Document 3Nxy3ZdDaVqe7pQmzKJ8eOpQJ

Monsanto FROM fNAWi LOCATIN-PHONE* Dept, of Medicine & Environmental Health o*te ^ EJECT: January 17, 1983 TCDD F.R. Johannsen G.J. Levinskas REFERENCE. Memo (DRB to G R ) , 20 Dec. 82 TO G .jRotish In response to item 1 of D.R. Bishop's memo (DRB to GR, 20 Dec. 82, attachment C) a literature search was c o n d ucted by M a r y Davis to identify synthetic substances which have some evidence of toxicity at doses comparable to 2 , 3 , 7 , 8-TCDD . In r e v iewing the 295 c i t a tions produced, a toxic response level of 0-10 parts per billion (ppb) was chosen as the range of toxicity for identifying such substances. Attachment A lists the single commercial synthetic substance and several naturally occurring substances which fell into the above category. With regard to item 2 of the memo, the m e l t i n g point of 2,3,7,8TCDD is 305C (5810F) and no b o i ling has ever been reported. This fact was confirmed by F. Hileman, MAC, Dayton, and is supported by the literature references cited in attachment B. dlj attachments Timothy J. Long SUBJECT TO PROTE- viz ORDER. liV-.WAfl ( R E V . 2 / 7 8 ) T ' V '. O VJ J O Attachment A Substance Toxic Effect/Specie Tested I. Commercial Substances Platinum (II) , diammine- intradermal T D L Q */man dichloro-,cis- (toxic effects upon skin) II. Natural Substances a) Botulinus toxin oral LD50**/unspecified b) Ba t r a c h o t o x i n i n A, 20-alpha- (2 ,.4,5trimethyl-lH-pyrrole3-carboxylate) subcutaneous LD50/mouse c) Castor bean, beta fraction - intraperitoneal LD50/mouse Dose 0.04 ppb(ug/kg) 0.01 ppb (ug/kg) 1 ppb(ug/kg) 1 ppb (ug/kg) *TDL0 = the lowest dose of the substance reported to produce any toxic effect. **LE>50 = the calc u l a t e d dose of the test substance w h ich will be expected to kill 50% of a population of test animals. TJL 1/17/83 Attachment B 1) EPA Dioxins; industrial Environmental Research Laboratory (IERC) Cincinnati, Ohio; EPA document no. EPA-600/2/80/197, November, 1980. 2) H a l o g enated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products; R.D. Kimbrough (ed.), Elsevier/ N o r t h - H o l l a n d Biomedical Press, New York, 1980; pg. 50. TJL 1/17/83 Monsato Attachment G D. R. Bishop - A3NB(N A M E -- L O C A T I O N -- P H O N E r X. L SU B JE C T December 20, 1982 TCDD REFERENCE T o : Dr. George Roush - G2WG CC. *}-< In your follow-up conversation with Dr. Neal, I would like to have additional information or confirmation of the following items: 1. Examples of other synthetic substances (in commerce) that are more acutely toxic ) to some test animals than 2,3,7,8 as? 2. 2,3,7,8 TCDD has a high boiling, about.500F. D R B :ec (h. ,, Dan R. Bishop v/ N - lO <REV. 8 / 7 7 l