Document 3Jqzgn5z6Qjg5X5yVXdmzV6XO

f A N D/ CHE M IC A L i y 4 C0 RPRATI ON W ESTVA CD CHEM ICA L DIVISION CABLE "CAUSTI'C"V, NE W Y>ORK Te l e ph o n e Mu r r a y h il l 7-7400 PLEASE REPLY TO CHRYSLER BUILDING EAST t6i e a s t 4 2 n d s t r e e t NEW YORK 17. N. Y. September 30, 1953 Robert Kehoe, M.D. UDnirievcetrosri,tyKoefttCeriinncginLnaabtioratories Cincinnati, Ohio ' Dear Doctor Kehoe: very mI uacmh uapppargecaiiantsetdaanpdrobolnemwhoinchwmhyiclhacykouorfamdveidciecawl oeudlducbaetion is proving a very serious handicap and upon which there seems itcnoadlbiveinidfaourramelsgartaeionttdna.bolregalnaiczkatioofnsunoannimwhiotmy wone dtheepenpdarftoor ftothxoisceologi DivisOiounr WofesPtovoacdoMCahcehminiecraylsanDdivCishieomnicaanldCtohrepoNraiatigoanraaCreheamcitciavlely engaged in the production of all sorts of economic poisons. pOCruhiremmSaiorcyualthpDroCidvhuiascrielorensstooisnf,mthWaeneysftooVrfmitruhgleaisnteoiarp, arolnaddbuodctrissattroainrbdieustthoear.reNiNathgieaagraara mlimaiinntaarinysscardeeeqnuiantge ogrfeeanhgoruesaet vanadriegtayrdeonf nfeawcicloimtipeosunfdosrpprordeu ced at Charleston with the hope that they may show suitable merits as economic poisons to justify large-scale field testing and ultimate introduction to the market. . Naturally, an early estimation of the toxic characteristics orefquthieresed.newInprthoedupcatsst(awveehraagveingreliniednumonbear d10eteorrm1i2naatiowneeok)f ithse LD50 by oral administration as Indicating the degree of toxicity ibtnryviaDollavvHeiddy.gWie.nInPe atashnsedetDOt,ecccMeump.Dbae.t,rio1na9na5dl2RMIosebsdeuicreitneLo.fthRAeo.Mrued.Aaa.bpuApsher,carhePidvhe.Dsan.o, af rItnicdlues eaaudntmthitoilnresidstvr"oaSitHcioOendRT-otThfEefReMroepdIiNnTiaRodAnvPaEtnhRtIaaTgtOeNstEhAoisLvemTrOeoXthrIoCadlITYaodfTmiEnSintTriSas"pt.reartiiTothoneneinal Ke 00.123 N14010 page 2 To Robert Kehoe, M.D* September 30, 1953 that It gave better Indication of the probable toxicity of the material v/hen administered by vapor inhalation or skin contact than would the simple oral administration, please understand that this question applies only to the very first toxicity tests on these new materials. It not infrequently happens that the results of these early tests Indicate such a high degree of toxicity to humans and other warm-blooded animals, irrespec tive of their merits as economic poisons, that we have abandoned further development of these products because we consider their toxic characteristics too high. If the preliminary tests indi cate a degree of toxicity falling within what we consider reasonable limits, we then go ahead with further greenhouse and garden screening tests to determine their potential value as economic poisons. These screening tests result in the elimination of upwards of 90% of the samples submitted for test ing. The remaining 10% that qualify for further greenhouse, garden, or field testing, we submit for further toxicological examination, including inhalation and skin contact or any other special determinations deemed necessary by the nature of the product, and suitable safety procedures are formulated for the guidance of both our own employees and any outside individuals who may be participating in field tests or ultimate market distribution* proceTdhueresab. oveThies qtuheestibornieIfeasmt rpaoisssiinbgleisouwtlhineteheorfoorunrobusuthael ' preliminary toxicity determination of chemicals as determined btiyoninmtraadpeebriytoonreaal laidnmjeicntiisotrnatiiosn.to be preferred to the determina to ofAfesrabinovethsistatceodn,neacntyioninfworilml abteionveoryr maduvchiceapyporuecfieaeteldp. repared With kindest personal regards, Xremain, Sincerely yours, WESTVACO CHEMICAL DIVISION FSL:hm prnk S. Low K 00123i6