Document 3NawdnxeoKNZx6Qp1dVzgk2qy

Ill STUDY DATA VALIDATION: REPEATED: EPA STATUS: CODE SHEET YES - submitted to regulatory agency HO * not submitted to regulatory agency Validation Codes: A = Acceptable PA B Probably Acceptable I Inconclusive ND B No Data If atudy has been repeated, name of contract laboratory will be shown. Status of Repeated Study Codes: S * Submitted to regulatory agency C * Completed - not submitted to regulatory agency IP Repeat study is in progress Comments: HR |158 = Hot required by Section 1S8 Obs. Form. = Obsolete formulation HONS 016973 AUDITED BY EMC ACt (Chlorinated Isocvanurates) in HUMBER STUDY TYPE 7S1 18 Month Mouse Skin Painting 756 Mutagenicity Mouse 756-A 75B-B 7SB-C 5204 3205 Teratology Rat (onoaodlun cyaaurate) Teratology Rat (calcium hypochloride) Teratology Rat (mooosodium cyanurate and chlorine) 24 Month Rat 10 Month Mouse VALIDATION Yes ** REPEATED No Tes No*** Questionable Yes PA IRDC Yes PA No Yes PA No Yes Yea I ** IRDC Hazleton EPA STATUS S IP IP ABORTED STUDIES 621-753 24 Month Rat' 621-755 18 Month Mouse Yea Yes I I ' Replaced by 3204 Replaced by 3205 * Additional mutagenicity studies completed, submitted to EPA ** riJC letter showing submission. Do not have audit results. HONS 016974 III NUMBER STUDY TYPE lOM Hone Nos* 90-Day Rat Suaaury-Rat Suasary-Dog None 90-Day Dog Neat J-6672 Acuta Inh.-Rat Quail Tox. J-6673 Quail Tox. A-6849 4-Day Fish A-6674 4-Day Fish A-6675 4-Day Fiah 651*03025 -Day Quail 651*03026 8-Day Duck 665-03027 4-Day Fish 622-05250 2-Yr. Rat 622-05252 Adda. Mutagenic Mouse 651-05254 Teratogenic Rabbit 623-06*41 3-Generation Rat 6530-09030 Cholinesterase 6560-09119 6531-09714 Neurotoxicity 4-Week Dog 6532-10762 90-Day Mouse 6532-09*20 2-Week Mouse *5*0-105*0 2-Year Dog 5*0-10813 Neurotoxicity Resubmitted 4/80 AVADEX6 VALIDATION Yea ND Yea ND Yea ND Yes ND Yes ND Yes A Yes A Yes ND Yes ND Yes ND Yes I Yes A Yes A Yes PA Yea PA Yes I Yes PA Yes PA Yes A Yes A Yes PA Yes A Yes PA Yes ND Yes PA REPEATED EHL EHL Bioresearch EPA STATUS C/90-Day Haanter C/90-Day Haaster EPA Valid EPA Valid EPA Valid EPA Valid EPA Valid IP/Lifetiae Baas ter Pending IP, Rat EPA Valid EPA Valid EPA Valid Pending EPA Valid HONS 016975 IIT NUMBER C-4835 STUDY TYPE 90-Dy Dog I-U34 J-6676 90-Day Rat Quail Tox. J-6677 A-6678 A-6679 A-8149 651-02842 651-03023 622-05251 Quail Tox. 4-Day Fish 4-Day Fish 21-Day Dermal 8-Day Duck 8-Day Quail 2-Year Rat 622-05253 Add Mutagenic Mouse 651-05255 Rabbit Teratology 623-06642 3-Geoeratloo Rat 6530-9030 Cholinesterase 6550-9120 Demyelination 6531-9715 4-Week Dog 6532-10763 90-Day Mouse 6532-09621 2-Week Mouse 6560-10581 2-Year Dog 6580-10814 Neurotoxicity Resubmitted 3/80 AVADEX9 BW VALIDATION Yes ND Yes ND Yes A Yes A Yea ND Yes ND Yes PA Yes A Yes I Yea PA Yes PA Yes I Yea PA Yes FA Yes A Yes A Yea PA Yes A Yes PA Yes Yes PA PA REPEATED EPA STATUS EKL Chroulc Dog Valid S IBT 651 2842 Valid NR f 158 ABC S ABC IRDC S S SPA Valid EPA Valid Bioasaay IP (re placing v/ life.hamster IRDC EHL EPA Valid S IP EPA Valid EPA Valid EPA Valid EKL IP/Chronic Mouse EHL S/90-Day Hasuter EPA Valid Abou-Donia/ Metcalf/Honson IP HONS 016976 LASSOO IBT MUMBER 621-01182 STUDY TYPE 18-Month House > 1182 J 1183 1 1184 622-01185 4-Week Mouse Teratogenic Rsbbit Mutagenic House 3-Ceoerstion Ret E 1755 Quell Residue K 2716 4-Day Fish 651-02841 8-Day Duck 651-03022 663-06288 8-Day Quail Acute Inhalation-Rat 663-06288 30-Day Inhalation-Rat 663-06288 90-Day Inhalation-Rat 8536-08850 Recoob Assay 8536-08852 Rev. Mutation 8533-08849 Host Mediated Assay 8533-08851 Host Mediated Assay 8530-9421 21-Day Deraal 8-4477 90-Day Rat C-4478 90-Day Dog A-5478 Acute Oral A-5478 Acute Dense 1 A-5478 Acute Skin A-5478 Acute Eye A-5478 Acute Vapor VALIDATION Yes PA Yes A Yes I Yes A Yes PA Yes I Yes PA Yes A Yes A Yes A Yes A Yea PA Yes A Yes MD Yes A Yes I Mo A Yes PA Yes m Yes m Yes PA Yes HD Yes HD Yes PA REPEATED Bio/dyanoics IRDC Bio/dynaaics Bio/dynamics 1ST (JAPAN) 1ST (JAPAN) EPA STATUS Pending EPA Valid s MR | 158 EPA Valid EPA Valid EPA Valid S Pending Pending S S EPA Valid EPA Valid Mot Regiat. Pharnacopathics S Blo/dynamics s Bio/dynamics s Bio/dynanics s Bio/dynamics s Bio/dynamics s HONS 016977 LASSO* 1R HUMBER STUDY TYPE A-5488 4-Dy Fish A-S488 4-Day Fish 5987 90-Day Rat (Metabolite) 4-62(5 Acute Intraperitoneal C-S988 90-Day Dog (Metabolite) J-5989 Meat & Milk Res. Cow J-5990 Meat Rea.-Swine A-8011 Acute Inhalation J-7215 Quail Tox. J-7489 Acute Oral Quail A-7274 4-Day Fiah (Foraul.) AUO Eye Irr.-Rabbit 21-01180 2-Year Rat C 1181 2-Year Dog VALIDATION Yea ND Yea ND Yea ND Yea A Yea A Yea ND Yea PA Yea A Yea A Yea i Yea ND Yea A Yea PA Yea PA REPEATED ABC Lab. ABC Lab. Bio/dynamica Bio/dyosmics Bio/dynamic* ERL EPA STATUS s S RR 1 158 EPA Valid NR | 158 Plsoainf EPA Valid S Ob* Fora Oba Fora n t 158 s s IP HONS 016978 MACHETES T HUMBER STUDY TYPE A-7679 A-7M0 21 Day Dermal 21 Day Dermal . ->703 C-8704 90 Day Rat 90 Day Dog A-M7S 4 Day Fish A-9966 21 Day Dermal 1-2314 Mutagenic Mouae C-2312 2 Year Dog <21-02310 <22-02313 2 Year Rat 3 Generation Ret <21-02311 18 Month Mouae <51-02315 Teratology Rabbit A-1S71 4 Day Carp <51-04349 <51-04350 Acute Quail Acuta Quail ~ <21-04644 4 Day Fiah <21-04644 <33-0<lBl 4 Day Fiah (Rogue) Rec t <33-06181 Amea 623-08180 Hoat Mediated Rat/Mouse <380-09730 Realdue - Meat/Milk 8580-09731 Residue - Chicken >580-09732 Residue - Swine <580-08812 4 Day Carp VALIDATION Yes A REPEATED Yes I Yes Yes PA PA Bio/dynamics Yes A Yes PA Yes A Yea PA Yes A Yes PA Yes I Yea I Bio/dynamics Bio/dynaaiics Hasleton IRDC Yes PA ABC Labs Yes Yes A I Wildlife Int . Yea A ABC Labs Yes A Yea PA IET (Japan) Yes Yes A A Dayton Labs Yes Yes FA PA Raltech Yes A Yes PA ABC Labs EPA STATUS Pending S Valid Chronic HR 8158 Obs. Fora. Planning KPA Valid IP IP IP 8 cm 8158 s HR 8138 S HR |1S8 S s Planning ip EPA Valid EPA Valid C/NR 8158 HONS 016979 POLARIS* 1ST HUMBER STUDY TYPE -8424 90-Day Rat C-8425 9Q-Day Dog A-8426 21-Day Deraul J-8427 Acute Quail A-8428 4-Day Flab J-9S62 Residue, Heat Milk J-9563 Residue, Swine J-9564 Residue, Chicken 1-955S 2-Year Rat >9558 18-Month Mouse C-9556 2-Year Dog 9560 3-Ceneratlon Rat 9561 Mutagenicity, Mouse J-9565 Teratology, Rabbit 330 90-Day Rat (Metabolite) A-9557 30-Day Fish 9559 Quail Residue >726 Residue Fish A-9615-A.B, Acute (Metabolite) c,o A-12I2 Acute Oral Rabbit 651-02(43 8-Day Duck 651-03024 8-Day Quail 651-05474 Residue Meat Milk 632-05475 Residue (Mctabolite) VALIDATION Yes A REPEATED Yes A Yes PA Yes A Yes I Yes I Yes A Yes PA Yes I Yes A Yes A Yes A Yes A Yes A Yes PA Yes HD Yes ND Yes ND Yes PA,A,A,A Yes A Yes PA Yes A Yes i Yes PA EPA STATUS EPA Suppl. Pending Pending Reading Reading Pending Pending SPA Valid Pending HR i 158 HR | 158 HR | 158 HR f 158 EPA Valid EPA Valid Pending Pending HONS 016980 POLARIS# IIT HUMBER STUDY TYPE 863*05685 Acute Inhalation 633*05711 Excretion (Metabolite) 632*05713 Residue Chicken 530*09030 Cholinesterase 380-09116 Neurotoxicity VALIDATION Yea A Yea i Yea i Yea PA Yea p REPEATED EPA STATUS Pending Pending Pending EPA Valid. EPA Suppl HONS 016981 RAMROD* IIT HUMBER STUDY TYPE VALIDATION 1*5083 Chronic Rat w/Metabolite No 1*5088 1*5085 Chronic Dog v/Metabolite No Reproduction w/Hetabolite No 1-5013 M-5088 90-Day Rat w/Hetabolite 90-Day Dog w/Matabolite No No A-7113 21-Day Deratal Yes PA A-7112 A-7542 4-Day Fiab, E.C. Acute Rabbit Tes A Yes A J-7214 821-01172 Quail Ranrod/Atrazine 24G Yes A 2-Year Rat Yes A C-1173 2-Year Do| Tes A 1-1178 821*01178 8-Week Houae 18-Month Mouse . Yes PA Yes PA J-1175 822-01176 Teratology Rabbit 3-Generation Rat Yes A Yes A 1-1177 Mutagenicity Mouse Yes A A-1330 21-Day Deraal Raatrod/ Atrazine Yes PA A-1721 Acute Deraal Ramrod/ Atrazine Yes PA 1*1751 1*2716 Quail Reaidue 4-Day Fish Raarod/ Atrazine Yes A Yes PA 651-02880 8-Day Duck Yes PA 651-03021 8-Day Quail Yes A REPEATED EHL IRDC EPA STATUS NR | 158 HR t 158 MR 1 158 HR t 158 HR i 158 Fending MR | 158 HR | 158 Obs. font. Pending Pending Completed Pending Ongoing Pending Pending Obs. fora. Obs. font. ABC Lab. EPA Valid Submitted Wildlife Int. Wildlife Int. Ongoing Ongoing HONS 016982 RAMRODS IK DUMBER STUDY TYPE 663-06289 663-06289 663-06289 Acute Inhalation 30-Day Inhalation 90-Day Inhalation 663-08178 601-08178 Acute Dermal-Hamster Acute Demal-Haaster VALIDATION Yea A A A Tea PA Yea A REPEATED EKL EPA STATUS Plannini NR | 158 NR | 158 MOMS 016983 1ST NUMBER 1 40 STUDY TYPE 90-Day Rat C 4807 90-Day Dog J 7181 Acute Quail A 7180 Acute Trout 623*7090 Dominant Lethal 651*0791 Teratology-Rabbit RANDOM VALIDATION ys I Tea I Yea ND Yea PA Yea A Yea A REPEATED EPA STATUS EPA Valid EPA Valid EPA Valid HONS 016984 ROUNDUPS IBT NUMBER STUDY TYPE VALIDATION SM J-565 SM B 567 J 5M > 569 1020 A 1549 C 1021 B 1753 A 2144 B 227B T 2279 > 2278 A 2277 A 2448 645-03629 (51-03918 651-03917 651-03920 651-03775 2-Tear Rat Yes PA 2-1etc Dog Yes A 3-Generation Rat Yes A Mutagenic Mouse Yes A Teratogenic Rabbit Yes A 18-Month Care. Mouse Yes FA 90-Day Rat Yes A 21-Day Dermal (HON 2139) Yes A 90-Day Dog Yes A Quail Residue Yes A 21-Dsy Dermal Rabbit Yes A 4-Day Fish Yes A Acute Inhalation Rat Yes A 4-Day Fish Yes A Acute Oral Rabbit Yes A 21*Day Deraal Penetration Yes A 4-Day Fish Yes A Chicken Residue Yes A Tox. & Repro. Chicken Yes A Swine Residue Yes A Meet & Milk Res.-Cattle Yes A 632-03894 621-04177 Milk & Fish Res.-Cov 4-Day Fish Yes A Yes A REPEATED Bio/dynamics Bio/dynamics IRDC IRDC Bio/dynamics Bio/dynamics IRDC ABC EHL ABC Bio/dynamics EPA STATUS S SPA Valid S S S c BPA Valid S EPA Valid NR | 158 S s s s NR i 158 c NR | 138 EPA Valid EPA Valid EPA Valid Invalid/ Determining Cause EPA Valid NR f 158 HONS 01698S ROUNDUP* IBT NUMBER STUDY TYPE 601-05044 21-Day Oral Rabbit (51*05275 Teratology Rabit <21*05412 4-Day Fish <01*05848 Acute House <63*06290 Acute Inhalation Rat <63-06290 30-Day Inhalation Rat <63*06290 <01*06527 <33-07801 90-Day Inhalation Rat Cbollnesteraae Rccoab. Assay <33-07507 Reverse Mutation <23-07508 Host Mediated Assay 8580-09117 Neurotoxicity VALIDATION Yea A Tea A Tea A Yea A Yea PA Yea PA Yea PA Yea A Tea HD Tea ND Yea I Tea A REPEATED Bio/dynanics IRDC Bio/dyoaoics EKL EHL gut IET (JAPAN) EHL EPA STATUS c S s EPA Valid S Ongoing Ongoing n 1158 S s EPA Valid HR { 158 HONS 016986 IIT NUMBER STUDY TYPE Pheasant LC50 C 4805 651-3332 651-3331 90-Day Dot Quail LC50 Duck LC50 623-7092 Dominant Lethal 651-7093 Teratogenic-Rabbit 8530-9030 Cbolineateraae 580-9118 Neurotoxicity 560-9701 4-Day Fish 8560-9701 4-Day Flab 8531-9716 4-Week Dog 8532-10764 90-Day Mouae 8 4804 90-Day Rat 580-10582 Chronic Dog 8580-10815 Neurotoxicity VEGADEX8 VALIDATION Yea ND Yea ND Yea PA Yea A Yea A Tea A Yea PA Yea A Yes A Yea PA Yea I Yea PA Yea I Yea PA Yea PA REPEATED EPA STATUS EPA Valid EPA Valid EPA Valid EPA Suppl EPA Valid MOMS 016987 CP 76100 IIT HUMBER STUDY TYPE 8S33-08920 Dominant lethal House 8580-08921 Teratology Rabbit 8580-08922 2-Year Dog 8533-08923 3-Generation Rat 8560-08924 28-Day Rat 8560-08924 2-Year Rat VALIDATION Yea A Yea A Yea A Yea PA Yea A Yea PA REPEATED IRDC EPA STATUS hading Pending Pending IF/House Study HONS 016988 HAP INTERMEDIATES IK NUMBER STUDY TYPE A 1013 Acute Dermal v/Ethyl PCt A 2002 4-Day Fiah v/CP 41820 A 2002 4-Day Flah v/ CP 41820 663-04291 Acute Inhalation w/2,6Dietbyl Aniline VALIDATION Mo A No A No A No PA 663-06291 30-Day Inhalation v/2,6Diethyl Aniline No I 663-06291 90-Day Inhalation v/2,6Diethyl Aniline No PA 663-06292 Acute Inhalation w/Niaoptopyl Aniline No ND 663-06292 30-Day Inhalation v/Niaopropyl Aniline No ND 663-06292 90-Day Inhalation w/Nlaopropyl Aniline No I 8362-10006 28-Day Inhalation v/ Dichlo ropropene No A 8562-10007 28-Day Inhalation w/Tricfaloropropene No A 8362-10008 28-Day Inhalation v/Tetra- No chloropropene A REPEATED Younger EHL ainr Bio/dynaaica Bio/dynaaica Bio/dynaaica EPA STATUS C IP 90-Day-C 90-Day-C 90-Day-C HONS 016989 1ST HUMBER STUDY TYPE 611-0S545 90 Day Rat 611-05544 90 Day Dog DEQUEST9 2010 VALIDATION Yea PA Tea A REPEATED 1ST NUMBER STUDY TYPE B-747 90 Day Rat C-749 90 Day Dog B-2423 90 Day Rat 661-04633 Kldnay Evaluation LEVH-LITE9 VALIDATION Tea PA Tea PA Tea PA Tea PA REPEATED STATUS STATUS MONS 016990 1ST HUMBER -666 C-667 STUDY TYPE 90 Day Rat 90 Day Dog SAMTICIZER9 97 VALIDATION Yes PA Yea PA REPEATED STATUS IBT HUMBER STUDY TYPE 562-09836 4 Week Inhalation SB0-098S9 Teratogenic Rabbit 560*09861 4 Week Oral Rat 560*10922 4 Week Feeding Rat SAHT1CIZER9 160 VALIDATION Yes PA Yes PA Yes PA Yes PA REPEATED EHL EPA STATUS C JSubchronic Data {available thru NTP SANT1CIZER8 334F/409 IIT HUMBER STUDY TYPE VALIDATION 652-02936 Abs, Dist 6 Exc Rats Yes I C-5101 2 Year Dog Yes A ^ P-5102 3 Generation Rat Yes A C-5101 2 Year Rat Yes HD REPEATED IBT HUMBER STUDY TYPE 722-04769 90 Day Rat 611-04770 90 Day Dog SANTOLITEB MHP VALIDATION Yea PA Yes PA REPEATED EPA STATUS EPA STATUS HOMS 016991 SAMT0PHEN8 1 1ST HUMBER STUDY TYPE VALIDATION 1-2014 Mutagenic Mouse Yes A A-2006-A A-2006-B Toxicity Study Toxicity Study Yes Yes I A A-20M-C Toxicity Study Yes i A-20M-D Toxicity Study Yes A A-2007 21 Day Deraal Ye* A B-2010 90 Day Rat Yea PA <22-02012 Teratogenic Rat Yes PA <22-02012 Perinatal & Lactation Rat Yes PA <22-02012 Reproduction Ret Yes PA C-2009 21 Day Oral Beagle Yes A C-2011 90 Day Oral Beagle Yes PA J-2013 Teratogenic Rabbit Yes I M-2014 3 Week Inhalation Rat Yes I REPEATED EHL EHL EHL EHL Bio/dynamic* EPA STATUS S s S 8 S HR HONS 0X6992 TCC 1ST NUMBER STUDY TYPE B-4533 J-4534 Reproduction: Fertility & Kepro Rat Teratology Rat Teratology Rabbit Peri & Postnatal Rat *-9333 Metabolism Rat 1-9501 Metabolisa Rat S-9S00 Metabolism Monkey T-9354 Pharmac. Profile 1-9571 Mutagenic Mouse J-9572 IB Month Dermal Mouse J-9573 1-9574 Reproduction: Fertility & Repro Rat Teratolngy Rat Teratology Rabbit Perinatal S Lac Rat 1-1706 Reproduction: Experiment One Experiment Two -9375 2 Year Chronic Rat 0-2445 Histologic Eval/Tissues M-9356 90 Day Oral Monkey 533-07685 3 Generation Rat 532-09668 12 Month Chronic Rat VALIDATION Yea Yea Yes Yea I I I ND Yes I Yen I Ten I Yes ND Yet A Yea A REPEATED * * *# ** ** EPA STATUS Yes Yea Yes Yes 1 A A A * * Yea Yes PA PA * Yes I ' Bio/dynamics S Tea ND Yea PA (PSG slides viewed by IBT) *** Yea Yes A PA Bio/dynamics **** C * Superseded by 3 generation study conducted at Bio/dynamics ** Information on metabolism of TCC8 in open literature (PSG) ** p&G conducted studies on neonatal oionkeys submitted in their NDA**** **** Superseded by 2 year chronic toxicity study conducted at Bio/dynamics MOWS 016993 IK NUMBER STUDY TYPE J-2027 90 Day Oral Dog J-2026 90 Day Oral Rat RPC-1110 - 1114 VALIDATION Yea A Yea PA REPEATED EPA STATUS HONS 016994 BENZYL CHLORIDE IIT HUMBER STUDY TYPE VALIDATION 1562-09502 2 Week Inhalation Rat 5*0-09764 Teratology Rabbit 560-09764 Pilot Teratology No PA No A Ho A REPEATED EPA STATUS IFT RUBBER STUDY TYPE >-2430 90 Day Rat DEQUEST8 2001 VALIDATION Ho I REPEATED EPA STATUS HONS 016995 IIT NUMBER 463-06293 643-06293 663*06293 MHA Calcium Salt STUDY TYPE VALIDATION Acute Inhalation Rat No FA 30 Day Inhalation Rat No PA 90 Day Inhalation Rat No PA REPEATED EPA STATUS IBT NUMBER STUDY TYPE >-162 Teratology Rat -327 Pup Diaaectioo -9447 Teratology -9447 Teratology NTA VALIDATION No PA No PA Ho A Ho I REPEATED EPA STATUS PHOSGARD C-22-R nr HUMBER STUDY TYPE - 451-08222 Chicken Deayalination VALIDATION No A . REPEATED STATUS PHOSGARD 2XC-20 IBT NUMBER STUDY TYPE VALIDATION B-2S63 90 Day Rat Mo PA 451-08221 Chicken Denyelination No PA REPEATED STATUS HONS 016996 IK NUMBER STUDY TYPE *562-9848 4 Week Orel Rat IK NUMBER STUDY TYPE >-1320 90 Day Rat B-1320 90 Day Rat PHTHALIHIDE VALIDATION No PA REPEATED EPA STATUS PYDRAUL* VALIDATION No A Ho A REPEATED BPA STATUS nr bimber STUDY TYPE SANTICIZER0 141 VALIDATION J-1B17 Chicken Denyelination Ho PA REPEATED STATUS SANTICIZERS 143 IK HUMBER STUDY TYPE VALIDATION *3*0-10466 Chicken Denyelination Ho A REPEATED STATUS HOMS 016997 IBT NUMBER J-1819 651*08220 5ANTICIZER8 148 STUDY TYPE VALIDATION Chicken Deayelination Ho PA Chickea Denyclinatioa Ho PA REPEATED m STATUS SAHTICIZER8 154 1>T HUMBER STUDY TYPE VALIDATION 622*06840 90 Day Rat Ho A 651-05406 Neurotoxicity o PA 651*06149 Neurotoxicity Ho PA 562-08642 90 Da; Inhalation Rat Ho A 530-08649 21 Day Denial Rabbit Ho PA REPEATED EPA STATUS SANTICIZER8 711 IBT HUMBER STUDY TYPE VALIDATION >-1248 90 Day Rat Ho PA T-2728 30 Day Inhalation Rat Ho PA 663-03716 6 Ho. Inh Rat/Monkey Ho PA 663-04915 Filter Analyst* Ho HD REPEATED EPA STATUS HONS 016998 SANT0FLEX8 13 IIT HUMBER STUDY TYPE VALIDATION 542-09721 4 Week Inhalation Rat No I 533-09722 3 Generation Rat No PA 5*0-09725 Rat Teratoloty No PA 5*0-09724 Pilot - Pregn. Rabbit No A REPEATED EPA STATUS SANTOFLEX 77 XBT HUMBER STUDY TYPE VALIDATION 942-09721 4 Week Inhalation Rat No FA 933-09723 3 Generation Rat No FA 3*0-09727 5*0-09726 Rat Teratolosr Pilot - Pregn. Rabbit No A Ho A REPEATED EPA STATUS UT NUMBER STUDY TYPE 932-540OA 2 Tear Rat 532-5400B 2 Tear Rat (None) Pilot SANTOFLEX* 13 & 77 VALIDATION No PA Ho PA Ho PA REPEATED STATUS SAMTOGARD PVI XBT NUMBER STUDY TYPE 5*0-09870 Rabbit Teratology VALIDATION No PA 562-09849 4 Week Inhalation Rat No PA REPEATED EPA STATUS Rons 016999 IIT HUMBER STUDY TYPE (21*07175 2 Year Chronic SANT0S0L9 100 VALIDATION Ho A REPEATED EPA STATUS UT HUMBER STUDY TYPE 621*07876 2 Year MCS 1045 621*07874 2 Year MCS 1302 SANT0S0L8 200 VALIDATION Ho A Ho A REPEATED EPA STATUS in HUMBER STUDY TYPE 622-04565 90 Da; Oral Rat SAHTOSOLft 300 VALIDATION Ho PA REPEATED EPA STATUS SAMT0S0L6 340 in HUMBER STUDY TYPE B-8833 90 Day Feedins VALIDATION Mb B ' 8562-06032 6 Ho Ioh Rit/Hustec/ Hookey No B REPEATED EPA STATUS UI HUMBER STUDY TYPE 632-03973 Mutagenic Mouse SAMTOHHITE* VALIDATION Ho PA REPEATED EPA STATUS 1ST NUMBER A-2I32 STUDY TYPE 21 Day Dermal SKYDROL9 LD VALIDATION No PA REPEATED EPA STATUS HONS 017000 IBT HUMBER STUDY TYPE 533-091IS Rat Teratology 5(2-9407 90 Say Inhalation HOHOCHLOROBEH2ENE VALIDATION No PA Mo PA REPEATED EPA STATUS IBT HUMBER STUDY TYPE B-161 1 Ganeration Repro Rat I-5E2A Mutagenic Mouae J-21S1 Teratology Rabbit 1-161 Teratology Rat 1-25(5 Metaboliam Rat (32-0(125 Metabolise Rat DMAC VALIDATION No I Ho A Ho I Ho I Ho A Ho I REPEATED STATUS HONS 017001 1R HUMBER STUDY TYPE -1315 90 Day Oral Rat THERMIMOL 55 VALIDATION Ho A REPEATED EPA STATUS 1BT HUMBER STUDY TYPE 1*1312 10 Week Oral Rat THERMIKOL 66 VALIDATION Ho PA REPEATED EPA STATUS TRIBUTE! PHOSPHATE IBT HUMBER STUDY TYPE VALIDATION J-2153 Xeurotoxlcity Chicken Ho PA REPEATED SPA STATUS XBT HUMBER J-1B16 TRIFKEHYL PHOSPHATE STUDY TYPE VALIDATION Xeurotoxlcity Cblckeu Ho PA , REPEATED EPA STATUS % HONS 017002