Document 3Z3ajdENaqE8w6RnRVE7B1ja

tjujJU CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE, POLYVINYL CHLORIDE AND STRUCTURAL ANALOGUES ic C'i~l aA^yY^xJ>u^ut ,, *'j ^ l* cVt Uoi, UWw( t A March 20-21, 1980 A tmu-Kj cLu*&i . tO <v A*.AH-4U-4V> ^ itu- V*X'V1^ Jii . tfWus (Lto -4^-u rfV^-^wtyV A /cZia ^/(uuZt. .. > *5* ^4*^ c* 4^V< 1 u~xu % v .JIU'vJtJZl cUZi^A Tl O G National Institutes of Health ~ / , . ut Masur Auditorium Uyr+AAu^U Building 10 wtCl 4*. Clinical Center $ u* /Ui ^ethesda' Maryland URL 15974 Cosponsors National Institutes of Environmental Health Sciences National Institute for Occupational Safety and Health Occupational Safety and Health Administration Thursday, March 20, 1980 URL 15975 8:00 A.M. REGISTRATION 8:30 A.M. INTRODUCTORY REMARKS Dr. David Rail, NIEHS SESSION I - CARCINOGENESIS BIOASSAYS OF VINYL CHLORIDE MONOMER Chairperson: Dr. Umberto Saffiotti, NCI 8:45 A.M. 1. Carcinogenesis Bioassay of Vinyl Chloride Monomer with Particular Reference to Multiple Sites and Dosage Review Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna 9:45 A.M. '2. Experimentally Induced Pulmonary Cancer Dr. Y. Suzuki, Mt. Sinai Medical School 10:00 A.M. Discussion 10:15 A.M. Break - 10:45 A.M. 3. The Role of Aging on Vinyl Chloride Monomer - Induced Cancer Dr. David Groth, NIOSH 11:00 A.M. 4. Carcinogenic Effects of Exposure to Vinyl Chloride Monomer and Ethyl Alcohol on Rats Dr. Martha Radike, University of Cincinnati 11:15 A.M. 5. Cancer Induction Following Single and Multiple Exposures to a Constant Amount of Vinyl Chloride Monomer Dr. Robert Hehir, CPSC SESSION II -- TOXICOLOGY STUDIES OF POLYVINYL CHLORIDE Chairperson: Dr. Peter Infante, OSHA 11:30 A.M. 6. Pneumoconiosis in Animals Exposed to Polyvinyl Chloride Dust Dr. David Groth, NIOSH 11:45 A.M. 7. Results of Carcinogenesis Bioassay of Polyvinyl Chloride * Dr. Chris Wagner, BMRC, Penarth, Wales Thursday, March 20, 1980 SESSION III-SPUTUM CYTOLOGY OF VINYL CHLORIDE WORKERS Chairperson: Dr. Peter Infante, OSHA 12:00 P.M. 8. Results of Sputum Cytology Among Vinyl Chloride Polymerization and Polyvinyl Chloride Fabrication Workers Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna \b 12:15 P.M. Discussion 12:30 P.M. LUNCH SESSION IV - MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE Chairperson: Dr. Philip Landrigan, NIOSH 2:00 P.M. 9. Multiple Site Risk Analysis of Vinyl Chloride Related Cancer in Workers - Review Dr. Peter Inf suite, OSHA 2:15 P.M. 10. Cohort Mortality Study of Vinyl Chloride Workers Dr. H. Weber, Der Staatliche Geverbearzt, Fed. Deutch Republic 3D c<n O) 2:30 P.M. 11. Epidemiological Study of Vinyl Chloride Workers Dr. Clark Cooper, Consultant 2:45 P.M. 12. Power Considerations in Epidemiologic Studies of Vinyl Chloride Workers Dr. Jay Beaumont, NIOSH 3:00 P.M. Discussion 3:15 P.M. Break SESSION V - LIVER AND BIOCHEMICAL CHANGES ASSOCIATED WITH VINYL CHLORIDE Chairperson: Dr. David Groth, NIOSH 3:45 P.M. 13. Epidemiologic Review of Hepatic Angiosarcoma in the United States Dr. Henry Falk, CDC --. fev --------- n F S T ? S ! C T T" -- Thursday, March 20, 1980 4:00 P.M. 14. United Kingdom Angiosarcoma Registry Dr. Peter Baxter, CDC 4:15 P.M. 15. Pathology of Vinyl Chloride Induced Liver Lesions Dr. Hans Popper, Mt. Sinai Medical School 4:30 .P.M. 16. Liver Screening Tests for Vinyl Chloride Exposed Workers Dr. Carlo Tambero, University of Louisville SESSION VI - INDUSTRIAL HYGIENE MEASUREMENTS OF POLYVINYL CHLORIDE OPERATIONS Chairperson: Mr. James Gideon, NIOSH 4:45 P.M. 17. Polyvinyl Chloride Processes and Products Dr. R. Nick Wheeler, Union Carbide 5:00 P.M. 18. Characterization of Polyvinyl Chloride Homopolymers, Copolymers and-Additives Mr. Jay Jones, NIOSH 5:15 P.M. Discussion c r> VI (ID :--------------------------------- T Friday, March 21, 1980 W L 15978 SESSION VII - MORBIDITY AND MORTALITY STUDIES OF POLYVINYL CHLORIDE EXPOSED WORKERS y^e:30 A.M. Chairperson: Dr. R. Greenberg, University of Louisville 19. Mortality Among Polyvinyl Chloride Fabricators Dr. Leonard Chiazze, Georgetown University 8:45 A.M. 20. Heart Disease in the Swedish Polyvinyl Chloride Fabricating Industry Dr. Gustavo Molina, Colombia 9:00 A.M. ^21. An Epidemiological Study of Respiratory Disease in United Kingdom Workers Exposed to Polyvinyl Chloride Dust Dr. Anthony Seaton, University of Edinberg 9:15 A.M. 22 Polyvinyl Chloride Dust Induced Pneumoconiosis Dr. A. Arnaud, Marseille, France 9:30 A.M. 23. An Epidemiologic Study of Pneumoconiosis in the Italian Polyvinyl Chloride Industry Dr. Guiseppe Mastrangelo, Padova, Italy 9:45 A.M. 24. A Case-Control Study of Lung Cancer Among Vinyl Chloride-Polyvinyl Chloride Workers - Dr. Richard Waxweiler, NIOSH 10:00 A.M. 25. Review of Pulmonary Effects of Polyvinyl Chloride Exposure Dr. Ruth Lilis, Mt. Sinai Medical School 10:15 A.M. Discussion 10:30 A.M. Break Friday, March 21, 1980 URL 15979 SESSION VIII - REPRODUCTIVE EFFECTS OF VINYL CHLORIDE Chairperson: Dr. Janes Wilson, University of Cincinnati 11:00 A.M. 26. Transplacental Teratogenic Effects of Vinyl Chloride in Experimental Animals Dr. Jackie John, DOW Midland 11:15 A.M. 27. Transplacental Carcinogenic Effects Dr. Jerry Rice, NCI 11:30 A.M. 28. Mutagenic Effects of Vinyl Chloride Dr. Jill Fabricant, University of Texas, Galveston 11:45' A.M. 29. Power Considerations in Studies- of Reproductive Effects Associated with Vinyl Chloride and Some Structural Analogues Ms. Maureen Hatch, Columbia University 12:00 P.M. Discussion 12:30 P.M. LUNCH SESSION IX - ENVIRONMENTAL EXPOSURE TO VINYL CHLORIDEPOLYVINYL CHLORIDE AND LIVER ANGIOSARCOMA Chairperson: Dr. Pier Bertazzi, Institute of Occupational Health, Milan 2:00 P.M. 30. Fugitive Emissions of Vinyl ChloridePolyvinyl Chloride Speaker to be Announced 2:15 P.M. 31. Case-Control Study of Liver Angiosarcoma Among Residents in New York Dr. Nicholas Vianna, N.Y.S. Department of Health Friday, March 21, 1980 URL 15980 SESSION X - CARCINOGENICITY OF SOME STRUCTURAL ANALOGUES OF VINYL CHLORIDE Chairperson: Dr. Kim Hooper, University of California, Berkeley 2:30 P.M. 32. Comparative Pathology of Vinyl Chloride and Vinyl Bromide Induced Liver Pathology in Animals Dr. William Busey, Experimental Pathology Laboratories 2:45 P.M. 33. Review of Experimental Carcinogenesis of Vinyl Chloride Related Compounds Dr. Ken Chu, NCI 3:00 P.M. 34. Review of Epidemiologic Study Results of Vinyl Chloride Related Compounds Ms. Rosanne Apfeldorf, OSHA 3:15 P.M. Discussion 3:30 P.M. Break SESSION XX -- RESEARCH NEEDS AND PUBLIC HEALTH INTERVENTION Chairperson: Dr. Anthony Robbins, NIOSH Panel Discussion: 4:00 P.M. 35. Dr. Dale Haddis, Center for Policy Alternatives, MIT 4:15 P.M. 36. Mr. Steve Wodka, OCAW 4:30 P.M. 37. Dr. Maurice Johnson, B.F. Goodrich 4:45 P.M. 38. Dr- Irving Selikoff, Mt. Sinai Medical School 5:00 P.M. 39. Dr. Joseph Wagoner, EDF 5:15 P.M. Discussion Proceedings from the Conference will be published. URL 15981 Program Planning Committee Dr. Richard B. Everson NIEHS, Research Triangle Park, North Carolina Dr. Peter F. Infante OSHA, Washington, D.C. Dr. Philip J. Landrigan NIOSH, Cincinnati, Ohio Dr. Raymond E. Shapiro NIEHS, Research Triangle Park, North Carolina Dr. Richard J. Waxweiler NIOSH, Cincinnati, Ohio \ \