Document 3ZRzqJgLD967pV7YQGxbyNBx

... c p , Monsanto Mnint Comimv 00 N. loultvtrd SI. Ifet*. UiMOn OIOS !3I4.` M4.tC00 July 18, 1975 Dr. J.C. Calandra Industrial BIO-TEST Laboratories 1010 Frontage Rd. Northbrook, 111. 60062 Dear Joe: re: AROCLOR 2-year Rat Feeding Studies The attached table summarizes a comparison of the 3 revised AROCLOR reports (1242, 1254, 1250). In 2 instances, the previous conclusion of "slightly tumorigenic" was changed to "does not appear to be carcinogenic". The latter phrase is preferable. May we request that the AROCLOR 125^ report be amended to say "does not appear to be carcinogenic". The number of hepatomas reported for AROCLORS 1200 and 1242 have been interchanged. This appears to have arisen from con fusion regarding the numbering of the animals. The original reports show tumors in animals with numbers in the 100-300 range for AROCLOR 1260 and in the 500 to 800 range for AROCLOR 1242. This leads me to conclude that the numbering scheme shown in the second set of reports is correct. With AROCLOR 1254 confusion is compounded. The original report showed tumors in animals with numbers in the units to teens, but the revised report shows animal numbers ranging from 40 to 1000. Can this be straightened out? I was unable to reconcile the differences in the animal numbers between the first supplemental report and the original reports, I had inquired as to the changes in the numbers. As I recall, I was told that the sections had been renumoered when the new slides were made and that a key relating to the sets of numbers 8360 1 00 737 voniwi RECEIVED jul ?. 1 19*5 orn.TEST WATER PCB-00052016 f Dr. J.C. Calandra July 18, 1975 Page -2-7 e ' would be supplied. This has not been done. It may not be necessary for AROCLORS 1260 and 1242, but AROCLOR 1254 remains unresolved. Insofar as I can see, the remainder of the reports appear acceptable. Kindest personal regards. Sincerely, George J. Levinskas, PhD Mgr., Environmental Assessment and Toxicology /bkp att. cc: Dr. George Roush, Jr., M.D. I 0019.72 10073* WATER PCB-00052017 Product Supplemental Report #1 (mailed) AROCLOR 1260 conclusion slightly tumorlgenlc hepatomas 3 range of test animal nos P- 9 P- 10 P- 11 P. 12 P. ll P- 600 to 800 1000 series 70 to 100 500 to 600 600 to 700 700 series .. Supplemental Report #2 (JCC delivered^ does not appear carcinogenic 7 100 to 300 800 to 900 10 to UO 80 to 200 200 to 300 200 to 300 AROCLOR 125^ conclusion hepatomas slightly tumorlgenlc 6 slightly tumorlgenic 6 AROCLOR 1242 conclusion slightly tumorlgenlc does not appear carcinogenic hepatomas 7 3 range of test animal nos. as In report #2 as In report #1 for AROCLOR 1260 AROCLOR 1260 | .001273 100 "Op ' < o. / WATER PCB-00052018