Document 3eK7Gj03MajrgGq9nwxJJ5aDO

-The Jefferson nodical College of BxLladelplrf.a 1025 V/alnufc Street Dept, of Preront&TO llodieins Division, of Industrial I-bdicine Jiao 17, 19h9 Dr* Manfred Bowdiich Director of Dealt: end Safety Lead. Industries Asseolation h20 Losington Avenue Hnr Yedc 1?,.H. X. Dear Doctor Bcwditca: I nave read with great surprise in Doctor Pisher *s letter of Day 17, 19h9* that, the authors of papers on poisoning due to the 'ingestion of wax crayons isve called trds type of pedacsoisg ^'aniline51 poisoning. As a matter of fact, not aniline but parardtrariilino coca bennidino ycHa? 13 taro been discussed as possi ble tonic agents by us as troll as by others. vAdlo Doctor Usher is absolutely light in emphasising that tie problem with idiich. t t q are confronted is tint of a breaMonxi of tho finished d/es and of re forming intermediates, he stated erroneously that feeding of tha crayons or pigaents in question to aniaalo "failed to shew toxic symptoms," ilin ct al, could not pro duce netl'joa^lobiaeaia in rats, dogs and cats, and xie, too, -iavo not seen aetheaoglobinetaia in dogs or rabbits* Hosevei', clogs and rabbits do net react easily to :cetliosoglobin-foaalng compounds, and Doctor uixuol 3, .ficex*, wnc Id-ndly offered to feed crayons unci pigments tc conditioned cata, his ..iron definite proof of nothenoglobin foxmfciun (J. Bediat,, 33* 739, IPhO), V/o have not deserved the formation of IlgS in acid stomach fluid, and acthemoglobin. but not oulaliaaogldbLn was found spoctrophotcmebri-caliy in the blood of the cats mentioned above and in the clinical cases. Doctor Ilchoc*a statement that tho formation of sulfher^gbabin occurs after dsath is generally accepted^ Hgs does not coabino with, tmogldbia in vivo, fha cyanosis in eovei'C IIpS poisoning is nob due to the formation of a specific hemoglobin ctrapound bub to acply-dation by res piratory paralysis, I aa at a loss to iwderatand hair absorption of Lithopoue can possibly produce the type of poisoning observed, 1 also wander whether lithoponc is presort in red, red-orange and other crayons. 1 am enclosing a carbon copy of this letter in case you want to send it to Doctor Fisher, I am also enclosing a reprint of several papers on carbon disulphide which have jost been published. If I can be of any farther assistance to you, feel free, please, to writs to esc. Sincerely yours, /s/ B. Dxieger KJ- 0014 If, Brioger, LI. D, Associate Professor and Director