Document 3e8N0mMMxbzjK7kk2d8yXxB6n

CertairileedH Subject Date April 25, 1985 PLAINTIFF'S EXHIBIT To See Below From J. P. McGinley - ap CT-1504 See Below Location and mail code 2125 To: Mr. J. L. Anderson - Hillsboro //257 Mr. J. A. Burke - Riverside 7/260 Attached is an interesting letter that I came across recently and I am passing it along for your information. There seems to be a continuing build-up of sentiment concerning the fact that amphibole (blue) is more harmful than the chrysotile (white). The letter also contains some information concerning the fact that the government's present policy regarding carcinogens is creating unnecessary concern among the general public. ' Att. * CTD001799 o J~ /CJ -b. United States Department of the Interior GEOLOGICAL SURVEY RESTON, VA. 22092 In Reply Refer To Hall Stop 959 February 28, 1985 Or. Bernard 0. Goldstein, M.D. Assistant Administrator for Research and Development United States Environmental Protection Agency 401 M St.. S.W., Washington, DC 20460 Dear Dr. Goldstein: This letter is In reply to your request for my comments on the paper by Dr. Churg and coworkers titled lung asbestos content In chrysotlle workers with mesothelioma.* I am quite familiar with Dr. Churg's previous work In the area of fiber counting and Identification In lung tissue. 1 have found his work to be well done, very useful, and In good agreement with data published by other scientists. His present paper published In the American Review of Respiratory Disease (Yol. 130, p, 1042-1045, 1984) Is a significant contribution, the major points being: (1) the ratio of amphlbole to chrysotlle fibers detected In the lung tissue of mesothelioma victims Is approximately eight to one, and (2) the concentration ratio of tremollte In the lungs of the mesothelioma cases compared to controls Is 9.3, while the ratio of chrysotlle Is only 2.8. The authors state on page 1045, *0ur observations in chrysotlle mine Industry workers thus raise the possibility that the amphlbole component of the chrysotile ore Is Important In the genesis of mesothelioma In this group.* It would appear from the work of Churg, et al. and other similar reports, that the human lung has the ability to concentrate amphlbole over chrysotlle even though the workers have been exposed to rock dust containing much more chrysotlle than amphlbole. A similar observation Is very strikingly made by Gylseth et al. (Brit. J. Ind. Med., Yol. 40, p. 375-379, 1983). Their analysis of fiber type In the lung tissue of eight workers from a Norwegian asbestos cement plant who died either of pleural mesothelioma or lung cancer showed that the percentage of amphibole asbestos in the tissue varied between 76% and 99% whereas the- percentage of chrysotlle varied between 0 and 9%. Yet the use of asbestos In the cement plant during the period 1942 to 1980 was 91.7% chrysotile and 8.3% amphibole asbestos (4.1% crocldollte, 3.1% amosite, 1.1% anthophylllte)! This extraordinary reversal of fiber ratios between exposure and lung burden supports an Idea alluded to in previous medical publications -- that chrysotile fibers are somehow cleared from the lung, perhaps by slow dissolution (we know that chrysotlle is more soluble than amphlbole asbestos). Other clearance mechanisms may also preferentially remove chrysotlle. CTD001800 Concerning asbestos exposure In the non-occupatlonal setting, It Is of Interest to note that measurement of fibers In the lung tissue of 20 urban dwellers who had no history of occupational exposure to asbestos showed that 84X of the fibers counted were chrysotlle, 16X amphlbole. Of the amphlbole, 95X was of the non-commercial type (Churg and Warnock, Am. Rev. Resp. Disease, Vol. 122, p. 669-678, 1980). I do not believe that the paper by Churg et al. should be treated as an epidemio logical study but rather as a census of fiber type within the lung tissue of mesothelioma victims. Nor do I believe that this paper can be Interpreted as disagreeing with the conclusion of Dr. J. C. McDonald and coworkers -- the conclusion that chrysotlle has a low potential to cause mesothelioma. I might cite Or. Churg's previous work In this regard: (1) "These observations suggest that most mesotheliomas are associated with Increased numbers of commercial amphlboles and not with chrysotlle asbestos" (Churg, Hum. Pathol., Vol. 13, p. 381, 1982), and (2) "Mesothelioma Is rare In chrysotlle miners" (Churg and Wlggs, Am. J. Pathol., Vol. 115, p. 441, 1984). Perhaps I misunderstood your Impression of Or. Churg's paper. In my opinion It does not say that chrysotlle asbestos causes mesothelioma In Quebec asbestos miners; It does not pertain In any way to the total Incidence or Incidence rates of this disease In those exposed to chrysotlle dust. Mesothelioma is a rare disease among the workers and residents of the Quebec asbestos mining towns as documented by J. C. and A. 0. McDonald and coworkers, G. P. Theriault, L. Grand-Bols, R. Pampalon, P. Toft and coworkers, and 0. Slemlatyckl. A striking example of low mesothelioma mortality In chrysotlle factory workers Is given by McDonald and Fry (Scand. J. Work Envlr. Health, Vol. 18, Suppl. 1, p. 53-58, 1982). Two factories, one In South Carolina and one In Connecticut, used predominantly chrysotlle asbestos. Among the 2,341 deaths In these two chrysotlle factories there was one mesothelioma death (recall that McDonald et al. report ^1 cases of mesothelioma in a series of 4,547 deaths in the Quebec chryso tlle miners and millers). Contrast this to a third factory in Pennsylvania which used amoslte and crocldolite asbestos In addition to chrysotlle asbestos. Among the 1,429 deaths In workers at this factory using mixed amphlbole-chrysotlle asbestos there were 18 mesothelioma cases. Or, consider 67 mesothelioma cases among 745 deaths In a London factory cohort exposed to amoslte, crocldolite, as well as chrysotlle (Newhouse and Berry, Annals NY Acad. Sc., Vol. 330, p. 53-60, 1979). McDonald (Annals Acad. Med., Singapore, Vol. 13, No. 2, Suppl., p. 345-352, 1984) summarizes mesothelioma Incidence in 30 male cohorts as follows: Type of Exposure (cohorts) No. of Deaths No. of Mesotheliomas Rate/1000 Chrysotlle ( 8) Amoslte ( 2) Anthophyllite ( 1) Crocldolite ( 2) TremolIte ( 2) Mixtures Total (IS) Wt 6,539 959 248 279 165 10,728 18,918 15 19 0 33 3 369 439 2.1 20.0 - 118.3 18.2 34.4 23.2 2 CTD001801 The possible health effects of exposure to rock dust containing one or more of the many amphlbole minerals 1$ an Important Issue. Amphlboles are contained within the gangue (waste rock) of many hard-rock mines; gold, vermlcullte, talc. Iron ore, crushed stone and aggregate, copper, etc. Certainly control of most dust, regardless of the mineral content, Is necessary for past heavy exposure to dusts containing crystalline silica (SlOg), slate, coal, talc, and radio-active minerals have caused significant disease. Unusually tight control of amphlbole mineral particles such as proposed by NIOSH in 1976 for asbestos fibers (0.1 fibers per cm3), however, would stop major mining In the United States. Several epidemiological studies have been performed on hard-rock miners who were exposed to non-commercial amphlbole dusts. One example Is a cohort of gold miners at the Horaestake Gold Nine, Lead, S. 0. who were exposed to rock dust containing very significant amounts of amphlbole belonging to the cummlngtonlte- ?runerite series. The 861 observed deaths Included 43 lung cancer deaths 43 expected) and no mesothelioma deaths. Non-malIgnant respiratory disease due to quartz dust, however, was excessive. This cohort thus showed no evidence of mortality that could be related to amphlbole dust (Brown et al., symposium, April 5, 1984, unpublished preprint). Studies of Reserve taconlte (Iron ore) miners who were exposed to cummlngtonlte amphlbole contained In the mine dusts also show no amphlbole-related disease (Ross, ASTM STP 834, p. 75, ref. 43, 1984). It should be noted that no mesothelioma deaths have been reported In Finnish anthophylllte asbestos miners and millers (Ross, ASTM STP 834, p. 74, Ref. 8. 1984). In addition to the very common exposure of man to naturally occurlng fibrous minerals, he Is also exposed to many different types of synthetically made fibers. Nore and more of these substances are being developed each year In the greatly expanding fiber and composite Industries. Our knowledge of the health effects of most of these fibers Is minuscule or non-existent. The health effects of those exposed to man made vitreous fibers, however, have been studied intensively and statistically significant studies are just now being reported. These glassy fibers, usually referred to as man-made mineral fibers (MMMF), Include slag wool, rock wool, glass wool, fiber glass, and continuous filament products. Two separate reports, one of 25,146 workers at 13 plants In Europe (Saraccl et al., Brit. J. Ind. Med., Vol. 41, p. 425-436, 1984), and one of 16,730 workers at 17 plants In the United States (Enterline and Marsh, WH0-EUR0, Biol. Effects Man-Made Mineral Fibers, Proc., In press) have just been published or are about to be published. The table below gives a summary of the lung cancer mortality for male workers In the European and United States MMMF Industries who lived at least 30 years since first exposure. 3 CTD001802 TABLE LUNG CANCER MORTALITY. MALES, AT LEAST 30 YEARS OBSERVATION SINCE FIRST EMPLOYMENT IN MMHF INDUSTRY LUNG CANCER EUROPE (13 FACTORIES) (Observed) (Expected) (Excess) Rock wool Glass wool Continuous filament Subtotal UNITED STATES (17 FACTORIES) 11 4 2 17 (Observed) 5.7 2.6 0.6 8.9 (Expected) 931 541 2331 911 (Excess) Glass wool Slag wool Rock wool Subtotal 47 36.0 311 45 28.1 601 14 8.1 731 106 7172 m TOTALS: 123 81.1 521 Thus, a statistically significant excess of lung cancer (521) Is seen In these > workers who lived at least 30 years since first exposure. Exposure was generally less than I fiber per cm3 and most commonly In the range of 0.01 to 0.1 fibers per cm3. Recall that Quebec chrysotlle asbestos miners and millers with at least 20 years service In the Industry and exposed to between 10 and 21 fibers per cm3 showed an excess of lung cancer of 121. (Ross, ASTM STP 834, p. 93, 1984). had a vendetta against fiber glass It could be said from these data that, fiber for fiber, man-made minerals products may be more dangerous than chrysotlle asbestos. There is ample epidemiological evidence available to show that under controls now In place at modern well run plants, except possibly asbestos textile factories, risk due to chrysotlle will be difficult, perhaps impossible to detect. The very low risk of non-occupatlonal exposure to chryso tlle asbestos has been well documented by various studies of the mortality of the women of the Quebec chrysolite asbestos mining towns, women who did not work In the asbestos Industry but who were exposed to very high levels of ambient chrysotlle dusts from the local mines and mills throughout their lives, 24 hours a day (Ross, ASTM STP 834, p. 82-86, Ref. 70, 71, 72, 73, 81, 86, 1984; see also J. Siemlatyckl, Proc. World Symp. Asbestos, Montreal, May 25-27, p. 337-348, 1982). 4 CTD001803 Many types of fibers produce tumors In animals subjected to suitable types of experiments. All forms of commercial asbestos (except perhaps for actlnollte asbestos) and various forms of man-made mineral fibers have been shown to cause cancer In man, usually after long-term exposure. In view of these facts what are we to say about control of fibrous materials In our environment? Should not all fibers falling within a critical size range be regulated? If so, to what levels? If all asbestos Is considered equally dangerous, the prevailing opinion In the United States, should all other fibers also be considered as equally dangerous? If all fiber In the critical size range Is banned, such as presently being attempted for major uses of asbestos or regulated to 0.1 fibers per cm^ (nIOSH proposal), what Industries will be affected? Is It proper to assume that a substitute for asbestos Is safe when there are no scientific data on human exposure to support such an assumption? Recall that a great variety of fibers, when Implanted Into the pleura of rats, cause tumors. Is It In the * public Interest to ban the use of materials which have had significant benefits, such as fire-proofing, Insulation, and materials strengthening, when proposed substitutes have not been proven to furnish similar benefits or economy? The prevailing cancer dogma In the United States espouses the "no threshold" theory for cancer genesis. It Is said repeatedly by Influential health specialists that since no one knows the minimum amount of a carcinogen required to Initiate the growth of a cancer tumor, It must be assumed that any amount of any carcinogen Is unsafe. Thus, what Is the school administrator to do when he Is required by law to post signs In his schools stating that asbestos is present? He has no option -- he has to have It removed for our cancer dogma translates the words on his building sign to "a little child breathing just one asbestos fiber may get mesothelioma 30 years later." The school administrator, the teachers, the parents, are In a box. The only way out of the box Is to call for full rlpout of the asbestos even though well Informed experts know that many asbestos rlpouts, perhaps most, will put more fiber Into the air than If It were left In place. And what are we to do about asbestos substitutes that also may be carcinogenic In man -- for example the man-made mineral fiber products such as rock wool and fiber glass? Since these products apparently cause excess lung cancer In long-term production workers a logical and honest cancer policy would require that they also be removed from schools and homes. The presence of asbestos In schools, homes, and other buildings is generating a national crisis of such proportions that the U.S. economy could be very adversely affected; this because full rlpout of asbestos Is the only viable option In view of the "one fiber can kill you* concept. Building owners, school systems, and local and state governments are suing many businesses for costs and damages related to asbestos removal. Insurance companies are dropping liability coverage on workers removing asbestos, and occupants of buildings are suing over health effects or potential effects alledged to be caused by exposure to asbestos during renovation. The asbestos removal workers themselves, I predict, will soon be suing their contractors because they too will believe that their health Is threatened by exposure to asbestos. Finally, this whole scenario may soon be replayed, the main actor being fiber glass products rather 5 CTD001804 than asbestos. Where will this all end? When a dozen major corporations go bankrupt? When the court system becomes so clogged with lawsuits that It can no longer keep up? When people become to afraid to work or live In any buildings that contain asbestos? When enough buildings are closed and vacated for rlpout, putting an Inordinate number of people out of work? And all this because a small number of people hypothesize a small health effect due to non-occupatlonal exposure to asbestos 1n bu11 dlngs, a postulated effect too small to measure In any feasible epidemiological study. In a letter to Mr. Oon R. Clay, then Director of the Office of Toxic Substances, EPA, I predicted that such a crisis might occur. This letter, dated 17 December, 1981, was a response to a request from Mr. Clay that I critically review an EPA Guidance Document on asbestos-containing materials In schools. I wrote then that "fear of asbestos" might require removal of asbestos from all buildings, homes, appliances, as we'll as replacement of asbestos cement water pipe. I also wrote that the requirement to notify the building occupants that asbestos Is present may cause them to refuse to work In the building until all asbestos Is removed. This correspondence Is enclosed. Concluding, I think It Is Imperative that our national health policy be re evaluated to recognize that many products, though carcinogenic under certain conditions, can be manufactured and used safely under economically feasible controls. This policy should also recognize that It does not make sense to spend huge sums of money to reduce or eliminate very small risks, for example, attempting to reduce cancer risk In schools through a potential multi- billion dollar asbestos removal program, when money (and Initiative) Is lacking to reduce the huge health risks associated with poor nutrition, tobacco use, and abuse of drugs and alcohol. __ I hope that this letter will be of use to you and other decision makers In gaining a somewhat different perspective on this asbestos and health issue. I thank you for this opportunity to reply to your letter. Yery sincerely, 0y\a$Cofar*\ Malcolm Ross, Ph.O. Research Mineralogist 12 Enclosures: Scientific papers by: Churg et al., 1984 Gylseth et al., 1983 Churg and Warnock, 1980 Churg, 1982 Churg and Wlggs, 1984 McDonald and Fry, 1982 Newhouse and Berry, 1979 McDonald, 1984 6 CTD001805 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C 20460 Mr. Malcan Ross U.S. Geological Survey Mail Stop 959 Keston, VA 22092 JAN II 1985 OFFICE OF RESEARCH ANO DEVELOPMENT Dear Dr. Ross: Enclosed is a recent article from the American Review of Respiratory Diseases by Churg, et al. The Canadian scientists report on the presence of six cases of mesothelioma among 90 consecutive autopsies of long-term workers in the Quebec chrysotile industry. This is an extremely high incidence of mesothelioma. Furthermore, mineralogical evaluation of the lungs revealed only chrysotile and chrysotile-related asbestos in five of the six cases. In view of the fact that these are additional findings which would appear to contradict your assertions concerning the mesothelioma-producing potency of chrysotile ores, I would appreciate any ccninent or critique of this journal article. Sincerely, Enclosure cc: Martin Smith Donald Ryan Jack Moore Bernard D. Goldstein Assistant Administrator for Research and Development CTD001806 Scientific papers by (continued): Brown et al., 1984 Ross, 1984 Saraccl et al., 1984 Correspondence with Mr. Oon R. Clay, 1981-1982 cc: Mr. Martin Smith Mr. Donald Ryan Dr. John A. Moore, D.V.M. Dr. Andrew Churg, M.D. Dr. J. C. McDonald, M.D. 7 CTD001807