Document 3ewb2MxejJMnXV8GrQxG6p0Ka

BC T 2 .4 3 -1 4 3 - 12 2732 Biochemical Research Laboratory The Dow Chemical Company COMPARATIVE EYE IRRITATION STUDIES CONDUCTED ON NINE EXPERIMENTAL HAIR SPRAY FORMULATIONS Signed /Z. /A f^l Checked ^ /?, T~ 7-/3--g-i-- DISTRIBUTION File Chg. Ref. Source Sub. By Rept. By T2.43-143-1 2505 See below TS+D R. Frankoski K. J. Olson The Dow Chemical Co., Midland Western Division R. H. Boundy Central Research Index CRI 0. R. Mclntire R. A. Lindsay [/ . -v, - . P < y Cz r , -12--' Texas Division Central Research Index L. 0. Litherland - ia J. R. LaCoume D. G. Arteberry L- S. McDonald R. K. Trlechler J. A. Skaggs G. F. Mackenzie C0?fD W MJ01AND CfU R. W. Dupree C. E. McCoy T. Anthony sep m 1999 R. M. Frankoski 29 1965 PROBLEM central research index Nine hair spray formulations (aerosols) were submitted to the Biochemical Research Laboratory for comparison Insofar as eye irritating properties are concerned. The composition of the formu lations appears in the accompanying table. The nine hair spray formulations were submitted subsequently to the Industrial Bio-Test Laboratories, Incorporated, of Northbrook, Illinois, for evaluation. The report by Bio-Test describing the laboratory procedure employed and the results of the tests are Incorporated in this report. R&St68029 GENERAL COMMENT It will be noted from the data presented by Industrial Bio-Test that there are no significant differences between the nine formu lations submitted. It will also be noted that the formulations are severely to extremely irritating to the rabbit eye. RESTRICTED: for use within The Dow Chemical Company only Biochemical Research Laboratory T2.43-143-1 Page 2 In order to further evaluate these results the writer contacted Dr. John Kay of Industrial Bio-Test in person. He indicated that relative to current hair spray products on the market these formulations are considerably more irritating. He further indi cated that most hair spray formulations are capable of producing some corneal Injury to the eye. In his opinion, while the subject formulations are severely injurious, the effects would likely not be of a permanent nature. In the opinion of the writer It would be highly desirable that any formulation which Dow would be interested in marketing should be no more irritating than those already on the market by other companies. RESTRICTED: for use within The Dow Chemical Company only. R&S168030 R&S168031 PER CENT CONCENTRATIONS OF COMPONENTS IN HAIR SPRAY FORMULATION Chlorothene NU Ethanol SDA 40 Vinyl chloride Freon 12 Freon 11's Nitrous oxide Dimethyl phthalate ?j/VA: 60/30 Butylene oxide* Nitromethane* 1,4-Dioxane* sec-Butanol* Propargyl alcohol* IA IB IC IIA I IB IIC IIIA IIIB me 50.0 29.8 50.0 29.8 25.0 44.8 50.0 29.8 50.0 29.8 25.0 44.8 50.0 29.8 50.0 29.8 25.0 44.8 -- 15.0 15.0 -- 15.0 -- -- 15-0 15.0 -- 15.0 -- -- 15.0 15.0 -- 15-0 -- -- 2.0-2.5 0.2 -- 2.0-2.5 0.2 10.0 2.0-2.5 0.2 -- 2.0-2.5 0.2 -- 2.0-2,5 0.2 10.0 2,0-2.5 0.2 -- 2.0-2.5 0.2 -- 2.0-2.5 0.2 10.0 2.0-2.5 0.2 2.5 0.25 0.25 2.0 -- 2.3 0.25 0.25 2.0 -- 2.5 0.125 0.125 1.0 -- 2.5 0.25 -- -- 0.125 2.5 0.25 -- -0.125 2.5 0.125 -- -- 0.062 2.5 0.25 -- 2.0 -- 2.5 0.25 -- 2.0 -- 2.5 0.125 -- 1.0 -- -- -- -- -- -- -- 0.25 0.25 0.125 *Chlorothene inhibitors - % in total formulation. PER CENT CONCENTRATIONS OP COMPONENTS IN HAIR SPRAY FORMULATION R&St 68032 Chlorothene NU Ethanol SDA 40 Vinyl chloride Freon 12 Freon 11's Nitrous oxide Dimethyl phthalate FyVA-- 60/30 Butylene oxide* Nitromethane* 1,4-DIoxane* sec-Butanol* Propargyl alcohol* IA IB IC IIA IIB IIC IIIA IIIB me 50.0 29.8 -- 15.0 -- 2.0-2.5 0.2 2.5 0.25 0.25 2.0 -- -- 50.0 29.8 15.0 -- -- 2.0-2.5 0.2 2.5 0.25 0.25 2.0 -- -- 25.0 44.8 15.0 -- 10.0 2.0-2.5 0.2 2-5 0.125 0.125 1.0 -- -- 50.0 29.8 -- 15.0 -- 2.0-2.5 0.2 2.5 0.25 -- -- 0.125 -- 50.0 29.8 15.0 -- -- 2.0-2.5 0.2 2.5 0.25 -- -- 0.125 -- 25.0 44.8 15.0 -- 10.0 2.0-2.5 0.2 2.5 0.125 -- -- 0.062 -- 50.0 29.8 -- 15.0 -- 2.0-2.5 0.2 2.5 0.25 -2.-0 -0.25 50.0 29.8 15.0 -- -- 2.0-2.5 0.2 2.5 0.25 -2.0 -- 0.25 25.0 44.8 15.0 -- 10.0 2.0-2.5 0.2 2.5 0.125 -- 1.0 --0.125 *Chlorothene inhibitors - % in total formulation.