Document 3QR2vpxzBV34On43XwDDqQNE

TO: Distribution FROM: DATE: Interoffice Communication SUBJ: T. G. Grumbles March 21, 1988 ANALYTICAL WORK FOR REGULATORY REQUIREMENTS Based on a review of the list Jim Yates prepared, it is clear that benzene and the PNA's are the chemicals with the potential to appear most often in our products. Therefore, initial efforts should be prioritized towards the analytical work for those two chemicals. From a Proposition 65 standpoint warnings are required now for benzene and will be required beginning in July for the PNA's. If analytical method development is required for the PNA analysis, this should be high priority. Second in priority, based on regulatory deadlines and product volume in commerce, would be EtO and dioxane. We already know a lot about these levels and additional work may only include data gathering, reviewing sampling frequency, and determining if current sampling frequency allows us to generate representative data. Third in priority would be the various chlorinated compounds on the Prop 65 list. These are BCME, CCL4, chloroform, epichlorohydrin, PCB's and vinyl chloride. These chemicals have the potential to be present in less volume for commercial purposes, but the warnings will be required in October of this year, except for BCME which is required now. The remaining analytical needs are for DEHP, nickel catalyst fines, lead acetate and arsenic. Arsenic warnings are required now. Attached is a suggested "project" organization based on the priorities described. Also, I've listed several general issues that should be considered. It should be noted that some PCB analysis and benzene in LAB work has been done in response to other regulations in the last two years. In several cases, collection of existing data will be our first step. Please review the enclosed then we'll schedule a conference call to discuss details of the project. \ cr*------------T. G. Grumbles aio .310 Enclosure DISTRIBUTION: Jim Yates Ron Poe Charlie Starks GENERAL. ISSUES How do we represent the data? Ranges, accuracy statements, not to exceed ... How do we collect samples and/or how many analysis do we do to assure representative data? How do we validate non-referenced methods? (This may or may not be an issue.) Pro/cons of doing the work or all of the work at an "outside" contract laboratory. Analytical method applicability to different products (i.e., is benzene in LAB method same as benzene in HCL?) Significant data currently exists for dioxane, EtO, and VCM residUal levies. Some data exists for benzene and PCB's. 7 VVV 000014819 PROPOSITION 65 CHEMTCAT-S (EFFECTIVE DATE> AND PRODUCTS TO BE ANALYZED - PRIORITY GROUPINGS BENZENE (3/1/88) LAB Hydrotropes Specialty Alkylates AICI3 Liquor Muriatic Acid Sulfonic Acids Na Salt Slurries N-Paraffins Solvents (LPA, MR) HAD LAC Plasticizers PNA's (7/1/88) LAB Hydrotropes Specialty Alkylates AICI3 Liquor Sulfonic Acids Na Salt Slurries N-Paraffins Solvents (LPA, MR) HAD LAC ALFOLS (mp greater than 70F) Plasticizers ETHYLENE OXIDE (7/1/88) Ether Sulfates ALFONICS 1.4 DIOXANE (1/1/89) Ether Sulfates ALFONICS Epichlorohvdrin BCME CCL/, Chloroform PCB's VCM (10/1/87) (3/1/88) (10/1/88) (10/1/88) (1/1/89) (3/1/88) EDC VCM MECL VCM EDC MECL VCM EDC MECL VCM EDC EDC VCM PVC LAB's MECL EDC PVC LEAD AfllHATE(1/1/89) Hydrotopes AICI3 Liquor HCL Sulfonic Acids Ether Sulfates Na Salt Slurries MECL Alumina PVC ARSENIC (3/1/88) Hydrotopes AICI3 HCL Sulfonic Acids Ether Sulfates Na Salt Slurries Ether Sulfates 1 1 \ V' t <\ P\/c- pw*. Iu(i .I~ n t- L tvcv'v NICKEL CATALYST FINES (10/1/88) ALFOLS ALFONICS Solvents vVV 00001*820 C o lle ct data: Correspond w ith p la n ts In /o u t d e c is io n : d e c is io n on whether to use o u tsid e c o n tra c t la b o ra to ry The end p ro d u c t w ould be a fo rm o r s ta n d a rd response le t t e r ftW M H s C3 r*i > i-i rtt> o a: V) 09 7? ns (p o. (0 3 l-> R* > n O (t> ns m n co OTJ 3* O B H' h T; - o c- m -w 3* n 1-- O ^ c no hoi na n rr \ H- o X "3 in W 3 N ft- 3 o> rt OO L*-1 to rr 09 09 rr I--1 (t> * 3* ^ -3 --P* a s <0 i-t (0 r* rt 3 n 3 .. I VVV 000014821 t SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 (PROPOSITION 65) CHEMICALS KNOWN TO CAUSE CANCER OR REPRODUCTIVE TOXICITY January 1, 1988 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. Comments should be directed to the State's lead agency for implementation of the Safe Drinking Water and Toxic Enforcement Act: State of California Health and Welfare Agency 1600 Ninth Street, Room 450 Sacramento, CA 95814 Note: (1) The identification number is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. (2) The date refers to the initial appearance of the chemical on the list. CARCINOGENS Chemical 2-Acetylaminofluorene Acrylonitrile Adriamycin AF-2;[2-(2 -furyl)-3-(5-nitro-2-furyl)]acrylamide Aflatoxins ortho-Aminoazotoluene 4-Aminodiphenyl * 2 Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole Amitrole ortho-Anisidine and ortho-Anisidine hydrochloride Analgesic mixtures containing phenacetin Aramite Arsenic (inorganic arsenic compounds) Asbestos Auramine Azaserine Azathioprine Benz[a]anthracene Benzene Benzidine [and its salts] Benzo[b]fluoranthene Benzo[j]fluoranthene Benzo[k]fluoranthene Benzo[a]pyrene Benzotrichloride CAS Number Date 53963 107131 23214928 3688537 -- 97563 92671 712685 61825 90040 -- 140578 -- 1332214 492808 115026 446866 July 1, 1987 July I, 1987 July 1, 1987 July 1, 1987 January 1, 1988 July 1, 1987 February 27, 1987 July 1, 1987 July 1, 1987 July 1, 1987 February 27, 1987 July 1, 1987 February 27, 1987 February 27, 1987 July 1, 1987 July 1, 1987 February 27, 1987 56553 71432 92875 205992 205823 207089 50328 98077 July 1, 1987 February 27, February 27, July 1, 1987 July 1, 1987 July 1, 1987 July 1, 1987 July 1, 1987 1987 1987 VVV 000014822 2- - Benzyl violet 4B Beryllium and beryllium compounds N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) Bischloroethyl nitrosourea (BCNU) Bis(chloromethy1)ether 1,4-Butanediol dimethanesufonate (Myleran) beta-Butyrolactone 1694093 -- 494031 154938 542881 55981 3068880 Cadmium and cadmium compounds Carbon tetrachloride Certain combined chemotherapy for lymphomas Chlorambucil Chlordecone (Kepone) 1-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea Chloroform Chloromethyl methyl ether (technical grade) 4-Chloro-ortho-phenylenediamine Chromium (hexavalent compounds) Coke oven emissions Conjugated estrogens para-Cresidine Cupferron Cycasin Cyclophosphamide (CCNU) * ___ 56235 -- 305033 143500 13010474 67663 107302 95830 -- -- -- 120718 135206 14901087 50180 Dacarbazine Daunomycin DDT (1,1,l-Trichloro-2,2-bis(p-chlorophenyl)ethane) Degraded Carrageenan (not food grade carrageenan) 2,4-Diaminoanisole sulfate 4,4'-Diaminodiphenyl ether 2,4'Diaminotoluene Dibenz[a,h]acridine Dibenz(a,j}acridine Dibenz(a,h Janthracene 7H-Dibenzo[c,g]carbazole Dibenzo[a,e}pyrene Dibenzo[a,h]pyrene Dibenzo(a,i]pyrene Dibenzo[a,1]pyrene 1,2-Dibromo-3-chloropropane (DBCP) 3-3'-Dichlorobenzidine 3,3'-Dichloro-4,4'-diaminodiphenyl ether Diepoxybutane --^Di(2-ethylhexyl)phthalate 1,2-Diethylhydrazine Diethyl sulfate Diethylstilbestrol # Dihydrosafrole 3-3'-Diraethoxybenzidine (ortho-Dianiasidine) 4-Dimethylaminoazobenzene trans- 2 -[(Dimethylamino)methylimino]-5 -[2-5-nitro-2- furyl)vinyl]-1,3,4-oxadiazole 3,3'Dimethylbenzidine (ortho-Tolidine) 4342034 20830813 50293 -- 39156417 101814 95807 226368 224420 53703 194592 192654 189640 189559 191300 96128 91941 28434868 1464535 117817 1615801 64675 56531 94586 119904 60117 55738540 119937 July 1, 1987 October 1, 1987 February 27, 1987 July 1, 1987 February 27, 1987 February 27, 1987 July 1, 1987 October 1, 1987 October 1, 1987 February 27, 1987 February 27, 1987 January 1, 1988 January 1, 1988 October 1, 1987 February 27, 1987 January 1, 1988 February 27, 1987 February 27, 1987 February 27, 1987 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 January 1, 1988 January 1, 1988 October 1, 1987 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 July 1, 1987 October 1, 1987 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 VVV 000014823 -3- Dimethylcarbaraoyl chloride 1,2 Dimethylhydrazine Dimethyl sulfate 1,4-Dioxane Direct Black 38 (technical grade) Direct Blue 6 (technical grade) 79447 540738 77781 123911 1937377 2602462 Epichlorohydrin Estradiol 17 B Estrone Ethinylestradio1 Ethylene dibromide 1,2-Dichloroethane (Ethylene dichloride) Ethylene inline Ethylene oxide Ethylene thiourea Ethyl methanesulfonate 106898 50282 53167 57636 106934 107062 151564 75218 96457 62500 Formaldehyde (gas) Formylhydrazino-4-(5-nitro-2-furyl)thiazole 50000 3570750 Glycialdehyde Gyromitrin (acetaldehyde methylforinylhydrazone) 765344 16568028 Hexachlorobenzene Hexachlorocyclohexane (technical grade) Hexamethylphosphoramide Hydrazine and hydrazine sulfate llydrazobcnzene 118741 -- 680319 302012 122667 Indeno [1,2,3-cd]pyrene Iron dextran complex 193395 9004664 Lead acetate 301042 Melphalan Methoxsalen with ultraviolet A therapy (PUVA) 2-Methylaziridine (propyleneimine) 4,4'Methylene bis(2-chloroaniline) 4,4'Methylenedianiline and its dihydrochloride Metronidazole Michler's ketone Mirex Mustard Gas 148823 298817 75558 101144 101779 443481 90948 2385855 505602 2-Naphthylamine 91598 Nickel refinery dust from the pyrometallurgical process - -- Nickel carbonyl 13463393 Nickel subsulfide 12035722 Nitrilotriacetic acid 139139 Nitrofen (technical grade) 1836755 Nitrogen mustard 51752 2-Nitropropane 108032 N-Nitrosodi-n-butylamine 924163 J anuary 1, January 1, J anuary 1, January 1, January 1, J anuary 1, 1988 1988 1988 1988 1988 1988 October 1, 1987 J anuary 1, 1988 January 1, 1988 January 1, 1988 July 1, 1987 October 1, 1987 J anuary 1, 1988 July l, 1987 <-- January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 October 1, October 1, January 1, January 1, January 1, 1987 1987 1988 1988 1988 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 February 27, 1987 January 1, 1988 July 1, 1987 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 February 27, 1987 October 1, 1987 October 1, 1987 October 1, 1987 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 October 1, 1987 VVV 000014824 -4- N-Nitrosodiethanolamine N-nitrosodiethylamine M-nitrosodimethy1amine p-Nitrosodiphenylaraine N-Nitrosodi-n-propylamine N-nitroso-N-ethylurea N-nitroso-N-methylurea N-Nitrosomethylvinylamine N-Nitrosomo rpho1ine N-Nitrosonornicotine N-Nitrosopiperidine N-Nitrosopyrrolidine N-Nitrososarcosine 1116547 55185 62759 156105 621647 759739 684935 4549400 59892 16543558 100754 930552 13256229 Oxymetholone Panfuran S Phenazopyridine and its hydrochloride Phenytoin and sodium salt of phenytoin Polybrominated biphenyls Polychlorinated biphenyls (containing 60 or more percent chlorine by molecular weight) Procarbazine and its hydrochloride Progesterone 1,3-Propane sultone beta-Propiolactone Propylthiouracil 434071 ___ 136403 57410 -- -- 366701 57830 1120714 57578 51525 iodium saccharin 128449 Safrole Soots, tars, and lubricant base oils and derived 94597 -- products, specifically vacuum distillates, acid treated oils, aromatic oils, mildly solvent-refined oils, mildly hydrotreated oils, and used engine oils; and mineral oils, when used in occupations such as mulespinning, metal machining, and jute processing. Streptozotocin 18883664 Sulfallate 95067 2,3,7,8 -Tetrachlorodibenzo-para-dioxin (TCDD) Thioacetamide Thiourea Thorium dioxide ortho-Toluidine and its hydrochloride Toxaphene (polychorinated camphenes) 2,4,6-Trichlorophenol Treosulfan Tris(l-aziridinyl)phosphine*sulfide (thiotepa) Tris(2,3 -dibromopropyl)phosphate 1746016 62555 62566 1314201 95534 8001352 88062 299752 52244 126727 Urethane Vinyl chloride 51796 75014 January 1, October 1, October 1, January 1. January 1, October 1, October 1, January 1, January 1, January 1, January 1. October 1, January 1, 1988 1987 1987 1988 1988 1987 1987 1988 1988 1988 1988 1987 1988 January 1, 1988 January 1, January 1, January 1, January 1, January 1, 1988 1988 1988 1988 1988 January 1, January 1, January 1, January 1, January 1, 1988 1988 1988 1988 1988 January 1, 1988 January 1, 1988 February 27, 1987 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 January t, 1988 January 1, 1988 January 1, 1988 February 27, 1987 January 1, 1988 January 1. 1988 January 1, 1988 February 27, 1987 VVV 000014825 -5- REPRODUCTIVE TOXICANTS Aminopterin Chlorcyclizine hydrochloride 1,2-Dibromo-3-chloropropane (DBCP) Diethylstilbestrol (DES) Diphenylhydantoln Ethyl alcohol in alcoholic beverages Ethylene oxide Etretinate Isotretinoin Lead Methyl mercury Thalidomide Valproate Warfarin 54626 82939 96128 56531 630933 64175 75218 54350480 4759482 -- -- 50351 99661 81812 July 1, 1987 July 1, 1987 February 27, 1987 July 1, 1987 July 1, 1987 October 1, 1987 February 27, 1987 July 1, 1987c July 1, 1987 February 27, 1987 July 1, 1987 July 1, 1987 July 1, 1987 July 1, 1987 vvv OOOOl^B26