Document 3NbRLxq6X4DRaKn1DXg02qnaO

J u ly 9 , 1932 M essrs, P o rte r and R itch ie B a rriste rs, E tc, S t , Jo h n , $ew Brunsw ick Bear S irs: W h ave y o u r l e t t e r o f Ju n e 2 5 th r e f e r r e d to u s by the E thyl G asoline C orporation, In aswer to your f i r s t q u estio n , I a s sending you under se p a ra te cover today a cor;; o f D r, Keho@*s r e p o r t o f th e m ost r e c e n t i n v e s t i g a t i o n on th e h azards a s s o c ia te d w ith E th y l g a s o lin e , and caxi your a tte n tio n to th e f a c t th a t the p o s s ib ility of poisoning from load te tra -e th y l is ah e n tire ly d iffe re n t co n sld erati-n than the p o s s i b ilit y of poisoning from E thyl g a s o lin e , Exposure^- to le a d t e t r a e t h y l I s l i m i t e d t o - r e l a t i v e l y few men em ployed in th e m anufacture and b le n d in g o f th e compound and h as no r e l a t i o n to th e g e n e ra l p u b lic , E th y l g a s o lin e , on the. o th e r b.-:nd, r e p r e s e n ts a. f o r a in w hich lo a d t e t r a e t h y l l a d i s t r i b u t e d and c o n ta in s a maximm of 3 c .c , o f lo ad te tr a e th y l p e r g allo n (O .s.) of gaso lin e, . '. A ll o f our work, as can be seen from th e r e p r in t of D r. itehoe *s , h a s shown no ev id en ce t h a t I n d iv id u a ls exposed to E th y l G asoline have absorbed ap r e c ia b le q u a n titie s of le a d as a r e s u lt o f th e ir exposure. In o th er words, lead poisoning as a r e s u l t o f E th y l G asoline exposure i s unknown to u s . In th e p a r tic u la r s itu a tio n w ith which you are d ealin g , the p o s s ib ility of Ingestion o f E thyl Gasoline in tro ; duces a n o th e r q u a n t ltiv e ly much more Im p o rtan t f a c t o r ; namely g a s o lin e * As l i t t l e a s 15-30 grama (1 /2 - 1 ounce) o f g a so lin e taken by so u th have been f a t a l In humans in fo u r h o u rs, As t h i s am ount o f g a s o lin e would c o n ta in l e s s th a n 2 d ecig ram s of le a d i t can be seen th a t th e amount o f lead p rese n t in E thyl G asoline I s of no im portance In cases of E thy l G asoline ingestion* I n answer to question 3 , lead te tra e th y l w ill rem ain In so lu tio n in gasoline In the presence of w ater, but in the p resen ce o f in o rg a n ic s a l t s and s o i l exposed to l i g h t and a i r , i s soon c o n v e rte d to in o r g a n ic le a d s a l t s w hich may go I n to so lu tio n in the ground w ater, depending upon i t s re a c tio n (acidity or a lk a lin ity ), . In answer to your la s t q u estio n , any in to x ic a tio n from le a d In g a s o lin e as f a r a s our knowledge g o es, would be m ost lik e ly to produce symptoms-resembling those o f P ain ter* s C o lic, - K 0011870 2 " - ; : ; r Your p ic tu r e o f c o rro sio n o f th e mouth and ill n e s s in a , " ch ild stro n g ly suggests the re s u lt of gasoline ingestion but determ ined by an aly sis of the contents o f the r '"v- ; C v - *" . ' V ,, . I t would seem t h a t you have two f a c t o r s to c o n s id e r and evaluate in your handling of th is case* F irs t, the p o s s ib ility o f g a s o lin e in to x ic a tio n from gasollne,jL n w e ll w a te r. Second, the p o ssib ility of lead in to x icatio n isT the leaching action of w ater o n -s o il p rev io u sly contam inated by le a d d e p o s its . In any event* th e occurence o f e i th e r type o f p oisoning would depend on the opportunity f o r exposure, and th is could b est be determ ined by a n a ly tic a l exam inations o f the w ell w ater, both for gasoline w hich i s somewhat s o lu b le in w a te r , am W ell a s f p r le a d . Another p o in t in an exam ination fo r the p o s s ib ility fo r exposure* i s th e amount o f g a s o lin e s p illa g e . At th e p re s e n t c o n c e n tra tio n s o f le a d te tr a e th y l in g a s o lin e , i t would re q u ire a s p illa g e o f co n sid erab le amounts to supply enough load to co n ta m in a te a w e ll some h u n d red s o f y a rd s away, assum ing t h i s w e ll to fee a d riv e n w e ll . I can th in k o f no b e t t e r way o f g e t tin g a t th e f a c t s o f t h i s case than by an exam ination o f the w e ll w a te r. I f g a so lin e is p resen t e ith e r fre e or in solution* then th ere are very d e f i n i t e o p p o r tu n iti e s f o r p o is o n in g by g a s o l i n e . The same holds tru e i f lead s a lts are presen t in concentrations g reater than 2 m illigram s per l i t e r . I f both are absent then there can be no p o s s ib ility of in ju ry from th e causes m entioned. 1# s h a ll be glad to conduct th e a n a ly tic a l exam ination fo r you or check any which you have alread y had done, i f you w ill send samples p er in stru c tio n s* If:we- can be o f any fu rth e r se rv ic e to you, do n o t h e s ita te to l e t us know. ( Very tru ly y o u rs, WMsIS P.S* Samples a re b e s t o b ta in ed in chem ically c le a n one g a llo n g la ss ju g s , clo sed w ith cork sto p p er and covered and sealed w ith p a p e r . Two one g a llo n ju g s o f th e w a te r w i l l be a d e q u a te f o r o u r p u rp o s e s . T hese may be s e n t e x p re s s t o D r. B o b ert A* Kehoe D spartsent of Applied Physiology, C ollege of M edicine, C in cin n ati O illO * ' '' .