Document 3eDkr3jjRgpQX2mKpJqDq2b7J

C> THE DOW CHEMICAL COMPANY 1803 BUILDING February 24, 1989 MIDLAND. MICHIGAN 48674 bcc: R. R Cook, M.D., 1803 Bldg. Klaus Giersiepen, M.D., M.P.H. BIPS 2800 Bremen St.-Jurgen-StraBe 1 Federal Republic of Germany PLAINTIFF'S EXHIBIT Dear Dr. Giersiepen: Thank you for your letter and comments regarding our work history validation paper recently published in the American Journal of Epidemiology, Vol. 128 pages 343-351. My colleagues and I have attempted to provide you with the information you requested. Enclosed find: 1. A listing of the 50 homogeneous work areas we used for analysis. la. A sample of the department titles which were combined together to form the work areas. 2. The 171 chemical and physical agents that were listed as potential exposures by the industrial hygienists. 3. Recall rates for some specific substances (the most commonly reported). 4a. The average number of agents listed by the hygienists for each subject. 4b. The average number of agents listed by the interviewee for each subject. 5. A copy of the questionnaire administered to the next-of-kin (identical to the one administered to living subjects except "your relative" was substituted for "your"). We have also included our interviewer instructions, etc. for your use. STO|G5022 Klaus Giersiepen, M.D. February 27,1989 Page 2 Ironically, much of this information was included in the original document that we had submitted for publication, but was eliminated at the request of the editor owing to space considerations. We hope this information meets your needs. Gregory G. Bond, Ph.D., M.P.H. Research Leader and Technical Coordinator The Dow Chemical Company Department of Epidemiology, Health and Environmental Sciences Midland, MI 48674 (517) 636-9063 sjl Enclosure cc. K. M. Bodner Epidemiology, H&ES 1803 Building Midland, MI 48674 STOI 65023 Examples of Department Titles Grouped into Work Areas Work Area Glycerine Chlorinated methanes Department Titles Glycerine Glycerine #1 Glycerine #2 Glycerine production Glycerine technical services Allyl chloride Chlorinated methanes Carbon tetrachloride Chlorinated methanes per-tet facility Chloromethanes CMP per-tet and HC1 distribution Chloromethanes per-tet maintenance Perchloroethylene Perchloroethylene A <--> cn cn CD ro STOI 65025 Bremer Institut fur Praventionsforschung und Sozialmedizin (BIPS) Abteilung Biometrie und EDV Leiter: Dr. rer. nat Kari-Heinz Jockel r 8'emef mstitut luf Pravntioftsforscnung und Soz aimed'zm St.-Jurgen S(ra6 1 2800 Bremen 1 Dr. Gregory G. Bond Dow Chemical Company Epidemiology,Health and Environmental Sciences 1803 Building 2800 Bremen 1 F.R.Gernany St.-JOrgen-StraBe 1 Tel.: 0421 - 4 99 94 50 (Sekretariat) Durchwahl: 4 99 94 - Midland, MI 48674 USA L. J Ihr 2eichen Ihre Mactincht vom KG^Sr Az.30/11 Bremen, den January 6,1989 Dear Dr. Bond: Our research group is presently conducting a study looking at work-related exposures and the development of lung cancer in order to generate hypothesis in this context. We are planning to recruit 1000 lung cancer patients and 1000 population controls for this case control study, attempting to include all incident lung cancer patients in the city of Bremen for a period of two years. Population controls are matched to cases by sex, age, and residence. Study participants are given a 1 1/2 hour lasting interview either at the hospital or at their homes by trained interviewers. While the emphasis of the study is on obtaining an accurate work history and to determine work related exposures, we also obtain a detailed active smoking history and - to a lesser extent - information on vitamin A/beca carotene intake, the family history of cancer, and passive smoking in non-smokers. In the context of questionnaire-derived data on work-related exposures we came across your article in the American Journal of Epidemiology, Vol. 128 p.343-351. We would like to congratulate you to this excellent study as it gives valuable information on the agreement between interview-derived data and industrial hygiene data within a particular company. We would like to ask you a few questions concerning the article, as we are planning to write a grant proposal on the same subject and we would like clarify a few items before writing up our proposal. 1. On page 344 you are mentioning that "50 homogeneous work area classifications were condensed from more than 400 departmental titles". Could you please supply us with a listing of these 50 work areas and possibly with another listing of the original for 400 + departmental titles so that we can understand the condensation process and see how specific the subgroups were after condensation. 2. On page 345 you are explaining that 96 chemical /physical agent exposures were mentioned by study subjects while 171 chemical/physical agents were catalogued by industrial hygienists. Again we axe interested in listings of these different exposures to get an idea of the specificity of the entities. 3. On page 348 you are mentioning recall-rates for some specific substances. We would be very interested in obtaining a more detailed list of recall rates for the specific substances. 4. We agree that the overall recall rate for specific substances of 2.6 % is very low. In order to understand this very low rate we are interested in learning more about the number of substances assigned for each study subject by the industrial hygienist (median or average) and the number of substances given by study participants during the interview (median or average). 5. Our final question refers to your offer in the article that a copy of your questionnaire may be obtained from you. We would be very pleased to receive a copy of your questionnaire. We would be very grateful to receive answers to our questions. Thanking you already in advance we remain, 920S9IU1S _____ _________t . D. , M.P.H. ADMINISTRATIVE SERVICES AGRICULTURAL RESEARCH ALLOYING DEPT ANTIFREEZE DEPT CATALYST DEPT CAUSTIC DEPT CHLORINATED ETHANES DEPT CHLORINATED METHANES DEPT CHLORINATED SOLVENTS RESEARCH CHLORINE DEPT CHLOROPYRIDINES CONSTRUCTION DEPT ELECTRIC SHOP ENGINEERING DEPT EPOXY RESINS DEPT ETHYL DOW DEPT ETHYLENE GLYCOL DEPT ETHYLENE OXIDE DEPT ETHYLENIMINE DEPT GAS & WATER DEPT GLYCERINE DEPT HYDROXYLALKYL ACRYLATE DEPT INSTRUMENT DEPT LATEX DEPT LEAD SHOP LIGHT HYDROCARBONS DEPT LIME DEPT MACHINE SHOP MAGNESIUM DEPT MAINTENANCE DEPT MARINE DEPT MATERIAL HANDLING DEPT METAL CLEANING & PICKLING DEPT METALS RESEARCH DEPT NITRO PROCESSES DEPT ORGANIC PROD RES DEPT ORGANIC RESEARCH DEPT OTHER PAINT SHOP PIPE SHOP PLANT SUPPORT SERVICES DEPT POLYETHYLENE DEPT POWER DEPT SHELF DRYER DEPT STYRENE DEPT VEHICLE MAINT DEPT VORANOL DEPT VI V2 DEPT WASTE CONTROL DEPT YARD & UTILITY DEPT STOI 65027 ACETALDEHYDE ACETIC ACID ACETONE ACETONITRILE ACETYLENE ACID MORTAR ACROLEIN ACRYLIC ACID ACRYLONITRILE ALLOY: MAGNESIUM ALLYL CHLORIDE ALUMINUM METAL AMMONIA ASBESTOS BARON HERBICIDE BENZENE BERYLLIUM BISPHENOL A BLASTING SAND (QUARTZ) BRINE-25% NACL BROMINE BUTADIENE BUTYL ACRYLATE BUTYL MERCAPTEN BUTYLENE CAB-O-SIL CADMIUM CALCIUM FLOURIDE CALCIUM OXIDE CARBON CARBON DISULFIDE CARBON MONOXIDE CARBON TETRACHLORIDE CHLORINATED SOLVENTS CHLORINE CHLOROFORM CLOPIDOL COPPER CHLORIDE CUMENE CUPROUS AMMONIUM ACETATE CUTTING OILS CYCLOHEXANE DEH 14 (POLYAMIDE) DICHLOROETHYL ETHER DICHLOROISOPROPYL ETHER DIESEL FUEL 7"" DIETHYL BENZENE DIETHYLENE TRIAMINE DIPROPYLENE GLYCOL DOWANOL EE DOWANOL EM DOWPON GRASSKILLER DOWTHERM A EDB LIGETI'S AS ETHYL BROMIDE EDB STILL BOTTOMS AS CBR4 EPICHLOROHYDRIN EPOXY RESINS: HYDROLIZED (DER 331) ETHANE ETHANOL ETHYL BENZENE ETHYLENE ETHYLENE DIAMINE (EDA) ETHYLENE DIBROMIDE ETHYLENE DICHLORIDE ETHYLENE GLYCOL ETHYLENE OXIDE ETHYLENEIMINE FIBERGLASS FLUORINE FORMALDEHYDE FREON 11 FUELOIL GALON HERBICIDE GASOLINE GLYCERINE GRAPHITE HEAT HEXACHLOROBENZENE HEXACHLOROBUTA-1,3-DIEN E HEXACHLOROETHANE HEXAMETHYL PHOSPHORIC TRIAMIDE HEXANE HIGH EXPOSURE TO WIDE VARIETY OF STRESS HYDROGEN (GAS) HYDROGEN BROMIDE HYDROGEN CHLORIDE HYDROGEN CYANIDE HYDROXY PROPYL ACRYLATE HYDROXYETHYL ACRYLATE STOI 65028 ISOBUTANE ISOBUTYL ALCOHOL ISOPAR C ISOPAR E ISOPAR M KEROSENE LATEX LEAD LUBRICATING GREASE LUBRICATING OIL M-DIOXANE MAGNESIUM CHLORIDE MAGNESIUM HYDROXIDE (SLURRY) MAGNESIUM OXIDE MANGANESE MERCAPTEN: TERT-BUTYLMERCURY METHANE METHANOL METHYL CHLORIDE METHYLENE CHLORIDE MINERAL OIL MINOR EXPOSURE TO WIDE VARIETY OF STRESS MOD EXPOSURE TO WIDE VARIETY OF STRESS NITROGEN DIOXIDE NO SIGNIFICANT EXPOSURE NOISE OTHER OZONE PAINT SOLVENTS AND THINNERS PHENOL PHENOLIC POLYMER PHENYL BENZENE PICLORAM POLYETHYLENE POWDER PORTLAND CEMENT PROPANE (LIQ) PROPANOL:2,3-DICHLOROPROPYLENE PROPYLENE DICHLORIDE PROPYLENE GLYCOL PROPYLENE OXIDE PYRIDINE PYRIDINE: PENTA-CHLOROPYRIDEME: 2-CYANO PYRIDINE: 2,3,5,6-TETRA-CHLORO RADIATION REDIPON HERBICIDE RONNEL RUELENE SILICON DIOXIDE SILICONE SPRAY LUBRICANT SODA ASH SODIUM HYDROXIDE STERIC ACID, ZINC SALT STYRENE STYRENE OXIDE STYRENE POLYMERS, FOAM SULFUR (MOLTEN) SULFUR DIOXIDE SULFURIC ACID TELONE TETRACHLOROETHYLENE TETRAETHYLENE PENTAMINE, TEPA TOLUENE TOLUENE DIISOCYANATE TRANSFORMER OIL TRICHLOROETHYLENE TRIETHYLENETETRAMIN E VARNISH VARSOL VERSENE ACID AND ACID SLURRY PH=N3 VINYL ACETATE VINYL CHLORIDE VENYLIDENE CHLORIDE VORANOL WELDING FLUXES WELDING FUMES WOOD ZINC ZINC OXIDE ZOALENE 1.1 DICHLOROETHANE 1.1.1 TRICHLOROETHANE 1.1.2 TRICHLOROETHANE 1.2 DICHLOROETHYLENE 1.3 DICHLORO-2-PROPANOL STOI 65029 Interviewee-Company Agreement Rates for Common Physical/Chemical Agent Exposures Agent Employee Reports Company Records Percent Agreemeni STOI 65030 OTHER EPICHLOROHYDRIN ETHYLENE CARBON TETRACHLORIDE BENZENE SULFUR DIOXIDE CHLORINE ASBESTOS HEAT OVERALL 81 2 6 7 4 2 36 13 1 152 4 334 28 78 264 81 267 337 151 220 5760 1.9 7.1 7.7 2.7 4.9 0.7 10.7 8.6 0.5 2.6 CHEMICAL/PHYSICAL AGENT EXPOSURE IN COMPANY RECORDS Number of Agents Recorded 1 2 3 4 5 6 7 8 9 10 + Number of Employees. 80 24 53 80 67 94 51 30 26 221 734 ST0I6503I Total Agents Recorded: Average Agents Per Employee: Median Agents Per Employee: 5760 7.85 6 REPORTS OF CHEMICAL/PHYSICAL AGENT EXPOSURES BY INTERVIEWEES STOI 65032 Number of Agents Recorded 0 1 2 3 4 5+ Number of Employees 512 123 51 18 12 18 734 Total Agents Reported: Average Agents Per Employee: Median Agents Per Employee: 433 0.60 0