Document 3NxX0oQMqMvaE4gvbE9Lzjnq0

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1950 May 15 DOC#: API098 DOCUMENT DESCRIPTION: Proposed Epidemiological Studies - Progress Report for The Subcommittee on Carcinogenicity of the API Medical Advisory Committee [Revision of Apr 23 Version] DEC-04-1998 15:10 H L HOBSON P .02/52 For Information only - Not for publication ' Kettering Laboratory University of Cincinnati THE PROJECT ON CARCINOGENICITY PROPOSED EPIDEMIOLOGICAL STUDIES Progress Report for The Subcommittee on Carcinogenicity of the API Medical Advisory Committee April 23, 1950 Revision - May 15/1950 ' ^ ~ 911230 BinEulM 01828 DEC-04-1998 15:11 H L HOBSON P.03/52 PPSS^NT STATUS . At the Subcommittee meeting held March 19> the following objectives were presented: 1^ The determination of incidence and prevalence rates .of retrograde, hypertrophic or neoplastic reactions in employees of the Petroleum Industry. ' II. The comparison of these rates with those of the general population and other industries* III. The evaluation of control procedures that have been accepted, employed or recommended. '=' IV. The recommendation, if the studies justify the action, of standardized safety and control measures. The possible approaches to these objectives are: I. A Retrospective or Historical Study of all available records of such cases among the employees of the Petroleum Industry. II. A Current Registry receiving reporta of such cases a3 they are discovered by and/or reported to-the _ a* various Medical Departments. ... ..XII . A study. of ..the..Employee Health Benef it..Plan,.re.CQr.ds...... with the hope that like data can be secured from other industries. IV. Field Surveys of retrogrado or hyperkeratotic losions on exposed akin surfaces. V. A repetition of the studies which have pointed out an unusual hazard in the Slack tVax Process. * - VI The establishment of a Consultation Service to assist In the planning of comparable company studies. This - last approach was not discussed at the Cincinnati meeting. " 911230 BinEutM 01.829 DEC-04-1998 15:11 H L HOBSON P .04/52 -2 - FUTURE PLANS A. It Jje proposed to implement immediately, insofar as possible and/or feasible, with due consideration and understanding of .. the wide variation in company policies, medical care programs, management interest and labor relations, the first two approaches, namely, (I) the Retrospective Study and (II) the Current Registry. > ' * I. Retrospective or Historical Study ' 1. Description This approach requires the assembling of the clinical ** records and employment histories of proyed cases of Neoplastic disease known to have occurred among"employee3 of the cooperating Petroleum Companies, regardless of site, type of tumor, degree of exposure to various carcinogenic hazards and employment status. ... * ' m The Medical Departments, under this plan, within the .. limits of'their ieg'''rsponaibilitios" (See'Appendix;- Page i); would be expected to forward to the Survey Group of the University of Cincinnati the records of all known cases of proved or suspected Neoplastic disease which have occurred " among thoir employees during the period covered by their _immediately available files. It would be expected that the details of the clinical records would be augmented, supplemented and/or verified, - insofar as possible, by the various Medical Departments 911230 BinEulM 01830 DEC-04--1998 15:11 H L HOBSON P.05/52 - 3- through their relationships with their subordinate offices, private physicians, hospitals, clinics and laboratorios* To determine the degree of possible exposure to various potential carcinogens, the various Medical Departments would be expected to request that their Personnel Departments ' furnish, insofar as their records permit, a detailed employment history, including not only information regarding the employment of the patient in the company or industry, but also any other employment in other industries as covered by their records. (See Appendix, Pages 2, 3, " and 6 for the details of the information to be requested on (1) the initial report, (2) the clinical record and (3) the employment history.) The Survey Group of the University of Cincinnati would be expected to set up the necessary clerical mechanism to receive the initial reports, to process the clinical records and employment histories and to provide interim and final ^summations to the Medical Advisory Committee. The tabulations and analyses would be arranged to protect the identity of the companies and/or the individual patients involved in the - study through the use of a codo system* 2. Objectives The serious defect in this plan arises from the great variation in the amount and type of information available in Tiles of the various Medical and Personnel Departments,. For some companies, the need to colloct this data is an entirely now concept. In others, even the provision of medical care programs for the employees is a relatively recent activity. ' 911230 BinEutM 01831 DEC-04-1998 15:11 H L HOBSON P.06/52 - L). - This approach, even with optlmum conditions, information and cooperation, can only furnish a crude estimate of the prevalence of Neoplastic disease among employees of the cooperating companies who have had exposures to the older conditions and processes. The tabulations cannot be used to ascertain the potential hazards of the newer processes. However, if a consistent pattern in the occupational histories of this group of cases was found, the presence of overlooked hazards in the older methods might be indicated. Furthermore, if an unusual distribution is reported with regard to type and site of tumor, further epidemiological studies of Neoplastic disease in employees of the Petroleum Industry ^ might be limited to only certain types and sites* 3 , Approximate Period of Study ... It is readily apparent that, due to the many diverse situations found in the industry, the variation in the- degree of cooperation offered by the different companies, tho time _ needed to secure general acceptance of a standardized report .. end thenecessary.-lag..that.will...bo. encounter<|d...ln ^?..ttirig up,, - the clerical mechanism at the University of Cincinnati, this approach will require approximately two years to complete. It would bo expected that the final report including cases as they have occurred up to and including January 1, 19^1 could not be submitted before 1 9 5 2 , 911230 BinEulM 01832 4 DEC-04-1998 15:12 H L HOBSON P.07/52 - 3' " II. Current Registry 1. Description This approach envisions the establishment of a continuing Central Registry for Neoplastic diseases to be employed by the various cooperating companies to report routinely through their Medical Departments proved or suspected cases of Neoplastic diseases which occur among their employees, regardless of site, type of tumor, degree of exposure,to various carcinogenic hazards and employment status. The Medical Departments, under this plan, within the limits of their legal responsibilities, would be expected to report currently to the Survey Group at the University of Cincinnati all cases of proved or suspected Neoplastic disease which occur among their employees, , It would be expected that, in addition to this notification, Insofar as possible, a detailed clinical record would be completed by the various Medical Departments, .. .augmented* supplemented and/pr.,.v<?rIfd.ed. through, thplr.regular, contacts with their subordinate offices, private physicians, hospitals, clinics and laboratories. Furthermore, in order to ascertain the degree of possible exposure of the reported cases to various carcinogenic hazards, processes or environment in or out of the Petroleum Industry, the various Medical Departments would be expected to request that their Personnel Departments furnish, insofar as their records permit, a detailed history, including not only-a - 911230 BinEulM 01833 Dtc-iM-iyyd 1 5 : 1 2 H L HOBSON P.08/52 - 6 - description of the Job of the individual in the company and/or industry, but also all other employment covered by their records. It is hoped that this record can be augmented or supplemented, if necessary, by the Medical Departments, since, in many instances, the patient will be in direct contact with the Medical Director or his immediate subordinates. (See Appendix, Pages 2, 3 li 5 and 6 for the details of the information to be requested on (1) the initial report, (2) the clinical record and (3) the employment history**) It would be expected that the various Medical Departments, either directly or by securing the assistance of their Personnel Department, would furnish, periodically, similar employment histories for certain groups of employees in their company. The groups or samples required for this phase of the study would be selected with a direct request from- the Survey Group, but only after personal consultation with the various Medical Directors and subject to the general approval, of the. . '"Medical Advisory Committee. . .'... (See Appendix1, Pages 5* and 6 for-the- employmenthistory. as used for eases which would be sought not for all, but only a sample of the total number of employees in the company or industry.) The Survey Group of the University of Cincinnati would be expected to set up the necessary clerical mechanism to receive the initial reports, to process the clinical records'jind employment histories and to* provide periodic interim summations to the Medical Advisory Committee. The tabulations 911230 BinEylM 01834 DEC-04-1998 15:12 H L HOBS0N P.09/52 - 7- and analyses would be so arranged that the identity of the companies and/or the individual patients involved would again be protected through the use of a code system* ,, In the attempt to calculate incidence rates for at least a fraction of the industry, it would be expected that the Survey Group would prepare the plan, subject to the approval of the Medical Advisory Committee, for selecting the needed employee groups for the population studies as previously described. '7 As an adjunct to the Central Registry, it would seem desirable to create a Central Pathology Service at the University of Cincinnati to whom the various cooperating __ Medical Departments could forward slides and/or tissues for diagnosis and a uniform classification* This particular activity would stimulate the cooperation of the physicians in the search and reporting of cases to the Central Registry. It would also establish a uniform level for acceptance of a 'case as one of proved Neoplastic disease. How this service can be established and-financed-still'-remains an open-question. 2. Objectives This approach would furnish, in contrast to the prevalence rates of the Retrospective Study, an approximate estimate of the incidence of Neoplastic disease among employees of the cooperating companies, since it is hoped that, for at least a portion of the industry, adequate estimates of the number of employees involved and possible exposures to various potentially carcinogenic hazards will be obtained. ' ' 911230 BinEulM 01835 DEC-04-1998 15:12 H L HOBSON P .10/52 - 8 - It would be expected that this plan would augment, supplement and finally supplant the Historical Approach in defining far more'accurately the hazard of the older processes* If successful, and since this will be a current registry providing for reports in the years to come, the analyses could be used to ascertain the hazards of the newer processes, provided that the study is maintained and supported for a sufficient period of time to take into account the long latent period commonly found with Neoplastic disease. It is also possible that this plan, in the future, will provide comparisons of incidence rates not only between various processes, but also geographic areas, racial groups,^, companies, other industries and the general population* 3- Approximate Period of Study - It would be well to call attention at this point to the fact that the greatest obstacle to this approach is the dynamic almost fluid state of the technology of the Petroleum **Industry. This situation will seriously interfere with any logical "attempt to define" accurately the degree'and period of exposure, except in the very broadest of terms. It will be, likewise, the most dangerous factor in the estimation of exposed populations, since process changes bring about the . frequent shifting of the employees in the refinery operations. Also, since it la generally accepted that Neoplastic reactions require usually a relatively long and heavy exposureto oven proved carcinogenic agents, and that there is, likewise, usually a very long period between exposure and 911230 BinEulM 018m36 DEC-04-1998 15:13 H L HOBSON P.11/52 -9 - reaction, it is readily apparent that the registry must be continued and adequately maintained for a considerable period of* time before it will even begin to measure the hazard of the newer processes. It is to be hoped, however, that satisfactory rates measuring the hazards of the older processes would be available much earlier. 911230 BinEutM 01837 DEC-04-1998 15:13 H L HOBSON - 10 - k P.12/52 B. It 13 proposed to continue the exploration and the possible imp lenientation, as soon and insofar as possible and/or feasible, ' . with due consideration and understanding of the wide- variation in company policies, medical care programs, management interest and labor relations, of the third and fourth approaches, namely, (III) Employee Health Benefit Plan Study and (IV) th^' Field Survey for Retrograde or Hyperkeratotic Lesions* The description, objectives and approximate period of study for both of these attractive and possibly feasible approaches must await further consultation, discussion and pilot trials before they can be brought to the Subcommittee ` ' ^and/or Medical Advisory Committee for their consideration. It is hoped' that these two avenues 'can-be explored sufficiently _ during the summer of 195>0 to penult firm planning at the November meeting. 911230 BinEulM 01838 DEC-04-1998 15:13 H L HOBSON P.13/52 -U - G, it Is proposed to implement, as soon and insofar as possible and/or feasible, with due consideration and underatending of the wide variation in company policies, medical care programs, management interest and labor relations, the last two approaches, namely, (V) Repetition of the Slack '/ax Studios and (VI) the Consultation Service. It is not proposed that the Survey Group take an active part in the Slack Wax Studies-, but that the observations will be repeated by individual companies. It is hoped that the Survey Group of the University of Cincinnati, through personal contact, can make certain that adequate observations are secured so this question can be thoroughly explored and evaluated. In serving as an agency to insure that the individual company protocols are valid, acceptable and comparable, it'is expected that they can act as a medium of dissemination ao that the various other cooperating Medical Departments will have access to this information. It Is planned, likewise, that the Survey Group of the University of Cincinnati will stand ready to assist, upon the specific request of any Medical Department, in the planning of other studies to determine particular and/or unusual hazards. It is not expected that the information 30 gathered would be disseminated generally unless the Interested company permitted '"this action. The sole objective for this approach would b to -insure comparability of studios and observations in ease general dissemination or comparisons became desirable.. ' 911230 BinEulM 01839 DEC-04-1998 15=13 H L HOBSON b APPENDIX P.14/52 t 911230 BinEutM 01840 DEC-04-1998 15:13 COPY H L HOBSON D e c e m b e r 20, 19^-9 P. 15/52 Appendix d Dr. Mclver Woody ESSO Standard Oil Co. building- Dear Doctor Y/oody: You have told me the plan is being developed to accumulate in the hands of investigators of the University of Cincinnati, who have been designated for the purpose, data with respect to operatives engaged in petroleum refining and petrolevm handling who may ha/e terminad to be suffering from or who may be suspected of suffering from cancer which may be attributed to their occupation or to"contact with petroleum products. You have asked me if I see . Y oblection from a legal standpoint to transmitting to the designated authorities at the University of Cincinnati the records of such patients , There has grown up a feeling, and perhaps alright, on the part of patients to have their consultations with their physicians 3n - nhvsicians1 records with respect to the patients treated as confidential between the physician and the patient. Even ,`r .^ a patient's right to have such communications and records treated as confidential is not fully established, I think our anxiety to develop- cordial relations between our employees and company doctors ought to compel us to regard those communications and records as confidential. -Starting from this premise, I think it is entirely proper from-a legal standpoint, and feasible from the standpoint of the relations we want to preserve with our employees, for you to report cases of the. herein mentioned, provided you keep the identity of the patient strictly confidential. I suggest that these reports may be madeJf1?! a series of code numbers or under fictitious names, you preserving Your confidential files the identity of tho code number or fictitious. Z e Z of the patient involved. I think if this enonymous observed in making the reports you have described to me, t offend the patient's legal rights. I feel equally strong it i * likely to cause any disturbance in.the relationship between slut . employees and our company doctors. " I would think that if the designated authorities at the Univer sity of Cincinnati desire to compilo and use generally in tho industry or with the public any statistics with respect to data of tho kind herein described, which they receive from our company and from other companies, they ought-to again use codo numbers so that the identitv of the company whose employees are embraced in tne statistics will be carefully concealed. If-thc foregoing restrictions aro observed, I think the confiden tial naturo of the physician-patient relationship will bo ' and, similarly, the confidential nature of the company be reserved and I do not anticipate any trouble would be involved. Very truly your3 , ' ESH A . , 911230 BinEulM 0 1 8 4 Origin'll s Hilll . Signed DEC-04-1998 15:14 H L HDBSN Preliminary Notification P.16/52 Appendix Page 2 [. identification Data A. Code Number - All Identifying data (Name-Address) to be retained by the Medical Director, correlated with the code number. ' % B. Age (Year born) _ C. Sex - D. Race 4TT * IX. Clinical Data A. Type of Tumor B. Site of Tumor C. Date of Diagnosis' . .' ` ' 911230 BinEulM 01842 DEC-04-1998 15=14 H L HOBSON P .17/52 Appendix Page 3 Detailed Clinical Record (To be completed in duplicate) . j/One copy to be retained by the Medical Director) X . . Identification Data A. Code Number - All identifying data (Name-Address) to be retained in the office of the Medical Director. ' * B. Age (Year born) C* Sex D. Race E. Marital Status . F. Employment Status IX. Clinical Data A , Dates 1. First Symptom 2. First Visit to Physician 3. First Diagnosis t. - [{.. First Treatment or Hospitalization. 5>. Death B. __ Clinical and Pathologic Diagnosis ~ List of tumors to be reported which will be placed on the reverse of record. This list is not exhaustive but comprises the great majority of terms usually used* when there is doubt concerning the malignant nature of a tumor, .. it should be reported* 911230 BinEulM 01843 DEC-04-1998 15:14 H L HOBSON P.18/52 Appendix Page ij. Carcinoma ^ Sarcoma ) and any term of which one Epithelioma j of these words is a part. Endothelioma Acanthoma fc Astrocytoma Brain Tumors ' Chorioma Chloroma Cholesteatoma Embryoma Ependymoma Ganglioneuroma Glioma Granulosa Cell Tumor (Ovary) Hyp ernephroma Hodgkin's Disease Leukemia Lymphoma Lymphosarcoma Linitia Plastica (Stomach) Melanoma Meningioma Myeloma Medulloblastoma Mesothelioma Mixed Tumor Neurocytoma Oilgodendrogli oma Pinealoma Syncytioma Seminoma Sympathoblas toma Spongioblastoma . Teratoma ,* Thymoma _ Paget's Disease (Breast) Wilma i Tumor (Kidney) Ewing's Tumor (Bone) Grawitz Tumor (Kidney) C. Primary Site and Stage * D, Treatment Advised and Received E, Complications - Metastatic Sites XII* unusual Exposure to Possible Carcinogens - Including estimates of Degree, 'Type and Length of Time (As elicited by the Physician) List which will be placed on the reverse of the record. - . A* Physical Agents . . 1. Trauma ' - 2* Radiant Heat 3, Solar Rays /(.* Ultraviolet Rays $ . Radioactive Substances or Roentgen Rays B. Inorganic Substances 1. Arsenic 2. Chromates C, Organic Substances ...... 1. Aromatic Amines 2. Tar or Pitch ' " 3. Soot ` ' 4* Creosote and Anthracene Oils __________________________:________________911230 BinEulM 01844 DEC-04-1998 15:14 H L HOBSON P.19/52 Detailed occupational Record (To "be completed in triplicate) (One copy to be retained by the Medical Director and Personnel Department) Appendix Page 5 I. Identification Data A. Code Number B. Age at Commencing Work C. Employment Status ' * II* Occupations and Detailed Employment Record - Listed in Chronological Order .sr A. Name of Companies and/or Plants B. Products Handled by Worker C. Job Descriptions - The Broad Classifications which will be placed on reverse of card. ** 1* Production a* Riggers and Drillers . b. others 2. Refining a. Cracking (1) Catalytic (2) Thermal (3) Others _ b. Lubricant and Paraffin (1) Crude Wax . - . (2) Others -- c* Straight Run Distillation and Light Ends - - d., Special Products ~ 911230 BinEulM 01845 DEC-04-1998 15:14 H L HOBSON P.20/52 Appendix Page 6 e. Maintenance (1) Pipe fitters and Boilermakers (2) Others k f. Control Laboratory g. Others 3. Transportation a. Pipe Line b. Fuel Oil Carriers c. others k - Marketing and Executive a. Service Station b. Others r ' - ' 5 Qther3 - Specify in detail D. Periods Employed III. Unusua! Exposure to Possible Irritants - Including estimates of Degree, Type and Length of Time (As elicited by the Employment Record) (See list - Detailed Clinical Record) 911230 BjnuiAf 01846 DEC-04-1998 15:15 H L HOBSON ^ 0 r! AMERICA]? PETROLEUM IBSTITUT1 BIJBCOMMITTEE OM CARCIVOfflEKI CITT m is u se s or is t e b im M am as J j w p 1. 1M9- P.21/52 I 'to "U 4 -Q ~ JL ^ ^ fxuy><f/' An Interim meeting o f the Subcommittee on Carcinogenicity was held on T riday, foie 3rd, 19^9, at 15 Vest 5 l* t S tr e e t, Tork C it y . MEMBERS PRESllfT ASSOCIATES PgESZffP Marshall Clinton TM. frank A .E . Hoag J .P , Holt T .J. Kelly M.H. tfevquiat MeIvor Voody CUESTS L.C Beard, J r , H.P tankslma K.a Mackeatle B.M Shepardeoa (representing B.0.M , flsch er) H.H Zuidema B,W. Vanik - S h e ll O il Company A . Wesley Horton - U niversity o f Cincinnati Aunsga, D .y. Stroop -A P I MEMBERS ABSZHT TOTAL IV ATTSITDAICS - 15 ASSOCIATES AB8IBT L .E . Curtis W.B. le v is C .A . Swan H .S . Bonsib A .X , Dooley H .O.K. Vischer Minutes o f the meeting o f March 11th were approved aa Issued, Mr. Stroop stated that the API prefers not to be included in the American Cancer S o c ie ty 's l i s t o f gra n ts-in -a id for cancer research. Ur. Horton submitted a progress report, (Copy o f the report 1 attached as Appendix A ) , Dr. Woody sa id the Vederal Security Administration has awarded over $450,000. in fe d e ra l grants fo r cancer control end teaching a c t i v i t i e s . The 911230 BintiulM 01574 DEC-04-1998 15 15 H L HOBSON P .22/52 1argil at amount, $35*000. want to the Pennsylvania Departnent o f Health, vhera Dr* Shilen D irector of tho D ivision of Industrial Hygiene, has at up an occupational cancer control program with a physlolan and a nuree. At a la te r date, two engineers and a s ta t is t ic ia n w ill he assigned to the p r o je c t. The attached forms (Append!* B) are feeing prepared In quantity fo r use In their surveys and are e s s e n tia lly id e n tica l with the fora submitted to then fey Dr. Eueper to Insure uniforn data from the various sta te s p a rticip a tin g in the in d u strial cancer program. The o i l industries located in the Philadelphia area are high on th eir agenda. Dr* Hoag end Dr. Bewqulst spoke "briefly concerning a r t ic le s on cancer they have w ritten for the Sseony-Vacuum Yews and Texaco Topics re sp e ctiv e ly , I t was agreed that other companies could w ell affo rd to follow their example. T,M. MASK Secretary HeIYER WOODY Chairman $ 911230 BlntulM 0 1 5 7 5 DEC-04-i998 15:15 H L HOBSON P.23/52 iprapii a API. PROJECT ON CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI The program at the Kettering Laboratory is roughly _ divided into, three major phases. Of perhaps most immediate importance is the effort to pin point throughout the industry materials and operations which represent potential hasards from the cancer standpoint. The second phase, which will be prosecuted simultaneously with the first phase, will involve the concentration 'and isolation of the compounds re sponsible for the carcinogenic action of certain catalytically cracked oils which have already been tested biologically* From the physical and chemical properties of such concentrates, an effort will be made to develop an analytical tool which may then be applied to any refinery stream to determine its carcinogenicity without resorting to animal testing. The third major phase will be an epidemiological study of cancer in the petroleum industry. In carrying out the first phase in the program, as described above, a series of typical refinery samples will be tested on suitable laboratory animals to determine their relative carcinogenic potencies. It is expected that, in the course of the coming year ending June 1, 1950, testing of approximately 150 to 200 such samples will be started at the Kettering Laboratory. Thus an average of about 12 samples from each of the foliowing processes will be studied: , 1. Non-catalytic gas oil cracking 2. Viscosity breaking of residues and 'extracts 3. Naphtha reforming 4. Polyforming 5. Coking operations ' ' 6. Houdry catalytic cracking 7. Fluid catalytic cracking 8. Therraofor catalytic cracking 9. Cycloversion ` 10. Houdryflow cracking 11. Hydroforming 12. Slack waxes and aromatic extracts therefrom 13 Sclvent extracts from lube oils and heavy gas oils. 91230 BnEulM 01576 DEC-04--199B 15=15 <- ' H L HOBSON P.24/52 ** 2 The potencies of the samples will be compared with those of coal tar and shale oil fractions on which clinical data is available from England. In considering the selection of samples from each of the processes listed, attention is at present being re stricted to those intermediates or products with a distilla tion end point above 650eF. On the basis of confidential information supplied to the Kettering Laboratory by each of the API member companies on such materials and the unit operations producing them, a sampling program is being^ organized which will cover the current range of variations in each process. Careful consideration is being given not only to the characteristics of the particular products which will be tested for carcinogenicity but to the feed stocks and the unit operating conditions as well. In this manner it will be possible to correlate the effect of the trends in available charge stocks and refining practices with the relative carcinogenic potencies of products formed. Thus, the results of the testing program now planned should permit prediction of potential hazards as unit operations change in the years to come. As yet, a list of the specific samples to be tested during the coming year has not been prepared since the necessary data from the individual companies is not complete. However, sufficient information is available to permit the selection of a small number of samples from thermal cracking of high boiling materials, both virgin gas oils and those previously subjected to catalytic cracking. In additionit is planned to request samples of high boiling oils from TCC units since to date no physiological testingof the heaviest products from these operations has been carried out. In reporting results of tests on future oil samples, a direct comparison With a solution of a known concentration of a standard carcinogenic hydrocarbon in a standard solvent will be made. Preliminary tests are being run with solu tions of methylcholanthrene in benzene, at concentrations from 0*01# tf, 0,6$, Previous results have indicated that the tumor incidence curves for typical heavy catalytically 911230 BtnEufM01577 DEC-04-1993 15:16 H L HOBSON P.25/52 - 3- cracked oils may be compared nicely with the curves for such standard ablutions. In further work the effect of the benzene solvent on the tumor incidence and the induction period in mice will be determined. Various non-volatile solvents, such as methylnaphthaiene, are being considered for this purpose. However, it must be kept in mind that benzene solutions of methylcholanthrene have been employed as standards for many years in studies by English scientists. Their use may therefore facilitate the interpretation of our laboratory results in terms of practical hazards to exposed workers. June- 3 ; 1949. A, Wesley Horton '911230 BlnEulM 01578 DEC-04-1998 15:16 H L HOBSON ,, 4 ' BTH-C-la ocGmgagioaaL casara iccoeo 1 , Mana Residence 3. State: *. Social Security Ho. 7. Date of Birth: 10. Occupation: 12. Cause of Death: ii..Ferns of Ffcysicienr 17. Clinical DiagnosiB: 2. P leca <rf Death; C i t y ; City; _sex_____ Age a. Toaras Moa. Baya; 1 1 . Induetry or Business: Method of Diagnosis 13. Clinical: Blopey: 1. Street; IB. Pathologic Diagnosis: H o sp itals Street: 6. Color or Race: 9. Date of Death: Autopsy: Other: 16. Cltr: 19. Primary Site: 80> Date at F ir s t Symptoms;_____________________ 21. Bata of F ir s t V is it to Physician: 82. Data of llr a t Blagaoala:__________________ ;_______________ 23. Stags at Dlaaase a t F ir s t Plagnosis: 2A, H istory of Other Xllneases of S it e A ffe cte d ? 25. Eletory of Injury to S ite Affected: 26. Bajoswa: Have you over handled carworked near any of.the following? If yea, giro datelie. S15E OP SUB3IAHC5 HAKE CC? WZLBtm DATE LHHCTH O f EKPCSIRE ! DESCRIBE TEES CF KEOSBKE AHD E Sm A T S EBSCHJT OF [ HOHKIflQ H U E EXPOSED: 5 911230 B i n t u l M 015 7 9 P.26/52 L ...... . BIH -C-lb Ocejjiatlaoal Cancer Record ar other Information pertaining to fuBwr i i l t i l t l j l i c i t y , s it e s , e t c . DEC-04--199S 15:16 H L HOBSON e & & 5 t ta 3 4N>J P U rg g< 5 0o3e TM 6 o o 5 aft 0 ?* & u1 o uH ?n a iH 13 o 8 9O <4 APPENDIX B P.27/52 n 4 3 9 h & | <5 o d 0 .3 S s 3 a y X (H ID Q11* v4 o ..g a * n s 8 sj %2 H wg<g *43 H a & 4B>J l-* o sO&4* S 5 0031 * $0? A n a? 8 1 isl *8o a A d S fDt % rl 9 -na AJi?o** * S5 4 go O j * 13 H9 3 *8 t S 43 ft 8 A & i g 9 b g *H 9 & 6 0 5 A s M ii 8 911230 BinEulM 01580 911230 BinEulM 01581 BXH-C-2 SLANT CANCER fiBOCRD 1 h'am# ot Company 3* In operation ediioe; 5 . Kenber o f worker^ employed: M t: T u ts i*: Whiter Colored: In plant: 11 8 L o ca tio n : . 4 . Products Manufactured: In o ffice ; Hen of plan t o f f i c i a l . 7 Nana c f P la n t Phvsl aian 6 . Incur anae C a rrie r: 10 Operations involved: IB . 3er o f exposed worters: tEslei _______________________ 8 , Careinoganlo hazards: ---------------------------- ---------------- ---------- ------- -- -- ____________________________ _ _ Fenale: 1 1. Number of w xfcers exposed; a . Constant exposure b . In te rm itte n t expoeure . c . Occasional. expoaur*________________ 13* Haoe* W hite; Colored; ' " " 14. Duration o f exposuse: Humber: Slasher: _ ____________________________ Hunter; 16 E at* o f turnover la e x jce e l group (a] Years: Tears: Tasra; Cancers Observed In exposed group fa) 17. Cancers hv slhen* Total ntu&er; Period: IS w t* - P.28/52 H L HOBSON DEC-04-199S 15:16 DEC-04--1998 15=16 H L HOBSON P.29/52 e h e k b u l i BIH-C-3 1, Kama of Company: FU ST CAUCJK BSC08D Data: B. location: 4. Products Ifanufeoturcd: 3 In Operation since: 5, ffuaber of Workers: Total Foules kales ' White Colored Office! Production: 6. Kane of Plant liti/agar* 8. Insurance Carrier: 9. Carcinogenic BasanJ*: 7. Plant PhTslci&n: 10, Operatic&e ImrolTCd a b d e t * fc 1 3 k 1 a n Sunber o f Workers E tp o iu rs Total, White Colored Main Taaale Constant Intermittent Occasional ' . 1J-' TyP* o f Exposure Inhalation Sfcln Insertion a b 0 d t e h 1 J k 1 a n Other IXiration A ftm o f Exposure Longsat lfi. Rat* ef U t fttraorofs Cancers Obserrad S lta Humber Fat-lad 911230 BinEulM 01582 DEC-04-1998 15:16 H L HOBSDN P.30^52 UnteriM auD-uom. Mea.Aav.Ah'ij Meeting held in New York, Friday, June 3, 9 0 0 A.M. HrtTKA i*nH fit* inncVTsa Room 6/3 ESSO S.O* Co, iSgff, TOE J P . J S T O I h __________ i s y, sist st! Samples iron processes listed in February 1 netting* Attsmpt to show offset of varying feed stocks and operating conditions with minimum number of samplss* 20 Beserve 150 of the Q sa*piss for refinery samples. Beet on samples for analytical tool fro* laboratory* Specific gaaplea 1* Clarified slurries fro* FCCtf already indicted - scat variation shown* 3632 nearly *ost potent. 2* Effect of thexsal cracking on heavy eat* cycle stock. 3* Effect of selected feeds In Houdry and TCC. 4 Highly aromatic sanples frc* 2 and 3 - pass Houdry operation, hoes recycling increase carcinogen concentration or destroy carcinogens previously formed? 5* Effect of sulfur and nitrogen Hydrogenation by Colon HCOOH extraction of H bases* 6 Slack wax (or slop on outside of presses). of those causing scrotal cancers. Rhodessa, g* Texas Ok* Crude sources Started 6 concentrations of Hehol* in bensen* fro* 0*0l to 0.6# 3 times a weak. Also 3631 and 3632. Ask Levis about meeting at Chester, Thursday, June 23. Nay 31 1949 911230 BinEulM 01583