide resins , Polyester resins, Epoxy Toxicology, Corrosive gases IDENTIFIERS: `Mine safety P3-214 124/0 NTIS Prices: PC36.00/MFS0.96 7'4 SP1-00341 r. Chemical a t. 1 Physical ;.opertie5 and Ther.-al Eecooposition Products of Certain Natural Products and 3 vn ife tic Materials Environmen tal Health Lao Kelly A f' B Tex (300925) Technical :e?t. AUTHOR: Mel v ir., Walter a.' Jr CC0 72I2 FLD: 111, HE, 13L, May 72 17Op* SEPT NO: EHl'(K) -7 2- 1 U PROJECT: EHL-70-7 .1C N IT 0 3 : 13 710, 71H, 711, 33C USGBDR7302 ABSTRACT: A limited review o the literature including the early history and current data on eaths, injuries and costs due to the con bustion and pyrolysis of resih s, plastics and natural materials is provided. E here is a limited dis cussion of the chemistry and physical properties of plastics. Appli cations of these materials in wearing apparel, co nstruction trades. he aircraft industry, and others are discussed, Experimental data <pn the pyrolysis products of five synthetic a r.d natural fiber c*. rpets are presented. An extensive col 1 action of tables from a nu miter cf sources give data on the trade r.arae, type olastic and manufacturer, pnvsical and chemical properties. decora position produc and other information. (Author) DESCRIPTORS: (`Plastics, `Corabu tion), (`Textiles, Combustion), ( `Floor coverings. Combustion), Reviews, Burning rate. Toxicity, Clothing, Nylon, Corrosive gases. Fire resistant materials. Pyrolysis, Thermal properties, Woolen textile s. Polyvinyl chloride, Plasticizers, Carbon monoxide EDENTIEI EPS: Eire safety, `Carp ts, Hydrogen chloride. Hydrogen cyanid `Flammaoility testing, Smoic e, AD-751 399 NTI3 Prices: PC33.0Q/ 1FS0. 9 5 7D SPI-00342 "aceriais (nan e: ia ly Proauktuv) rr , Based or. ?o 1 y v i ylchloride for Packaging Food Products r.a Osnove Poll vir.ilkhiorida dlya Upakovki Pishcherykh Army Foreign Science and Teenoology Center Charlottesville 038 3CG) AUTHOR: Chantseva, A. 3., Ch ?rnovskaya, R. ?., Ovchinnikov, Yu. A2752E3 FID: 111, 13D, 5 2(5 710 USGRDR7119 lu Jul 71 10p RZPT 'JO: FSTC-HT-23-386-71 Trans, from Plasticheskie .da$sy (USSR) c6 1 970. Va V. A3SI3ACT: The physical, m echar.ical and toxic properties of various types of polyvinyl chlori| e films suitable for use as food wrapping materials are presented. (A itho r) DESCRIPTORS: (`Polyvinyl Packing materials). Films, chloride, `Packing materials), (`Food, chanical properties. Toxicity, Additives, Thermal stability. Viscosity Tensile properties, USSR IDENTIFIERS: `Food packaging `Polymeric films. Translations AD-728 1 50 NTIS Prices: PC: 3.CO MFSC.95 76 SPI-00343 t ON IH Z '/JZS7I3N .proving jC.-Z POLYVINYL CHLG .DE PCLYNEP.S AND A .'I ZT .40 D 0? IMPROVING THEIR TOXIC! Y Air "c:ce Systems Cooaani, w Patterson AFB, Ohio. Technology Div.' A'JT HOP : Gorban , G . M . 6C11F1 FLD: 1 1G SrARC709 Apr 60 13p PZP? NO: AD-600924, FTD-HT-23-1 4 |jU-6 7 Tran- Tran si. Into Zr. glish From Kosaich. Biol. Ned. (USSR), 2, 1967 p 47-51 ?oreign 7. 1, No. DESCRIPTORS: 'Electrical pro)erties, 'Plastic tapes, 'Polyvinyl chloride, 'Ureas, Degassing, Electrical insulation. Nitrogen compounds N69-20342 CFSTI Prices: PCS3.00 fl F S 0. 9 5 ABSTRACT: A method is developed for improvi ng the polyvinyl chloride tapes for the purpose of decreasing their gas emanat on. The overall gas emission of organic substances from the improved specimens of polyvinyl chloride tapes as a result of the treatment with 50% urea solution is reduced by a factor of 2-1/2. The improved polyvinyl chloride tapes give $ff volatile chemical substances in small concentrations, which with long duration of their action on the organism cause only a weak btilogical effect. As a res ult of the treatment with a solution of urea there is an improvement in the electri Cc 1 insulation properties of the polyvinyl chloride tapes serving the purpose for hich the materials are intended without change in their strength characteristics 77 SPI-00344 f ( ( THE EFFECTS OF ST J?. A 31 C0'O:TI0NS OF PLASTIC b*.OCD CONTAINERS O') THE ANTICOAGULANT (ACD) AND TH: PRESERVAT IOK OF VHOLE 3LOOD AND ITS DE3 IV AT T V ES Texas Ur.iv., Austin Drug Plustic Research and Toxicology Lab. Terminal rept. AUTHOR: Guess, Wallace L. 58U212 FLD: 6L, 6T, 1 3D 1968 ulp* CONTRACT: PH-U3-68-97 US GRDR6909 ABSTRACT: On the basis of tli is study, it was concluded that there is clear evidence of a toxic ty potential from some PVC blood bags currently available. There is insufficient evidence at the present time to evaluate the effect:; of storage conditions beyond a one year period, but the study indical ed no drastic alterations due to the one year storage period at temper tures up to 50 degrees C. (Author) DESCRIPTORS : ( Blood, Polyvinyl chloride. Storage) , ( Bags (Contamers) , 31ood), ( To::icity) , Plastics, Bags (Containers), Anticoagulant s. Preservation, Sice, Rabbits, Chromatographic analysis, Ten perat ure, Pathology PB-182 732 CFSTI Prices PC) 6.00 3FS0.95 78 t SPI-00345 ( ON 7 H QUESTION Of .. T ?RO VI NG 1E POLYVINYL CHLoNIDE POLY 1E 3 S AND A NET HOD 0" I ,v. ? ? 0 V I N G THEIR TOXIC 7 Y Foreign Technology Di7 VJrignt-Pc tterson A PD Ohio AUTHOR: Gorban, G. M., Yablochki r., 7 . D. 56C3E1 FLO: 1 II, 22A USGRE A 6 9 0 6 15 Apr 63 12? SEPT NO: FTD-HT-23-1464-67 Unedited rough draft trans. of Fosaicheskaya (USSP) v 1 n2 p47-51 1967, by E. Harter. (141600) 3iologiya Neditsina ABSTRACT: A method is developed for 'improving* the polyvinyl chloride tapes for the purpose of decreas ing their gas emanation. The overall gas emission of organic substa nces from the 'improved' specimens of polyvinyl chloride tapes as a result of the treatment with 50* urea solution is reduced by a fact or of 2 1/2. The 'improved' polyvinyl chloride tapes give off vola tile chemical substances in small concentrations, which with Ion g duration of their action on the organism cause only a weak biological effect. As a result of the treatment with a solution of urea there is an improvement in the electrical insulation properti es of the polyvinyl chloride tapes serving the purpose for which the materials are intended without change in their strength charact ristics. (Author) DESCRIPTORS: ("Polyvinyl chlor de. Processing), Tapes, Gases, Urea, Spacecraft cabins. Carbon d Loxide, Aldehydes, Car bon monoxide, Hydrocarbons, Toxicity, Degasifi at ion, USSR IDENTIFIERS: Translations AD- 630 92a CFSTI Prices: PCS3. )0 MFS0.95 79 gpl-00346