Document 3NOodKjw1GmzmX11NdqQG6ZdO

Monsanto Monstnto Compiny 800 N. Lirdb*rgh Boulevard St. Lou*t> Missouri 03106 <3141 OXford 4-1000 April 15, 1969 Dr. Joseph Calandra Industrial Bio-Test Laboratories, Inc. 1810 Frontage Road Northbrook, Illinois 60062 Dear Joe: Concerning my recent telephone conversations with Otis and the exchanges of correspondence concerning the Aroclor studies at your laboratory, this letter is to authorize you to initiate as soon as possible studies 5 through 9 on the attached. The dollar coats are taken from Dr. Fancher's letter and suggested protocols dated September 9, 1968 and his letter and revised protocol for the chicken and duck studies dated April 10, 1969. In a conversation with Otis yesterday he indicated that the cost of the chicken and duck studies using three dosage levels for three materials would be $20,000 for chickens and $20,000 for the mallards rather than the $22,500 shown on his letter of April 10. In an attempt to keep our expenditures to approximately $90,000 for the year 1969, I have shown prorated costs of $96,250 for 1970 and $36,000 for 1971, for those projects which will run through 1970 and into 1971* I would appreciate it if Dr, Fancher or Mr. Berndt could let me know the date that these various studies are started, perhaps, using your usual forms such as you send Dr. Hunt. Please note that we are deferring the subacute fish toxicity studies unti^we get a better idea of work which is underway in Europe or other laboratories in the U. S. Best personal regards. Sincerely, A"i: M0N5 087904 Imer P. Wheeler Manager, Environmental Health EPW-.cJs CC*. Otis Fancher, W. R. Richard, R. E. Keller, E. S. Tucker, H. S. Bergen, J. E. Springgate, C. Paton EXHIBIT E '"WBF83UT TOWOLDMON0003307 WATER_PCB-00000329 1 TOXICITY STUDIES ON AROCLORS FOR MONSANTO CO. AT INDUSTRIAL BIO-TEST LABORATORIES , ,, 1) Rat tissue studies (completed) 4 Aroclors, DDT, Toxaphene 2 chlorinated naphthalenes 12^2 4,500 1210 2) same as above in chickens ? 3) Acute Fish toxicity (underway) 4 Aroclors - 4 day TLM 1,600 4) Sub-acute fish toxicity to be deferred ------ 5) 3-generatlon rat study 10,000 Aroclors 1242, 1254, 1260 Takes 18 months-total cost $35,000 25,000 6) 2-yr chronic-rats 3 Aroclors as in (5) Total cost $57;500 12,750 28,750 7) 2-yr chronic-dogs 3 Aroclors as above Total cost - $85,000 8) Chicken reproduction, egg shell thickness Ca and P content, etc. 3 Aroclors as above 22,500 20,000 42,500 9) Same as 8) but In Mallard ducks 20,000 191350 $95,250 1971 16,000 20,000 MOMS 07219? TOWOLDMON0003308 WATER_PCB-00000330