Document 3Qr5eOeeKg9N1YODorzqarm00
Toxicological Summary PFOS
Dietary Acute Mallard Study
Test Substance: Perfluorooctanesulfonate (PFOS) Structure: p1o-tOacstsainucsmuslaflot,niCcASa#cid2,7915,-13,92323,3,4:4,5,5,6,61.7,888-heptadecafluoro-,
Remarks:
Tsthoeredtesutndseubrsatamnbcieenits caonwdhiittieonpsoawndderpu(ri3tMy wloats#o2r1i7g)i.nalTlyhedestaemrpmlienedwatso
bteech9ni0qu4es%.
by In
aLsOuMbSse,que'nHt-aHnMaRly,sis "oFf-tNhMe Rfesatnsdubcstlaenmceen,tpluraitnyalywsaess
cdeotnecremnitnreadtio(n ibnethi8s6s9u%m.maryThaerenboamsiendaoln athned8m6e.a9s%upruerditdyivcatlaurey. PFOS
"vTahleueisn-bliafseedphoansethreep9o0r.t4w0a%spuorriigyineasltliymactoimopn.letTehdeinre2po0r0t0,waasndrerveipsoerdteidn T2o0x0i4coltoogicraelfleScutmmtaherysruebfsleecqtusenttheserecvhiasinognes ians wsealmlpalse inpculriutdyi.ng resTuhlitss tfhieominalllfeofphatshee.associated reports of analyse of tissues collected during
METHODS
MAeStThoMd:StaOnPdParTdSE885507.-28270(019(D9r7a)f), FIFRA Subdivision E, Section 71-2, OECD 205 and
Type: Dietary Acute
Years 1999 in life test, 2000 for report, 2004 for amended report
Species: Mallard (nas playrhynchos)
Test Phases: AExcpocsluriempearitoidd-aoy5nsdays
Post-exposure respectively)
recovery
period
3o
17days
(Experimental
Day
or
22,
"Test Bird Age: 10 days old at est initiation
rNeuplmibcaetres
oinf
eRaecphlitceasttessu:bsTthaenrcee
twreeratemesnitx.
reTphleirceatewseroef ftihvee
control treatment, and two mallards per replicate (pen)
ftorreaatmteontatlo(wfh3i0chmianlcllaurddesd icnigthhtedcoosnetrgorloutprse)a.tment and 10 mallards in each test substance
1
20879
8",Thehaalnfitmhaelsrewpelirceataelsl cfxrpoomsccdacfhortrfeiavtemdeanyts,graonudpt(h3enofhetldhf6orraeprleiccaotveesryfrpoemriotdh.e ActontDraoyl cgornotuipnuaenddn1 threpslitcuadtyeufnriolmDeaaych2.dose level) were sacrificed while the other half were FteesetdingapnhdasWeasotefrt:heFsotouddy.anTdhewamtaelrlawredrsedipdronvoidreedceaidvelainbyitfumordmuroifnagntaicbicoltiimcattrieoantmaenndt uring either the acclimation or test phaseofte stud. mAanlallayrtdiclailverMoannidtsoerirnugm:byThreevetresste-spuhbassteanHcPeLcConacenndtmraatsisonspwecatsrodmeettreyr.mined in feed and pStoaptuilsattiicoanl fMoerthaodgsi:venLCeSx0pos(Luertehatlimceo)nceanntdratLiTonSth(aLtetrheaslultsimien t5h0at% rmeosrutltaslitiyn o5f0%a umsoirnaglitthyeoSftataistpiocpaullaAtniaolnysifosrSaysgtievmen(SdoAsSeI)STvAalTu:esPwReOrCe PcaRlOcBulIaTt)e.d bByopdryobwiteiagnhalydsaitsa w1e99r0e).coAmlplaortehderbsytatDiustminceatlte'vsaltueasttiounssinwgerTeOcXoSndTuAcTtedsowfittwharEexc(eDlunwnoertkts,he1e9t5s5;inGculluldeiyn,g regressions with concentrations of PFOS in tisues bAavseirsaagnedDdaiidlynoInttaakkee i(nAtDoIa)ccoofunPtFpOoStenftoiraleadcihffetrreenactemsenbtetgwreoeunp mwaalseeasntdimfaetmeadleosn. aFpoeond cexopnossuumrpetipoenriaonddanaddutlhtemAalDlIarwdabsocdaylcwueliatgehdtadsatfaolwleorwse (aEvqeuraatgieodno1v);er the durationofthe ADI W(nghay) A) -ATAvZeRraegeAFgeedTeCotEnsuwSmepiigoChng(GOidOidARaNy)M) POGorNem(omm, p08) (eEoguaion) mTeesatnsDioetfaPHroebpaarrtatmiioxne:r.TNheo tceasrtriseurbwsatasncuseedw.asNommiixneadlddiiretcatrlyy cionntcoetnhtezatfeieodnsraotfiPonFObyS puesredmiilnlihoins(psptmu)d.y were 0 (control), 8.7, 17.6, 35.1, 703, 141, 281, 562, and 1125 parts RESULTS oMfeaPsFuOrSedinDitehte Ctoesntcedniett.ratiTohnes:meWialndipfeerceInnttermeactoivoenrayl Loif.thdeetmeartmrixncesdpickoendcenfteerdatiwoanss 9f4r.o7m%9,2wthoil1e1t9h%e otefstthfeeendomsianmapllevsaluhea.d mMeeaassuurreedd cmoencaenntcroantcieonntsraotifonPsFOofSPtFhaOtSrawnergee:d <LOQ, 941,18.7,38.6, 71.5,167,279,516, and 1148 ppm. MweoarttmleinttegsroaunpdisCgliinviecna(lTaObblseer1)v,ations: A summary of the percent mortality for cach
2
GCO580
PTaRbOlSe v1i.aChuemudliar.tive percent tesment elated moralityof juvenile mallard exposed 0
Nomwl
pm
Ce" Mgmnt sn
Exposureperiod |RecoveryPeriod
Co8nvol
<LOmGT 9s
gLh0i00a) 0 T7340 50060 07050 0 271 0 0 0 0 0|o 0 0 0
3w1e 31867 s12m0 00 00 00 00 oo|o0 00 00 00
WW5 oems B
wese 2
00 0
00 0
00 0
00 0
ooloo 00 00 0|0 dl 2
00
52 lsiae Average Fa ke ADT:
2499 00 00 00 200 e10l|m2 33 03 x10 ROSE Sy gh) ced wi 58 wos Ted
CLmim oeenotassmieneeesFon(rLs0DiGa)ys 05sPeRaOmSein ehedliswhoe te1n5dpend.recovery perio fom Day8 0 Day 2
waInneyrtehovneocrrotmnsatiloglnisngorafoptupopex,aircnaiontcymeotrahtrnaodluitgbiehehosauvtoisotcrh.uerseTldheyarteaatwnceyornepchennaotsrefaetoiafomntehsneets-struodhytaenadnodrmaoclruatmlaalltlosartdohsre
d1o4s1esppofm2n8o1m,i5n6a2l. dos1e1.25HopwemvePrE,OmSorianltihteydwita.s noted for mallards rete wih nominat
aInndthceo2n8t1inpuepdmutnrteilattmheenta,fseignnosoonf otofxiDcaityy 5w.ereThobeseersviegdnsprinicolordeddeartuhfsfteadrtpinegaartaDnacye,& 2Mreo0dr%uaclweiadtsyrooebafscemtraivolenlda.rtodsFsootcilmcluoulwriiend(gsooDnuanDyda5ya,sntdh7 mnordteimo5ani)na,inndlgebtmyhaalrDglaya,yrd8an4idnctluhoemwe2ur8t1vlipempbmmowrreaaalktinmteeysnso.tf ad retumed 1. normal appearance and behavior for the duration ofto ty.
DcInoanytthienu5e6fdo2runpttoihlmostewecrmabitinrmadetsnitosnagcfrrooirufpih,coesdsigonbnsirodDfsaosyaxcri2i2i.fitceSwdiegornnes Dnoaafyltl8oyawneodtbysuerncvleuhddeoenfdeDraayomo3nadnodf mapopreaarlainecse,wererduncoetdedroeanctDiaonysto, s6t3i0mdu,7foIeth3artgoya,] caunmdullaotwievre mloirmtbalwietyakonfe2ss0% bSyinaglye b7.ehRaevmioarinfionmg mDaalyla9rdosfatphpeesatrueddy.o have recovered and were normal in appearance and
ciInnocntlrhuiednead1t1ir2ou5nf,fppeordmosattpapeteseamrpeaonnsctteu,rgerr,oeuddpeu,pctesedisgirnoeanoc,tfictooonnxvitucolistsiyiownmsue,le,anfldrestlthoaorwbgeys,emrdveeypdrewosensaikoDnnae.sysl.2o,saBnoydf amDpoapryeaal7ri,atnyacecwuaamsnudloabbtesiehvraevveimdo.orrwalTsihtenyooorfnmea9l0m%tahrlwoualgshotoubhtstetrhvseeudrr.veimvaeFidonld1leorwDoiafnygthDe8aryrece7ov,veenrroepa.edriadondodn1ss
3
n0681
Both LC50s and (Table 2). The
LTS0s dietary
were Say
determined by probit LCSO for PFOS was
analysis 603 ppm
using with
the mortality data a 95% confidence
Binotderyvawleiogfh4t3a1ndtofo9o3d8cpopnms.umpTthieonsdlaotpae woefrtehethceonncuesneidrattoieosnt-irmeastpeonasveercaugrevedawialysd3o.s6e55o.f
PonFOaSvearnadgeprdoabiiltyanianltyaskees(wAaDsI)conwdauscte1d50wimthgtPheFOmSor/tkaglitbyoddayta.weTihgeht8d-adyaywLitDhS0a b9a5se%d
croensfpiodnesencecuirnvteerwvaalso5f.417197.
10 201 The
lmeagstPLFTOSS0/,kgesbtoidmyatewdeifgrhotmdatyh.e
The slope 1125 ppm
of the dose. dose group
`dmaotrat,alwitaysw4a.s97obsdaeyrsv.ed aTthdis ar4esauynltd a9g0r%eedmowrittahlitcyumwualsatoibvseervmoerdtaatlidtayyd7a.ta where 20%
o`Tfajbulveen2i.leEsmtailmlaatredssoifn laetdhiaeltacroynaccenuttreattoixoinci(tLyCsst0u)dyanwdithletPhFaOlSt.imAe (LTso) ofa population
Effect metric LCS0
Day LCS0 (ppm) __95% CT
5
1002
743-2039
Siope__ 5244
6 3
799 603
595-1126 431.938
5832 3.655
-- 130
NominalDose _LT30 (ays) 95% Cl
281 ppm
923
NA
Slope 12.39
562 ppm 1125 ppm
9.18 497
738-555 432.555
5433 8403
NAATinSdiaciatseis enomeaapsluiraebslcetiNmaotceodnfbiydePnrcoebinaterivasl wa(sScKaSlc/uSlaTtAedTPROC PROBIT)
oBbosdeyrveWdeigthhtr:ougThroeuattmetnet.rsetluadtyed(Tcafbfelcets3)o. n
body weight Statistically
and body significant
weight gain were treatment-related
orfedcuocnttiroonls) ionrbgroedaytewreciognhctenwterraetioobnssesrtvaerdtining abtirDdasyex5paonsdedcotnotPinFuOiSngaotn28t1hromuggkhgDa(y4215,%
On Day treatment
2l2e,veblso.dyWhwielieghtthewraeswaaslsao
sstiagtniisftiiccaalnltylysirgenidfuicceadnt
irnedtuhceti1o4n6inppbomdyanwdeihgihgtheirn
`tmraelaltamrednstfrreolamtetdh.e T8h.i7spcpomncltruesaitomnewntasfobraDseadyson5 tahnedf8a,cttthheastetehfefemcatsllwaerdrse innotthceon8s.i7dperpemd
doobsseergvreodupatwtehiigshdeodsleesmsatyhanhatvhee cboenetnroldsuean1d0otthhiesr itnrietaiatlmednitffgerroeunpcse aannddtnhoetditfofePreFnOcSes
`exposure. from the
In addition, there were 17.6, 35.1 and 70.3 ppm
ngoroduopsse-trhealtatweodurleddubceticoonnssiisntebnotdwyitwheiaghdtosien-rmeaslploanrsdes.
relationship.
4
0n0582
`cToanbcleent3r.atAivoenrsoagfePbFoOdSy.weight () ofjuvenile mallards exposed to various ditary
T(rpepamt)ment
BodDyayW0e*ight
BoDday yWesight
Body Weight Day
Body Weight Day 15
Body Weight Day 22
Con8t7rol 11395521244 226709244336 341170043606 6S1450:23526 877233423489
176 351
M6214 47216
277226 275+32
377432 375237
5:42 60:44
81148l 28473
03 141
143230 M319
26055 242637
34390 331448
579297 564556
7824135 6StL86
281 562
129617 144223
1610228 1370527
2200455 175434
467xSl 3040%82
70124] 613049]
Bo0d2ysweights re1po4r7te2d2s5 cansan1d1s2t0an2da2r8d deviions1o85s%wner weg B3a7.3
634
S= iStnatcisetnica1,lldyadtifafrceonutldrmoomtbceonetvraollugartoeudpssttatpistica<l0.l05y(wDituhnDnunentettte'stL)4es.
`tThrateaotbmseentr-vreedlaftoerdmeofrfteacltistyo.n BbyodDyawyeig(htthegaeinndowfertehenoetxepdosautrleespshearsceo)ntcreenattrmaetnitonrseltahtaend
eofrfegcrtesatoenr tthheanchtahneg7e0i.n3 bpopdmy dwoesieg.ht TfhriosmtDraenyd0cowneirneuneodteidntion tthreeaotbmseenrtvagtrioounpspeerqiuoadlifno
tghaaitnb(yp D<a0y.085,)thinermeawllaasrdassftartoimstitchaelly70s.i3gn(if1i2c%an)t,di1f4f1eren1c7e%)in, t2h8e1ra(t6e0o%f)boadnydwSe6i2gh(t-
8we7i%g)htprpemmatirneeadtmseingtnigfricoaunptslywrheednucceodmaptatrreedattmoenctonctornoclenmtarlaltaridosn.s grHeoawteervetrha,nowhrielqeuablodtyo
e7x0.p3ospuprem,perrieocdo.verByyinsttuedrymsteormfinwaetiigohnt
gain (Day
was 22),
athpepraerewnetrein
nmoalsliagnridfsictahnatt
osrurtvrievaetdmetnhte.
related 22) for
eafnfyeoctfsthnoetterdeoatnmetnhte
total change groups
of
body
weight
(Day
8-15,
Day
15-22
or
Day
-
TtroeaetxmaemnitngetrohuepiwmepraectcoaflcPulFaOtSed ofnorgrvaorwitohusoftijumveensiplaensmawliltahridns,tthheesgtruodwyt(h0-ra8tedsayfso,r e8a-c2h2
dianycsl,udaenddd0u-e22todagyrse)at(eTrabthlaen4)2.5%(DactuamuflraotmivtehemoSr6t2alaitnyd
1125 prior
ptopmdatyre8a).tmenGtrsowwtehrernatoet
(1/day) was estimated then fitted to the body
with a weight
dgaetnaercaolllgercotwedthdumroidngelth(eEqstuuadtyi.on
2)
that
was
linearized
and
W, = Wop
(Equation 2)
Where: `WWyoiisstthheebbooddyywweeiigghhtt((8g))oofafa mmaallllaarrddaattthiemoen(s1e)otofftthheessttuuddyy (1-0)
gis the overall growth rate (day)
Cit time (days)
`The data.
regression There was
saulmtasrkoefdthreedgurcotwitonh
irnattehdeagtaroawrteh
inraategrfeoermethnet
2w8i1thptphme
btroedaytmweenitgh3t5
compared to the control group Day 0-8. The overall growth rate for mallards in the 17.6,
5
%9583
c35o.n1t,ol70g3ro,upa.nd 141 ppm treatments did not differ from the growth at of mallards in the
`Table 4. Growth rates (1/day) for juvenile mallards exposed to PFOS via the diet for 5
days
Days
and
observed
0
for
17 days
87
posvt-eeTxrpeoastumreen.ts*gsrioup
(pm0P3FOS)
wom
TO80F2 0001559 0001634 000150 000158% 0001%0 0010025 000088
R0E022 008 0085 e0r0% _ 0077 00% er 00m 00s
ctFhoeenesd2u8m1Cpotpniposnmumdpturtreiianotgnme:tnhteWe(hxTepanoblseucro5e)m.ppearrFiueorddtihnetrothmocrotenr,teraottlhsme,enrttehdgeurrcoetuipowsnaesiqnuaafleer(d0edacunocdntisgournmepattienirontfheaaetnd
ntfohetecsdpeeccroomnnascnueemnnptttriaatonindonatshtacstotnrhteeitnmuuameledldatrotdosbceionnotthbrsoelrrelvemevadeilntsihnirgnodutigrcheaatDitnmageyntt1h5ga.rtohuHposewhfeafvdeetrr,eocfobvPyerFDedaO.y w2a2t,
`Table . Average feed consumption (FC) ofjuvenile mallards exposed fo various
dieTtraperaymtcm)oennctentrationsof0-P5TdFCaOySs*
68TdCays
822TCdays
Con87trol
00331315
00332592
00225758
315716
00334226
00333429
0022715
71013
002493%2
0208417
281
0264
0279
00226308 0211
151622s
00226054
00134114
00226610
RE
ssGuurbrojvseiscvtienNdgec1mraolaplasgryrd:osssoAflnlehcamrlaoflpstlhya.rdpseFntoshraattmaddlialeyadrd8,sduarfniodnuganldthdreeeamcdaoiudnruisrneigngomfatlhtlehaersdtssutduya,dtyDt,haaylnl2ec5orfowpetshrye.e aafienndadmienegmnspttiyrnecllagutaedsdet.droitNnhetiencsrtcoionpnadsliytitroersanuc,lttslsos(fsToarobfmlemsuts6)cm.laellTmaharedsss,etahlafttiensrdueirdnvgisvpewdeernteo cDoclaooynrs,ideaemnrpdetdyDatcoyro2bp2se were unremarkable as compared to contol reals
6 60584
`dTiacbtlare6y.PFNOuSmbexeproosfugrerodsursinpgatthhoelosgtiucdaylpearnioodm.alies in mallards that died in response fo
2N8o1minal Treatmen5t62Dose (ppm)125
Finding Crop, empty
2)
~-y oi)
0
7
7
GELm.actiraatctedempty
11
11
41
GGiizzzzaarrdd,ceomntpetnyts bile stained
00
20
41
IKneteels,tipnraolmcionnetnetnts black and tarlike
00
00
21
Kidneys, pale Loss of muscle mass
0 2
0
1
2
5
SSpplleeeenn,, sgmraalyl and pale
0 1
0 1
1 2
ThSpilenen, pale
01
2i
43
M0 oNottRRee0 mmaadrkaabb0 llee 0000000000
CfoorncmeanltlraardtsiotnhsatofdiPeFd OdSuriinngTitshseuesst:udLyivaenrdcofnorcetnhtorsaetiosancrdiaftiaceadreatprsetsuednytetdersmeipnaartaitoenl.y
cSoelrleucmteddatfarowmemraellaalrsdos ctohlaltecdtieedd dfurroimngmtahlelafridsst astevsetnuddyaytseromfintahteiosnt.udyLwievreer asnaamlpylzeesd
tfhoer FstOudSy,comnatlelnatr,danmodrtahleitdyatawaasreapsrseosceinatteedd iwnitThablPeFO7.S Dcuornicenngtrtahteifornsst sinevleinvedrsaytshaotf
e7xicnetehdeed1112155 gp/pgm., ST6h2ispcpomncaenntdr2a8ti1onppwamstarteaatimneendtsi,nrtehspelcitveirveblyy.DaSyin3c,eDmaayll5aradnsdwDearye
not sampled conducted to
ienvaalusaytsetetmhaetiucptmaaknenaenrd,
elpimhianramtaicoonkikinneettiiccsoanfalPysFiOsSofinthtehedsaetamaclolualrddsn.ot
be
tr`eTaatblmeen7t..rAevlaetreadgemorctoanlcietnytrdautriionngs
of the
aPcuOteSdi(eutga/rgy)stiundy.the*
liver
of
select
mallards
with
Day TmNominalsPFOp S Dose (ppm) ms
75
NNoo mmoorrttaalliittyy
N2o16mo(rNta-l1i)ty
T16I0O ((NN~=42))
6 7
No mortality 148(N-1
118907 ((NN-=1)
112768 ((NN==21))
lallAylmzlaellldiav,rerdnsFofFtrOhoSemmcamodbnoceserentothfaabttioidnesdrtehoptnorheteerdssipnseuucnbiifstitsedofudagys.ga,Nulwmebitewrei1ghptareTnhtheesdeastaisrtheepmurmbeaensrvoeefrsnaamtplfeosr
7
620685
(tShTaaamtbplPleeRsOSofwlaivserreatnadinsederiunmtchoelleexcptoesdefdrmoamllsaurrvdisvifnoglomwaillnagrdtsheonfivDeaydasyeaxnpdos2u2reinpdeirciaotde
`Table 8. Measured concentrations of PFOS in the liver and serum collected from
mallTarrdesamonenDtays 8 andT2i2voefrthe sDtauydy" Serum
Tiver Diy 22 Serum
Con8t7rol
460750150
<Li0mQ) <L0Q 7384196 | 1032032
<L0iQm.) 149070
E17n6 03
61655355237980 275148
31035822967856|| 32306452103452 4812819 | 9212127
648322+5109592 1132749
218411 62
B$561+40691 595235
6S5I894L612898 || 91220742342815 1074465 | 202781
1183942759s4 340:i54
SaAmTpSloencsewnieraetosnstehpaanrtiheedlinmieoafqnsaannidoSanrd.aLrdOQde-via0t.i0o0n5s EonmTneruwemi,gLhOBGa= 0.0 ug (iver
DtThhaeeybal2vo2e.ordaTgsheeerrruaetmiwotoeorftehcanotoncinesintgthnreiaftliiicvoaennrtso(dfSiPfLf)FerOfeoSnrceafslolrimnaaltllhldeaorSsdesLgwrraaostuipo1s.b7e(3ctoownneterDnolamynaol8teaiannncdldu1df.ee6dm4)aolinen
tbmhaeeltlwaeernedtsni,rtertehdaeortsemefeonrtreadnotghseee,searnardtahtseicrosrutwhmeeranerdelnalotitvieorrnescphooinrpctseednwtersraepteairoalntosegolayfr.itPhFmTiOhcSe. w|oevrTeehreanlotrrellliaantteioaornnssohhviieppsr
Dbeatywe8eanrePgFiOveSn:treatment dose and liver and serum PFOS concentations measured on
Liver PFOS (ug/g) = 14.49Ln(Dose, mg) - 32.51
R=0.7967
Serum PFOS (ug/ml) = 21.39*Ln(Dose, mg/kg) - 45.49
R= 0.7461
ocAonsncDewaniyttrh2a2ttihwoeensrSeIoL nnoDtraaatyniao8sl.,yzTtehhdeerserienlcwaeetrigeornoswnhtoihpsbaenexdtwdseepeepncuirPfaiFtciOoSdnifdmfoaesryeenahcnaedvsetiisnsisgunseiefcrioucnamcnetanlytnrdaalteliirovenedsr
stihteuarteiloantsionships, and the information gained would not be applicable to environmental
ATPhosissstumedixepncogrseutarhseee,biPwoFalsOogSimccoalosntmceelncithkraealntyiiosdnmusefionrtoleilvitemwriondaetfciarocetnaosrwsea,dstgthrhroeowustghahmodueitlauttthileoonwreearcnobvdeordeyyxcprbeeurtiriododen..n
flervoemls,liavesrimdpulee tooncd-ecpuormaptairotnmefnrtommotdheelmwalalsaredmsp(lEoqyueatdiotno evaluates th rae of loss ofPFOS from liver:
e3s).timaTtheethfeolllooswsinogf
PmoFdOeSl
8
C0686
C=C rep Where: CCoyisistthheeccoonncceennttrraattiioonnaatttthiemeon(s1e)todufrienlgimeilniamtiinoanti(oung/pgh)ase
tKiisstithmeeo(vdearysa)l elimination rate constant (day")
(Equation 3)
scTothnuecdeyonvt(erDraaatlyilsone8l-ii2nm2)i.lniavteiHroonpwlerovattetered,coainstsitasaniftmupn(ocKrt')itoawnnatosftoetsritemiemmeadtmuebrdeirnbgythtdahetetteehrlemiimenisintnaitgmiaottnheedpshclaloispmeeionofafttithohene tdroaitleutthcieoonneslatianmnditneatxtacikreoetnsioionnf.to PaIFcncOaoSudnitfornloo,msstemhsaelsfleraortmdwsotwbpoarsocceoednscsouenrsreamngatey,prdsoiecfxfeesrsaenisnd, isomespasosrodtnua.encteoForgerrloattwhitivshe sanuaclhystihsa,t tithewaosvearaslsluemleidmitnhaattiobnotohrplrooscsecsosuelsdabcteerdeipnreasnenitneddeapsenfdoelnltowbsu:t additive manner
Kektg
rinectohrisdeedqudautriionng, thies stthuedgy,rowwhtihlerake'thwaatswaesstiemsattimeadteads ftrhoemovbeordayllweriatgehtofmedaescurreeamseentins `w`gmaresoawsteuhsrteridamtaletisveederst(PkiuFm).OatSedcBoafnscreeondmtrobanotidotynhsew.emieOgahnstcusermeked'aascnoundrcegednwtbreeartteiwocenaeslncuoDlfaatyPesFd,O8Stthoeien2l2i,tmheienlailtmiviienorantarianotdne (aTtaeblceon9s)t.anBtsasweedreonestthiemsaeteredsuflotrs,thtehe8.a7v,er1a7g.6e,e3l5i.m1i,na7t0i.o3n, r1a4t1e oafndPF28O1Sp(pbamsetdreoantmleinvtesr acopnpcreonxtirmaattieolnys)17.w5asdays0..0397 day! with a halflife in the liver estimated to be
`Table 9. excretion
rGartoewctohnstraatnetss,
floirvePrFaOnSd
isnerjuuvmeneilliemimanlaltairodns.co*nstants,
and
overall
liver
Treatment GWhoowlheRBoadey ETiK ver
Serum Ka
(m`gCoPnFtOrSo/lkg)
day! 0.0586
day'! (aay
NA
NA
ou NA
87 176
0.0636 00547
0001801717 000024614 o00n77i6
351 703
00565 00590
oli 00767
00546 00177
0.1065 on?
141 281
00523 0.0828
00.01842811 000069583 000.7s6t5
NAunyAtsT5aGp1cl0oi2nct2aeb)nets ase on dis derived Tom messaement ade daring th ecovey pod
9
GrOG687
DoCobansyceer2nv,terdatthfeiooranvsleirvoeafrgePPRcFlOOiSmSinciaontnicotennhterraabtelioocnoosdn.stsaenFrtourm(ktsdh)eecfprooersatPseFedOxpSionsfuraroemsipsmeeirlriauordm,mwDaaansyn0e.8r10ta1hsrdotuahgayth oswfaitmPheFaeOnxSpeesirtniimmteahnteteadslehrapluefrm:iolwdiaf,esosfea6rp.up8mro6cxoidnamcyaestn.etlryWathifeoonnls dcdoemlceprsaesartsehedadntaotthalievgeerrsetcaiotmenarcterenadttreh.aatliTfohniesfheoavliefnr tithfhese bfliorvdoermy. lbiTuvhreedrseaennrdaefsoeutlrhteserxipntiodsisscuuaretesesatrhhaeatvswelhoicweleaersePadF.ndOSIanrieasdmrdaoiptriiedolnly,ickitlliyimsitanoastcseoudnmtefirdboumttheastetrotuhame,Sbitighonelioflgioicscasanelts co`rlmiemmciohnraaentoiisofnmtchfaoernciblnetiimeaixlntarbtaoipodonlyaitbseudtrhdteoesnoawrmeeemraatibnoledodyweabrtubrddoaedyny2lb2e,uverlidts.eins lienvdeelt.ermSiinnacteetiypitchaellryte20o%f
LTCohDneSc0lduibscatiasorenyds:BodnaAyDLICwSaOsf1or50PmFOgSPFwOaSsI6k0g3bopdpymw(eCi1gh=t'4d3a1y-(9C3I8=1p1p7m-)20w1himlge tPhFeOS8./dkagy wPbeoFidOgySh/twkegaitgbhotDidadyyayw)e8.i,ghtt`hT/ehdeaNyno)obOambsoseretdarolvinatby$ledcaoynAcsdevoneftrresaxetpiooEsnfufrweeca.ts BCoa13ns1ceednptoprnmatthiPeoFnrOe(SduNc(OtoiAroEn6oC1f).3bwomadgs.y bOdebotsdeeyrrmvwiaenbielgdehtAtdodavybee)r.s3e5.E1ffTpehcpetmCdo(naocryen12t.N0roatmiOobgnseP(rLvFaOObAlSEeCgA)dbwvoaedrsys7e0w.eE3ifgfphetpcitmdaL(yeo)rve2wl0h.i(4leNmOgtAheEPLFLO)oSwIaenskdtg bwLaeosrweeedst1o5.n4Obsseaernrudvma2bc9lo.en7cAeudngtv/regartsPieoFnEOsfSfw,eecrrteesLp3ee0vc.et5livae(nlLyd.O4A8E.T1Lh)egv/$amdlluaeysPFNbOaOSsA,edEroLesnpaelcnitvdievrLelcOyo.AncEeHnLotwrvaeatvlieuoren,ss `DtchaoeynsNe8r,OvaAtthEirveLee deasantydismaLptoOesstA-oEefxLtphovrsaeulsruheeosladnbdvaasldeuodeess.onnTothcihtsaekires bilenitcvoearuascaecnotduhnestseeprodutametnatciwoanelcreeenltciromalitlnieaoctntiseodnaoronef `PgFeoOmSetrbiectmweeeann doafyNsOSAEanLda8n. d LTOhAeENLO)AaErLe,suLmmOaArEiLz,eda(nTdabtlhere1s0)h.old doses (TD) (the
fTraobmlea m10a.llNarOdAaEcLu,te LfeOeAdiEngLsatunddy.th*reshold doses (TD) of PFOS derived
Endpoint Dietary (ppm)
ENOAE EL TOE RFLY E 15
SAveerruamg(egD/aiml)y Dose (mgkgday) 310250
Liver (ug)
154
124 318536 297 214
*NAFOTFAOEvSLalcioasnncbdeaLnsOaciAooEnLs5vmaedlauseiusrofeodnr ArDoofIomdaDnaydyiwcetaigmahprtleebsa.eseed odn dairadrsy.conTcevnetrraotidones rr
Serum and ve fst vila ar mesure vies
DATA QUALITY: Reliability: Kiimish Ranking =1
10
:
C0688
References:
tDruenantemtetn,tsCw.W.iaco1t9n5t5rh.ol.AJ. Ammueltri.plSetatciso.mpAsasroics.on5'0s:1p0r9o6c-e1d1u2r1e for comparing several
LGaClSla0ghSetru,dSy.Pw.i,tChastehye, MCa.Sl.l,ardB.eavAemres,nd1.eB.d,
RaenpdorVta,nWHioldvleinf,e RI.nLt.em2a0t0i4o.naPlFOSLi:d.A,
Dietary Project
NO.: 454-102.
Gulley, D.D. 1990. TOXSTAT Release 3.2. The University of Wyoming.
Hansen, K. 2001. (Sera and Liver).
ARneavliystiiocnal1.Re3poMrtEnovfiDraotnamefnotraPlFLOaSboDraiteotrayr.y
LCS0 Study Report No.:
with Mallards FACT-TOX-
130.
SAS Institute. NC. USA.
1999. SASISTAT User's Guide, Release 8.02 Edition, SAS Institute, Cary
WPuabglniecrat,ioJnsG.Inc.1,97H9a.milFtuonnd,amTle.nt4a6l1sp.of Clinical Pharmacokinetics.
OTHER: Last Changed: 5/05/04
Drug Intelligence
1 C0689