Document 3ew5zEYXvXz7g2bbMbNDv0RyD

?Sd4ffcooo - loiT* I PLAINTIFF'S | EXHIBIT I -------- ------------------ ~~ ____ . For Iden'K'Citlcn ________ Jn Evidence I SL-181 Clerk % &;$ - x. M< T* Vl^ January 26, 1956 wH-i, .. :.v.r V Jy V-V.'- Dean F. Davies,. K.D. American Cancer Society 521 West 5?th Street Ncu Tork 19, New Tork '< Dear Doctor Darle*1 Pursuant to your telephonic request of a few day* ago, herewith the further Information your office need* in view of the ehanf* in application formal (a) Curriculum Vitae, Dr. 0. J. Dobrogorskl Attached! Appendix A (b) Tin* of Staff Available for A.C.S. project Attached! Appendix B (c) Additional person* participating in the atud^r and not supported by the grant (already \ answered under 6A and 12(a) on the applies* tion for*. Complete list attached! Appendix 8 : fa #?: !' S&:,v JVf ;; ; , (d) Publication* which have resulted fros this par ticular research grant! None a* yet. However, it should be pointed out that the laboratory has pioneered the pathology of Asbestoale and Beryllium diaeas* a* a confidential service to Industry for 2C and 12 years, respectively, releasing a number of restricted reports'. In addition, we include for your benefit a list of publications from the staff covering the period 1937 to present, which represents the time during which members of our staff who are still with us gained experience in the field of experimental diseases of the lungi Ca the eojy Z am-sending you X have narked off those papers which have epeclal reference to either problem* in isbestosis or in Beryllium'disease. Attached! Appendix C 010472 . t 1032 1 Page 2. u-^: ;,,Dewi F. Davies, M.D., American Cancer Society Too will, of course, appreciate the fact that since moat of our studies are long term experiments, papers reporting the resuits of our findings must often be delayed for a long time after the initiation of the project. Vlth kind regards. Tours sincerely. GWKSiLB Enclosuresi Appendix A B -C 0. V H. Schepers, H.D., D.So. Director ciom 4 1033 010476. Appendix B Saranac Ltborutory 1-26-56 ft' "> TIME OF STAFF AVAILABLE FOR WORK OS AMERICAS C.MiCER SOCIETY PROJECT Kama and Title r.'': O'.W.H. Sch*pers,N.D.,D.$c. Director Duties "n** Supported by E?X-gasJt *C<S. Supervliing program, technical procedure*, end detailed etudie* on histopathologyj write reporta 25 0 T. X. Durban, X.E. Chemist 0. 3. DobrogoraVi, X.D, Pathologist L. D. School, Ph.D. Biochemist /t K. L. P-oberts, K.S,fe. Engineer Supervise engineering phasas; in organic chemistry of dusts and organa 10 Blatopathology interpretations t animal autopaiea 25 Flocbemistry of enzyme change* and beryllium coocentratloo in lung and other tissues 25 Construction and auperriilon of all dust chamber* 10 0 Tee Tee 0 S. , Easier, M.E..E.E. Bldstatlstlclan A. B. Delahant Research Biologist D. A. Bailey P*trogr*ph#r Collating and analyzing all bio logical and engineering observa tion* 15 Control of animal protocol* and sacrificing achedulea; animal autopsies 15 Preparing all dusts for dispersion Chambers; identifying dusts in tissues 10 0 0 0 J. G. Schmidt Clinical Pathologist 0. 3, Boula . Animal Caretaker b T. Boooey x~ Radiographer L. Oockeler Photographer F. T. Creedon Histology Technician V. C. Gay Histology Technician E. Tear Histology Technician Blood counts, phosphatases, bacteri ology, etc., on animals under study 5 Cleaning dust chamber* j feeding ani mals (beryllium chambers) 35 Serial radiography of animal* 10 .A Photography of slides and spedmens Prvp&rlag slid** in/'' ' jfr 5 <*' 20 p 20 20 0 Tea Tee 0 Tea 0 ol036 010477 Appendix 8 (cont'd) Saranac Laboratory 1-26-56 TIKE OF STAFF AYU1ABLE FOR WORT OH AMERICAN CANCER SOCIETT PROJECT fJ Kwr.e and Title Duties Tav#. V ' Time Supported tix per cent ACS J. V. Jacob*on Engineering Technician .Serial dust douhtaand beryllium determinations of exposure chsabers 10 0 F. Dogan Engineering Technician ditto 15 0 X. Koody Mechanic R. V. Clark Pathology Technician Preparing exposure ohaabers and apparatus Animal autopsies 10 0 0 R. E. Llddy Chemistry Technician Beryllium determinations 10 0 C. Philipp, Ph.D. Blochaolatry Technician A. J. Redlln Chemistry Technician V. L. Ottlng Chemistry Technician Serial alkaline phosphatase de terminations Silica detersinationa of lungs of exposed animals Cleaning of glassware 10 10 10 0 0 0 B. A. Whitelav Animal Caretaker L. E. Flinn Secretary Cleaning cages and feeding animals (asbestos chambers) Typing reports . 30 10 0 0 SMS k- .. * 1037 2. auuu -10HO * / -for Id.nlifJcjllan -In llvlcl.nc. . CUi>. Appendix C 1-26-56 SARANAC LABCttATCRI STUDIES tr Current timbers of the Staff ** <- d/.A /. j cv ftACivvC "/t - 1937 - . ; 'u^_cC DWORSKI. H0RRI3 Comparative Ventricular Whits Blood Counts in Normal Guinea Figs* Am. Rev, Tuboro. 35*740, June 1937. y DWORSKI. kORHIS and DKLAHANT. ANTUCNI B. Comparative Ventricular White Blood Counts in Experimental Primary Tuberculosis in Guinea Pigs. Am. Rev. Tuberc. 25*753, June 1937. - 1938 . .s VCRWALD, ARTHUR J, and DKLAKAKT. ANTHONT B. The Influence of Silica on the Natural and Acquired Resistance to the Tubarcle Bacillus. An. Rev. Tuberc. 36:347, September 1338* - 1339 - VOBWAID, .ARTHUR J., DELAHACT. ANTHONT B. and DWOBSKI. nCRRIS Silicosis and Type in Pneumococcus Pneumonia: An Experimental Study. J. Indust. Hyg. and Tex, 22:64, February 1940. CUKMNGS, DOMAIN E., DOWNS. ROBERT N. and BERG, KELVIN Tuberculous Lesions in Male Industrial Workers. Am. Rev. Tuberc. 39:439, April 1939. GARDNER, LEROI U., DUBKAH. THOMAS H.. E50KFIEL, DANIEL H. and SAMPSON, HCMR L. Survey in Seventeen Cement Plante of Atmospheric Dusts and Their Effects Upon the Lunge of Twecty-TVo Hundred Baployees. J. Induet. Hyg, and Tcou 21:279, September 1939* DUKKAN. Thonae M. Gypsum Industry-- Atmospheric Conditions. Fourth Sara nac Laboratory Symposium an Silicosis, Saranac Lake, N.7., June 13 to June 23, 1939, conducted and edited by Gardner, L.U. and Kuechle, B.E., Vice-President and Clalma Manager, Employers E5itu.il Liability Insur ance Company, Wausau, Wis. - p. 166. EORKAN, THC&A5 M. Cement Industry-- Atmospheric Conditions, Idea,' p. 177. - 1940 - GARDNER, LEROI U., V0RHA1D, ARTHUR J, end DELAHANT. ANTHONT B. Therapeu tic Effect of Dodecaneyl-Sulfanilamide on Tuberculosis in Guinea Figs. Trans. Thirty-Sixth Annual Meeting of the National Tubercu losis Association, 1940. . - 1941 - GARDNER, LEROI U., DWOBSKI. MORRIS aal DELAHANT. ANTHONT B. Experimental Study of Inhibitory Effects of Aluminum Compounds in Silicosis. Bull. American Ceramic Society, 20, August 1941. 010480 t 1040 1 ( SARANAC UttlUTOtO: STUDIES t<r Current Members of the Stiff (cont'd.) - 1942 - GARDNER, LEROI U. and. REDLIN. ANDREW J. The Significance of Chemical Examination In the Diagnosis of Siliooeie. J Induet, Hyg. and - Tox 24:125, June 1942* - 1943- GARDNiR, IE80Z U. and OELAHANT. ANTHONX B. Action of Finely Divided Magnesium Upon the lunge. Abu J. Pub. Health 33:153, February 1943. -1944 - OABDHER, XEROX U., WCRSKI. HCRRI3 and PKLAHANT. AMTHOHX B. Aluminum Therapy in Siliooeie. An Experimental Study. The Donald S. Cuaminga Memorial lecture. J. Induet. Hyg. and Tax. 26:211, Sep tember 1944. - 1946 - DURKAH. THCKAS H. The Determination of Free Silica in Industrial Dust. J7"5nduet7"byg. and Tax. 28:217, September 1946. - 1947 - BAHET. DONALD A. Conversion of Silica taring Ignition. A Possible Source of Error in Anolysie of Powdered Samples. J. Indust. Hyg. and Tax. 29:242, July 1947. DWCRSlg. MORRIS The Beryllium Problem: Certain Aspects of the Acute Toxicity of Beryllium Injected Intraperitoneally, Harold C. Hodge, Ph.D., William L. Downs and Elliott A. Maynard, Discussion of: Sixth Saranac Symposium, Pneumoconiosis- Beryllium, Bauxite Fumes, held in Saranac lake, H.I., Sept. 29 - Oct. 3, 1947, Editor, Arthur J. Vorwald, Leroy 0. Gardner Memorial Volume, published by Peal B. Hoeber, Inc., Medical Bode Department of Harper and Brothers, p. 299. PKLAHANT. ANTHCKX B. The Beryllium Problem: Preliminary Studies in the Toxicology of Beryllium: The Effect of Intratracheal Injection of Beryllium in Experimental Animals, Charles W. laBalls and Martha Bald Cued, Discussion oft Idea, p. 323. EPBKAH. THCMAS M. The Beryllium Problem: A Review of Analytical Methods for Beryllium, William F. Neuman, PtuD., Discussion of: Idem, p. 356. DPBEAM, THOMAS M. The Beryllium Problem: Chemical Methods, Idem, p. 426. O104B1 2 t 1041 SARANAC LAUOHATOOX STUDIES by Currant Members of tin Staff (coat'd.) - 1949 - BAILST. PCMALP A. 4 Note oa the Coarersion of Amorphous Silica to Quarts. Am. Mineralogist 34:601, 1949* VQRWAID, ARTHUR J., DURHAM. THOtiAS K.. PRATT, PHILIP C. art DELAHAI1T. AMTHOHT B. Diatouaceoua Earth Pneumoconiosis. Proo. of Tbo Ninth International Congress on Indust. Mod., London, 1949. - 1950 - VCRWALD, ARTHUR J., PRATT, PUHIP C., DUBKAN. THOMAS M.. DELAHAHT. AMIBOHT B. and BALLET. DONALD A. Sideroeial An Experimental Study of the Pulmonary Reaction Following Inhalation of Dust Generated by Foundry Cleaning Roots Operations. Indust. Ked. and Surg. 19:151, April 1950. VCRWALD, ARTHUR J., PWCRSKI. MORRIS. PRATT, PHILIP C., and DELAHAHT. AMTHOHT B. BCG Vaccination in Silicosis. Am, Her. Tubero. 62:455, November 1950. - 1951 - VCRWALD, ARTHUR J., DPEKAH. TUCMA3 M. and PRATT, PHILIP C. Experimental Studisa of Asbestsis i Arch. Induat. Ryg. and Oecup. Med. 5:1, January 1951. PURKAM. THOMAS H. Tbs Inhalation of Certain Industrial Substanoes: Silica, Seventh Saranao Symposium, Pneumoconiosis and Pulmonary Cancer, Including Medical and Legal Aspects, held in Saranac Lalce, H.I., Sept. 22 - 26, 1952. (Publication pending). - 1953 - PRATT, PHILIP C., BAILET. DONALD A.. PELAHAMT. AMTHOHT B. end VCRWALD, ARTHUR J. Relationship Between the Piexoelectrie Property and the Flbrogenle Capacity of Dust. Arch. Induat. Ryg. and Oecup. Med. 8:109, August 1953. - 1954 - VCRWALD, ARTHUR J,, PWCRSKI. MORRIS, and PRATT, PHILIP C. The Use of Quarts Dust for Challenging the Viability of Tubercle Baaini in Tuberculous Lesions. Am, Her. Tubero. 69:841, May 1954, VCRWALD, ARTHUR J., PWCRSKI. HCRRI3. PRATT, PHILIP C., art DELAHAMT. AHTBOST B. BCG Vaccination in Silicosis. ZZ. An Experimental Study of the Influeace of Inhaled Quarts Dust Upon Infection by BCG (Aronson), H37Ra, art K. Karinua Strains of Tubercle Bacilli. Am. Her. Tubero. 69:766, May 1954. ' 010482 1042 3 SABANAC LAJXSIATORI STUDIES by Current Mcabsrs of the Staff (cant'd,) . - 1954 - cont'd, - SCHEPEBS. O.W.H. Industrial Kadietna In South Africa. Indust. Had, and Sure* 23>278, June 1954* S&IEPEB3. O.W.H. Tha Bheunatlo lung. Induct. Had. and 8urg. 23*374* Auguat 1954* - 1955 - SCHEPEBS. O.W.H. Industrial Asthma and Bronchitis. Indust. Mad. and Surg. 24:53* February 1955* SCHEPJjSS. O.W.H.. Editor, Mclntyre-Saranao Conference on Occupational Cheat Disease* February 7* 8* and 9* 1955* at Saranac lain* M.I., published tqr tha American Medical Association* Chicago* 111. Also published In July* August and September 1955 Issues of tbs AJ1.A. Arch. Induet. Health. SCHEPEBS. O.W.H. Cooperative Vascular Pathology of Occupational Cheat Diseases. A4UA, Arch. Znduat. Health 12*7*.July 1955. SCHEPEBS. O.W.H. Occupational Cheat Diseases In Gold Miners. Idea, p. 33, SCHEPEBS. O.W.H. and DELAHAMT. AlffllOMI B. Tha Antagonistic Biological Aotion of (Starts and Potaasiua Carbonate. AJ4.A. Arch. Indust. Health 12:109, August 1955. deuhast. Awniacr b. An Experimental Study of tbs Effects of Bara Metals on Animal lungs Idea, ~p. 116. SCHEPEBS. O.W.H. The Bjological Action of Tantalum Oxide. Idea, p. igi T \/^ SCHEPEBS, O.W.H. The Biological Action of Cobaltlo Oxide. Idea, p. 124. SCHEPEBS. O.W.H. Tha Biological Action of Particulate Cobalt Metal. Idea, p. 27, SCHEPEBS. O.W.H. Tha Biological Action of Particulate Tungsten Metal. Idea, p. 134. v/ SCHEPEBS. O.W.H. Tha Biological Action of Tungsten Carbide and Carbon. Idea, p. I37. \/ SOHEPshS'. O.W.H. Tbs Biological Action of Tungsten Carbide and Cobalt. ' idea, p. UO. SCHEPEBS. O.W.H. The Pulmonary Disability Legislation of South Africa. Idea, p. 147. / SCHEPEBS. O.W.H. and DURBAN. THOMAS & The Effects of Inhaled Tale-Mining v Dust on tha Lung. Td<*. n. HB. ^ . 010483 1043 -4- 1 SARANAC UBCKATCfil STUDIES Current Heaters of the Staff (coat'd.) 1955 -- coat'd. -- SCHEPERS, Q.W.H. end DUHKAM. THCtiAS K. Pathological Study of the Effects of Inhaled Gypsum Duet oa HumanLuncs. Idem, p. 209* . MORRIS Propfayludn and Treatment of Experimental Silicosis fay of Alundniau A.H.A. Arch. Indust. Health 12i229, Sspteafcer.1955, SCHESL. LESTER D. Study of Surface ftroperties of Quarts Dust. Idea, p. 262. SCHEPfcRS. Q.W.H. Cytobiological Manifestations of tbs Surface Properties of Quarts. Idea, p. 266. SCHEPERS. Q.WtH. Aa Experimental Study of the Effects of Claes Wool oa Animal lungs. Idea, p. 276. y SCHERERS. Q.W.H. the Biological Action of dase Wool. Idea, p, 280. SCHERERS. Q.W.H.. 'DKUHAKT. ANPiCBT B. and REDUH. ANDREW J. Aa Experi mental Study of the Effecta of Rare Earths on *"<^1 Lungs. Idea, p. 297. SCHEPERS. Q.W.H. The Biological Action of Rare Earths. I. The Experi j mental Pulnonary Hlstopatbology Produced by a Blend Having a Relatively High Oxide Content. Idea, p. 301. SCHEPERS. Q.W.H. The Biological Action of Rare Earths. II. Tbs Experi j mental Pulmonary Hlstopatbology Produced fay a Blend Having a Relatively High Fluoride Content. Idea, p. 306. y SCHEPERS. Q.W.H. and PUKKAH. THCKA3 H. An Experimental Study of the Effects of Tale. Dust on Anlaal Tissue. Idea, p. 317. SCHEPERS. Q.W.H.. DURHAM. TOCHAS M. and DEUHAHT. ANTHOWT B. The Biological Effects of Calcined Gypsum Dust, Idea, p. 329, y SCHEPERS. Q.W.H.. DURKAH. THOMAS H. ami DEUHAMT. ANTHCHT B. Effect of Inhaled Ccnmsrcial Hydrous (Jalciua 3<Hcatj ant ^ Animal tissues. Idea, p. 348. y ROBERTS. MALCOLM L. Relationship of Particle Count, Weight, Shape and Size of Air-Boras Basts. Idea, p. 361. - 1956 - y SCHKPEB3, Q.W.H. Chronic Pulmonary Beryllium Diseases Recent Observations. Trans, of tbs Industrial Rygiens Foundation, Twentieth AnrmaT Meet- > lag, 1955. In press. 010484 -5- 1044