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AR 286- 0729 ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) IESTSUBSTANCE 0000 Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203. (1Octanesulfonic acid) (CAS # 2795-39-3). Remarks: The 3M production lot numberwas not noted. The test sample disieFtCh-y2l0e3n.e gCluycrorlenbtutiynlfeotrhmeart,io3n7.in8d5i%cawtaetseirt,is2a0%mixettuhryeleonfe1g.l3yc4o%l,P2F.O6S6,%35% Sultone foamer, 3% sodium octyl sulfate, 0.1% sodium lauryl sulfate, and 0.05% tolyltriazole. The following summary applies to a mixture with incompletely characterized concentrationsofimpurities. Data may not accurately reflect toxicity of the fluorochemical component of the test sample. METHOD: 000000000 Method: OECD Guideline 202 Type: Acute static GLP: No Year completed: 1991 Species: Daphnia magna Supplier: In-house cultures maintained at EnviroSystems Division, Hampton, NH. Analytical monitoring: Temperature, pH, conductivity, and dissolved oxygen. Exposure period: 48-hours Test organism age: <24 hrs. old Statistical method: LCs values calculated using a computer program from Stephan, 1983. Test conditions: Dilution water: Filtered natural well water. - Dilution water chemistry: Conductivity: ~ 700 ymhos/cm pH: 7.9 Lighting: Cool-white fluorescent lights at 12 uEin/secim?. A daily photoperiod of 16 hours light and 8 hours dark was maintained throughout the testing period. Stock and test solution preparation: A 1000 mg/L primary stock solution was prepared by dissolving 2.0 g of test substance in 2000 mL of dilution water. Exposure concentrations were prepared by addition of the appropriate volume of stock solution. Exposure vessels: 250 mL beakers with 200 mL exposure solution and a water depth of approximately 6 cm. 000664 Number of replicates: 4 Numberof Number of dcoanpchennitdrsatpieornsr:eplfiicvaetpel:us5a blank control Water chemistry during the study: PH range (048 hours): 7.9-8.3 (control exposure) 8.08.3 (1000 mg/L exposure) `Temperature range (048 hours): 19.7 -- 20.6 C (control exposure) 19.4 -- 20.6 C (1000 mg/L exposure) Conductivity range: (0-48 hours) 640- 700 umhos/cm (control exposure) 640 - 660 mhos/cm (1000 mg/L exposure) Dissolved oxygen range (0-48 hours): 8.3 -8.8 mg/L (control exposure) - 8.0-9.9 mg/L (1000 mg/L exposure) REswts 000 Nominal concentrations: Blank control, 150, 250, 400, 600, and 1000 mg/L. Element values: 48-hour ECs) = >1000 mg/L. Element values based on nominal concentrations SRuebmsatraknsc:e TReesmtianrgkwsafsielcdo. nTduhcetveadlouenstrheepmoirxtteudreapapslydetosctrhiatbemdixitn utrhee aTnedstnot the fluorochemical proportion alone. co0 nclusio0 ns 0000 Thihgehetsetstcsonucbesnttarnacteio4n8-tehsotuerd.ECNso; wmoarstadleittyeromrisnuebdlettohablee>ff1e0c0ts0wmegrleL,obthsee.rved. SPauublm,itMtienrn:esot3aM, C5o5m1p33any, Environmental Laboratory, P.O. Box 33331, St. - pa0 taQuaw0 ry 0000 tReesltiianbgi.litHy:oweKvieirm,istchhersaankmipnlge=pu2.ritTyhiwsasstundoty mpreoeptesrltyhcehcarriatcertiearfiozredquaalnidtythe study in the lacks analytical solution. confirmation of the amount of fluorochemical proportion REFERENCES 00000 000665 `This test was conducted by Envirosystems Division, of Hampton, NH at the request of the 3M Company, Resource Analysts, Inc., Lab Request number H2864-9, 1991 o0rWOe0RO0O0O000O0000O000O0O0@O@O0O0O0 Last changed: 6/27/00 000666 f-- BEST COPY AVAILAB!LE . stot tse StSats maentaIsonetty of 1 193 stens [mra--u-- RR sur 9, 19m 7 3 ReportAnended : . pe 4 Cl EORRRLGE iaan STEeTll AhT aa 5: EE ER Casas AT as EDaanlesdmGaEE eaamrmsernroii ielSlEaie g SSHthEaShE adEERseR R wh aSa d IRS ma e eRE es a a his nei estenlatnall E LE wFORdGETae haaa e mSoornn isoar {To4 Cen DLorrorihEg TaRv ay Ci 000667 BEST COPY AVAILABLE I. GOODLABORATORYPRACTICESTATEMENT : JOMisasgtatrlwsecvontctMadpsecuring tMoy:OMD hGnadceLareeronnrairsyRgpeisericdn circustances that would affect the integrity of this study. a Tofhr'ancLaai sShtaeteFptgreMctorP--P onltfabe sL 227300.09 : Delta 204) : SH te v3 gSAbRE cohmanbs BORsDp oe TaEytSaEs anea SfoEoRRa E TEEER a e Matte TexicolontatSENCvs GSE erLeRa e BE RR ten ai SERnee aER IR OT R reeSinG ns e = SE mintymeee sonics) Sh ene Ee 000668 | BEST COPY AVAILABLE II. que assaser sare . Sumitted by: ESOaemvseioruLoarstcraearntsetsstiseraDdtiosvs,itsiIoancorporated Tiaston, ev Tampabire 03842 cartitieation: DLuateantteipsrrtieesvdsaasitnepdatchteatotsrehecitsieidaorsnecpcooforrtdthiveearcTeeevpdioetrrthivTeeandvtiibrtyolbemydesttmheeostsdhsoPdraosntdoacwneidlthM0a1tm7ea4rt-ie3erlisaa.la-sd HTPahrpeaecrePatr,oodruPecastt,uerRmelKgoi.vsatlriTatotiti,oTnoRLoAibqceuiratttyicbtoeTustoti,vciosalopodussyTtiomLroaatbehedyrabatyroErdly.leSnSTShAteirnodtroirgOeip,nearSlaetsiarnmagev eSoausu0d yTeianrse. Teport wil) bBa archived at Resource Maalrate, Toc. for at 27\iAXm1c1cruirdanacctyae, ttsorudadsi+st1cs1rivGdeaertdeapfvererorfmeorvtseherediforinaevd dbaytQauitlotythMeasreepuonrcte wAenrbeitocrhse.ckGeudalfiocry SE EN Daautste sRtuupdoyrtDeidre0ctor RBeappoertaeedntto RE ee = TsEta eEr e RREE E LSp s| TnAusPmaTL r lS iaS ne Im ss dsTeoeerrnss a SE SE C cS hAmh eEnN ma rae y co aay SE gEeEe R SStpaned aiMPeIIEt RRe TLE WS TSiiR a I R a R s L 70 5 R RNRI RyleTuaityAssLufrafaden0 ce sSeSperaeseaantnatriv3ea a Ta el RL oiEuRSEEERA EERE LLoe nRagg oSaBnE Thin On phe S EoGl ERT Biarirosystanse Seats Fesbere 3014-n 3 is e RAAT. ShaAir ERIRTR E h overE alesenEeRs COSRN CBOE. ER ee fe a apr a Eri TA fSriR SRI a SsE Een sie YT RSEi SiS i 000669 BEST COPY AVAILABLE rpp-- : secrton: race I GoodLaboratory Practics statement 2 IL cualtey assurance statencat s HL Table of contents . I. laodfTeablnes s vo sumei ` VE Tatcodaction) . VIL MethodGsat" materials . Cee EL Se vmmei EE gt Go FT EITT ENISREeterRencesNEsRoE Thwii Pe oEaE a t ie LSUES aEEERIE Ce aiTla R sea oRh Continnll A NARI 1 NGEeES LSE OR AR e Sr EE 5 a Biel 0 ne dagen GG RGTR E ae Givi CmhhCemo ness R o iuR BR G Sd E aE SERSaS R n RE E L a Sai t 0006770 BEST COPY AVAILABLE tv. ooor muss nee Thiet cCheatecal chmaracateriznatioen of L 3 represeE ntative . Thea suvinl tate tron tonicity test un Tle. eattaefnfectivTesconcentrations (30s) Tile 01. bCwoenotcntigvioty, 5i8,bgtesmipreriaitet,fnddadissolved ; M; Tig on Pa SE Ea E ie Bee e ns d SheeGlo Rell E Ee R R0 t oe : Sg GEpraEa a Ta S ER E 2 Co BeE 0 pa Ti did SESE Jaroad ans TE Anes aS nNT em ediC pn gR asO tn N n TUT oe B SRa LL Te CRS SAR GT SEeS E heama E wEEGE te i o a LE o eam seE samisenaNE BH COREE kiln wie 000671 _ _ Amended 8/5/91 BEST COPY AVAILABLE v.. soma iBnactchhisT1h3heatoancdu31tF,eept1oo9rx9t3i.,citTtyheotfhteeFsCEtov2vi0as)socstoyonedttuehcnetsedd.Duibfvaoirsii,3o1nDCooafmdpBoaenssyosuTarogcraes4,a8 vhfeosurrdsses,dcurrioibcne.gd SaFeavveeBrlaaoppXteoodwni,t1oorNnetyT,aBvuiRaropabisebyristrteeB.noserISstt,uvdayasnNdcuomnHbdeiruacottJeh0dyLTbAWy-i.EdllesnecSotranifnogrd,fo Jasnheseprgoatozcoel Cost sTuhbesttaenscte vuansd paerEtHolrenteidonunvdaetrerstactoinecrcoolndaittiAontseawpietrhatfuirree ocfon3c0e'nstr1at0i.onsThofe dNCioolnucteBinuotanrpaavthaiitozeners. wsahsorAee.ir1atvteairoendaccmweaaptstaarabDlloebveJlee)mvpevllao.tyeerd NcootwlollsencmltaeidaStofanriconemstwmreialstlsiseolnavstedRoufsopRtr`oLoenes,ht $Ci2b0a0tinscerei.vereR:o`a0taaRta/cLonlceeonnttrraotli)ons15v0erwealik,ed25f0or804/1k, c4o0l0ea3ta3t/io6n0s:0 alk, and CLeosnstrCohDlaanapph3hn4aiiBatoussrssheedcdiidaanAtFeherthateegseStEavvreettreosFeplrsgoahtetacSe(edDalttortoeneAdSaRar:pa)-48boofhuos0u.er0s0c1uo7lftu5s.rneorusetnsid.tviefnrhgee DSu2g3iahnSoioondrddisonefgattuThaneteesttufodafys.i0i.v0Ee0a8cpooGns/cuLer.netroafAtLdiIaopnGhars(ihBda3si0d)tsoSwteehareteetreisntthgsiounobds1t,ca0on0nc0deiatrieposnulFaEtted0t3hi,en tha' bighest tested concentration. A EROS ET cahg y CEE a i3: Co SRaRSAR eTmEiN GEEER OCTo odSaaEliEnNeA alblE eh NSahie Pie AARNE BR LT OT GR WR es PERE lol r S oobiR oo oApAtTing 5 SLAnREdT FiTB hL$aolrmmaaeniarEotiyaeitennaeitsteRadey wistLhoeos 90176300 iATEEae8 onoSe ises S opRVEEERB OF T FEEE T ahrEl snot eSemroneaie h SR E E SN EE EE E oy RECRST R R TU 000672 Aneated 8/9/91 BEST COPY AVAILABLE vi. omovocrion ASGecWsuCttoemtTphThaaointrsyl,vraieSstptyo.crootPnfAdUvuFLacC,ste1aMd0im3nednnatedroseiodnttghate.oardiaTcnphchhelaui1odd9be,j4ed04catt2fia1rv,eefsr1oho9fwm9a1ttt.hehereTsfootievunedasrylttoveddabeyyrfaivttnaoeist.disevpteToeonretsaooixrrnieeecdpiottrhbytey rCee2a8steuTnhitenserastsehuceittiwsoantosefrthtQhauetalSdiaetvsyecardtiaibtgeaattcihoeolnml.eetcThthoeeddsrde4upnrodirntMgatAtelhrseioatcleossntst.wapilsosyeend aipnpetnhdeisxtutdhya,t viz. mesons a mrmILS Test svasmaker: oTnubeNioivFeeCdab2ve0ir3th1(5tB,haevi1fr3oo%lsly.oswtienaIgst tSwaaitspolraecaoNtniutosanbitenre"d826i39n89654)&-5v3,a5s0FCdBe12l0i3vgel.rueedsTotehoottEetasitveirshouasbyststtavenancsse "fTaohsre dS3aurpwypilnaiifeadurnoboyonf3tHe1m0Cpoeymerpraartnsay.r,e.St.A rPaeusle.rviessateaspolteav,illPEbLoofartcohisveed aitt vEeasvisrotsoyraetdesisn Drumion warm: Saga T uas coWlalteecrteudsefdrofnorwealclcsliantaEtoivoinroofsytaetsetssorignanBiassepsiona,ndNfeovrRaamlpatboixciec,itVyatteerstivnags Hind sntiolrveediisn o5f00&-graelplroenspeontlayteitvheylesnaemptlaenkosf wahteerer iatrevapsraeesreantteedd. iRaesTualbtlse o1f.chemical L IRSkREE LEG TSESTOfSRhuGevAniNdkIiaSsNEip:eohda n.iindgs1aexsp9lpoC rreodpR esianE ttee;sttiGAorngoumnRiicsihseyv.er|eDafprhoamidssstLsaegedleoinsnoutirhcedetaesdt' : SBE i580 TerteoexiceDirvoyttuacnetd.'fprroimoirntiont-eohsotutisneIg,Coupdlatupushraeti,idwsoeanrvdserwveeesmlathTieendsts8ahithnaiWenhnde210c0-0bo0oucdriesdutotlaidosonaftbw.Toaothhtneee'r,,| SAATTRTSEBNE o(oartetrtrseataatteidnc fcoalortndditiithsieeo'ainbsseegiolaaunnd4riatJgihteeyorfwtgehlraae1s,tfserseatss'isoRfiiD`Duaurprpiianrngegnttahcescilscickncnaletisisso,ant(iiaonpnjhuprieidresis,ovdaen2dr1si=: "SBEEIRAA rhouerstperioSreatno ethreouttescthoiwnitaiatniondthtehs/frtaesmohpmeartraetru.realwgaas 19.6C%Daphanpirdiccourlntutuarnesi: \: S PFhEaEE sSeeatlysbeeotR sopreytr he estD . Ouhteae dMRINas ERe TTLn SEs iy Cel CL SREH T EE ee n a e HE EEERREEE . r8naL ovigroieovaft,ens1:0 ste ay mtbnesesRoeNRIe BE I GG TSlRE fi e F FG etet rb a rah n r eRsLE LpA i Eg R aEEElm LL eH TEt ERTR Ee E TinSn BOOT CE a BT 000673 Aaanded 919/91 BEST COPY AVAILABLE Table 1: Chenier characterizI ation ofPa reEpresenatatiyve saaple of satursl T racsaeter rsn et eTinie e e eTaminea E PH units - 1.9 Conductivity `umhos/ca. - 700 y opregsutmioccitdteosrine walt 2 " cSxgiopctonorss sort 50 rTioplhyeenhnlioart2anted salt a0st o by eT EE 5 pas F fo A FTL OEREE Won wor fetected ve the wert IL TTehErandwcaotenrduecotliivaicttyedvTalruoemsswecornetrdoeltetmeisntedvienssealsaatmpltehoe fbegins z i etRCEEIEn alhawitoTtenreEdtatina ag otctioboern,E1h3er3n0tueanpaprrtasosftTrofominesntivneerebsbaeasuaulrdns 2 CEeaia rn SE tiU se Ie NLn bi ae Fo ELSi OR f YSlEea aem E e eaa mC r dETiRRe E L TE e eG CLoSRaRE i ul dl E T Ei RO wria to en rc ayveL eDsIa oGt SS a etiIloio Hwiats BRE iwiAe nn AREER a Bea AORRRR, sisIBISSTR. +SOL AS 51SRG 000674 Sealed 5/5/91 BEST COPY AVAILABLE soxzery sting: . 2t0271,,0A1090s%crn.ege/nLNi.onugtAoEtaealsrtco4v8nictbehanuttrrhsaetoitfoensestxopsfuobsGseetsatnactseu1bevasaststanc7co0en8dmusecurtreeesdivOdaoulkrsioacg1c-u0Drrercee1d0m1baetr10a0l;i5 11S97e90s10t.0edacooo/mnLic.neantlArfacttoeinrocnes4n.8trhaotAuiroGsnesfoiofnfitsmitpveosestatresesu.tbssvtiaabsnlceaettitwaeelmrpeet:fefd1e5dc0at,rsi3nv5ge0r.Jeum4mv0ae0r,esd630A0tt,o aa111n,1i atCitaetredaicaogncteenattr)at1iodns.th(esutbelsetthwaals erfefpeecnttsedv.ere sot 3een at 1.000 mo/L duriog the accordTihneg dteotiEnaivtiirvoesytaotseincsitTyesttesPtrovtaoscopnerSOfIoTrAe-dD d(uSrtiantgicsMarhcehute19Ttoorle2t1,tr1F9e91s,t DWiirtehctFoCr 2o0n3 NAonrdsabTehre 1D6a,ph1a9i9d0,. 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A ape aipida ndiERex SE FgSRaEAevSitnae aBii eodynl SL aEwEaE RAR he 000677 ---- BEST COPY AVAILABLE Tle 2. Survival data trom tostetty teat : TceonWcme amotraoe n we. OWmeTNwnAEweBwEw M W Trwee W atm e teew r Wr Clam) 13P : oo3PE ofrsS rsorLos A s aoeo 150 1 PPoos oorr ! 5o3 rf f8t 03sar3s : s3 0 AP PPo ooo r roE b r8FE o sreos 3' "w Co3sbdoodbPsoeoobsdgssmto139o.918 238 i AELam ol ma tgtd o aii.d essfCeed hTFeaaimgn laun se3So e3 tBEmhdo eBeI oa ndE Spd e TeElEeE lT ti R CsoYtLnyShseEaT lthaASnEt 0 ry ORCEE agFEA f Soepn a BER For Eattneed tattyvee reeeRe Toachiiass Geabtieo sein aelid iwi r= LLEe % | os atessetlasttation Cgedfiene tTTIN VIR bLeidia iMoS e o ddm baa isa0 n me S f fF D r r I ee e R te Se EuR n1 B shia ChaRUnSesEu AesFoR latnR aeSEaED SnERIe E TR afaS gbe a PE ReR i eAr RNYa|| P {Apa E E iSsR ea s T a aORa ELBTle TT a i a Re | Ee LL a Can 000678 BEST COPY AVAILAL. fa Tole 3. Metian ottective concentrations (3iS0s) fron tonicity tent a Exposure Whew When sso 1,000 sen 1.000 st co9n5tpeerncenhtinits - ots Caleamation = - & Seana ShhoRSreRelsaEIFUiEEaELtL BERET TTe HB Teme Saba i 5 L Gow TN CBRE ws or Chan ug a Cpe an 3SE a me vdbgoeea a tL CaXlR Ho SRE Ch LEREl aee a R Lada Ao b EeaAL G+ Fr heiihnPASE 5% 000679 BEST COPY AVAILABLE IX. REFERENCES ` P0irn8aDct.thieceA1.5d8s1e.iss(eD3n1e)tcis3oi0fonC(hPoeifnmailct)ha.els.CounAcmimlexCo3n.cerOnEiCoDg PtrhiencNiaptlueasl oAfccGeopotdancLeaboofratDoirtya OKcD. 1984, Guidelines for Testing of Chemicals, Section 3: Etfects on Biotic TSyestt.ens.AdopMteetdhoAdpr2i0l2,4,Da1p9h8n4i,d sp., Acute Immobilization Test and Reproduction CStoempmhuatn,atCi.oEn.. 1983. Computer progeas for calculation of CSO values. Personal EABe iEdeEn Co R SEaRGGlE RIE Ge Saogg gB DiEeHSJDREE A S HEEREEE s RSIa TeA dAI eRdEaagt y iyBRRIETEAFgEEesSnSs tThe SRT iiye 3GES hioboieoaiSdEaR geR 0S ERiE goRIelRagEaee LdEnTs 2d Ziihrda) pit BSReoEaTmmmviresstisHceEnsRSuTdynEwulaNbeo r s0176-i3 gl LsaagR CE Es E ee E aee Rd AaR rnSLSRAEEDRLTERERE E I i Basesamonairen po lana onl BE od 000650 BjEST copyAVAlLag v tom AppendixA.VATERQUALITYDATAFROMTOXICITYTEST oos e EeAeRS Fein i SHEE e neid | tne d Ca SAME fe pov aRle ias.= am Sos |P| R Ra EN Sa eas A e S abgES En GoH na o Ce a n L REFEE R ST EnTe do Tiana RR i: el ei i Era oa Ca LA Ra soa if en a ie | TEESE TORE | His Ci a Th URE SELA BRR Spi o oRis fan z AEs a 000681 Asended 3/3/91 BEST co PY AVAILAB, Table Al. SCeoansduucrteidvidtuyr,iagpi,toxtiecmpietryattuerset, aad dissolved oxygen concentration TcToncveonstinraaltion Bci.oiamieituiW semanw esnrieiRNE ..E.wmA, CL a Boma olor 1$P0o dd0mm Eee wo eesoo 717sss eamb3n wsaooo dm eo eo 7s ss se 150 3I1 fGeoow e eeoo eeseo sswooo wemzaa assooo Lo Ww we wa as I P 1 G Gew eGeooo egeeo moaaoo aam33a enwooe io wo Eas ; w I 1I feGwo dTaooo.e sdseeo wssoeo. aaszn1 aawoo 1 & ek woe am i 1 2 wed Cae ois enan,' Tan Eien ae ie ee no SE ER RE h31 Sa3tn 666600, T7 "G:S664d0%% 661600R iii S s800=iEE F1E s8y3 oslsoo Sa E essdh Ca3Seol0no TGeeepDHaisaelL oH t e e GRe dTia EEaSoIEAAaSs 8aalS0o 4 SAaLnA BRAETT SenRi eL o)1 60 TR ho ay 50 - SS EE TE EEMRT R eeEeT CR RR oe- F EOrRE BnARaRt AS, nLE B m Eee v sR nl E in n fapka eTRL n EEn a Awhan TaERERTEavate 16 ooftH 17 0MLa iE vGyhSEISERT NR TY F 3 GEaEeREl S i AREAT NYmene lmie ro [oa5 ge os Se aeR RINEReNg F SUoN TRESE 000682 r------------------ amented 3/3/51 Tle AL Continued. BEST COPY AVAILABLE conceNnontsraaattion TT wnw e Tw R CE a Ba e5 tte onaes w tarts --_ lem ThMMww 13.33 w1aho1a9 ossse ass a3 3 obwhowos wnhnookaEs owpob mo 150 F ImEma3J ows 1oawhowwBsEe Bsmys ASen owldowdoow 3 ay ue 0 1 3ooomoaamalomo15apnnooBpmo3B333oodasoEwe se a aauee wou : 00 rGa,at cEmAs 030020 1 ln adellanRl 1i 909 O1TsE gs eEg an agy 81 i OSBFo lLp pC S y0e FiElaAR lhRa a20(2s 30.v4oCaa9ln7ss0TB0EeAHnieRgaTta Lh ysealsLioie els ag asl2o Baae EFarR Caa pa20s136T1 521050.24 F4d9a1le baiase aCeBs70fo e Fa e4p *- Fe EE igE h RE R "E eit neSR i807 ER Nea Ge S FHeese SU hyaN d eR Sa uEES. T e SE eEe S BER GEle i f3oDF% aoo5gn7 Ei T uvicoosysn E tenststuiR y niabes.CER 0o1l74-e35 E SSE hsaEra Rs iEy NR LE E 5 a Cies C LHiomea S ssh r aiEr a BEe a EEE meron 5: a Se 0063